WO2005046464A1

WO2005046464A1 - Papillary light reflex measuring instrument for evaluating relaxed feeling

Info

Publication number: WO2005046464A1
Application number: PCT/JP2004/016718
Authority: WO
Inventors: Yoshinao Nagashima; Hidetoshi Sadachi; Yukihiro Yada
Original assignee: Kao Corporation
Priority date: 2003-11-13
Filing date: 2004-11-11
Publication date: 2005-05-26
Also published as: JP4179968B2; JP2005143684A

Abstract

A papillary light reflex measuring instrument for evaluating a relaxed feeling (10) used when evaluating a relaxed feeling by tracking papillary light reflex, comprising a three-dimensional mask set (11) mounted on the face so as to cover eye portions, a pupil imaging means (12) and a light stimulating means (13) disposed on the inner surface side of the mask set (11) so as to face the eyeball of at least one eye, and a control analyzing means (14) connected with the pupil imaging means (12) and the light stimulating means (13) to control them, for recording a picked-up image sent from the pupil imaging means (12) and performing a computing analysis relating to a constricted pupil and a dilated pupil based on the image, wherein a total weight at mounting of the three-dimensional mask set (11) including the pupil imaging means (12) and the light stimulating means (13) is 30-120 g.

Description

Specification

Pupil-to-photoresponse measuring instrument for relaxation evaluation

Technical field

The present invention relates to a pupil-to-light reaction measuring instrument for evaluating a feeling of relaxation.

Background art

[0002] The pupil is a space that has an afferent path starting from the retinal optic nerve and is surrounded by iris muscles whose main autonomic nerve is the efferent path, and can provide information on the central nerve as well as the cranial nerve and the autonomic nerve. . Pupil research is remarkable, and in basic research, new knowledge has been obtained on the relevance to other nervous systems and the cerebrum and cerebellum by reviewing the light response pathway. In the area of clinical research, the scope of research has been expanded as a means of objectively evaluating visual inputs and as a means of elucidating the pathology of various neurological diseases.

[0003] Further, as a typical method of pupil examination, a pupil examination based on the principle of infrared Pupillogram is known. The principle of the infrared Pupillogram is that the human retina has no sensitivity S to the infrared light, so it is not possible that the infrared light incident on the retina by irradiating the infrared light will affect the light response, which is the mechanism of adjusting the amount of visible light. Therefore, changes in the size of the pupil due to visible light can be attributed to the force detected by the photoelectric element as a change in the amount of light reflected from the iris by irradiating the eye with infrared rays, or the change in the pupil area by the television camera. Recording and its screen power The principle is that it can be recorded continuously as an analog electric signal proportional to the pupil area! / ヽぅ.

[0004] Devices have been developed that analyze pupil movement due to light response based on the principle of infrared Pupillogram, and can clinically determine a subject's nervous disorder or consciousness disorder (for example, see Patents). According to these devices, the input system (mainly the optic nerve) is impaired, for example, by prolonging the light response latency, reducing the amount of miosis, and reducing the ratio of miosis. It is determined that the output system (sympathetic / parasympathetic) disorder is determined through the fact that the parasympathetic nervous system is reflected in the miotic phase and the sympathetic nervous system is reflected in the mydriatic phase.

Patent Document 1: JP-A-7-163522

Patent Document 2: JP-A-7-171104 Disclosure of the invention

[0005] On the other hand, due to various stress factors in modern society, in recent years, even healthy people, many people are suffering from stress, and the degree of such stress can be objectively evaluated. Therefore, it is desired that stress reduction methods such as exercise perromatherapy, etc., be incorporated into daily life as appropriate, so that a relaxed feeling can be obtained, and that daily health maintenance and improvement can be achieved more effectively. . Here, if physical and mental stress is imposed, the parasympathetic and sympathetic nervous systems may become out of balance, resulting in ataxia in the autonomic nervous system, which may lead to a state of mental hyperactivity, promptly falling asleep, It is generally known that adequate sleep is disturbed. It is also known that parasympathetic function can be made relatively superior to sympathetic function to alleviate these stresses and achieve a feeling of relaxation.

[0006] Therefore, in order to objectively and appropriately evaluate the degree of stress and relaxation, a method of determining whether the parasympathetic nerve is dominant or a method of determining whether the sympathetic nerve is dominant is employed. As a method for examining such a state in which the parasympathetic nerve is dominant or a state in which the sympathetic nerve is dominant, an apparatus for analyzing pupil movement due to light response based on the principle of the above-mentioned infrared pupilogram is used. Can be used.

