WO2005038037A3 - Methods for preparing phospholipids containing omega-3 and omega-6 moieties - Google Patents

Methods for preparing phospholipids containing omega-3 and omega-6 moieties Download PDF

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Publication number
WO2005038037A3
WO2005038037A3 PCT/IL2004/000958 IL2004000958W WO2005038037A3 WO 2005038037 A3 WO2005038037 A3 WO 2005038037A3 IL 2004000958 W IL2004000958 W IL 2004000958W WO 2005038037 A3 WO2005038037 A3 WO 2005038037A3
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Prior art keywords
omega
methods
moieties
phospholipids containing
preparing
Prior art date
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PCT/IL2004/000958
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French (fr)
Other versions
WO2005038037A2 (en
Inventor
Dorit Platt
Hala Laouz
Dori Pelled
Avidor Shulman
Original Assignee
Enzymotec Ltd
Dorit Platt
Hala Laouz
Dori Pelled
Avidor Shulman
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Publication date
Application filed by Enzymotec Ltd, Dorit Platt, Hala Laouz, Dori Pelled, Avidor Shulman filed Critical Enzymotec Ltd
Publication of WO2005038037A2 publication Critical patent/WO2005038037A2/en
Publication of WO2005038037A3 publication Critical patent/WO2005038037A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6481—Phosphoglycerides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J7/00—Phosphatide compositions for foodstuffs, e.g. lecithin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6458—Glycerides by transesterification, e.g. interesterification, ester interchange, alcoholysis or acidolysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Methods for the production of omega-3 and/or omega-6 enriched glycerophospholipids are provided, which are based on enzymatic transesterification and esterification through phospholipases PLA1 and PLA2, chemical synthesis, and enzymatic synthesis through phospholipase D. Phosphatidylserine, phosphatidylcholine, phosphatidylinositol and phosphatidylethanolamine preparations are also provided, as well as food articles, pharmaceutical compositions and capsules comprising thereof.
PCT/IL2004/000958 2003-10-22 2004-10-21 Methods for preparing phospholipids containing omega-3 and omega-6 moieties WO2005038037A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL158553 2003-10-22
IL15855303A IL158553A0 (en) 2003-10-22 2003-10-22 Method for preparing phosphatidylserine containing omega-3 acid moieties

Publications (2)

Publication Number Publication Date
WO2005038037A2 WO2005038037A2 (en) 2005-04-28
WO2005038037A3 true WO2005038037A3 (en) 2005-12-01

Family

ID=34044223

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2004/000958 WO2005038037A2 (en) 2003-10-22 2004-10-21 Methods for preparing phospholipids containing omega-3 and omega-6 moieties

Country Status (2)

Country Link
IL (1) IL158553A0 (en)
WO (1) WO2005038037A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9028877B2 (en) 2007-03-28 2015-05-12 Aker Biomarine Antarctic As Bioeffective krill oil compositions
US9220735B2 (en) 2007-03-28 2015-12-29 Aker Biomarine Antarctic As Methods of using krill oil to treat risk factors for cardiovascular, metabolic, and inflammatory disorders

