WO2005019193A3 - Phenylurea derivatives useful in the treatment of conditions mediated by polo-like kinases (plk) - Google Patents

Phenylurea derivatives useful in the treatment of conditions mediated by polo-like kinases (plk) Download PDF

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Publication number
WO2005019193A3
WO2005019193A3 PCT/US2004/027418 US2004027418W WO2005019193A3 WO 2005019193 A3 WO2005019193 A3 WO 2005019193A3 US 2004027418 W US2004027418 W US 2004027418W WO 2005019193 A3 WO2005019193 A3 WO 2005019193A3
Authority
WO
WIPO (PCT)
Prior art keywords
plk
polo
kinases
treatment
conditions mediated
Prior art date
Application number
PCT/US2004/027418
Other languages
French (fr)
Other versions
WO2005019193A2 (en
Inventor
David Harold Drewry
Jr Robert Anthony Mook
James Michael Salovich
Frank J Schoenen
David S Wagner
Richard W Wagner
Original Assignee
Smithkline Beecham Corp
David Harold Drewry
Jr Robert Anthony Mook
James Michael Salovich
Frank J Schoenen
David S Wagner
Richard W Wagner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp, David Harold Drewry, Jr Robert Anthony Mook, James Michael Salovich, Frank J Schoenen, David S Wagner, Richard W Wagner filed Critical Smithkline Beecham Corp
Publication of WO2005019193A2 publication Critical patent/WO2005019193A2/en
Publication of WO2005019193A3 publication Critical patent/WO2005019193A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides compounds of formula (I); pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents mediated by Polo-like kinase (PLK).
PCT/US2004/027418 2003-08-20 2004-08-17 Phenylurea derivatives useful in the treatment of conditions mediated by polo-like kinases (plk) WO2005019193A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49648803P 2003-08-20 2003-08-20
US60/496,488 2003-08-20

Publications (2)

Publication Number Publication Date
WO2005019193A2 WO2005019193A2 (en) 2005-03-03
WO2005019193A3 true WO2005019193A3 (en) 2005-03-31

Family

ID=34216013

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/027418 WO2005019193A2 (en) 2003-08-20 2004-08-17 Phenylurea derivatives useful in the treatment of conditions mediated by polo-like kinases (plk)

Country Status (1)

Country Link
WO (1) WO2005019193A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7504513B2 (en) 2006-02-27 2009-03-17 Hoffman-La Roche Inc. Thiazolyl-benzimidazoles
CA2647592C (en) 2006-05-26 2014-01-28 Abbott Laboratories Inhibitors of polo-like kinases
EP2100894A1 (en) 2008-03-12 2009-09-16 4Sc Ag Pyridopyrimidines used as Plk1 (polo-like kinase) inhibitors
CN102256972A (en) 2008-12-18 2011-11-23 霍夫曼-拉罗奇有限公司 Thiazolyl-benzimidazoles

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002057242A2 (en) * 2001-01-19 2002-07-25 Almirall Prodesfarma, S.A. Urea derivatives as integrin alpha 4 antagonists

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002057242A2 (en) * 2001-01-19 2002-07-25 Almirall Prodesfarma, S.A. Urea derivatives as integrin alpha 4 antagonists

Also Published As

Publication number Publication date
WO2005019193A2 (en) 2005-03-03

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