However, according to the pupil-to-light reaction test apparatus based on the principle of the infrared Pupillogram described above, the test apparatus is a device capable of clinically determining a subject's neuropathy or consciousness disorder. Therefore, it is unsuitable as a test device that can be used easily by ordinary healthy people to find out the degree of stress and relatation for daily health management. In other words, the conventional pupil-optical response test device was used clinically to check for neurological disorders and consciousness disorders. As shown in Fig. 7, a large weighing device with a considerable weight of, for example, about 200 to 500 g was used. When this device is used to evaluate the feeling of relaxation, when the device is worn on the face, for example, a load that falls forward due to its weight is applied, and an extra load is applied to the neck to support the device. Because it is necessary to apply force or hold down the hand with the forward force, such an action appears as stress rather than affecting the feeling of relaxation, and the degree of stress and relaxation is objectively measured. It may be difficult to evaluate with high accuracy. [0008] Further, according to the pupil-to-light reaction inspection apparatus based on the infrared Pupillogram principle described above, the stimulus light for irradiating the pupil with visible light uses a convex lens between the light source and the eyeball in the open loop method. By placing the lens, the light is once converged in front of the eyes by the convex lens, and is narrowed down to a smaller diameter than the pupil at the time of miosis, and then is injected into the eyeball as a certain amount of stimulus. If the relative positional relationship between the light source and the pupil changes at each measurement, the light irradiation position may shift. Therefore, even if the irradiation light amount of the light source power is constant, each subject or the same subject Even in this case, the amount of light incident on the pupil changes at each measurement, which may make it difficult to objectively and accurately evaluate the degree of stress and relaxation.

[0009] The present invention provides a pupil-to-photoreaction measurement for evaluating a feeling of relaxation that can be easily used by, for example, a normal healthy person, and that can easily and objectively and accurately evaluate the degree of stress or relatation. About the tool.

[0010] The present invention relates to a pupil-to-light reaction measuring instrument for evaluating a feeling of relaxation used when tracking a pupil-to-light reaction to evaluate a feeling of relaxation, and is a three-dimensional mask that is worn on a face covering an eye portion. A pupil imaging unit and a light stimulating unit attached to the three-dimensional mask unit so as to face the eyeball of at least one eye; and connecting and controlling the pupil imaging unit and the light stimulating unit, Control analysis means for recording an image sent from the pupil imaging means and performing arithmetic analysis on the miosis and mydriasis of the pupil based on the imaging, and the pupil imaging means and the pupil imaging means of the three-dimensional mask unit The weight when mounted, including the light stimulus, is 30-120 g.

[0011] In the present invention, the three-dimensional mask portion is a mask having a three-dimensional shape with a hollow inside, and is attached to the three-dimensional mask portion when the pupil is attached to the face while covering the eyes. It has a shape-retaining rigidity enough to hold the imaging means and the light stimulating means at a predetermined distance from the eyeball of the eye. For example, a goggle-type mask can be used.

Brief Description of Drawings

FIG. 1 is a perspective view showing a state in which a three-dimensional mask portion of a pupil-to-light reaction measuring instrument for evaluating a feeling of relaxation according to an embodiment of the present invention is attached to a face of a subject. FIG. 2 is a perspective view illustrating a configuration of a three-dimensional mask portion of a pupil-to-light reaction measuring instrument for evaluating a feeling of relaxation according to one embodiment of the present invention.

FIG. 3 is an explanatory diagram of a control analysis mechanism in a pupil-to-light reaction measuring instrument for evaluating a feeling of relaxation according to one embodiment of the present invention.

[4] FIG. 4 is a chart for explaining the analysis parameters calculated and analyzed by the control analysis means.

FIG. 5 (a)] FIG. 5 (a) is an explanatory diagram of the photostimulator of the present invention in Reference Example 1.

圆 5 (b)] FIG. 5 (b) is a diagram of the relative light emission intensity distribution on the light receiving surface obtained in Reference Example 1. FIG. 6 (a)] FIG. 6 (a) is an explanatory diagram of the photostimulation device in Reference Example 2.

FIG. 6 (b)] FIG. 6 (b) is a diagram of the relative light emission intensity distribution on the light receiving surface obtained in Reference Example 2.

[FIG. 7] FIG. 7 is a perspective view showing a state in which a mask unit of a conventional pupil-to-light reaction test apparatus is attached to the face of a subject.

FIG. 8 (a)] FIG. 8 (a) shows the results of measurement of the degree of relaxation performed using the pupil-to-photoresponse measuring instrument for evaluating a feeling of relaxation according to the present invention and an electrocardiogram.

FIG. 8 (b)] FIG. 8 (b) shows the results of measurement of the degree of relaxation performed using the pupil-to-light reaction measuring instrument for evaluating a feeling of relaxation according to the present invention and an electrocardiogram.

FIG. 8 (c)] FIG. 8 (c) shows the results of measurement of the degree of relaxation performed using the pupil-to-photoresponse measuring instrument for evaluating a feeling of relaxation according to the present invention and an electrocardiogram.

