WO2005025511A3 - Potassium channel mediated delivery of agents through the blood-brain barrier - Google Patents

Potassium channel mediated delivery of agents through the blood-brain barrier Download PDF

Info

Publication number
WO2005025511A3
WO2005025511A3 PCT/US2004/029787 US2004029787W WO2005025511A3 WO 2005025511 A3 WO2005025511 A3 WO 2005025511A3 US 2004029787 W US2004029787 W US 2004029787W WO 2005025511 A3 WO2005025511 A3 WO 2005025511A3
Authority
WO
WIPO (PCT)
Prior art keywords
blood
agents
brain barrier
potassium channel
mediated delivery
Prior art date
Application number
PCT/US2004/029787
Other languages
French (fr)
Other versions
WO2005025511A2 (en
Inventor
Keith L Black
Nagendra S Ningaraj
Original Assignee
Cedars Sinai Medical Center
Keith L Black
Nagendra S Ningaraj
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cedars Sinai Medical Center, Keith L Black, Nagendra S Ningaraj filed Critical Cedars Sinai Medical Center
Priority to EP04783849A priority Critical patent/EP1663239A4/en
Priority to JP2006526362A priority patent/JP2007505142A/en
Publication of WO2005025511A2 publication Critical patent/WO2005025511A2/en
Publication of WO2005025511A3 publication Critical patent/WO2005025511A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

This invention includes pharmaceutical compositions, methods and. kits for the treatment or diagnosis of a malignant tumors, including brain tumors, and diseases or disorders characterized by abnormal brain tissue.
PCT/US2004/029787 2003-09-10 2004-09-10 Potassium channel mediated delivery of agents through the blood-brain barrier WO2005025511A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP04783849A EP1663239A4 (en) 2003-09-10 2004-09-10 Potassium channel mediated delivery of agents through the blood-brain barrier
JP2006526362A JP2007505142A (en) 2003-09-10 2004-09-10 Potassium channel-mediated delivery of drugs across the blood brain barrier

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US50215903P 2003-09-10 2003-09-10
US60/502,159 2003-09-10
US52844003P 2003-12-10 2003-12-10
US60/528,440 2003-12-10
US54863604P 2004-02-27 2004-02-27
US60/548,636 2004-02-27

Publications (2)

Publication Number Publication Date
WO2005025511A2 WO2005025511A2 (en) 2005-03-24
WO2005025511A3 true WO2005025511A3 (en) 2005-11-03

Family

ID=34317476

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/029787 WO2005025511A2 (en) 2003-09-10 2004-09-10 Potassium channel mediated delivery of agents through the blood-brain barrier

Country Status (4)

Country Link
US (1) US20050089473A1 (en)
EP (1) EP1663239A4 (en)
JP (1) JP2007505142A (en)
WO (1) WO2005025511A2 (en)

