WO2005039647A2 - Radium target and method for producing it - Google Patents
Radium target and method for producing it Download PDFInfo
- Publication number
- WO2005039647A2 WO2005039647A2 PCT/EP2004/011510 EP2004011510W WO2005039647A2 WO 2005039647 A2 WO2005039647 A2 WO 2005039647A2 EP 2004011510 W EP2004011510 W EP 2004011510W WO 2005039647 A2 WO2005039647 A2 WO 2005039647A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- radium
- aluminium
- target
- aluminium foil
- coated
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
- C25D3/00—Electroplating: Baths therefor
- C25D3/02—Electroplating: Baths therefor from solutions
- C25D3/54—Electroplating: Baths therefor from solutions of metals not provided for in groups C25D3/04 - C25D3/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1282—Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
Definitions
- the present invention refers to a method for producing a radium target for the production of radionuclides by means of accelerated protons according to the preamble of claim 1. Further, the invention refers to a radium target according to claim 25.
- the targets according to the present invention serve for the production of radionuclide 225 Ac, which is successfully used in nuclear medicine - bound to tumorspecific antibodies - in various clinical trials in the treatment of cancer, particularly in form of its daughter nuclide 213 Bi.
- Cyclohexyl-DTPA is, for example, described in NIKULA, T.K., McDEVITT, M.R., FINN, R.D., WU, C, KOZAK, R.W., GARMESTANI, K., BRECHBIEL, M.W., CURCIO, M.J., PIPPIN, C.G., TIFFANY-JONES, L, GEERLINGS, M.W.,Sr., APOSTOLIDIS, C, MOLINET, R., GEERLINGS, M.W.,Jr., GANSOW, O.A.
- the medical-clinical significance of the present invention may be seen for example from two promising therapeutic approaches:
- the side effects range from immunosuppression, coagulopathy, metabolic anoxia, mucositis and hyperuricaemia to the danger of cytostatica induced secondary tumors.
- Particularly affected is here quickly proliferating tissue as bone marrow and the epithelium of the gastrointestinal tract as well as of the oral mucosa.
- the radioimmunotherapy in contrast, uses protein structures located on the membrane, that are expressed by tumor cell lines in order to bind cytotoxic active substances via a carrier. Usually, an overexpression of the binding molecule at the tumor cell is central to a radioimmunotherapy. The target molecule for the tumor associated antibodies is thus also expressed to a lower extend in physiologic cells of the organism. This implies that any therapeutic agent for radiotherapy also binds to these cells.
- the meaning of the present invention takes effect, namely for the preparation of a suitable ⁇ -emitter, namely 225 Ac which forms through decay reaction the bound, for example, to a tumorspecific antibody.
- the 213 Bi atom decays via ⁇ -decay to 213 Po, which releases its ⁇ -decay energy of 8,4 MeV with a half life of 4 ⁇ s in the tissue within a distance of 80 ⁇ m when decaying and thus kills effectively cells in its immediate neighborhood due to its high linear energy transfer.
- ⁇ -emitters can already be excluded from in vivo application for practical reasons (cf. GEERLINGS 1993). These ⁇ - emitters have to meet requirements like sufficient chemical and physical purity, economic availability and an adequate half-life. The latter has to be long enough for binding to the antibodies and for the biologic allocation and has to be short enough so that the patient is not put at an unnecessary risk due to excessive exposition to the rays.
- 213 Bi has become available via the production of 225 Ac, for example according to EP 0 752 709 B1 and EP 0 962 942 A1 and particularly via the so called "thorium cow” according to US 5,355,394.
- the production via the above-mentioned "thorium cow” is very expensive, as it derives from a neutron irradiation of 226 Ra over several years, whereby finally among others an isotope mixture of 228 Th and 229 Th is assembled, whereby
- the mother-daughter nuclide pair 225 Ac / 213 Bi is available in principle, however, neither in an adequate quantity and continously nor at an acceptable price, however - as mentioned initially - first clinical studies with 225 Ac/ 213 Bi conjugated to HuM195, a humanized anti-CD33 monoclonal antibody are very successful against myeloid leukaemia.
- the first clinical phase I trials with 213 Bi -HuM195 were carried out with excellent therapeutic results at leukaemia patients at the Memorial Sloan-Kettering Cancer Center in New York (JURICIC et al. 2002).
- protons can be accelerated with the help of a cyclotron with currents that are high enough to such high velocities that they can be used in experimental and applied nuclear physics for the production of isotopes in a quantitative scale.
