WO2005022125A1 - Integrated apparatus for hematological analyses and related method - Google Patents
Integrated apparatus for hematological analyses and related method Download PDFInfo
- Publication number
- WO2005022125A1 WO2005022125A1 PCT/IB2004/002824 IB2004002824W WO2005022125A1 WO 2005022125 A1 WO2005022125 A1 WO 2005022125A1 IB 2004002824 W IB2004002824 W IB 2004002824W WO 2005022125 A1 WO2005022125 A1 WO 2005022125A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- blood
- detect
- measuring assembly
- speed
- pick
- Prior art date
Links
- 238000004458 analytical method Methods 0.000 title claims abstract description 37
- 238000000034 method Methods 0.000 title claims abstract description 23
- 230000002489 hematologic effect Effects 0.000 title claims abstract description 10
- 239000008280 blood Substances 0.000 claims abstract description 68
- 210000004369 blood Anatomy 0.000 claims abstract description 68
- 238000004062 sedimentation Methods 0.000 claims abstract description 18
- 230000003287 optical effect Effects 0.000 claims abstract description 14
- 238000002835 absorbance Methods 0.000 claims abstract description 9
- 238000005259 measurement Methods 0.000 claims description 17
- 238000011144 upstream manufacturing Methods 0.000 claims description 4
- 230000004087 circulation Effects 0.000 claims description 3
- 238000001514 detection method Methods 0.000 claims description 2
- 230000017531 blood circulation Effects 0.000 claims 4
- 238000007789 sealing Methods 0.000 claims 1
- 238000005534 hematocrit Methods 0.000 description 7
- 239000003146 anticoagulant agent Substances 0.000 description 5
- 229940127219 anticoagulant drug Drugs 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 230000002596 correlated effect Effects 0.000 description 3
- 230000005670 electromagnetic radiation Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 230000008901 benefit Effects 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000007792 addition Methods 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 238000012631 diagnostic technique Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000007430 reference method Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000012883 sequential measurement Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/04—Investigating sedimentation of particle suspensions
- G01N15/05—Investigating sedimentation of particle suspensions in blood
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/491—Blood by separating the blood components
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N2015/1486—Counting the particles
Definitions
- the present invention concerns an integrated apparatus to perform hematological analyses on blood samples .
- the invention concerns an apparatus that integrates in the same machine at least a cell-counter function, or other type of analysis connected with a cell-counter function, and the function of detecting the speed of blood sedimentation, or ESR.
- the invention also concerns the method performed by such apparatus .
- pathological states defined as inflammatory, are ascertained by measuring also the speed of sedimentation of the corpuscular part of the blood (ESR).
- ESR ESR-related predictive metric analysis
- known methods to measure ESR are generally characterized by long analysis times (from 30 to 60 minutes), which prevent such analysis being performed in succession with other, faster analyses, for example cell-counter analyses.
- known methods generally have to use throw-away containers, which entails an increase in costs both for purchasing them and for their disposal.
- a great quantity of blood is needed to perform the analysis, normally from 1 to 3 ml, and this entails problems in particular cases, for example when the analysis is to be made on children.
- a method to detect the ESR is known, proposed by the same Applicant in EP-A-1.098.188, which provides to take a sample of blood to be analyzed, not diluted and to which no anti-coagulants or other substances have been added, from a container in which it is preserved, and to introduce this sample into a capillary tube, which is used for various measurements made on different samples.
- This method is based on detecting the optical density or absorbance of the blood at a point of the measurement volume, by instantaneously stopping the flow of blood inside the capillary, in which a photometric signal correlated to the ESR examination is detected, according to the reference method known as estergren (see for example the article "Determination of the Length of Sedimentation Reaction..” by Piva E., Fassina P. and Plebani M. , published in Clin. Chem. Lab. Med. 2002; 40(7); pages 713- 717) .
- estergren see for example the article "Determination of the Length of Sedimentation Reaction..” by Piva E., Fassina P. and Plebani M. , published in Clin. Chem. Lab. Med. 2002; 40(7); pages 713- 717) .
- the study of absorbance over time allows to work out the ERS value by eliminating the initial dead times, and thus considerably reducing the overall times needed, and obvi
- the necessary quantity of blood to be analyzed is smaller and hence the analysis can be carried out without difficulty even on pediatric patients.
- Another known method for determining the speed of sedimentation of blood is described in EP-A-0.732.576, also in the name of the present Applicant.
