WO2005017115A3 - Cord blood-derived hematopoietic progenitor cells - Google Patents

Cord blood-derived hematopoietic progenitor cells Download PDF

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Publication number
WO2005017115A3
WO2005017115A3 PCT/US2004/026238 US2004026238W WO2005017115A3 WO 2005017115 A3 WO2005017115 A3 WO 2005017115A3 US 2004026238 W US2004026238 W US 2004026238W WO 2005017115 A3 WO2005017115 A3 WO 2005017115A3
Authority
WO
WIPO (PCT)
Prior art keywords
cord blood
progenitor cells
hematopoietic progenitor
derived hematopoietic
bone marrow
Prior art date
Application number
PCT/US2004/026238
Other languages
French (fr)
Other versions
WO2005017115A2 (en
Inventor
Paul S Frenette
Andres Hidalgo
Original Assignee
Sinai School Medicine
Paul S Frenette
Andres Hidalgo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sinai School Medicine, Paul S Frenette, Andres Hidalgo filed Critical Sinai School Medicine
Publication of WO2005017115A2 publication Critical patent/WO2005017115A2/en
Publication of WO2005017115A3 publication Critical patent/WO2005017115A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/7056—Lectin superfamily, e.g. CD23, CD72
    • C07K14/70564—Selectins, e.g. CD62
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/145—Thrombopoietin [TPO]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/59—Lectins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes

Abstract

The present invention provides cord blood hematopoietic progenitor cells treated with fucosyltransferase. Such cells exhibit increased homing and enhanced bone marrow engraftment, and are useful in methods of bone marrow transplantation.
PCT/US2004/026238 2003-08-11 2004-08-11 Cord blood-derived hematopoietic progenitor cells WO2005017115A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49431703P 2003-08-11 2003-08-11
US60/494,317 2003-08-11

Publications (2)

Publication Number Publication Date
WO2005017115A2 WO2005017115A2 (en) 2005-02-24
WO2005017115A3 true WO2005017115A3 (en) 2005-06-02

Family

ID=34193209

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/026238 WO2005017115A2 (en) 2003-08-11 2004-08-11 Cord blood-derived hematopoietic progenitor cells

Country Status (1)

Country Link
WO (1) WO2005017115A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106687581A (en) * 2014-07-07 2017-05-17 塔尔加泽梅股份有限公司 Manufacture and cryopreservation of fucosylated cells for therapeutic use

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7332334B2 (en) 2003-04-18 2008-02-19 Oklahoma Medical Research Foundation Hematopoietic stem cells treated by in vitro fucosylation and methods of use
FI20055398A0 (en) 2005-07-08 2005-07-08 Suomen Punainen Risti Veripalv Method for evaluating cell populations
EP2035546B1 (en) * 2006-06-02 2018-01-24 Robert Sackstein Compositions and methods for modifying cell surface glycans
AU2014202669B2 (en) * 2006-06-02 2016-05-12 Robert Sackstein Compositions and methods for modifying cell surface glycans
JPWO2009020201A1 (en) * 2007-08-08 2010-11-04 協和発酵キリン株式会社 Isolated cell population
EP2166085A1 (en) 2008-07-16 2010-03-24 Suomen Punainen Risti Veripalvelu Divalent modified cells
WO2010096264A2 (en) 2009-02-03 2010-08-26 Children's Medical Center Corporation Methods for enhancing hematopoietic stem/progenitor cell engraftment
US9051548B2 (en) 2009-02-03 2015-06-09 Children's Medical Center Corporation Methods for enhancing hematopoietic stem/progenitor cell engraftment
EP3589296A4 (en) * 2017-02-28 2020-09-09 University of Central Florida Research Foundation, Inc. Pm21 particles to improve bone marrow homing of nk cells
CN114642401A (en) * 2020-12-18 2022-06-21 中国科学院深圳先进技术研究院 System and method for in vivo observation of capillary blood vessels in animal bone

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040209357A1 (en) * 2003-04-18 2004-10-21 Lijun Xia Hematopoietic stem cells treated by in vitro fucosylation and methods of use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040209357A1 (en) * 2003-04-18 2004-10-21 Lijun Xia Hematopoietic stem cells treated by in vitro fucosylation and methods of use

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BARKER ET AL, BLOOD, vol. 97, no. 10, May 2001 (2001-05-01), pages 2957 - 2961 *
FRENETTE ET AL, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCE USA, vol. 95, November 1998 (1998-11-01), pages 14423 - 14428 *
HILDAGO ET AL, THE JOURNAL OF CLINICAL INVESTIGATION, vol. 110, no. 4, August 2002 (2002-08-01), pages 559 - 569 *
KOBZDEJ ET AL, BLOOD, vol. 100, no. 13, December 2002 (2002-12-01), pages 4485 - 4494 *
LI ET AL, THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 6, February 1996 (1996-02-01), pages 3255 - 3264 *
PAPAYANNOULOU ET AL, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCE USA, vol. 92, October 1995 (1995-10-01), pages 9647 - 9651 *
XIA ET AL, BLOOD, vol. 104, no. 10, November 2004 (2004-11-01), pages 3091 - 3096 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106687581A (en) * 2014-07-07 2017-05-17 塔尔加泽梅股份有限公司 Manufacture and cryopreservation of fucosylated cells for therapeutic use

Also Published As

Publication number Publication date
WO2005017115A2 (en) 2005-02-24

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