圆 9 (a)] FIG. 9 (a) shows the results of measurement of the degree of relaxation performed using a commercially available pupil-to-photoresponse measuring instrument and an electrocardiogram.

[9 (b)] FIG. 9 (b) shows the results of measurement of the relatability using a commercially available pupil-to-photoresponse measuring instrument and an electrocardiogram.

圆 9 (c)] FIG. 9 (c) shows the results of measurement of the degree of relaxation performed using a commercially available pupil-to-photoresponse measuring instrument and an electrocardiogram.

[FIG. 10 (a)] FIG. 10 (a) shows the result of measuring the pupil diameter before light stimulation measured 15 minutes after entering the room in Example 2.

[FIG. 10 (b)] FIG. 10 (b) shows the results of measuring the amount of miosis changed by light stimulation measured 15 minutes after entering the room in Example 2. [FIG. 10 (c)] FIG. 10 (c) shows the results of measurement of the miosis rate changed by light stimulation measured 15 minutes after entering the room in Example 2.

[FIG. 11 (a)] FIG. 11 (a) shows the result of measuring the pupil diameter before light stimulation measured 45 minutes after entering the room in Example 2.

[FIG. 11 (b)] FIG. 11 (b) shows the results of measuring the amount of miosis changed by light stimulation measured 45 minutes after entering the room in Example 2.

[FIG. 11 (c)] FIG. 11 (c) shows the results of measurement of the miosis rate changed by light stimulation measured 45 minutes after entering the room in Example 2.

Detailed description of the invention

[0013] A pupil-to-light response measuring instrument 10 for evaluating a feeling of relaxation according to a preferred embodiment of the present invention is a light-response measuring instrument used for tracking a pupil-light reaction to evaluate a feeling of relaxation. As shown in FIGS. 1 and 2, a three-dimensional mask portion 11 that is attached to the face so as to cover the eyes, and a pupil imaging means 12 that is attached to the three-dimensional mask portion 11 so as to face at least one eyeball. And the light stimulating means 13 and the pupil imaging means 12 and the light stimulating means 13 are connected to each other to control them, record the image sent from the pupil imaging means 12, and based on the image, the miosis of the pupil and Control analysis means 14 (see Fig. 3) for performing arithmetic analysis on mydriasis is provided, and the weight of the three-dimensional mask unit 11 including the pupil imaging means 12 and the light stimulating means 13 when attached is 30-120 g. Has become.

According to the present embodiment, the pupil imaging means 12 includes an infrared CCD camera 15 and a light emitting diode 17 for infrared illumination, and the light stimulating means 13 scatters a plurality of visible light emitting diodes 18. It is composed of a cover 19.

Further, according to the present embodiment, the pupil imaging means 12 and the light stimulating means 13 are arranged so as to face the eyeball of one eye, and the inner face of the three-dimensional mask section 11 is provided with the other eye. A fixation light emitting diode 20 is provided so as to face the eyeball.

The three-dimensional mask section 11 constituting the pupil-to-light reaction measuring instrument 10 of the present embodiment is a goggle-type two-part mask formed of a non-light-projecting material, When the camera is worn on the face via the wearing belt 21 with each part covered, the peripheral part is in close contact with the skin of the face, blocking light from entering the hollow interior from the outside, and night vision Condition In addition to this, it is possible to effectively track the pupil-to-light reaction accompanying the light emission of the light stimulating means 13. This eliminates the need for a darkroom for dark adaptation.

The pupil imaging means 12 is composed of an infrared CCD camera 15 and a light-emitting diode 17 for infrared illumination. The infrared CCD camera 15 has a main body protruding outside the three-dimensional mask section 11 and its The lens part 16 faces one of the parts of the three-dimensional mask part 11 with the lens part 16 facing the center hole 22 of the annular band plate-shaped light scattering plate 19 arranged on the inner surface of the three-dimensional mask part 11. Installed. Further, a pair of the light-emitting diodes 17 for infrared illumination are mounted on the light scattering plate 18 in the shape of an annular band plate on both sides in the diametrical direction with respect to the center hole 22. The infrared CCD camera 15 has a frequency of, for example, about 30-60 Hz and a sampling performance of about 0.017-0.033 ms per frame, and is controlled by the control analysis means 14 to continuously photograph the pupil. At the same time, the obtained image is transmitted to the control analysis means 14.

The light stimulating means 13 is composed of, for example, eight visible light emitting diodes 18 and a light scattering plate 19, and each of the eight visible light emitting diodes 18 emits, for example, about 7 to 13 W. The light-scattering plate 19, which has strength, is disposed at an equal angular interval of 45 degrees in the circumferential direction on the annular-shaped plate-shaped light scattering plate 19, and is covered by the light-scattering plate 19. It is buried in the light scattering plate 19. Further, the visible light emitting diode 18 emits visible light at a predetermined lighting time of, for example, about 0.1 to 2 seconds and a predetermined lighting interval of, for example, about 10 to 60 seconds, under the control of the control analysis means 14. I can do it.