- the method uses the detection of the optical density, or absorbance, of a blood sample at a point of the measurement volume while said sample is subjected to centrifugal rotation inside a capillary tube.
- the study of the absorbance in the blood sample subjected to analysis allows to find other parameters too, correlated to the speed of sedimentation, such as viscosity, elasticity or density, as indicated particularly in EP'188.
- Cell-counters are a category of measuring instruments used in clinical analysis laboratories which provide the fundamental parameters of hematology, such as counting red corpuscles, white corpuscles, platelets, hematocrit, and other parameters concerning the form and size of the corpuscle part of the blood.
- the machine uses a so-called primary blood sample, taken from the patient and collected in a sealed container which has a top that can be perforated by a needle in order to pick up the sample to be analyzed. It must be considered that, in diagnostic techniques, the analysis performed by the cell-counters has always been considered not compatible time-wise with what is connected to measuring ESR, and hence also with reference to the parameters of viscosity, elasticity, density or similar, which can be obtained from the study of absorbance as proposed in EP'188 and EP'576.
- Document O-A-95/14224 describes an apparatus that uses the measurement obtained by a cell-counter in order to find, empirically and by means of calculations, the ESR value.
- the apparatus provides a first analysis section wherein a blood sample is sent to a measuring cell provided with four electrodes, inside which the electric impedance of the blood sample is measured.
- a second analysis section another blood sample is subjected, possibly after being suitably mixed with a diluting product, to a step to determine the hematocrit. It is necessary to use another blood sample in an apparatus of this type since the measurement of the impedance, performed in the first analysis section, alters the sample irreversibly, which cannot therefore be used in sequence and in line to perform the measurement of the hematocrit too.
- the data relating to the impedance of the blood and its hematocrit, plus the value of the temperature relating to the impedance measuring cell as measured by a suitable measuring element, are sent to a processing unit that calculates empirically, from these data, the ESR value.
- the limits and disadvantages of an apparatus of this type are first of all its complexity and the large number of components it requires, both to detect the parameters and also to calculate and process the data. Above all, however, the result obtained does not guarantee reliability and precision, on the one hand because intrinsically the empirical calculation process does not allow to ensure that precise values are obtained, and on the other hand because it adds together errors of tolerance due to no fewer than three different measuring systems .
- this known apparatus does not perform an analytical and reliable measurement, in line, in sequence, and with the same blood sample, both of the speed of blood sedimentation and also of the hematocrit.
- the purpose of the invention is therefore to achieve a device and propose a relative method to perform hematological analyses which integrates, in a single apparatus - small, compact and easy to transport - the functions of measuring, in line, in close sequence and with the same blood sample, the speed of blood sedimentation (ESR) in a machine able to perform at least the cell-count function and/or other connected analyses.
- ESR blood sedimentation
- the integrated apparatus comprises at least a collection element for one or more suitably sealed containers; each container is equipped with a relative top suitable to be perforated by means of at least a pick-up needle, in order to pick up the sample to be analyzed, in a quantity of between 30 and 200 ⁇ l.
- the sealed container is a so-called "primary test tube" normally used in cell-count machines, wherein the blood remains in a state of rest, and only a dry state anti- coagulant of the EDTA type is added, and it is not further diluted or mixed with other liquid or solid substances.
- This sample is sent, by means of pump means and through a circulation circuit, inside a capillary tube cooperating with an optical system suitable to emit electromagnetic radiations in the field of 100-1500 nm, advantageously 200- 1000 nm, and to detect the radiation transmitted through the sample after having interrupted the flow of blood instantaneously, according to the teaching of EP'188. From this transmitted radiation, the ESR value is obtained by studying the optical density, or absorbance, of the blood sample as described for example in EP'576.
- the same sample can then be sent, substantially without any break in continuity, and in a very close sequence, inside the measuring assembly of the cell-counter in order to perform the processes connected with such measurement.
- the blood sample is discharged into a discharge container.
- at least some of the measuring components of the cell-counters are located upstream of the device to measure the ESR.
- the same device, of the type with a pick-up needle, and the same system with a pump that feeds the blood sample can be shared both by the device that measures the ESR and also by the one that functions as a cell-counter.
- the two measuring devices can therefore be arranged in series together, at a close distance from each other, and the whole thing can be housed inside a small container, compact, transportable and easily located inside a laboratory or a hospital surgery.