Families Citing this family (142)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070086954A1 (en) * 1998-11-23 2007-04-19 Miller Christopher C Method and apparatus for treatment of respiratory infections by nitric oxide inhalation
US20040077702A1 (en) * 2001-09-14 2004-04-22 Wen-Mei Fu Treatment of nuerodegenerative diseases
US7799832B2 (en) * 2003-10-23 2010-09-21 Valeant Pharmaceuticals North America Combinations of retigabine and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains
DE602005023489D1 (en) * 2004-06-23 2010-10-21 Neurotec Pharma S L COMPOSITION FOR USE IN THE DIAGNOSIS OF ACUTE INJURIES OF THE CENTRAL NERVOUS SYSTEM
WO2006000607A1 (en) * 2004-06-23 2006-01-05 Neurotec Pharma, S.L. Compounds for the treatment of inflammation of the central nervous system
AR050084A1 (en) * 2004-07-27 2006-09-27 Novartis Ag BENCIMIDAZOLONE DERIVATIVES AS HSP90 INHIBITORS
DK1781265T3 (en) * 2004-08-25 2010-08-02 Essentialis Inc Pharmaceutical formulations of potassium ATP channel openers and applications thereof
EP1850852A4 (en) * 2005-02-22 2009-11-18 Cedars Sinai Medical Center Use of sildenafil, vardenafil and other 5-phosphodiesterase inhibitors to enhance permeability of the abnormal blood-brain barrier
WO2007002285A2 (en) * 2005-06-21 2007-01-04 The Trustees Of The University Of Pennsylvania Methods for treating neurological and psychiatric conditions
DE102005047946A1 (en) * 2005-10-06 2007-05-03 Bayer Healthcare Ag Use of soluble guanylate cyclase activators for the treatment of acute and chronic lung diseases
EP1973948B1 (en) 2005-12-15 2015-02-11 Genentech, Inc. Methods and compositions for targeting polyubiquitin
TW200732305A (en) * 2005-12-23 2007-09-01 Yung Shin Pharmaceutical Ind Cancer chemotherapy
AU2006335153B2 (en) * 2006-01-05 2012-03-15 Essentialis, Inc. Salts of potassium ATP channel openers and uses thereof
WO2007112367A2 (en) * 2006-03-27 2007-10-04 Portola Pharmaceuticals, Inc. Potassium channel modulators and platelet procoagulant activity
WO2007131133A2 (en) 2006-05-04 2007-11-15 Genentech, Inc. Methods and compositions relating to zpa polypeptides
US7960436B2 (en) * 2006-06-05 2011-06-14 Valeant Pharmaceuticals International Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators
KR20170098978A (en) 2006-07-14 2017-08-30 에이씨 이뮨 에스.에이. Humanized antibody against amyloid beta
WO2008011348A2 (en) 2006-07-14 2008-01-24 Ac Immune S.A. Humanized antibody against amyloid beta
US20080045534A1 (en) * 2006-08-18 2008-02-21 Valeant Pharmaceuticals North America Derivatives of 1,3-diamino benzene as potassium channel modulators
US8993593B2 (en) * 2006-08-23 2015-03-31 Valeant Pharmaceuticals International N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators
US8293911B2 (en) * 2006-08-23 2012-10-23 Valeant Pharmaceuticals International Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators
US8722929B2 (en) * 2006-10-10 2014-05-13 Valeant Pharmaceuticals International N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators
CN101578259A (en) * 2006-11-28 2009-11-11 威朗国际制药公司 1,4 diamino bicyclic retigabine analogues as potassium channel modulators
US7960139B2 (en) 2007-03-23 2011-06-14 Academia Sinica Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells
CN103071154A (en) 2007-04-13 2013-05-01 千年药品公司 Combination anticoagulant therapy with a compound that acts as a factor XA inhibitor
RS53793B1 (en) 2007-06-12 2015-06-30 Ac Immune S.A. Humanized antibodies to amyloid beta
EP2170953B1 (en) 2007-06-12 2015-07-15 AC Immune S.A. Monoclonal anti beta amyloid antibody
US8367684B2 (en) * 2007-06-13 2013-02-05 Valeant Pharmaceuticals International Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
CN101795691A (en) * 2007-07-02 2010-08-04 伊森舍丽斯有限公司 Salts of potassium atp channel openers and uses thereof
US8563566B2 (en) 2007-08-01 2013-10-22 Valeant Pharmaceuticals International Naphthyridine derivatives as potassium channel modulators
US7786146B2 (en) * 2007-08-13 2010-08-31 Valeant Pharmaceuticals International Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators
CA2701790A1 (en) 2007-10-05 2009-04-16 Ac Immune S.A. Use of humanized anti-beta-amyloid antibody in ocular diseases