The light scattering plate 19 disposed over the visible light emitting diode 18 is made of, for example, acrylic resin, and has a size of about 3 to 14 mm in inner diameter, 25 to 45 mm in outer diameter, and about 0.5 to 5 mm in thickness. It is formed in the shape of an annular belt plate. The light scattering plate 19 is interposed between the visible light emitting diode 18 and the eyeball and is attached to the inner surface of the three-dimensional mask portion 11 so that a light beam output from the visible light emitting diode 18 is scattered. This makes it possible to form an image by forming an image after repeating reflection and refraction on the plate 19, thereby making the photostimulating means 13 function as a surface-emitting type element. is there.

[0020] In addition, since the light scattering plate 19 can increase the light emission area (bright spot) of the light stimulating means 13 and make the amount of light irradiated to the pupil uniform, for example, the face shape of the subject can be improved. Even if there is a physical individual difference or a relative displacement due to a difference in the distance between the light stimulating means 13 and the pupil due to a difference or a different measurement opportunity by the same subject, such a variation or displacement is caused by a large bright spot. By absorbing, it becomes possible to evaluate the relaxed feeling with high accuracy by making the irradiation light amount uniform.

It is preferable that the light stimulating means 19 composed of the visible light emitting diode 18 and the light scattering plate 19 be arranged at a distance of 13 to 35 mm from the eyeball of the eye. By arranging the light stimulating means 19 at a distance of 13-35 mm from the eyeball of the eye, the infrared CCD camera can be used even when there is a difference in pupil size between individuals or when the pupil moves and is not stable. When the image of the pupil falls within the range of the captured image, effective measurement can be performed.

The control analysis means 14 which controls the pupil imaging means 12 and the light stimulus means 13 and performs arithmetic analysis on the pupil miosis and mydriasis based on the image taken by the pupil imaging means 12, as shown in FIG. For example, a central processing unit (CPU) that combines a computer control unit and an arithmetic unit, a light stimulus control circuit that controls the lighting time and light intensity, and captures video signals from infrared CCD camera power Display board (CRT) that displays an image board, pupil image, pupil binarized image, and analysis parameter chart, pupil moving image, pupil diameter (Z value), and data recording device that records trigger signals, etc. It has. The control analysis means 14 comprises an infrared CCD camera 15 constituting the pupil imaging means 12, a light emitting diode 17 for infrared illumination, and a light stimulating means 13 via various wirings 23 (see FIGS. 1 and 2). It is connected to the visible light emitting diode 18 or the fixation light emitting diode 20 described below, etc., and controls these, records the image sent from the pupil image pickup means 12, and based on this image, According to various known arithmetic analysis methods, arithmetic analysis relating to miosis and mydriasis of a pupil is performed. The imaging and analysis results are displayed on a display device as needed.

According to the present embodiment, referring to FIG. 4, as analysis parameters, for example, the pupil diameter value in the initial state (Dl: mm), the changed pupil diameter value after light stimulation (D2: mm), Pupil ratio (CR: D2 ZD1), time required for the pupil to be minimized (Tl: m _Sec ), time required for the pupil to return to 63% of the minimum value from the minimum mydriasis (T2 : msec), miotic velocity (VC: mm / sec), The pupil acceleration (AC: mm / sec ² ) and the mydriatic velocity (VD: mm / sec) are calculated and analyzed by the constant force control analysis means 14.

Since the pupil-light response parameter cannot be absolute valued in pixel units, the pupil ratio can be obtained but cannot be applied to other parameters, and the measurement results are only used for data comparison within individuals. It will be limited. On the other hand, by expressing the pupil diameter in mm with the absolute value calibrator, other useful parameters (VC, VD, etc.) can be used. In addition, for simple absolute value calibration of the pupil diameter, the iris diameter with little individual difference can be regarded as a constant, and its value can be calculated by proportional calculation with 11 mm.

The miosis rate CR is interpreted depending on the type of stimulus, because depending on the type of stimulus presented, even if it affects the same autonomic nervous activity, it may not show a certain tendency due to the balance between D1 and D2 May be different. Thus, Dl, D2 and CR in mosquito卩Ete, VC, point force it is useful to use parameters such as V _D is also preferable.

In some cases, the pupil is determined not by diameter but by area. This is a point that the area can more accurately detect the size of the pupil. However, if the pupil is obstructed by eyelashes or the eyelids are not completely open, this may cause an error, so it is preferable to use the diameter.

According to the pupil-to-light response measuring instrument 10 for evaluating a feeling of relaxation of the present embodiment, the pupil imaging means 12, the light stimulating means 13, the fixation light emitting diode 20, the wiring 23 and the like are included. At this time, the weight of the three-dimensional mask portion 11 is 30 to 120 g, preferably 30 to 80 g. By setting the range, the goggles can be easily fixed to the face, for example, via a belt, and the measurement can be performed while supporting the goggles with a hand or the measurement result due to excessive load applied to the neck. The advantage is obtained that the effect of can be effectively avoided.