- a single pick-up needle is connected to two paths that divide, one passing through the optical system to measure the ESR and the other through the cell-counter measuring systems or suchlike.
- two pick-up needles are used to pick up the respective samples to be sent to the relative measuring systems.
- the two measuring systems are commanded and governed by the same command and control unit which selectively activates and coordinates the functioning thereof; the command and control unit is associated in known manner with interfaces that connect and communicate with the outside, such as a monitor, a keyboard to forward commands and to insert data and parameters, and possibly a printer to print out the values resulting from the analyses .
- the measuring system is connected on line for the automatic exchange of information between remote users.
- the pump means are reversible and allow to invert the flow inside the circuit; it is thus possible to re-homogenize the blood sample and rapidly repeat measurements thereon.
- the capillary is also able to be thermostated in order to allow analysis to be carried out at a constant temperature, which can be pre-set as desired.
- the apparatus 10 comprises as its main components: a pick-up member 11, of the needle type, able to selectively pick up a sample of blood to be analyzed from containers 22 housed in a storage drum 23, which can be made to rotate by a motor 21 in order to mix the blood;
- a device to measure the ESR 14 comprising a capillary container 12, transparent to electromagnetic radiations in a field between 100 and 1500 nm, preferentially between 200 and 1000 nm, inside which the blood sample is able to be introduced;
- circuit 13 which connects the pick-up member 11 to the capillary 12 and inside which the blood sample is able to circulate;
- a measuring assembly 18 arranged in series with the capillary 12 and inside which the blood sample, after the speed of sedimentation has been measured, is able to circulate so that hematological measurements can be performed, such as counting the red cells, white cells, platelets, the hematocrit and other parameters relating to the form and size of the corpuscle part of the blood;
- a blood sample can be picked up, by means of the needle member 11, from one of the containers 22 arranged in the storage drum 23.
- the blood sample is sent, through the circuit 13 and the pump (not shown here), inside the capillary 12 where, by means of the pump, it is instantaneously stopped in order to measure the ESR with the stopped-flow process described in EP'188. Then, the flow is re-started by making the same blood sample (which has not undergone any chemical-physical alteration during the measurement of the ESR) pass without any break in continuity through the cell-counter measuring assembly 18, which performs the desired measurements, and from which the blood sample is then discharged into the tank 19.
- the pump that makes the blood sample circulate in the circuit 13 can be arranged either upstream or downstream of the capillary 12 and, in a preferential embodiment, is of the reversible type and allows the blood to circulate in both directions.
- the circulation circuit 13 is divided into two branches, a first passing through the device 14 to measure the ESR, and a second passing through the measuring assembly 18 which counts the cells.
- two or more pick-up needles 11 are associated with respective branches of the circuit 13 to send respective blood samples to the relative measuring devices 14 or 18.
- the data acquired by the measuring devices 14 and 18 are transmitted in real time to the command and control unit 20 which memorizes them and processes them in order to obtain the ESR value, and correlated parameters, and also the count of the cells and the other values obtained in the measuring assembly 18.
- the data acquired can be compared or integrated with parameters present in a database inside the unit 20.
- the results of the analysis can then be displayed on the display 24 and/or printed by the printer 26 while the blood sample is discharged into the tank 19.
- the analyst also has the advantage that he can make the desired comparisons and corrections according to the crossed parametric comparison of the respective values.
- modifications and/or additions can be made to the apparatus 10 and method as described heretofore, without departing from the field and scope of the present invention.
- some components of the measuring assembly 18 can be upstream of the device 14 to detect the ESR.