- EP 0 752 709 B1 describes, for example, a method for producing Actinium- 225 from Radium-226, whereby accelerated protons are projected in a cyclotron onto a target of radium-226, characterized in that protons accelerated in a cyclotron are projected onto a target of radium-226 in a cyclotron, so that the instable compound nucleus 227 Ac is transformed into Actinium-225 while emitting two neutrons (p,2n-reaction), whereby after a waiting period, during which the Actinium-226, which has been created simultaneously due to the emission of only one neutron, decays mostly due to its considerably shorter half-life and Actinium is chemically separated, so that an almost exclusively pure isotope Ac-225 is obtained.
- EP 0 962 942 A1 also describes a method for producing Ac-225 by irradiation of 226 Ra with protons, which are accelerated in a cyclotron to an energy of 10 to 20 MeV.
- the target nuclide 226 Ra is used in the form of RaCI 2 , which can be obtained for example by precipitation with concentrated HCI or radiumcarbonate (RaC0 3 ). These radium substances are then pressed into target pellets. Prior to irradiation of the radium salts with protons, the pellets are heated to about 150°C in order to release crystal water and are then sealed in a silver capsule. The capsule is then mounted on a frame-like support and connected to a water cooling circuit. The target itself exhibits a window, which is arranged in a way that the proton beam hits the target through the window.
- the target exhibits a surface of about 1 cm 2 .
- this target construction can heat itself under certain conditions due to the proton beam in such a way that the silver capsule tears open and might thus both destroy the target and contaminate the peripheral compounds.
- Central to the present invention is a process for producing a radium target for the production of radio nuclides by means of accelerated protons, wherein an electrodeposition of radium containing material of at least one aqueous- organic solution, which contains radium ions, is carried out on at least one aluminium surface, whereby the aluminium surface is connected as cathode.
- 2 6 Ra chlorides or 226 Ra carbonates can also be used, which are transformed for the electrodeposition, preferably before the carrying out of the electrodeposition, by means of HN0 3 into the nitrate salt.
- the radionuclide 225 Ac from 226 Ra by means of cyclotron accelerated protons or by means of linear accelerated protons, as with the targets of the present invention it becomes possible for the first time to produce Actinium-225 continuously for the production of radioimmunotherapeutic compounds as for example 225 Ac - and 21 Bi labelled antibodies, in particular monoclonal antibodies, for the radioimmunotherapy of cancer and metastases.
- radioimmunochemical methods are for example summarised nuclear chemically and clinically in the dissertation of HUBER, M ⁇ nchen 2003, which was mentioned in the introduction.
- the radiotherapeutic effect essentially takes place through the daughter isotopes of Actinium-225, namely Bismuth-213 and the Polonium-213 resulting therefrom, which is particularly suitable as ⁇ -emitter for highly specific and locally restricted irradiation of tumors.
- the electrodeposition of 226 Ra material out of the aqueous-organic solution preferably takes place in an acidic environment, whereby nitric acid is used as mineral acid.
- an 0.05 molar solution of nitric acid is particularly suitable in order to positively influence the electrodeposition of 226 Ra containing material.
- ammonium ions to the aqueous-organic solution of the 226 Ra salts, as after the deposition of the radium containing material the film of radium oxides/hydroxides and/or peroxides formed on the aluminium surface is stabilised, or fixed, respectively, by ammonium ions.
- an aluminium foil which exhibits for the purposes of the present invention a purity of at least 99% and for example a thickness of about 0.01 mm to 0.05 mm, in particular preferred about 0.015 mm, as aluminium surface is preferred.
- the advantage lies in the fact that the aluminium foil is industrially available in various sizes and thicknesses and thus it can be made use of as a base material that is readily available and furthermore relatively cheap.
- a platin anode as counter electrode yields the best results for the electrodeposition of radium.
- the method according to the invention is carried out preferably with a D.C. voltage of about 10 to 600 V, in particular about 200V and an electric current of about 20 to 1000 mA, in particular about 60 mA, and at a pH value of about 4 to 5 or about 11 , since at this value the most even layers of 226 Ra material on the aluminium surface are achieved.
- the advantage lies in the fact that the aluminium foil can easily be connected as cathode over the conductive stainless steel support.
- an electrically inert support for example made of plastics, whereby the aluminium foil is connected via a connected electrode as cathode.