According to the present embodiment, the fixation light emitting diode 20 attached to the inner surface of the other part of the three-dimensional mask portion 11 so as to face the eyeball (non-measuring eye) of the other eye is It is provided to stabilize the measurement eye by removing the influence of the miosis of the eyeball (measurement eye) of one eye to be measured by turning on the visible light and gazing at the other eye. And has a wavelength of, for example, about 490-770 nm.

The sensation of relaxation is evaluated using the pupil-to-light reaction measuring device 10 for evaluating relaxation in the present embodiment. In order to evaluate, the three-dimensional mask part 11 is attached to the face so as to cover both eyes with each part, for example, after waiting for 90 seconds for dark adaptation, taking a reference time of 20 seconds, and controlling by the control analysis means 14, For example, a light stimulus with a lighting time of 0.25 seconds and a lighting interval of 20 seconds is performed five times via the light stimulating means 13. During this time, pupil imaging by the pupil imaging means 12 is performed continuously at an interval of, for example, 0.017 ms, and the imaging is completed 10 seconds after the fifth lighting. In addition, the captured images are sequentially sent to the control and analysis means 14 to perform arithmetic analysis, calculate various analysis parameters, and evaluate the degree of stress and relaxation.

[0027] That is, it is known that the action of the parasympathetic nerve is relatively superior to the action of the sympathetic nerve in a state of feeling relaxed. Is observed and the velocity factor is suppressed, and changes in analysis parameters such as increased caloric time of miotic period (T1), decreased miotic speed (VC), and decreased miotic acceleration (AC) appear. In the state of nerve suppression, suppression of the mydriatic phase and activation of the miotic phase are recognized. Therefore, by tracking changes in these analysis parameters, it is possible to objectively and appropriately evaluate the degree of relaxation. Will be possible.

[0028] It is also known that the function of the sympathetic nerve is relatively superior to the function of the parasympathetic nerve in a state of feeling stress. The pupil phase is increased and changes in analysis parameters such as shortening of the mydriatic time (T2) and increasing of the mydriatic velocity (VD) appear. And remarkable activation of the mydriatic phase, it is possible to objectively and appropriately evaluate the degree of stress by tracking changes in these analysis parameters.

According to the pupil-to-light reaction measuring instrument 10 for evaluating a feeling of relaxation of the present embodiment, for example, a normal healthy person can easily use the pupil-light reaction measuring instrument to easily know the degree of stress and relaxation, And the degree of relaxation can be objectively and easily evaluated with high accuracy. That is, according to the present embodiment, a goggle-type three-dimensional mask unit 11 that is worn on the face covering the eyes, a pupil imaging unit 12 and a light stimulus unit 13 that are attached to the three-dimensional mask unit, and control these. And a control analysis means for performing arithmetic analysis on the miosis and mydriasis of the pupil based on the obtained image. The three-dimensional mask portion has a lightweight and compact weight of about 30 to 120 g when worn. The structure makes it easy to handle Yes, while attaching and detaching the three-dimensional mask part 11 smoothly with a simple operation, for example, while standing

Alternatively, it is possible to easily evaluate the feeling of relaxation while sitting.

Further, according to the present embodiment, since the three-dimensional mask portion has a light weight of about 30 to 120 g when worn, even when the three-dimensional mask portion is worn on the face, the subject does not need extra Therefore, it is possible to easily and objectively evaluate the degree of stress and relaxation with high accuracy.

Further, according to the present embodiment, the light stimulating means 13 is configured by covering the visible light emitting diode 18 with the light scattering plate 19, increasing the light emitting area (bright point) to the pupil. Since the irradiation light amount of the subject can be made uniform, physical differences and relative positions due to variations in the distance between the light stimulating means 13 and the pupil can occur due to differences in the facial shape of the subject and different measurement opportunities by the same subject. Even if there is a shift, the degree of stress and relaxation can be evaluated more objectively and accurately by effectively absorbing such variations and position shifts by the large bright spots.

Further, according to the present embodiment, even if the time for adapting the B sound is as short as about 90 seconds, it is possible to appropriately track the pupil-light reaction thereafter, and It takes a considerable amount of time to adjust, for example, about 15 minutes, and there is no danger of causing drowsiness to the subject in night vision conditions compared to a conventional pupil-light reaction test device. It is possible to effectively avoid the influence on the pupil-light reaction due to drowsiness as described above. Also, by significantly reducing the measurement time, for example, the lighting time to 0.25 seconds and the lighting interval to 20 seconds, it is possible to effectively avoid the stress caused by the long measurement time. Will be possible. Therefore, it becomes possible to more objectively and accurately evaluate the degree of stress relaxation.