- the instantaneous blockage of the flow of the blood sample along the circuit 13 can be performed by means of valve means associated with the circuit 13 and/or the capillary container 12.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Ecology (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Dispersion Chemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006525917A JP4648905B2 (en) | 2003-09-03 | 2004-09-01 | Integrated apparatus and related methods for hematological analysis |
EP04769234A EP1671102B1 (en) | 2003-09-03 | 2004-09-01 | Integrated apparatus for hematological analyses and related method |
US10/570,527 US7541191B2 (en) | 2003-09-03 | 2004-09-01 | Integrated apparatus for hematological analysis and related method |
DE602004030027T DE602004030027D1 (en) | 2003-09-03 | 2004-09-01 | INTEGRATED DEVICE FOR HEMATOLOGIC ANALYSIS AND ASSOCIATED METHOD |
CA2537500A CA2537500C (en) | 2003-09-03 | 2004-09-01 | Integrated apparatus for hematological analyses and related method |
AT04769234T ATE487933T1 (en) | 2003-09-03 | 2004-09-01 | INTEGRATED HEMATOLOGICAL ANALYSIS APPARATUS AND ASSOCIATED METHOD |
CN2004800288494A CN1864060B (en) | 2003-09-03 | 2004-09-01 | Integrated apparatus for hematological analysis and related method |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT000174A ITUD20030174A1 (en) | 2003-09-03 | 2003-09-03 | INTEGRATED SYSTEM FOR HEMATOLOGICAL ANALYSIS AND ITS METHOD. |
ITUD2003A000174 | 2003-09-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2005022125A1 true WO2005022125A1 (en) | 2005-03-10 |
Family
ID=34260042
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2004/002824 WO2005022125A1 (en) | 2003-09-03 | 2004-09-01 | Integrated apparatus for hematological analyses and related method |
Country Status (10)
Country | Link |
---|---|
US (1) | US7541191B2 (en) |
EP (1) | EP1671102B1 (en) |
JP (1) | JP4648905B2 (en) |
CN (1) | CN1864060B (en) |
AT (1) | ATE487933T1 (en) |
CA (1) | CA2537500C (en) |
DE (1) | DE602004030027D1 (en) |
ES (1) | ES2354159T3 (en) |
IT (1) | ITUD20030174A1 (en) |
WO (1) | WO2005022125A1 (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008006897A1 (en) * | 2006-07-14 | 2008-01-17 | Alifax Holding Spa | Integrated apparatus and method to detect inflammatory states present in a sample of whole blood |
WO2008046292A1 (en) * | 2006-10-13 | 2008-04-24 | Tecom Science Corporation | Analysis method for 5-differential complete blood cell based on visual image |
WO2014020392A2 (en) | 2012-07-31 | 2014-02-06 | Alifax Holding Spa | Apparatus and method to determine the blood sedimentation rate and other parameters connected thereto |
US9017610B2 (en) | 2008-04-25 | 2015-04-28 | Roche Diagnostics Hematology, Inc. | Method of determining a complete blood count and a white blood cell differential count |
US9083857B2 (en) | 2008-04-25 | 2015-07-14 | Roche Diagnostics Hematology, Inc. | Systems and methods for analyzing body fluids |
US9111343B2 (en) | 2011-01-18 | 2015-08-18 | Roche Diagnostics Hematology, Inc. | Microscope slide coordinate system registration |
ITUA20163693A1 (en) * | 2016-05-23 | 2017-11-23 | Alifax Srl | SYSTEM AND CONNECTED METHOD FOR HEMATOLOGICAL ANALYSIS |
WO2022163384A1 (en) | 2021-01-26 | 2022-08-04 | Nihon Kohden Corporation | Measuring method and measuring device for inflammation index parameter of blood sample |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0709844A2 (en) | 2006-03-29 | 2011-07-26 | Catholic Healthcare West | Cranial nerve micrograde electrical stimulation for the treatment of medical conditions |
CN102539792B (en) * | 2010-12-31 | 2014-08-13 | 深圳迈瑞生物医疗电子股份有限公司 | Blood sample absorption detection method and device and blood treating device |
CN102872640A (en) * | 2011-07-15 | 2013-01-16 | 江苏美诚生物科技有限公司 | Blood sample clot filtering device |
CN103091287B (en) | 2011-10-31 | 2015-04-01 | 深圳迈瑞生物医疗电子股份有限公司 | Self-diagnosis method for measure result of blood analyzer, and device thereof |
US8741234B2 (en) * | 2011-12-27 | 2014-06-03 | Honeywell International Inc. | Disposable cartridge for fluid analysis |
US9279800B2 (en) | 2012-01-13 | 2016-03-08 | Alcor Scientific, Inc. | Apparatus, method, system for the determination of the aggregation rate of red blood cells |