- the support it is preferred to rotate the support during the electrodeposition, as by doing so an even coating with the desired radium isotope, especially at bigger coating thicknesses, is achieved.
- a basically circular-shaped aluminium disc with radium containing material can be coated largely on the whole surface.
- support and aluminium foil partially dip into an aqueous- organic solution containing radium ions, and support as well as aluminium foil rotate during the electrodeposition, so that a ring shaped coating with radium containing material is obtained.
- the ring shaped coating is sufficient and thus combines the advantages of an easy and safe carrying out of the method and obtains at the same time an optimum yield for the proton nuclear reaction.
- the obtained, aluminium disc which is largely coated on the whole surface with radium, is folded repeatedly for the creation of the target used in the proton beam.
- This easy measure enables an increase of yield with the given target geometry of the irradiation window.
- the method currently preferred to build the target used in the proton beam is, however, to pile up a plurality of the obtained discs which are coated with radium in a ring shaped manner, also in order to increase the effective cross section of the proton radiation.
- the aluminium coil is wound up under pressure with a roll.
- the high surface density of the deposited 226 Ra -containing material that was obtained due to the two-sided coating is only to be achieved by a relatively high procedural effort, compared to the piled up aluminium foils.
- the preferred fixing agent is NH 3 , which may be added to the plating solution about one minute before the termination of the electrodeposition.
- radium containing films on the aluminium foil are dewatered, in particular by IR irradiation.
- This has the advantage that for the nuclear transformation by means of accelerate protons the target virtually does no longer contain water and thus, the danger of steam creation, which may be produce undesired pressures in the. target capsule and may severely disturb the whole target system by creating cracks in the layer, can largely be avoided.
- the method according to the invention can be carried out continuously, since thereby in an industrial or semi industrial process a bigger amount of 226 Ra targets can be produced for the continuous production of radioimmuno antibodies for therapeutic purposes and can be stored at least for a short period of time.
- the aluminium foil used for the electrodeposition of radium- containing material may additionally be surface activated by the usual measures.
- the radium targets obtained by the method according to the invention may then be subjected to proton irradiation with sufficient energy in a cyclotron or in a linear accelerator, for example between about 10 and 25 MeV, more preferably between about 18 and 23 MeV, in order to obtain the desired 225 Ac.
- the typical radium targets according to the present invention have the form of aluminium foil, which at least contains on one surface a layer made of radium containing material, particularly radium oxide and/or radium peroxide and/or radium hydroxide.
- a preferred embodiment of the present invention is a radium target, in which the radium-coated aluminium foil is present in folded form, as wound coil or as pile of single foils coated with radium containing material.
- the radium content of the radium containing layer may lie within the nanogram range to gram range in form of the radium oxide and/or peroxide and/or hydroxide.
- a radium target which exhibits an activity of about 1 nCi to 1.5 Ci, preferably 500 mCi of 226 Ra.
- a circular disc shaped radium target whereby it is present as circular disc shaped radium coated aluminium foil which exhibits the radium coating preferably formed in a ring shaped manner on the outer edge of the aluminium circular disc.
- a particularly preferred radium target of the present invention is one where it is present as pile of several ring shaped radium-coated circular discs made of aluminium.
- the radium target may be present in a folded form, particularly several times folded, if the aluminium foil is largely coated on the whole surface with radium containing material.
- Another possibility of the target form is to form it as rectangular formed foil und to wind it into a coil. Thereby it is possible to store a relatively big amount of target foil and separate required pieces of foil like in the use of an "aluminium foil for the household".
- Al-mesh targets can be used as carrier of Ra.
- Al-mesh targets have an advantage in the achieved yield during electrodeposition.
- the amount of Ra that can be deposited per disc could be increased. While, e.g. on an Al-foil disc the amount of Ra (experiments conducted at mg levels wHh Ba and at microgram levels with Ra-226) deposited was below 10 mg (2-3 mm at the edges of one disc), in the case of the mesh disc, the amount of Ra was to approximately 70 mg (depending on the thickness of the deposit and other parameters, thicker deposits were not well adhered to the mesh anymore).
- the dimensions of the Al-mesh might be for example: Nominal spacing: appr. 0,11 mm Wire diameter: appr. 0,1 mm Total open area: 27 mm 2
- a special advantage of the radium targets according to the invention is that they exhibit basically pure radium material in their radium containing coating.