TWI468417B (en) 2007-11-30 2015-01-11 Genentech Inc Anti-vegf antibodies
JP5986745B2 (en) 2008-07-15 2016-09-06 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ Glycan arrays on PTFE-like aluminum-coated glass slides and related methods
KR102100066B1 (en) 2008-10-14 2020-04-10 제넨테크, 인크. Immunoglobulin variants and uses thereof
KR20110081862A (en) 2008-10-22 2011-07-14 제넨테크, 인크. Modulation of axon degeneration
US20120009182A1 (en) 2008-12-23 2012-01-12 Genentech, Inc. Immunoglobulin variants with altered binding to protein a
EP2473522B1 (en) 2009-09-02 2016-08-17 Genentech, Inc. Mutant smoothened and methods of using the same
BR112012009257A2 (en) 2009-10-22 2016-11-22 Genentech Inc axon degeneration modulation.
US10087236B2 (en) 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
US11377485B2 (en) 2009-12-02 2022-07-05 Academia Sinica Methods for modifying human antibodies by glycan engineering
WO2011071577A1 (en) 2009-12-11 2011-06-16 Genentech, Inc. Anti-vegf-c antibodies and methods using same
CA2784385A1 (en) 2009-12-23 2011-06-30 Genentech, Inc. Anti-bv8 antibodies and uses thereof
WO2011130332A1 (en) 2010-04-12 2011-10-20 Academia Sinica Glycan arrays for high throughput screening of viruses
AU2011250970B2 (en) 2010-05-10 2016-12-15 Sinica, Academia Zanamivir phosphonate congeners with anti-influenza activity and determining oseltamivir susceptibility of influenza viruses
SG187173A1 (en) 2010-07-30 2013-02-28 Ac Immune Sa Safe and functional humanized anti beta-amyloid antibody
WO2012020124A1 (en) 2010-08-12 2012-02-16 Ac Immune S.A. Vaccine engineering
EP2625197B1 (en) 2010-10-05 2016-06-29 Genentech, Inc. Mutant smoothened and methods of using the same
DK2625198T3 (en) 2010-10-07 2015-09-28 Ac Immune Sa Antibodies that recognize the phosphorylated tau
US9687447B2 (en) 2010-10-26 2017-06-27 Ac Immune S.A. Method for preparing liposome-based constructs
US20120171120A1 (en) 2010-11-30 2012-07-05 Genentech, Inc. Low affinity blood brain barrier receptor antibodies and uses therefor
CN104080806B (en) 2011-10-07 2018-01-19 Ac免疫有限公司 Identify Tau phosphorylation specific antibody
EP2776047A4 (en) 2011-11-07 2015-07-22 Gen Hospital Corp Treatment of red blood cells
MX356800B (en) 2012-04-05 2018-06-13 Ac Immune Sa Humanized tau antibody.
US10130714B2 (en) 2012-04-14 2018-11-20 Academia Sinica Enhanced anti-influenza agents conjugated with anti-inflammatory activity
EP2852584B1 (en) 2012-05-22 2018-02-28 F. Hoffmann-La Roche AG Substituted dipyridylamines and uses thereof
AU2013266398A1 (en) 2012-05-22 2015-01-22 Genentech, Inc. N-substituted benzamides and their use in the treatment of pain
MX2015000164A (en) 2012-07-06 2015-08-12 Genentech Inc N-substituted benzamides and methods of use thereof.
US9914956B2 (en) 2012-08-18 2018-03-13 Academia Sinica Cell-permeable probes for identification and imaging of sialidases
EP2888238A4 (en) 2012-08-21 2016-01-27 Academia Sinica Benzocyclooctyne compounds and uses thereof
WO2014049047A1 (en) 2012-09-27 2014-04-03 F. Hoffmann-La Roche Ag Substituted sulfonamide compounds
BR112015016395A2 (en) 2013-01-18 2017-07-11 Hoffmann La Roche 3-substituted pyrazoles and use as dlk inhibitors
RU2015143906A (en) 2013-03-14 2017-04-18 Дженентек, Инк. SUBSTITUTED TRIAZOLOPYRIDINES AND WAYS OF THEIR APPLICATION
EP2970452A2 (en) 2013-03-15 2016-01-20 AC Immune S.A. Anti-tau antibodies and methods of use
KR20160002850A (en) 2013-05-01 2016-01-08 에프. 호프만-라 로슈 아게 C-linked heterocycloalkyl substituted pyrimidines and their uses
PE20200447A1 (en) 2013-05-01 2020-02-28 Hoffmann La Roche BIHETEROARIL COMPOUNDS AND USES OF THEM
US20140350097A1 (en) * 2013-05-23 2014-11-27 Medinox,Inc. Treatment of hypotension associated with hemodialysis
WO2014210397A1 (en) 2013-06-26 2014-12-31 Academia Sinica Rm2 antigens and use thereof
WO2014210564A1 (en) 2013-06-27 2014-12-31 Academia Sinica Glycan conjugates and use thereof
EP3041484B1 (en) 2013-09-06 2021-03-03 Academia Sinica Human inkt cell activation using glycolipids with altered glycosyl groups
JP2016532673A (en) 2013-10-11 2016-10-20 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Substituted heterocyclic sulfonamide compounds useful as TRPA1 modulators
