WO2005024040A3 - Target and method for inhibition of bacterial rna polymerase: minimized derivatives of peptide antibiotic mccj25 - Google Patents

Target and method for inhibition of bacterial rna polymerase: minimized derivatives of peptide antibiotic mccj25 Download PDF

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Publication number
WO2005024040A3
WO2005024040A3 PCT/US2004/028640 US2004028640W WO2005024040A3 WO 2005024040 A3 WO2005024040 A3 WO 2005024040A3 US 2004028640 W US2004028640 W US 2004028640W WO 2005024040 A3 WO2005024040 A3 WO 2005024040A3
Authority
WO
WIPO (PCT)
Prior art keywords
inhibition
mccj25
minimized
derivatives
target
Prior art date
Application number
PCT/US2004/028640
Other languages
French (fr)
Other versions
WO2005024040A2 (en
Inventor
Richard H Ebright
Jayanta Mukhopadhyay
Original Assignee
Univ Rutgers
Richard H Ebright
Jayanta Mukhopadhyay
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2003/027457 external-priority patent/WO2004023093A2/en
Application filed by Univ Rutgers, Richard H Ebright, Jayanta Mukhopadhyay filed Critical Univ Rutgers
Priority to US10/571,226 priority Critical patent/US20070196886A1/en
Publication of WO2005024040A2 publication Critical patent/WO2005024040A2/en
Publication of WO2005024040A3 publication Critical patent/WO2005024040A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G01N2333/91245—Nucleotidyltransferases (2.7.7)
    • G01N2333/9125—Nucleotidyltransferases (2.7.7) with a definite EC number (2.7.7.-)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Abstract

Disclosed are targets, methods, and reagents for specific binding and inhibition of RNAP from bacterial species. The invention has applications in analysis of RNAP structure and function, control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, antibacterial therapy, and drug discovery.
PCT/US2004/028640 2003-09-04 2004-09-02 TARGET AND METHOD FOR INHIBITION OF BACTERIAL RNA POLYMERASE: MINIMIZED DERIVATIVES OF PEPTIDE ANTIBIOTIC MccJ25 WO2005024040A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US10/571,226 US20070196886A1 (en) 2004-09-02 2004-09-02 Target And Method For Inhibition Of Bacterial Rna Polymerase Minimized Derivatives Of Peptide Antibiotic Mccj25

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US2003/027457 WO2004023093A2 (en) 2002-09-04 2003-09-04 Target and method for inhibition of bacterial rna polymerase
USPCT/US03/27457 2003-09-04

Publications (2)

Publication Number Publication Date
WO2005024040A2 WO2005024040A2 (en) 2005-03-17
WO2005024040A3 true WO2005024040A3 (en) 2005-08-04

Family

ID=34271655

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/028640 WO2005024040A2 (en) 2003-09-04 2004-09-02 TARGET AND METHOD FOR INHIBITION OF BACTERIAL RNA POLYMERASE: MINIMIZED DERIVATIVES OF PEPTIDE ANTIBIOTIC MccJ25

Country Status (1)

Country Link
WO (1) WO2005024040A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007089310A1 (en) 2005-11-04 2007-08-09 Rutgers, The State University Of New Jersey Bipartite inhibitors of bacterial rna polymerase
WO2013119564A1 (en) 2012-02-06 2013-08-15 Rutgers, The State University Of New Jersey Antibacterial agents: combination of a rifamycin and a switch region inhibitor
CN113072627B (en) * 2020-11-02 2022-07-05 重庆市畜牧科学院 MccJ25 mutant and preparation method and application thereof
CN113774006B (en) * 2021-06-30 2022-06-28 安杰利(重庆)生物科技有限公司 Engineering strain for efficiently expressing McJ 25 and fermentation process thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DELGADO M.A. ET AL: "Escherichia coli RNA Polymerase Is the Target of the Cyclopeptide Antibiotic Microcin J25", J BACTERIOLOGY, vol. 183, no. 15, August 2001 (2001-08-01), pages 4543 - 4550, XP002977874 *
MUKHOPADHYAY J. ET AL: "Antibacterial peptide microcin J25 inhibits transcription by binding within and obstructing the RNA polymerase secondary channel.", MOLECULAR CELL, vol. 14, 18 June 2004 (2004-06-18), pages 739 - 751, XP002987795 *
RODRIGUEZ E. ET AL: "The Proton Channel Is the Minimal Structure of ATP Synthase Necessary and Sufficient for Microcin H47 Antibiotic Action", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 47, January 2003 (2003-01-01), pages 181 - 187, XP002988205 *

Also Published As

Publication number Publication date
WO2005024040A2 (en) 2005-03-17

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