WO2005044089A3 - High resolution metabolic brain - Google Patents

High resolution metabolic brain Download PDF

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Publication number
WO2005044089A3
WO2005044089A3 PCT/US2004/036644 US2004036644W WO2005044089A3 WO 2005044089 A3 WO2005044089 A3 WO 2005044089A3 US 2004036644 W US2004036644 W US 2004036644W WO 2005044089 A3 WO2005044089 A3 WO 2005044089A3
Authority
WO
WIPO (PCT)
Prior art keywords
subject
high resolution
provides
metabolic brain
afflicted
Prior art date
Application number
PCT/US2004/036644
Other languages
French (fr)
Other versions
WO2005044089A2 (en
Inventor
Scott A Small
Original Assignee
Univ Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Columbia filed Critical Univ Columbia
Publication of WO2005044089A2 publication Critical patent/WO2005044089A2/en
Publication of WO2005044089A3 publication Critical patent/WO2005044089A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4076—Diagnosing or monitoring particular conditions of the nervous system
    • A61B5/4088—Diagnosing of monitoring cognitive diseases, e.g. Alzheimer, prion diseases or dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4058—Detecting, measuring or recording for evaluating the nervous system for evaluating the central nervous system
    • A61B5/4064—Evaluating the brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
    • A61B6/501—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for diagnosis of the head, e.g. neuroimaging or craniography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/06—Measuring blood flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
    • A61B8/0808—Detecting organic movements or changes, e.g. tumours, cysts, swellings for diagnosis of the brain

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Child & Adolescent Psychology (AREA)
  • Developmental Disabilities (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Neurosurgery (AREA)
  • Physiology (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

This invention provides a method for determining whether a subject is afflicted with Alzheimer's disease by comparing the metabolic activity of the subject's hippocampal entorhinal cortex with that of a second region of the subject's brain. This invention further provides a method for determining whether a subject is afflicted with Alzheimer's disease by comparing the metabolic activity of the subject's hippocampal entorhinal cortex determined at a first and second time point. Finally, this invention provides a method for determining the amount of blood in a volume of cerebral tissue in vivo, wherein the volume of tissue is 1mm3 or less.
PCT/US2004/036644 2003-11-04 2004-11-03 High resolution metabolic brain WO2005044089A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15741903P 2003-11-04 2003-11-04
US60/157,419 2003-11-04

Publications (2)

Publication Number Publication Date
WO2005044089A2 WO2005044089A2 (en) 2005-05-19
WO2005044089A3 true WO2005044089A3 (en) 2005-09-15

Family

ID=34572359

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/036644 WO2005044089A2 (en) 2003-11-04 2004-11-03 High resolution metabolic brain

Country Status (1)

Country Link
WO (1) WO2005044089A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101371261A (en) * 2005-11-14 2009-02-18 纽约哥伦比亚大学理事会 Imaging correlates of neurogenesis with MRI
KR102305828B1 (en) * 2019-09-27 2021-09-30 주식회사 엔서 Apparatus and System for Diagnosing Dementia

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3577678A (en) * 1969-08-14 1971-05-04 Microphor Inc Combined waste treatment and growth chamber process
US4259182A (en) * 1979-07-26 1981-03-31 Houston Systems Manufacturing Co. Waste treatment apparatus
US5334533A (en) * 1990-05-07 1994-08-02 Colasito Dominic J Oil contamination clean-up by use of microbes and air

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3577678A (en) * 1969-08-14 1971-05-04 Microphor Inc Combined waste treatment and growth chamber process
US4259182A (en) * 1979-07-26 1981-03-31 Houston Systems Manufacturing Co. Waste treatment apparatus
US5334533A (en) * 1990-05-07 1994-08-02 Colasito Dominic J Oil contamination clean-up by use of microbes and air

Also Published As

Publication number Publication date
WO2005044089A2 (en) 2005-05-19

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