[0033] The present invention is not limited to the above embodiment, and various modifications can be made. For example, the pupil imaging means does not necessarily need to include an infrared CCD camera and a light emitting diode for infrared illumination.The light stimulating means does not necessarily include a plurality of visible light emitting diodes covered with a light scattering plate. It is not necessary to be. The pupil imaging means, the light stimulating means, and the fixation light emitting diode may be provided in a pair on the three-dimensional mask unit so as to face the eyes of both eyes, for example, so that both eyes can be measured simultaneously. it can. Furthermore, if the measurement can be performed in a dark room or quasi-dark room, for example, about 51 ux, do not face the pupil imaging means and the light stimulating means! / Open the three-dimensional mask part of the non-measurement eye part. For example, a fixation point provided at a distance of, for example, about 5 m may be fixed at a distance, and the measurement eye may be measured while being stabilized.

[0034] Furthermore, the number of visible light emitting diodes constituting the light stimulating means is not limited to eight, and is arbitrary, and the light scattering plate does not necessarily need to be in the shape of an annular band plate. Example

[0035] By using the pupil-to-light reaction measuring device for evaluating a feeling of relaxation according to the present invention, the evaluation result of the feeling of relaxation with high accuracy corresponding to the evaluation of the feeling of relaxation by analyzing the electrocardiogram (chest V5 lead) RR interval fluctuation spectrum analysis can be obtained. A demonstration test that supports the obtained results will be described as Example 1. Also, a test in which the pupil-to-photoreaction measuring device for evaluating a feeling of relaxation according to the present invention is evaluated to be effective in causing a relaxed state of cedrol force S will be described as Example 2. Note that the present invention is not limited to Examples 1 and 2.

[Example 1]

Twenty healthy women in their thirties were divided into two groups, and the ten in Group A heard white noise first, followed by the sound of the babbling brook. On the other hand, 10 people in group B heard the babbling of the brook first and then the white noise. By changing the order in which the sounds were heard, counter-nomination was achieved between groups. For the physiological state at that time, a pupil-light response test using a pupil-light response measuring device for evaluating the feeling of relaxation having the same configuration as in the above embodiment, and an electrocardiogram (thoracic V5 lead) RR interval fluctuation spectrum analysis were performed. Was.

First, ECG electrodes were installed in a constant environment at a temperature of 23 ° C and a relative humidity of 50%, and continuous monitoring was started. After acclimatization for 15 minutes after the electrodes were mounted, the pupil-photoreaction measuring device (weight 80 g) for evaluating the feeling of relaxation of the godal type of the present invention was attached to the face, and after dark adaptation for 1 minute 30 seconds, Light stimulation was performed 5 times for 0.25 seconds at intervals of 2 seconds. After the pupil-light reaction, the goggles were removed, and for 15 minutes, group A heard white noise and group B heard the babbling of the brook. Then, goggles were put on the face again, and after dark adaptation for 1 minute and 30 seconds, the same pupil-optical response test as described above was performed. Here, for the purpose of washing out the effects of each sound, keep the resting state for 15 minutes, and then for 15 minutes, Hear the murmuring sound, and group B hears white noise. Finally, the goggles were put on the face again, and after dark adaptation for 1 minute and 30 seconds, the same pupil-optical response test as above was performed. The results are shown in FIG. Figures 8 (b) and 8 (c) show the results of analysis by ECG RR interval fluctuation spectrum analysis.

[0037] According to the results shown in Figs. 8 (a), (b), and (c), the miotic velocity obtained from the pupil-optical response test

(VC) and electrocardiogram RR interval fluctuation spectrum analysis power One-way analysis of variance (One factor ANOVA) using the obtained HF and LF / HF as fluctuation factors, respectively, showed a significant difference (HF : p <0.05, other: p <0.0001), and further analyzed by Tukey-Kramer method as a multiple comparison test (Post-hoc test). In groups A and B, no significant difference was observed in the miotic velocity (VC) after hearing the white noise, as compared with after the environmental ordering. HF and LF / HF by ECG R-R interval and fluctuation spectrum analysis showed no significant difference. On the other hand, after hearing the sound of the babbling babble, a significant increase (p-0.01) was observed in the miotic rate (VC) compared to after acclimatization. In addition, HF showed an increasing tendency by the analysis of the electrocardiogram R-R interval fluctuation spectrum, and a significant decrease (p-0.01) was observed in LF / HF. Compared to hearing the white noise, a significant increase (p-0.01) was observed in the miotic rate (VC) after hearing the sound of the babbling babble. Furthermore, HF showed a tendency to increase by the analysis of ECG R-R interval fluctuation spectrum, and a significant decrease (p 0.01) was observed in LF / HF. Here, LF is the low-frequency component obtained by integrating the amplitude of 0.03-0.12 Hz by the fast Fourier transform of the electrocardiogram, and HF is the integrated value of the amplitude of 0.12-0.5 Hz. Refers to high frequency components.