- the targets are free of carriers or diluents, for example barium salts, which had to be added to the conventional radium targets of the prior art, i.e. the target pellets mentioned in the introduction, in order to homogenize the radium-containing material. Due to the possibility to be able to work without such carrier materials as barium compounds, the chemical separation and purification of the created 225 Ac becomes substantially more simple and the yields of irradiation are optimized, as competitive nuclear reactions, as for example those from barium nuclei, are not possible.
- the present invention further comprises all combinations of all disclosed single features together, independent from their AND- or OR-linkage.
- Example 1 deposition by means of a fixed aluminium disc as cathode
- aluminium discs with a thickness of 0.015mm and a diameter of about 5 cm with a minimal 99% purity of the aluminium are punched out and fixed on a stainless steel support.
- the support facilitates the handling of the aluminium foils and is removed after the electrodeposition itself, before the positioning of the radium-coated foil in the target itself.
- a solution of a radium-226- nitrate is used, whereby in particular 226-radium chloride or 226-radium carbonate are absorbed beforehand for the transformation into the corresponding nitrate in about 0.05 M HN0 3 .
- the stainless steel support, on which the aluminium foil is fixed is weighted and the net weight of the aluminium foil is determined.
- the electric current is adjusted to about 60 mA and a voltage of about 200V is applied, monitored for a few minutes and, if necessary, readjusted.
- Example 2 deposition by means of a rotating aluminium disc as cathode
- the stainless steel support with the aluminium foil fixed on it is, however, being dipped about 5 mm into the electroplating solution according to example 1 and a platin anode (Pt-conductor or Pt-net) is arranged within a distance of about 1 cm of the aluminium/stainless steel cathode and the stainless steel carrier is rotated with the aluminium foil arranged on it by means of a motor drive.
- a platin anode Pt-conductor or Pt-net
- the electric current is adjusted to about 60 mA and a voltage of about 200V is applied, monitored for a few minutes and, if necessary, readjusted.
- the dipping depth of the aluminium disc to be coated, or the level of the solution, respectively, are kept at a constant level during the coating period. Subsequently the deposition takes place for about 20-30 minutes at 60 mA. A decrease of the voltage after 20 to 30 minutes indicates the termination of the electrodeposition.
- a quantitative electrodeposition might time from about 20 to 40 minutes the deposition on aluminium foils with a diameter of up to 2 cm, while a deposition on aluminium foils with up to 15 cm diameter might time about 2 to 3 hours.
- the Al-target discs prepared in the example with a diameter of about 5.5 cm take about 1 hour for the radium deposition.
- the plating solution is poured out, the support is rinsed with 2 to 3 ml isopropanol and the cell is disassembled and the aluminium foil is additionally rinsed with about 1 to 2 ml isopropanol.
- the support with the 226 Ra coated aluminium foil arranged on it is dried under an infrared lamp until the weight remains constant, in order to render the radium-containing coating anhydrous.
- the stainless steel support with the fixed, coated aluminium foil is weighted and the net mass of the coated aluminium foil is determined. Then the yield is determined from the weighted mass of the 226 Ra containing layer.
- An alternative way to monitor the yield of the electrodeposition - instead of weightening - is to measure the ⁇ -activity of 226 Ra by means of a high resolution ⁇ -spectrometer. Subsequently, the stainless steel support and the aluminium foil are separated from each other.
- the dry aluminium foil coated with radium compounds is carefully covered with a new aluminium foil and the edges of the aluminium foil with which the Aluminium foil carrying the active layer is fixed are cut off, in order to minimize the amount of aluminium in the target itself.
- a pile of the of the circular disc shaped aluminium foils prepared according to present example 15, which are coated with radium-containing material in a ring shaped manner, are piled in a so called target cup.
- one or more aluminium foils in the case of this example, coated on one whole surface with 226 Ra are covered in a way with another aluminium foil that the radium containing film is covered entirely. Then, the aluminium foil is folded several times until stripes of about 2mm are obtained. The folded aluminium foil, which contains the layers of radium-containing material, in particular radium oxides, is then placed into the target for proton irradiation in the cyclotron or in the linear accelerator.
- the method according to the present invention permits in particular to deposit films that are highly homogenous on the aluminium- 226 Ra target. This is particularly important for the irradiation of the target in the cyclotron, as the atomic nuclei of radium are thereby exposed homogenously to the proton flux.
- the use of aluminium as substrate for 226 Ra offers various advantages for the irradiation in a cyclotron and the subsequent radiochemical processing of the irradiated target.
