WO2005033130A3 - Mutated ig binding domains of protein l - Google Patents

Mutated ig binding domains of protein l Download PDF

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Publication number
WO2005033130A3
WO2005033130A3 PCT/GB2004/004174 GB2004004174W WO2005033130A3 WO 2005033130 A3 WO2005033130 A3 WO 2005033130A3 GB 2004004174 W GB2004004174 W GB 2004004174W WO 2005033130 A3 WO2005033130 A3 WO 2005033130A3
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WO
WIPO (PCT)
Prior art keywords
protein
mutated
binding domains
binding
domain
Prior art date
Application number
PCT/GB2004/004174
Other languages
French (fr)
Other versions
WO2005033130A2 (en
Inventor
Carolyn Enever
Ian Tomlinson
Original Assignee
Domantis Ltd
Carolyn Enever
Ian Tomlinson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Domantis Ltd, Carolyn Enever, Ian Tomlinson filed Critical Domantis Ltd
Publication of WO2005033130A2 publication Critical patent/WO2005033130A2/en
Publication of WO2005033130A3 publication Critical patent/WO2005033130A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci

Abstract

Isolated synthetic Ig binding domain of Protein L having enhanced binding affinity for an antibody VK domain, said binding affinity being enhanced over that of the wild type 131 binding domain of Protein L, said isolated Ig binding domain exhibiting at least one mutation of at least one amino acid residue corresponding to residues 25, 28, 31, 33-41, 45, 49, 50, 52-59, 61, 62, 76 and 78 of seq id no 1.
PCT/GB2004/004174 2003-10-03 2004-10-01 Mutated ig binding domains of protein l WO2005033130A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0323238A GB0323238D0 (en) 2003-10-03 2003-10-03 Synthetic LG binding domains of protein L
GB0323238.6 2003-10-03

Publications (2)

Publication Number Publication Date
WO2005033130A2 WO2005033130A2 (en) 2005-04-14
WO2005033130A3 true WO2005033130A3 (en) 2008-01-03

Family

ID=29415497

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2004/004174 WO2005033130A2 (en) 2003-10-03 2004-10-01 Mutated ig binding domains of protein l

Country Status (2)

Country Link
GB (1) GB0323238D0 (en)
WO (1) WO2005033130A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7159175B2 (en) 2017-09-25 2022-10-24 Jsr株式会社 Immunoglobulin-binding protein and affinity carrier using the same
JP7159151B2 (en) 2017-09-25 2022-10-24 Jsr株式会社 Immunoglobulin-binding protein and affinity carrier using the same

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* Cited by examiner, † Cited by third party
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WO2008020823A2 (en) 2005-05-23 2008-02-21 University Of Hawaii Cooperative reporter systems, components, and methods for analyte detection
US8795170B2 (en) * 2005-11-29 2014-08-05 Venture Gain LLC Residual based monitoring of human health
GB0621513D0 (en) * 2006-10-30 2006-12-06 Domantis Ltd Novel polypeptides and uses thereof
JP5405316B2 (en) 2006-12-27 2014-02-05 サノフイ Cycloalkylamine substituted isoquinoline derivatives
GB0809069D0 (en) 2008-05-19 2008-06-25 Univ Leuven Kath Gene signatures
JP6369807B2 (en) * 2014-10-21 2018-08-08 株式会社プロテイン・エクスプレス Protein L mutant
WO2016096643A1 (en) 2014-12-17 2016-06-23 Ge Healthcare Bioprocess R&D Ab Modified kappa light chain-binding polypeptides
JPWO2016121701A1 (en) 2015-01-26 2017-11-09 株式会社カネカ Affinity separation matrix for protein purification containing immunoglobulin κ chain variable region
JP6663360B2 (en) * 2015-01-26 2020-03-11 株式会社カネカ Mutant immunoglobulin kappa chain variable region binding peptide
WO2017195638A1 (en) 2016-05-09 2017-11-16 株式会社カネカ Method for refining antibody or antibody fragment containing κ-chain variable region
KR102637595B1 (en) * 2022-05-03 2024-02-16 아미코젠주식회사 Immunoglobulin-binding protein variant with increased alkali-tolerance and use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000015803A1 (en) * 1998-09-14 2000-03-23 Affitech As Immunoglobulin binding protein

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000015803A1 (en) * 1998-09-14 2000-03-23 Affitech As Immunoglobulin binding protein

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BECKINGHAM JA ET AL: "Interactions between a single immunoglobulin-binding domain of protein L from Peptostreptococcus magnus and a human kappa light chain", BIOCHEMICAL JOURNAL, PORTLAND PRESS, LONDON, GB, vol. 340, no. 1, 15 May 1999 (1999-05-15), pages 193 - 199, XP002128552, ISSN: 0264-6021 *
HOUSDEN N G ET AL: "Immunoglobulin-binding domains: Protein L from Peptostreptococcus magnus.", BIOCHEMICAL SOCIETY TRANSACTIONS, vol. 31, no. 3, June 2003 (2003-06-01), pages 716 - 718, XP002318665, ISSN: 0300-5127 *
KASTERN W ET AL: "STRUCTURE OF PEPTOSTREPTOCOCCAL PROTEIN L AND IDENTIFICATION OF A REPEATED IMMUNOGLOBULIN LIGHT CHAIN-BINDING DOMAIN", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 267, no. 18, 1992, pages 12820 - 12825, XP002318664, ISSN: 0021-9258 *
KIM D E ET AL: "A breakdown of symmetry in the folding transition state of protein L", JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB, vol. 298, no. 5, 19 May 2000 (2000-05-19), pages 971 - 984, XP004470883, ISSN: 0022-2836 *
SVENSSON HENRIK G ET AL: "Contributions of amino acid side chains to the kinetics and thermodynamics of the bivalent binding of protein L to Ig kappa light chain.", BIOCHEMISTRY, vol. 43, no. 9, 9 March 2004 (2004-03-09), pages 2445 - 2457, XP002318666, ISSN: 0006-2960 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7159175B2 (en) 2017-09-25 2022-10-24 Jsr株式会社 Immunoglobulin-binding protein and affinity carrier using the same
JP7159151B2 (en) 2017-09-25 2022-10-24 Jsr株式会社 Immunoglobulin-binding protein and affinity carrier using the same

Also Published As

Publication number Publication date
GB0323238D0 (en) 2003-11-05
WO2005033130A2 (en) 2005-04-14

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