[Comparative Example 1]

For the same subject as in Example 1, in place of the goggle-type relaxation pupil-light reaction measuring instrument of the present invention, a commercially available pupil-light reaction measuring instrument (Iriscoder C7364, manufactured by Hamamatsu Photonics Co., Ltd.) was used. (The weight was 500 g), and the test was conducted under the same conditions and method as in Example 1. The results are shown in FIGS. 9 (a), (b) and (c).

[0039] According to the results shown in Figs. 9 (a), (b), and (c), a significant difference was observed as a result of performing one-way analysis of variance (One factor ANOVA) as in Example 1. (LF / HF: p <0.0001), so that analysis was performed by the Tukey-Kramer method as a multiple comparison test (Post-hoc test). A In group and group B, there was no significant difference in the miotic rate (VC) after hearing the white noise compared to after the environmental ordering. In addition, HF and LF / HF by ECG RR interval fluctuation spectrum analysis showed no significant difference. On the other hand, after hearing the sound of the babbling of the brook, the pupil velocity (VC) tended to increase compared to that after environmental ordering, but there was a significant difference between individuals, indicating a significant difference. Unacceptable strength. Furthermore, HF by ECG RR interval fluctuation spectrum analysis showed an increasing trend, and a significant decrease in LF / HF was observed (p <0.01). Even after hearing the sound of the babbling of Ogawa, the pupil velocity (VC) tended to increase compared to after hearing the white noise, but the variation among individuals was significant and significant. The difference was unrecognizable. In addition, HF by ECG RR interval fluctuation spectrum analysis showed an increasing trend, and a significant decrease in LF / HF (p <0.01) was observed.

Further, based on the results of the miosis rate (VC) of Example 1 and Comparative Example 1, the type of the pupil-to-light reaction measuring instrument was determined between the individual (between-subject), and the type of the sound was determined within the individual (within-subject). As a result of the repeated measure analysis of variance (ANOVA) as the subject), a significant difference was observed between the pupil-to-light response measurement device (a measurement device having the same configuration as the above embodiment and a commercially available measurement device). A difference (P <0.0001) was observed. There was also a significant difference (p <0.0001) between the types of sound (acclimation, white noise, and babble brook).

[0040] Based on the above results, the degree of relaxation was changed by the electrocardiogram R-R interval fluctuation spectrum analysis method and the pupil-to-photoreaction measuring device of the shift after hearing the white noise compared to after the environmental ordering. Was unacceptable. On the other hand, in the state where the sound of the babbling of the brook was heard, the ECG RR interval fluctuation spectrum analysis method and the goggle type pupil-to-light reaction measuring device of the present invention for evaluating the sense of relaxation significantly increased the degree of relaxation. However, there was no significant difference in the degree of relaxation due to large variations among individuals using a commercially available pupil-optical response measurement device.

Example 2

The study was conducted on 12 healthy women in their 30s and 40s in three environments. Ie, an environment when stripped at a concentration of environment, and cedrol 800 gZm ³ when the normal air only environment, stripped at a concentration of 100 gZm ³ a cedrol. In order to cancel the order effect and residual effect due to presentation of cedrol, 4 groups of 12 persons, 3 groups (A (Group B, Group B and Group C) were set up in a Latin square as shown in Table 1 so as to experience all environments. In addition, the three-day study was adjusted so that each subject measured pupil-to-light response at the same time. Subjects environment variable chamber (temperature 23. 0 ° C, humidity 50.0%, the chamber volume 25 m ³⁾ and enter the, after acclimatization, pupillary light response, entering after 15 minutes, and 4 5 Measured after minutes. Pupil-to-light response was measured by wearing the goggles (weight 80 g) shown in Fig. 2 on the face, and the pupil diameter D before light stimulation and the amount of miosis D changed by light stimulation,

The miosis rate CR, which is the ratio of 1 2, was set to each parameter. The measurement was performed by wearing goggles, adapting to the B tone for 5 minutes in the light-shielded state, and then applying 0.25 seconds of light stimulation 5 times at 20-second intervals. Indicated by standard error. The measurement results 15 minutes after entering the room are shown in Figs. 10 (a)-(c), and the measurement results 45 minutes after entering the room are shown in Figs. 11 (a)-(c).

[Table 1]

Table 1 Experimental group settings

Control: normal air only environment, 100-Ced: cedrol a when stripped at a concentration of 100 / g / m ³ environment, 800-Ced: cedrol a when stripped at a concentration of 800 / _g / m ³ environment.