MX2016008110A (en) 2013-12-20 2016-08-19 Hoffmann La Roche Pyrazole derivatives and uses thereof as inhibitors of dlk.
US10150818B2 (en) 2014-01-16 2018-12-11 Academia Sinica Compositions and methods for treatment and detection of cancers
TW201620939A (en) 2014-01-16 2016-06-16 中央研究院 Compositions and methods for treatment and detection of cancers
WO2016114819A1 (en) 2015-01-16 2016-07-21 Academia Sinica Compositions and methods for treatment and detection of cancers
AU2015214264B2 (en) 2014-02-04 2018-12-20 Curis, Inc. Mutant Smoothened and methods of using the same
CN106415244B (en) 2014-03-27 2020-04-24 中央研究院 Reactive marker compounds and uses thereof
EP3149036A4 (en) 2014-05-27 2017-12-27 Academia Sinica Anti-cd20 glycoantibodies and uses thereof
KR102512592B1 (en) 2014-05-27 2023-03-21 아카데미아 시니카 Anti-her2 glycoantibodies and uses thereof
KR102576850B1 (en) 2014-05-27 2023-09-11 아카데미아 시니카 Fucosidase from bacteroides and methods using the same
US10118969B2 (en) 2014-05-27 2018-11-06 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
AU2015267044A1 (en) 2014-05-28 2016-12-15 Academia Sinica Anti-TNF-alpha glycoantibodies and uses thereof
CN106715418A (en) 2014-07-07 2017-05-24 基因泰克公司 Therapeutic compounds and methods of use thereof
CN107001404B (en) 2014-09-08 2021-06-29 中央研究院 Activation of human iNKT cells using glycolipids
RU2730668C2 (en) 2014-11-19 2020-08-24 Аксон Ньюросайенс Се Humanised tau antibodies in alzheimer disease
US10495645B2 (en) 2015-01-16 2019-12-03 Academia Sinica Cancer markers and methods of use thereof
US9975965B2 (en) 2015-01-16 2018-05-22 Academia Sinica Compositions and methods for treatment and detection of cancers
AU2015378564A1 (en) 2015-01-24 2017-07-13 Academia Sinica Novel glycan conjugates and methods of use thereof
JP2018510844A (en) 2015-01-24 2018-04-19 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ Cancer marker and method of use thereof
DK3250590T3 (en) 2015-01-30 2021-10-18 Academia Sinica Compositions and Methods relating to universal glycoforms for enhanced anti-SSEA4 antibody efficacy
JP2018512597A (en) 2015-02-04 2018-05-17 ジェネンテック， インコーポレイテッド Mutant smoothened and method of using the same
CN107406462B (en) 2015-03-09 2020-11-10 豪夫迈·罗氏有限公司 Tricyclic DLK inhibitors and uses thereof
CR20170591A (en) 2015-05-22 2018-05-07 Genentech Inc BENZAMIDS REPLACED AND METHODS TO USE THEM
CN108137477A (en) 2015-08-27 2018-06-08 基因泰克公司 Therapeutic compounds and its application method
JP2018532990A (en) 2015-09-04 2018-11-08 オービーアイ ファーマ，インコーポレイテッド Glycan arrays and methods of use
US10899732B2 (en) 2015-11-25 2021-01-26 Genentech, Inc. Substituted benzamides useful as sodium channel blockers
EP3411396A1 (en) 2016-02-04 2018-12-12 Curis, Inc. Mutant smoothened and methods of using the same
JP2019515876A (en) 2016-03-08 2019-06-13 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ Methods for module synthesis of N-glycans and their arrays
US10980894B2 (en) 2016-03-29 2021-04-20 Obi Pharma, Inc. Antibodies, pharmaceutical compositions and methods
EP3436482A4 (en) 2016-03-29 2020-03-11 OBI Pharma, Inc. Antibodies, pharmaceutical compositions and methods
EP3854782A1 (en) 2016-03-30 2021-07-28 Genentech, Inc. Substituted benzamides and methods of use thereof
SG11201809024UA (en) 2016-04-22 2018-11-29 Obi Pharma Inc Cancer immunotherapy by immune activation or immune modulation via globo series antigens
CN109476628B (en) 2016-07-20 2022-01-11 豪夫迈·罗氏有限公司 Sulfonylcycloalkylamide compounds as TRPA1 modulators
JP7043483B2 (en) 2016-07-20 2022-03-29 エフ．ホフマン－ラ ロシュ アーゲー Bicyclic proline compound
AU2017302038B2 (en) 2016-07-27 2024-03-21 Obi Pharma, Inc. Immunogenic/therapeutic glycan compositions and uses thereof
EP3491026A4 (en) 2016-07-29 2020-07-29 OBI Pharma, Inc. Human antibodies, pharmaceutical compositions and methods
US11304963B2 (en) * 2016-07-29 2022-04-19 Biogen Chesapeake Llc Methods of medical treatment with SUR1-TRPM4 channel inhibitors
EP3497093B1 (en) 2016-08-12 2021-09-15 F. Hoffmann-La Roche AG Sulfonyl pyridyl trp inhibitors
JP7213549B2 (en) 2016-08-22 2023-01-27 シーエイチオー ファーマ インコーポレイテッド Antibodies, Binding Fragments, and Methods of Use