- the advantages of the aluminium lie in the nuclear physical and chemical properties of the aluminium:
- Aluminium has just one single stable isotope.
- the activation products formed from the aluminium are very short-lived.
- the formation of only short lived radionuclides on aluminium facilitates the radiochemical purification of Ac-225 and reduces the cooling time of the target after irradiation.
- Aluminium is a light metal with good thermal and electrical conductivity. It is easy to handle and can be adapted easily to the required geometry.
- Aluminium can easily be dissolved in mineral acids and it can be easily separated from the resulting Actinium. Aluminium foils are available with a high degree of chemical purity and at reasonable prices.
- the deposition of 2 6 Ra as oxide or peroxide allows to obtain a layer with a high content of radium, in particular higher than 70% of the deposited material per cm 2 .
- the electrodeposition yield is high if all the instructions of the present invention are followed.
- folded aluminium layers as substrate for 226 Ra facilitates the sample processing, as after the irradiation these foils can be easily removed from the target supports without loosing their mechanical integrity. This prevents the loss of material and the radioactive contamination of the compounding line, which otherwise could not be prevented.
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Materials Engineering (AREA)
- Metallurgy (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Particle Accelerators (AREA)
- Physical Vapour Deposition (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE602004020085T DE602004020085D1 (en) | 2003-10-13 | 2004-10-13 | RADIUM TARGET AND MANUFACTURING METHOD THEREFOR |
EP04765955A EP1673492B1 (en) | 2003-10-13 | 2004-10-13 | Radium target and method for producing it |
JP2006530151A JP4690328B2 (en) | 2003-10-13 | 2004-10-13 | Radium target and production method thereof |
CA2542178A CA2542178C (en) | 2003-10-13 | 2004-10-13 | Radium target and method for producing it |
US11/402,143 US20070076834A1 (en) | 2003-10-13 | 2006-04-11 | Radium Target and method for producing it |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10347459A DE10347459B3 (en) | 2003-10-13 | 2003-10-13 | Radium target and process for its preparation |
DE10347459.5 | 2003-10-13 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/402,143 Continuation US20070076834A1 (en) | 2003-10-13 | 2006-04-11 | Radium Target and method for producing it |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2005039647A2 true WO2005039647A2 (en) | 2005-05-06 |
WO2005039647A3 WO2005039647A3 (en) | 2005-08-18 |
Family
ID=34484740
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2004/011510 WO2005039647A2 (en) | 2003-10-13 | 2004-10-13 | Radium target and method for producing it |
Country Status (6)
Country | Link |
---|---|
US (1) | US20070076834A1 (en) |
EP (1) | EP1673492B1 (en) |
JP (1) | JP4690328B2 (en) |
CA (1) | CA2542178C (en) |
DE (2) | DE10347459B3 (en) |
WO (1) | WO2005039647A2 (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005105160A1 (en) * | 2004-05-05 | 2005-11-10 | Actinium Pharmaceuticals, Inc. | Radium target and method for producing it |
JP2007287538A (en) * | 2006-04-19 | 2007-11-01 | Hitachi Ltd | Accelerator |
WO2008028664A1 (en) | 2006-09-08 | 2008-03-13 | Actinium Pharmaceuticals, Inc. | Method for the purification of radium from different sources |
US9534277B1 (en) | 2006-02-21 | 2017-01-03 | Actinium Pharmaceuticals, Inc. | Method for purification of 225AC from irradiated 226RA-targets |
CN109310789A (en) * | 2016-06-24 | 2019-02-05 | 塞控斯公司 | Preparation212The monoclonal antibody of Pb label |
CN114127340A (en) * | 2019-06-19 | 2022-03-01 | 日本医事物理股份有限公司 | Method for producing 226Ra target, method for producing 225Ac, and electrodeposition liquid for producing 226Ra target |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8271252B2 (en) * | 2007-11-08 | 2012-09-18 | Nvidia Corporation | Automatic verification of device models |
