WO2005020881A3 - Compositions of flavonoids and flavonoid-containing extracts and the treatment of diseases - Google Patents

Compositions of flavonoids and flavonoid-containing extracts and the treatment of diseases Download PDF

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Publication number
WO2005020881A3
WO2005020881A3 PCT/IB2004/003998 IB2004003998W WO2005020881A3 WO 2005020881 A3 WO2005020881 A3 WO 2005020881A3 IB 2004003998 W IB2004003998 W IB 2004003998W WO 2005020881 A3 WO2005020881 A3 WO 2005020881A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
flavonoid
flavonoids
containing extracts
treatment
Prior art date
Application number
PCT/IB2004/003998
Other languages
French (fr)
Other versions
WO2005020881A2 (en
Inventor
Bang Qiang Gong
Ren Jin
Han Xin Chun
Original Assignee
Shanghai Comman Pharmaceutical
Bang Qiang Gong
Ren Jin
Han Xin Chun
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CNB031507026A external-priority patent/CN1266144C/en
Application filed by Shanghai Comman Pharmaceutical, Bang Qiang Gong, Ren Jin, Han Xin Chun filed Critical Shanghai Comman Pharmaceutical
Publication of WO2005020881A2 publication Critical patent/WO2005020881A2/en
Publication of WO2005020881A3 publication Critical patent/WO2005020881A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Abstract

In this invention we describe a group of flavonoids and flavonoid-containing extracts that have pharmaceutical properties which are useful in the medicinal therapy of fibrotic diseases for the treatment or reparation and prevention of fibrotic lesional tissues. Representative flavonoids and flavonoid-containing extracts have the active compositions of the below formula (I). Those compositions can be extracted and purified from the botanicals, including Scutellaria baicalensis Georgi, Scutellaria scordifolia Fish, Oroxylum indicum (L.) Vent, Plantago major L. The compositions of the invention are novel as an anti-fibrotic drugs, as agents for treating fibrosis.
PCT/IB2004/003998 2003-09-01 2004-08-31 Compositions of flavonoids and flavonoid-containing extracts and the treatment of diseases WO2005020881A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN03150702.6 2003-09-01
CNB031507026A CN1266144C (en) 2003-09-01 2003-09-01 Compound of flavonoid as well as application and dosage form of extract product of the compound
US10/746,632 2003-12-23
US10/746,632 US20050049206A1 (en) 2003-09-01 2003-12-23 Compositions of flavonoids and flavonoid-containing extracts and the treatment of diseases

Publications (2)

Publication Number Publication Date
WO2005020881A2 WO2005020881A2 (en) 2005-03-10
WO2005020881A3 true WO2005020881A3 (en) 2005-07-28

Family

ID=34276299

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2004/003998 WO2005020881A2 (en) 2003-09-01 2004-08-31 Compositions of flavonoids and flavonoid-containing extracts and the treatment of diseases

Country Status (1)

Country Link
WO (1) WO2005020881A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101040760B1 (en) 2005-11-30 2011-06-10 한국과학기술연구원 Novel flavone derivatives, process for the preparation thereof and composition containing the same for prevention and treatment of brain-nervous system disease
US20080227829A1 (en) * 2007-02-14 2008-09-18 Hammerstone John F Neurogenic compounds
WO2022080846A1 (en) * 2020-10-13 2022-04-21 서울대학교병원 Composition for preventing or treating fibrosis, comprising flavone

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5972995A (en) * 1997-10-16 1999-10-26 Children's Hospital Medical Center Of Northern California Compositions and methods for cystic fibrosis therapy
CN1526389A (en) * 2003-03-03 2004-09-08 张俊平 Application of 5,7,4'-substituted flavone in preparing medicine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5972995A (en) * 1997-10-16 1999-10-26 Children's Hospital Medical Center Of Northern California Compositions and methods for cystic fibrosis therapy
CN1526389A (en) * 2003-03-03 2004-09-08 张俊平 Application of 5,7,4'-substituted flavone in preparing medicine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
XU D.H. ET AL: "Effect of the Rice Flavone on Experimental Rat Hepatic Fibrosis.", JOURNAL OF CHINA PHARMACEUTICAL UNIVERSITY., vol. 33, no. 3, 2002, pages 234 - 237 *

Also Published As

Publication number Publication date
WO2005020881A2 (en) 2005-03-10

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