WO2018073193A1 (en) 2016-10-17 2018-04-26 F. Hoffmann-La Roche Ag Bicyclic pyridone lactams and methods of use thereof
US11000601B2 (en) 2016-11-21 2021-05-11 Obi Pharma, Inc. Conjugated biological molecules, pharmaceutical compositions and methods
TW201831477A (en) 2016-11-28 2018-09-01 瑞士商赫孚孟拉羅股份公司 Oxadiazolone transient receptor potential channel inhibitors
TW201831478A (en) 2016-12-02 2018-09-01 瑞士商赫孚孟拉羅股份公司 Bicyclic amide compounds and methods of use thereof
US11072607B2 (en) 2016-12-16 2021-07-27 Genentech, Inc. Inhibitors of RIP1 kinase and methods of use thereof
CN110461838B (en) 2017-03-07 2022-05-06 豪夫迈·罗氏有限公司 Oxadiazole transient receptor potential channel inhibitors
US10793550B2 (en) 2017-03-24 2020-10-06 Genentech, Inc. 4-piperidin-n-(pyrimidin-4-yl)chroman-7-sulfonamide derivatives as sodium channel inhibitors
KR20200030558A (en) 2017-07-14 2020-03-20 에프. 호프만-라 로슈 아게 Bicyclic ketone compounds and methods of use
CA3078653A1 (en) 2017-10-11 2019-04-18 F. Hoffmann-La Roche Ag Bicyclic compounds for use as rip1 kinase inhibitors
CR20200168A (en) 2017-10-31 2020-07-12 Hoffmann La Roche Bicyclic sulfones and sulfoxides and methods of use thereof
BR112020010903A2 (en) 2017-11-30 2020-11-17 Hanmi Pharm. Co., Ltd. compound, salt of a compound of formula (I), pharmaceutical composition, use of a pharmaceutical composition, use of a compound, method of preparing a crystalline form of the salt
WO2019164778A1 (en) 2018-02-20 2019-08-29 Genentech, Inc. Process for preparing 1-arylsulfonyl-pyrrolidine-2-carboxamide transient receptor potential channel antagonist compounds and crystalline forms thereof
US11028075B2 (en) 2018-02-26 2021-06-08 Genentech, Inc. Therapeutic compounds and methods of use thereof
US10710994B2 (en) 2018-03-19 2020-07-14 Genentech, Inc. Oxadiazole transient receptor potential channel inhibitors
WO2019191702A1 (en) 2018-03-30 2019-10-03 F. Hoffmann-La Roche Ag Substituted hydro-pyrido-azines as sodium channel inhibitors
CN112074519A (en) 2018-04-20 2020-12-11 豪夫迈·罗氏有限公司 N- [ 4-oxo-2, 3-dihydro-1, 5-benzoxazepin-3-yl ] -5, 6-dihydro-4H-pyrrolo [1,2-B ] pyrazole-2-carboxamide derivatives and related compounds as RIP1 kinase inhibitors for the treatment of e.g. Irritable Bowel Syndrome (IBS)
TW202003490A (en) 2018-05-22 2020-01-16 瑞士商赫孚孟拉羅股份公司 Therapeutic compounds and methods of use thereof
US11203645B2 (en) 2018-06-27 2021-12-21 Obi Pharma, Inc. Glycosynthase variants for glycoprotein engineering and methods of use
TW202024023A (en) 2018-09-03 2020-07-01 瑞士商赫孚孟拉羅股份公司 Therapeutic compounds and methods of use
JP2022516651A (en) 2019-01-11 2022-03-01 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Bicyclic pyrrorotriazole ketone compounds and their usage
MX2022005775A (en) 2019-11-13 2022-06-09 Genentech Inc Therapeutic compounds and methods of use.
WO2021110995A1 (en) 2019-12-04 2021-06-10 Ac Immune Sa Novel molecules for therapy and diagnosis
US11787775B2 (en) 2020-07-24 2023-10-17 Genentech, Inc. Therapeutic compounds and methods of use
WO2022034228A1 (en) 2020-08-14 2022-02-17 Ac Immune Sa Humanized anti-tdp-43 binding molecules and uses thereof
JP2023544037A (en) 2020-10-02 2023-10-19 ジェネンテック， インコーポレイテッド Methods for preparing biheteroaryl compounds and their crystalline forms
EP4229082A1 (en) 2020-10-16 2023-08-23 AC Immune SA Antibodies binding to alpha-synuclein for therapy and diagnosis
WO2023028056A1 (en) 2021-08-24 2023-03-02 Genentech, Inc. 3-amino piperidyl sodium channel inhibitors
WO2023028077A1 (en) 2021-08-24 2023-03-02 Genentech, Inc. Sodium channel inhibitors and methods of designing same
TW202332429A (en) 2021-11-24 2023-08-16 美商建南德克公司 Therapeutic compounds and methods of use
US20230203062A1 (en) 2021-11-24 2023-06-29 Genentech, Inc. Therapeutic compounds and methods of use
CN114452404B (en) * 2021-12-14 2023-09-08 中山大学附属第三医院（中山大学肝脏病医院） Vesicle with anchoring and charge overturning functions and preparation and application thereof
TW202342519A (en) 2022-02-16 2023-11-01 瑞士商Ａｃ 免疫有限公司 Humanized anti-tdp-43 binding molecules and uses thereof
WO2023194565A1 (en) 2022-04-08 2023-10-12 Ac Immune Sa Anti-tdp-43 binding molecules