EP3773996A4 (en) | 2018-03-26 | 2022-03-30 | Triumf | Systems, apparatus and methods for separating actinium, radium, and thorium |
CN115552548A (en) * | 2019-06-21 | 2022-12-30 | 核研究和咨询集团 | Equipment for producing actinium-225 by radium-226 and application thereof |
US20220367081A1 (en) * | 2019-07-02 | 2022-11-17 | Nihon Medi-Physics Co., Ltd. | METHOD FOR PURIFYING 226Ra-CONTAINING SOLUTION, METHOD FOR PRODUCING 226Ra TARGET, AND METHOD FOR PRODUCING 225Ac |
KR102211812B1 (en) | 2019-07-23 | 2021-02-04 | 한국원자력의학원 | The method of producing actinium by liquified radium |
KR102233112B1 (en) * | 2019-07-25 | 2021-03-29 | 한국원자력의학원 | The apparatus of producing nuclide using fluid target |
EP3828899B1 (en) * | 2019-11-29 | 2022-01-05 | Ion Beam Applications | A method for producing ac-225 from ra-226 |
RU2752845C1 (en) * | 2020-05-13 | 2021-08-11 | Акционерное Общество "Наука И Инновации" | Method for obtaining high-purity radium-223 |
KR102500942B1 (en) | 2021-01-08 | 2023-02-17 | 니혼 메디피직스 가부시키가이샤 | Method for preparing Ac-225 solution and method for preparing medicine using Ac-225 solution |
US11541134B1 (en) | 2021-08-02 | 2023-01-03 | Rayzebio, Inc. | Stabilized compositions of radionuclides and uses thereof |
WO2024036411A1 (en) * | 2022-08-19 | 2024-02-22 | Atomic Energy Of Canada Limited/ Énergie Atomique Du Canada Limitée | A target for subsequent exposure to an accelerated proton beam and method of making same |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0962942A1 (en) * | 1998-06-02 | 1999-12-08 | European Community | Method for producing Ac-225 by irradiation of Ra-226 with protons |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4293617A (en) * | 1979-12-26 | 1981-10-06 | Gould Inc. | Process for producing strippable copper on an aluminum carrier and the article so obtained |
US4514266A (en) * | 1981-09-11 | 1985-04-30 | Republic Steel Corporation | Method and apparatus for electroplating |
US4454106A (en) * | 1982-06-07 | 1984-06-12 | Gansow Otto A | Use of metal chelate conjugated monoclonal antibodies |
US4663129A (en) * | 1985-01-30 | 1987-05-05 | The United States Of America As Represented By The United States Department Of Energy | Isotopic generator for bismuth-212 and lead-212 from radium |
JPS6393402A (en) * | 1986-10-06 | 1988-04-23 | Sumitomo Metal Ind Ltd | Production of thin-web h-shape steel |
LU87684A1 (en) * | 1990-02-23 | 1991-10-08 | Euratom | METHOD FOR PRODUCING ACTINIUM-225 AND WISMUT-213 |
JPH04234765A (en) * | 1990-08-29 | 1992-08-24 | Xerox Corp | Base body, belt and electrostatic photographic image forming member, and these manufacture |
JPH04326096A (en) * | 1991-04-26 | 1992-11-16 | Daiichi Rajio Isotope Kenkyusho:Kk | Producing method of target body for particle accelerator and radioactive isotope |
LU88636A1 (en) * | 1995-07-03 | 1997-01-03 | Euratom | Process for the production of Actinium-225 |
KR970061416A (en) * | 1996-02-28 | 1997-09-12 | 마리오 파테크, 죄르그 모제르 | Side-cut shears for sheet and band |
US5809394A (en) * | 1996-12-13 | 1998-09-15 | Battelle Memorial Institute | Methods of separating short half-life radionuclides from a mixture of radionuclides |
-
2003
- 2003-10-13 DE DE10347459A patent/DE10347459B3/en not_active Expired - Lifetime
-
2004
- 2004-10-13 JP JP2006530151A patent/JP4690328B2/en active Active
- 2004-10-13 CA CA2542178A patent/CA2542178C/en active Active
- 2004-10-13 WO PCT/EP2004/011510 patent/WO2005039647A2/en active Application Filing
- 2004-10-13 EP EP04765955A patent/EP1673492B1/en active Active
- 2004-10-13 DE DE602004020085T patent/DE602004020085D1/en active Active
-
2006
- 2006-04-11 US US11/402,143 patent/US20070076834A1/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0962942A1 (en) * | 1998-06-02 | 1999-12-08 | European Community | Method for producing Ac-225 by irradiation of Ra-226 with protons |
Non-Patent Citations (2)
Title |
---|
