WO2005028650A3 - RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS C VIRUS (HCV) EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) - Google Patents

RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS C VIRUS (HCV) EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) Download PDF

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Publication number
WO2005028650A3
WO2005028650A3 PCT/US2004/031012 US2004031012W WO2005028650A3 WO 2005028650 A3 WO2005028650 A3 WO 2005028650A3 US 2004031012 W US2004031012 W US 2004031012W WO 2005028650 A3 WO2005028650 A3 WO 2005028650A3
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WO
WIPO (PCT)
Prior art keywords
nucleic acid
expression
short interfering
sina
hcv
Prior art date
Application number
PCT/US2004/031012
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French (fr)
Other versions
WO2005028650A2 (en
Inventor
Vasant Jadhav
Karl Kossen
Shawn Zinnen
Narendra Vaish
James Mcswiggen
Original Assignee
Sirna Therapeutics Inc
Vasant Jadhav
Karl Kossen
Shawn Zinnen
Narendra Vaish
James Mcswiggen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority claimed from US10/667,271 external-priority patent/US20040209831A1/en
Priority claimed from US10/693,059 external-priority patent/US20080039414A1/en
Priority claimed from US10/720,448 external-priority patent/US8273866B2/en
Priority claimed from US10/727,780 external-priority patent/US20050233329A1/en
Priority claimed from US10/757,803 external-priority patent/US20050020525A1/en
Priority claimed from US10/780,447 external-priority patent/US7491805B2/en
Priority claimed from US10/826,966 external-priority patent/US20050032733A1/en
Priority claimed from PCT/US2004/013456 external-priority patent/WO2005041859A2/en
Priority claimed from PCT/US2004/016390 external-priority patent/WO2005019453A2/en
Priority to EP04816223A priority Critical patent/EP1670915A2/en
Priority to JP2006526440A priority patent/JP2007505606A/en
Application filed by Sirna Therapeutics Inc, Vasant Jadhav, Karl Kossen, Shawn Zinnen, Narendra Vaish, James Mcswiggen filed Critical Sirna Therapeutics Inc
Publication of WO2005028650A2 publication Critical patent/WO2005028650A2/en
Publication of WO2005028650A3 publication Critical patent/WO2005028650A3/en

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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Abstract

This invention relates to compounds, compositions, and methods useful for modulating HCVgene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of HCV gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of HCV genes.
PCT/US2004/031012 2003-09-16 2004-09-15 RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS C VIRUS (HCV) EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) WO2005028650A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2006526440A JP2007505606A (en) 2003-09-16 2004-09-15 RNA interference-mediated suppression of hepatitis C virus (HCV) expression using small interfering nucleic acids (siNA)
EP04816223A EP1670915A2 (en) 2003-09-16 2004-09-15 RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS C VIRUS (HCV) EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)

Applications Claiming Priority (20)

Application Number Priority Date Filing Date Title
US10/667,271 US20040209831A1 (en) 2002-02-20 2003-09-16 RNA interference mediated inhibition of hepatitis C virus (HCV) gene expression using short interfering nucleic acid (siNA)
US10/667,271 2003-09-16
US10/693,059 2003-10-23
US10/693,059 US20080039414A1 (en) 2002-02-20 2003-10-23 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US10/720,448 US8273866B2 (en) 2002-02-20 2003-11-24 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA)
US10/720,448 2003-11-24
US10/727,780 US20050233329A1 (en) 2002-02-20 2003-12-03 Inhibition of gene expression using duplex forming oligonucleotides
US10/727,780 2003-12-03
US10/757,803 2004-01-14
US10/757,803 US20050020525A1 (en) 2002-02-20 2004-01-14 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US54348004P 2004-02-10 2004-02-10
US60/543,480 2004-02-10
US10/780,447 2004-02-13
US10/780,447 US7491805B2 (en) 2001-05-18 2004-02-13 Conjugates and compositions for cellular delivery
US10/826,966 2004-04-16
US10/826,966 US20050032733A1 (en) 2001-05-18 2004-04-16 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SiNA)
PCT/US2004/013456 WO2005041859A2 (en) 2003-04-30 2004-04-30 Conjugates and compositions for cellular delivery.
USPCT/US04/13456 2004-04-30
USPCT/US04/16390 2004-05-24
PCT/US2004/016390 WO2005019453A2 (en) 2001-05-18 2004-05-24 RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC ACID (siNA)

Publications (2)

Publication Number Publication Date
WO2005028650A2 WO2005028650A2 (en) 2005-03-31
WO2005028650A3 true WO2005028650A3 (en) 2005-12-29

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PCT/US2004/031012 WO2005028650A2 (en) 2003-09-16 2004-09-15 RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS C VIRUS (HCV) EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)

Country Status (3)

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EP (1) EP1670915A2 (en)
JP (1) JP2007505606A (en)
WO (1) WO2005028650A2 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8202979B2 (en) 2002-02-20 2012-06-19 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid
US9994853B2 (en) 2001-05-18 2018-06-12 Sirna Therapeutics, Inc. Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
US20080207542A1 (en) * 2002-03-26 2008-08-28 Sirna Therapeutics, Inc. RNA inteference mediated inhibition of hepatitis C virus (HVC) gene expression using short interfering nucleic acid (siNA)
US9181551B2 (en) 2002-02-20 2015-11-10 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US7935812B2 (en) 2002-02-20 2011-05-03 Merck Sharp & Dohme Corp. RNA interference mediated inhibition of hepatitis C virus (HCV) expression using short interfering nucleic acid (siNA)
US9657294B2 (en) 2002-02-20 2017-05-23 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US7923547B2 (en) 2002-09-05 2011-04-12 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US10508277B2 (en) 2004-05-24 2019-12-17 Sirna Therapeutics, Inc. Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
KR100733186B1 (en) * 2005-05-31 2007-06-27 재단법인 목암생명공학연구소 Small Interfering RNA specific for HCV and Therapeutic Agent for Hepatitis C Comprising the Same
US7465561B2 (en) * 2005-06-30 2008-12-16 Roche Molecular Systems, Inc. Probes and methods for hepatitis C virus typing using single probe analysis
CA2619876A1 (en) * 2005-08-17 2007-02-22 Sirna Therapeutics, Inc. Chemically modified short interfering nucleic acid molecules that mediate rna interference
US20070099858A1 (en) * 2005-10-03 2007-05-03 Sirna Therapeutics, Inc. RNA interference mediated of inhibition of influenza virus gene expression using short interfering nucleic acid (siNA)
JP2009519033A (en) * 2005-12-16 2009-05-14 ディアト Cell penetrating peptide conjugates for delivering nucleic acids to cells
RU2008129711A (en) * 2005-12-19 2010-01-27 Сирна Терапьютикс, Инк. (Us) Mediated by RNA Interference Inhibition of Hepatitis C Virus Gene (HCV) Gene Expression Using Short Interfering Nucleic Acid (KINK)
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