US8647886B1 (en) | 2012-01-13 | 2014-02-11 | Alcor Scientific, Inc. | Apparatus, method, system for the determination of the aggregation rate of red blood cells |
JP6360696B2 (en) | 2014-03-18 | 2018-07-18 | 日本光電工業株式会社 | Blood test apparatus and blood test method |
JP6710512B2 (en) * | 2015-09-14 | 2020-06-17 | シスメックス株式会社 | Blood analysis device, blood analysis method, and computer program |
KR101701334B1 (en) * | 2015-11-24 | 2017-02-13 | 전북대학교산학협력단 | Portable blood viscostity measuring device |
CN107884563A (en) * | 2017-11-26 | 2018-04-06 | 张延艳 | A kind of medical treatment device and its application method for blood analysis |
IT201800004630A1 (en) * | 2018-04-17 | 2019-10-17 | APPARATUS AND PROCEDURE FOR DETERMINING THE SPEED OF BLOOD SEDIMENTATION AND OTHER PARAMETERS RELATED TO IT | |
CN112305245B (en) * | 2019-07-30 | 2024-04-19 | 深圳迈瑞生物医疗电子股份有限公司 | Sample analysis method and sample analysis system |
WO2021097610A1 (en) * | 2019-11-18 | 2021-05-27 | 深圳迈瑞生物医疗电子股份有限公司 | Sample analyzer and sample analysis method |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3192969A (en) * | 1962-07-02 | 1965-07-06 | Warner Lambert Pharmaceutical | Automatic sample handling apparatus |
WO1995014224A1 (en) * | 1993-11-15 | 1995-05-26 | Swelab Instrument Ab | Apparatus for determining the erythrocyte sedimentation rate |
EP0732576A1 (en) * | 1995-03-15 | 1996-09-18 | Sire Analytical Systems S.R.L. | Method to determine the sedimentation of blood and relative device |
EP1098188A2 (en) * | 1999-11-08 | 2001-05-09 | Sire Analytical Systems S.R.L. | Method to determine the speed of sedimentation of blood and other parameters correlated thereto, and relative apparatus |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000329779A (en) * | 1999-05-19 | 2000-11-30 | Sefa Technology Kk | Sedimentation speed measuring method and its device |
JP2003240777A (en) * | 2002-02-21 | 2003-08-27 | Sefa Technology Kk | Blood inspection system |
US7207939B2 (en) * | 2002-10-03 | 2007-04-24 | Coulter International Corp. | Apparatus and method for analyzing a liquid in a capillary tube of a hematology instrument |
-
2003
- 2003-09-03 IT IT000174A patent/ITUD20030174A1/en unknown
-
2004
- 2004-09-01 JP JP2006525917A patent/JP4648905B2/en not_active Expired - Lifetime
- 2004-09-01 CN CN2004800288494A patent/CN1864060B/en not_active Expired - Lifetime
- 2004-09-01 DE DE602004030027T patent/DE602004030027D1/en not_active Expired - Lifetime
- 2004-09-01 ES ES04769234T patent/ES2354159T3/en not_active Expired - Lifetime
- 2004-09-01 AT AT04769234T patent/ATE487933T1/en not_active IP Right Cessation
- 2004-09-01 CA CA2537500A patent/CA2537500C/en not_active Expired - Lifetime
- 2004-09-01 WO PCT/IB2004/002824 patent/WO2005022125A1/en active Application Filing
- 2004-09-01 EP EP04769234A patent/EP1671102B1/en not_active Expired - Lifetime
- 2004-09-01 US US10/570,527 patent/US7541191B2/en active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3192969A (en) * | 1962-07-02 | 1965-07-06 | Warner Lambert Pharmaceutical | Automatic sample handling apparatus |
WO1995014224A1 (en) * | 1993-11-15 | 1995-05-26 | Swelab Instrument Ab | Apparatus for determining the erythrocyte sedimentation rate |
EP0732576A1 (en) * | 1995-03-15 | 1996-09-18 | Sire Analytical Systems S.R.L. | Method to determine the sedimentation of blood and relative device |
EP1098188A2 (en) * | 1999-11-08 | 2001-05-09 | Sire Analytical Systems S.R.L. | Method to determine the speed of sedimentation of blood and other parameters correlated thereto, and relative apparatus |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8425843B2 (en) | 2006-07-14 | 2013-04-23 | Alifax Holding Spa | Integrated apparatus and method to detect inflammatory states present in a sample of whole blood |
WO2008006897A1 (en) * | 2006-07-14 | 2008-01-17 | Alifax Holding Spa | Integrated apparatus and method to detect inflammatory states present in a sample of whole blood |
WO2008046292A1 (en) * | 2006-10-13 | 2008-04-24 | Tecom Science Corporation | Analysis method for 5-differential complete blood cell based on visual image |
US9017610B2 (en) | 2008-04-25 | 2015-04-28 | Roche Diagnostics Hematology, Inc. | Method of determining a complete blood count and a white blood cell differential count |