INGELBRECHT C ET AL: "Improved electrodeposited actinide layers" NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH, SECTION - A: ACCELERATORS, SPECTROMETERS, DETECTORS AND ASSOCIATED EQUIPMENT, NORTH-HOLLAND PUBLISHING COMPANY. AMSTERDAM, NL, vol. 397, no. 1, 21 September 1997 (1997-09-21), pages 34-38, XP004093028 ISSN: 0168-9002 * |
J. OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, vol. 160, no. 2, 1992, pages 477-485, XP008047777 cited in the application * |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005105160A1 (en) * | 2004-05-05 | 2005-11-10 | Actinium Pharmaceuticals, Inc. | Radium target and method for producing it |
US8349391B2 (en) | 2004-05-05 | 2013-01-08 | Actinium Pharmaceuticals Inc. | Radium target and method for producing it |
US9790573B2 (en) | 2006-02-21 | 2017-10-17 | Actinium Pharmaceuticals Inc. | Method for purification of 225AC from irradiated 226RA-targets |
US9534277B1 (en) | 2006-02-21 | 2017-01-03 | Actinium Pharmaceuticals, Inc. | Method for purification of 225AC from irradiated 226RA-targets |
JP2007287538A (en) * | 2006-04-19 | 2007-11-01 | Hitachi Ltd | Accelerator |
EP2796575A1 (en) | 2006-09-08 | 2014-10-29 | Actinium Pharmaceuticals Inc. | Method for the purification of radium from different sources |
US8715598B2 (en) | 2006-09-08 | 2014-05-06 | Actinium Pharmaceuticals Inc. | Method for the purification of radium from different sources |
US8153087B2 (en) | 2006-09-08 | 2012-04-10 | Actinium Pharmaceuticals Inc. | Method for the purification of radium from different sources |
WO2008028664A1 (en) | 2006-09-08 | 2008-03-13 | Actinium Pharmaceuticals, Inc. | Method for the purification of radium from different sources |
CN109310789A (en) * | 2016-06-24 | 2019-02-05 | 塞控斯公司 | Preparation212The monoclonal antibody of Pb label |
CN109310789B (en) * | 2016-06-24 | 2021-12-03 | 塞控斯公司 | Preparation of212Pb-labeled monoclonal antibody |
CN114127340A (en) * | 2019-06-19 | 2022-03-01 | 日本医事物理股份有限公司 | Method for producing 226Ra target, method for producing 225Ac, and electrodeposition liquid for producing 226Ra target |
US20220328208A1 (en) * | 2019-06-19 | 2022-10-13 | Nihon Medi-Physics Co., Ltd. | PRODUCTION METHOD OF 225Ac |
US20220356591A1 (en) * | 2019-06-19 | 2022-11-10 | Nihon Medi-Physics Co., Ltd. | PRODUCTION METHOD OF 226Ra TARGET, PRODUCTION METHOD OF 225Ac, AND ELECTRODEPOSITION SOLUTION FOR PRODUCING 226Ra TARGET |
US12046385B2 (en) * | 2019-06-19 | 2024-07-23 | Nihon Medi-Physics Co., Ltd. | Production method of 226Ra target, production method of 225Ac, and electrodeposition solution for producing 226Ra target |
Also Published As
Publication number | Publication date |
---|---|
EP1673492A2 (en) | 2006-06-28 |
DE10347459B3 (en) | 2005-05-25 |
EP1673492B1 (en) | 2009-03-18 |
DE602004020085D1 (en) | 2009-04-30 |
US20070076834A1 (en) | 2007-04-05 |
CA2542178C (en) | 2013-03-19 |
CA2542178A1 (en) | 2005-05-06 |
JP2007508531A (en) | 2007-04-05 |
WO2005039647A3 (en) | 2005-08-18 |
JP4690328B2 (en) | 2011-06-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20070076834A1 (en) | Radium Target and method for producing it | |
US9790573B2 (en) | Method for purification of 225AC from irradiated 226RA-targets | |
EP1742670B1 (en) | Radium target and method for producing it | |
US6676988B2 (en) | Radioactively coated devices | |
EP2796575B1 (en) | Method for the purification of radium from different sources | |
EP1076905B1 (en) | Production of palladium-103 | |
Chunfu et al. | Cyclotron production of no-carrier-added palladium-103 by bombardment of rhodium-103 target |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2004765955 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2542178 Country of ref document: CA Ref document number: 2006530151 Country of ref document: JP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 11402143 Country of ref document: US |
|
WWP | Wipo information: published in national office |
Ref document number: 2004765955 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 11402143 Country of ref document: US |