[0043] FIG. 10 (a) (c) and FIG. 11 (a) - According to the measurement results (c), the compared with the environment only normal air, in the environment Cedrol 800 / gZm ^3, entry After 15 minutes, the pupil diameter D before light stimulation shows a decreasing tendency, and the change amount D of the pupil diameter after light stimulation shows an increasing tendency.

1 2 As a result, a significant increase in the miosis rate CR was observed, and a further remarkable increase was shown 45 minutes after entering the room. In addition, an increasing trend even in an environment of cedrol 100 / zg / m ³ was observed. These results suggest that cedrol exerts a relaxed state in a concentration-dependent manner and predominates the parasympathetic nerve.

The following demonstration demonstrates that the photostimulation means, in which a plurality of visible light emitting diodes are covered with a light scattering plate, can easily distribute the light intensity above a certain level over a wide range and uniformly irradiate the pupil. The test is described as a reference example. (Reference Example 1)

The light source of the photostimulator of the pupil-to-photoreaction measuring device for evaluation of relaxation in Reference Example 1 was used as shown in FIG. 5 (a). As the light source of the photostimulator, eight light emitting diodes of 660 nm are arranged on a circumference of 15 mm radius at equal angular intervals of 45 degrees, and a light scattering plate of 2 mm thick made of acrylic resin is placed on top of it, with an outer diameter of 20 mm. Process into a shape with an inner diameter of 10mm. The position of the light-emitting surface of the light stimulator is defined by defining two-dimensional orthogonal coordinates with the origin at the position of the light-receiving surface (the position at a vertical distance of 20 mm) corresponding to the subject's pupil, perpendicular to the center of the light scattering plate. The light intensity on the light receiving surface was normalized with the light intensity at 1 as 1. Figure 5 (b) shows the normalized emission intensity distribution of the light-receiving surface.

[Reference Example 2]

FIG. 6 shows a commonly used closed loop method as a light source of the photostimulator. Using a single 660 nm light emitting diode, determine a two-dimensional orthogonal coordinate originating at the position of the light receiving surface (at a vertical distance of 20 mm) corresponding to the subject's pupil, perpendicular to the optical axis of the light emitting diode The light intensity on the light-receiving surface was normalized with the light intensity on the light-emitting surface of the photostimulator as 1. Fig. 6 (b) shows the normalized emission intensity distribution of the light receiving surface.

According to the test results shown in FIG. 5 (b) and FIG. 6 (b), eight light emitting diodes are arranged evenly below the light scattering plate rather than the light irradiating device consisting of one light emitting diode. The light stimulator that has been used can distribute a certain amount or more of light intensity over a wide range on the light receiving surface corresponding to the subject's pupil. It has been found that the use of a photostimulator in which the light emitting diodes are evenly arranged makes it possible to easily equalize the irradiation light amount to the pupil.

Industrial applicability

According to the pupil-to-light reaction measuring device for evaluating a feeling of relaxation of the present invention, for example, a normal healthy person can easily use it, and easily and easily evaluate the degree of stress and relaxation objectively and accurately. Can be.

Claims

The scope of the claims

[1] A pupil-to-light response measuring device for evaluating a feeling of relaxation, which is used when tracking a pupil-to-light response to evaluate a feeling of relaxation,

A three-dimensional mask portion that is attached to the face so as to cover the eyes, a pupil imaging unit and a light stimulating unit that are attached to the three-dimensional mask unit so as to face at least one eyeball; Control analysis means for connecting to and controlling the light stimulating means, recording an image sent from the pupil imaging means, and performing arithmetic analysis on the miosis and mydriasis of the pupil based on the imaging; With

And a pupil-to-light reaction measuring instrument for evaluating a feeling of relaxation, wherein the weight of the three-dimensional mask portion at the time of attachment including the pupil imaging means and the light stimulating means is 30 to 120 g.

[2] The pupil imaging means comprises an infrared CCD camera and a light emitting diode for infrared illumination, and the light stimulating means is constituted by covering a plurality of visible light emitting diodes with a light scattering plate. Item 6. A pupil-to-light response measuring instrument for evaluating a feeling of relaxation according to the item.

[3] The light-scattering plate has an annular band shape having an inner diameter of 3 to 14 mm and an outer diameter of 25 to 45 mm, and a lens portion of the infrared CCD camera is provided at a central hole of the light-scattering plate. 3. The pupil-to-light response measuring instrument for evaluating a feeling of relaxation according to claim 1 or 2, which is arranged.

4. The pupil-to-light reaction measurement for evaluating a feeling of relaxation according to any one of claims 1 to 3, wherein the light stimulating means is arranged at a distance of 13 to 35 mm from the eyeball of the eye. Utensils.

[5] The pupil imaging means and the light stimulating means are attached so as to face the eyeball of one eye, and the stereoscopic mask portion is provided with a fixation lamp for facing the eyeball of the other eye. 5. The pupil-to-photoreaction measuring device for relax feeling evaluation according to claim 1, further comprising a light emitting diode.