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5011837A (en) * 1988-08-09 1991-04-30 E. R. Squibb & Sons, Inc. Aryl cyanoguanidines: potassium channel activators and method of making same
US5234922A (en) * 1992-09-28 1993-08-10 University Of Iowa Research Foundation Use of sulfonylureas and other potassium channel regulators to treat secretory diarrhea
US5256688A (en) * 1988-07-18 1993-10-26 E. R. Squibb & Sons, Inc. Method for inhibiting myocardial cell necrosis and preserving heart function during myocardial ischemia and/or reperfusion

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7018979B1 (en) * 2000-01-26 2006-03-28 Cedars-Sinai Medical Center Method for using potassium channel agonists for delivering a medicant to an abnormal brain region and/or a malignant tumor
AU2001233052A1 (en) * 2000-01-26 2001-08-07 Cedars-Sinai Medical Center Method for using potassium channel activation for delivering a medicant to an abnormal brain region and/or a malignant tumor

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5256688A (en) * 1988-07-18 1993-10-26 E. R. Squibb & Sons, Inc. Method for inhibiting myocardial cell necrosis and preserving heart function during myocardial ischemia and/or reperfusion
US5011837A (en) * 1988-08-09 1991-04-30 E. R. Squibb & Sons, Inc. Aryl cyanoguanidines: potassium channel activators and method of making same
US5234922A (en) * 1992-09-28 1993-08-10 University Of Iowa Research Foundation Use of sulfonylureas and other potassium channel regulators to treat secretory diarrhea

