WO2005041891A3 - Neutrophil activation by immune response modifier compounds - Google Patents

Neutrophil activation by immune response modifier compounds Download PDF

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Publication number
WO2005041891A3
WO2005041891A3 PCT/US2004/036351 US2004036351W WO2005041891A3 WO 2005041891 A3 WO2005041891 A3 WO 2005041891A3 US 2004036351 W US2004036351 W US 2004036351W WO 2005041891 A3 WO2005041891 A3 WO 2005041891A3
Authority
WO
WIPO (PCT)
Prior art keywords
neutrophils
activating
immune response
response modifier
neutrophil activation
Prior art date
Application number
PCT/US2004/036351
Other languages
French (fr)
Other versions
WO2005041891A2 (en
Inventor
Mark A Tomai
John P Vasilakos
Paul D Wightman
Original Assignee
3M Innovative Properties Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3M Innovative Properties Co filed Critical 3M Innovative Properties Co
Priority to EP04810205A priority Critical patent/EP1680080A4/en
Priority to CA002543685A priority patent/CA2543685A1/en
Priority to JP2006538418A priority patent/JP2007509987A/en
Priority to AU2004285575A priority patent/AU2004285575A1/en
Publication of WO2005041891A2 publication Critical patent/WO2005041891A2/en
Publication of WO2005041891A3 publication Critical patent/WO2005041891A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0642—Granulocytes, e.g. basopils, eosinophils, neutrophils, mast cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention provides a method of activating neutrophils. Generally, the method includes contacting neutrophils with a neutrophil-activating IRM compound and/or aTLR8-selective agonist in an amount effective to activate the neutrophils. In some embodiments, the method may be used to treat a condition treatable by activating neutrophils. In another aspect, the invention provides pharmaceutical compositions that generally include a neutrophil-activating IRM compound and/or a TLR8-selective agonist, or a pharmaceutically acceptable form thereof, in an amount effective to activate neutrophils.
PCT/US2004/036351 2003-10-31 2004-11-01 Neutrophil activation by immune response modifier compounds WO2005041891A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP04810205A EP1680080A4 (en) 2003-10-31 2004-11-01 Neutrophil activation by immune response modifier compounds
CA002543685A CA2543685A1 (en) 2003-10-31 2004-11-01 Neutrophil activation by immune response modifier compounds
JP2006538418A JP2007509987A (en) 2003-10-31 2004-11-01 Neutrophil activation by immune response modulator compounds
AU2004285575A AU2004285575A1 (en) 2003-10-31 2004-11-01 Neutrophil activation by immune response modifier compounds

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US51611603P 2003-10-31 2003-10-31
US60/516,116 2003-10-31
US51780503P 2003-11-06 2003-11-06
US60/517,805 2003-11-06

Publications (2)

Publication Number Publication Date
WO2005041891A2 WO2005041891A2 (en) 2005-05-12
WO2005041891A3 true WO2005041891A3 (en) 2006-10-26

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/036351 WO2005041891A2 (en) 2003-10-31 2004-11-01 Neutrophil activation by immune response modifier compounds

Country Status (6)

Country Link
US (1) US20050096259A1 (en)
EP (1) EP1680080A4 (en)
JP (1) JP2007509987A (en)
AU (1) AU2004285575A1 (en)
CA (1) CA2543685A1 (en)
WO (1) WO2005041891A2 (en)

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EP1680080A4 (en) 2007-10-31
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US20050096259A1 (en) 2005-05-05
AU2004285575A1 (en) 2005-05-12
JP2007509987A (en) 2007-04-19
WO2005041891A2 (en) 2005-05-12

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