US9083857B2 (en) | 2008-04-25 | 2015-07-14 | Roche Diagnostics Hematology, Inc. | Systems and methods for analyzing body fluids |
US10764538B2 (en) | 2008-04-25 | 2020-09-01 | Roche Diagnostics Hematology, Inc. | Systems and methods for analyzing body fluids |
US10094764B2 (en) | 2008-04-25 | 2018-10-09 | Roche Diagnostics Hematology, Inc. | Systems and methods for determining a complete blood count and a white blood cell differential count |
US10068126B2 (en) | 2011-01-18 | 2018-09-04 | Roche Diagnostics Hematology, Inc. | Microscope slide coordinate system registration |
US9111343B2 (en) | 2011-01-18 | 2015-08-18 | Roche Diagnostics Hematology, Inc. | Microscope slide coordinate system registration |
US9280699B2 (en) | 2011-01-18 | 2016-03-08 | Roche Diagnostics Hematology, Inc. | Microscope slide coordinate system registration |
WO2014020392A2 (en) | 2012-07-31 | 2014-02-06 | Alifax Holding Spa | Apparatus and method to determine the blood sedimentation rate and other parameters connected thereto |
US9494507B2 (en) | 2012-07-31 | 2016-11-15 | Alifax Holding Spa | Apparatus and method to determine the blood sedimentation rate and other parameters connected thereto |
ITUA20163693A1 (en) * | 2016-05-23 | 2017-11-23 | Alifax Srl | SYSTEM AND CONNECTED METHOD FOR HEMATOLOGICAL ANALYSIS |
WO2022163384A1 (en) | 2021-01-26 | 2022-08-04 | Nihon Kohden Corporation | Measuring method and measuring device for inflammation index parameter of blood sample |
Also Published As
Publication number | Publication date |
---|---|
US7541191B2 (en) | 2009-06-02 |
EP1671102A1 (en) | 2006-06-21 |
ITUD20030174A1 (en) | 2005-03-04 |
US20060288760A1 (en) | 2006-12-28 |
EP1671102B1 (en) | 2010-11-10 |
CA2537500C (en) | 2013-10-22 |
JP4648905B2 (en) | 2011-03-09 |
ATE487933T1 (en) | 2010-11-15 |
CA2537500A1 (en) | 2005-03-10 |
CN1864060B (en) | 2011-02-16 |
DE602004030027D1 (en) | 2010-12-23 |
JP2007504468A (en) | 2007-03-01 |
CN1864060A (en) | 2006-11-15 |
ES2354159T3 (en) | 2011-03-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1671102B1 (en) | Integrated apparatus for hematological analyses and related method | |
CA2489177C (en) | A disposable cartridge for characterizing particles suspended in a liquid | |
US5734468A (en) | Probe and method for determining serum indices of a serum sample | |
US5827746A (en) | Method to determine the sedimentation of blood and relative device | |
JP4490069B2 (en) | Clinical laboratory system | |
US6632679B1 (en) | Method to determine the speed of sedimentation of blood and other parameters correlated thereto, and relative apparatus | |
US20060275906A1 (en) | Method for ascertaining interferents in small liquid samples in an automated clinical analyzer | |
JP6117900B1 (en) | Specimen test system, information processing apparatus, information processing method, and program | |
EP0101688B1 (en) | Method and apparatus for detecting insufficient liquid sample quantity | |
US11906413B2 (en) | Apparatus and method to determine erythrocyte sedimentation rate and other connected parameters | |
JP2020060601A (en) | Specimen inspection system, information processing device, information processing method, and program | |
JP7319986B2 (en) | Analysis method for biological sample containing living cells and analyzer for implementing the analysis method | |
EP4187228A1 (en) | System, apparatus, and method for measuring erythrocyte sedimentation rate | |
JPS61107161A (en) | Automatic analyser | |
KR20180077820A (en) | Blood cell analysis apparatus, blood specimen and container detecting method thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 200480028849.4 Country of ref document: CN |
|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2537500 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2006288760 Country of ref document: US Ref document number: 10570527 Country of ref document: US Ref document number: 2006525917 Country of ref document: JP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2004769234 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 2004769234 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 10570527 Country of ref document: US |