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8052992B2 (en) 2003-10-22 2011-11-08 Enzymotec Ltd. Glycerophospholipids containing omega-3 and omega-6 fatty acids and their use in the treatment and improvement of cognitive functions
US7935365B2 (en) 2003-10-22 2011-05-03 Enzymotec, Ltd. Glycerophospholipids for the improvement of cognitive functions
US20050130937A1 (en) 2003-10-22 2005-06-16 Enzymotec Ltd. Lipids containing omega-3 and omega-6 fatty acids
CA2654631A1 (en) * 2006-06-09 2007-12-13 Erasmus University Medical Center Rotterdam Modulation of the immune system by inositol phospholipids
WO2009020406A1 (en) * 2007-08-07 2009-02-12 Granate Seed Limited Methods of making lipid substances, lipid substances made thereby and uses thereof
US8372812B2 (en) 2009-02-26 2013-02-12 Aker Biomarine Asa Phospholipid and protein tablets
WO2011095836A2 (en) * 2010-02-02 2011-08-11 Soluciones Extractivas Alimentarias, S.L. (Solutex) Trackable therapeutic macrophages
US11712429B2 (en) 2010-11-29 2023-08-01 Amarin Pharmaceuticals Ireland Limited Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
NZ744990A (en) 2010-11-29 2019-10-25 Amarin Pharmaceuticals Ie Ltd Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
US8846604B2 (en) 2011-09-02 2014-09-30 Artic Nutrition AS Lipid compositions with high DHA content
WO2013136183A2 (en) 2012-03-12 2013-09-19 Innolipid, As Oxidixable fatty acid composition delivery form
CN104379757B (en) * 2012-06-13 2017-03-15 株式会社钟化 Contain the manufacture method of phospholipid composite and contain phospholipid composite
US20140080791A1 (en) 2012-09-19 2014-03-20 Aker Biomarine As Omega-3 phospholipid supplements for females
AU2014229540A1 (en) 2013-03-14 2015-10-08 Aker Biomarine Antarctic As Omega- 3 phospholipid supplements for improved brain maturity
AU2014203179C1 (en) 2013-06-14 2017-05-04 Aker Biomarine Antarctic As Lipid extraction processes
CA2932766C (en) 2013-12-05 2018-05-01 Enzymotec Ltd. Serine glycerophospholipid preparation and method for treatment of seizures
GB201400431D0 (en) 2014-01-10 2014-02-26 Aker Biomarine As Phospholipid compositions and their preparation
ES2745226T3 (en) 2014-11-20 2020-02-28 Enzymotec Ltd Preparation of phospholipids for the improvement of communication skills
KR102515207B1 (en) 2015-02-11 2023-03-29 에이커 바이오마린 앤탁틱 에이에스 Lipid compositions
WO2016128830A1 (en) 2015-02-11 2016-08-18 Aker Biomarine Antarctic As Lipid extraction processes
US10894056B2 (en) 2015-07-13 2021-01-19 Enzymotec Ltd Phospholipid preparations for the improvement of sleep
AU2017231891B2 (en) 2016-03-10 2022-03-10 Frutarom Limited Phospholipid preparations for the improvement of brain plasticity
FI4056176T3 (en) 2018-09-24 2024-05-30 Amarin Pharmaceuticals Ie Ltd Methods of reducing the risk of cardiovascular events in a subject
WO2020177728A1 (en) * 2019-03-05 2020-09-10 四川国为制药有限公司 Fatty acid composition and application thereof
CN109852643B (en) * 2019-03-18 2022-05-06 威海深蓝奇迹生物科技有限公司 Method for preparing sn-1-DHA-lyso-phosphatidylserine
CA3145418A1 (en) * 2019-06-26 2020-12-30 Kannalife Sciences, Inc. Use of certain phosphatidylcholines containing long chain polyunsaturated fatty acids as neuroprotective agents
CN111154813A (en) * 2020-01-19 2020-05-15 烟台新时代健康产业日化有限公司 Preparation method of euphausia superba phospholipid
CN111518814B (en) * 2020-05-19 2022-07-01 西南大学 Application and method of brassica napus Bna.A05DAD1 gene
AU2022263358A1 (en) 2021-04-21 2023-11-30 Amarin Pharmaceuticals Ireland Limited Methods of reducing the risk of heart failure
US20230091294A1 (en) * 2021-09-22 2023-03-23 Wilson Martinez Gutierrez Enzymatically synthesized omega-3 structured phospholipids

Citations (7)

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9028877B2 (en) 2007-03-28 2015-05-12 Aker Biomarine Antarctic As Bioeffective krill oil compositions
US9034388B2 (en) 2007-03-28 2015-05-19 Aker Biomarine Antartic As Bioeffective krill oil compositions
US9072752B1 (en) 2007-03-28 2015-07-07 Aker Biomarine Antarctic As Bioeffective krill oil compositions
US9078905B2 (en) 2007-03-28 2015-07-14 Aker Biomarine Antarctic As Bioeffective krill oil compositions
US9119864B2 (en) 2007-03-28 2015-09-01 Aker Biomarine Antarctic As Bioeffective krill oil compositions
US9220735B2 (en) 2007-03-28 2015-12-29 Aker Biomarine Antarctic As Methods of using krill oil to treat risk factors for cardiovascular, metabolic, and inflammatory disorders
US9320765B2 (en) 2007-03-28 2016-04-26 Aker Biomarine Antarctic As Bioeffective krill oil compositions
US9375453B2 (en) 2007-03-28 2016-06-28 Aker Biomarine Antarctic As Methods for producing bioeffective krill oil compositions

Also Published As

Publication number Publication date
IL158553A0 (en) 2004-05-12
WO2005038037A2 (en) 2005-04-28

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