Also Published As

Publication number Publication date
US20050089473A1 (en) 2005-04-28
EP1663239A2 (en) 2006-06-07
JP2007505142A (en) 2007-03-08
EP1663239A4 (en) 2008-07-23
WO2005025511A2 (en) 2005-03-24

Similar Documents

Publication Publication Date Title
WO2005025511A3 (en) Potassium channel mediated delivery of agents through the blood-brain barrier
WO2006064453A3 (en) Targeting agents for molecular imaging
WO2006064451A3 (en) Targeting contrast agents or targeting therapeutic agents for molecular imaging and therapy
WO2005046603A3 (en) Pyridine compounds
WO2002078766A3 (en) Combination therapy
WO2005002515A3 (en) Delivery of therapeutic compounds to the brain and other tissues
WO2004113275A3 (en) Methods and compositions for treating amyloid-related diseases
HK1092467A1 (en) N-alkyl-hydroxamic acid-isoindolyl compounds and their pharmaceutical uses n-
TW200600087A (en) Methods and compositions for treating amyloid-related diseases
CA2449729A1 (en) Prodrugs of gaba analogs, compositions and uses thereof
WO2004111192A3 (en) Targeted delivery to legumain-expressing cells
WO2002064083A3 (en) Synthesis of 3-amino-thalidomide and its enantiomers
WO2007109236A8 (en) Microrna fingerprints during human megakaryocytopoiesis
EP2862867A3 (en) Methods and compositions for the treatment of Marfan syndrome and associated disorders
TW200528117A (en) Methods and reagents for the treatment of proliferative diseases
WO2005048935A3 (en) Methods of modulating immunity
PL1663244T3 (en) Pteridine derivatives for the treatment of tnf-alpha-related diseases.
WO2006058869A8 (en) Substituted pteridines for treating inflammatory diseases
WO2004039322A3 (en) Novel combination therapy for schizophrenia focused on improved cognition: 5-ht-2a/d2 blockade with adjunctive blockade of prefrontal da reuptake
WO2005092062A3 (en) Compounds for neurodegenerative disorders
IL169889A0 (en) Methods for diagnosis and monitoring of neurological disease by detection of an encephalotoxin
ATE405568T1 (en) CYTOTOXIC AGENTS
WO2004009609A3 (en) Nucleoside compounds and their use for treating cancer and diseases associated with somatic mutations
WO2004073615A8 (en) Deazaflavin compounds and methods of use thereof
WO2006019685A3 (en) Compounds and their preparation for the treatment of alzheimer's disease by inhibiting beta-amyloid peptide production

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BW BY BZ CA CH CN CO CR CU CZ DK DM DZ EC EE EG ES FI GB GD GE GM HR HU ID IL IN IS JP KE KG KP KZ LC LK LR LS LT LU LV MA MD MK MN MW MX MZ NA NI NO NZ PG PH PL PT RO RU SC SD SE SG SK SY TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SZ TZ UG ZM ZW AM AZ BY KG MD RU TJ TM AT BE BG CH CY DE DK EE ES FI FR GB GR HU IE IT MC NL PL PT RO SE SI SK TR BF CF CG CI CM GA GN GQ GW ML MR SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2004783849

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2006526362

Country of ref document: JP

DPEN Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed from 20040101)
WWP Wipo information: published in national office

Ref document number: 2004783849

Country of ref document: EP