WO2005014653A3 - Humanized chicken antibodies - Google Patents

Humanized chicken antibodies Download PDF

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Publication number
WO2005014653A3
WO2005014653A3 PCT/US2004/006343 US2004006343W WO2005014653A3 WO 2005014653 A3 WO2005014653 A3 WO 2005014653A3 US 2004006343 W US2004006343 W US 2004006343W WO 2005014653 A3 WO2005014653 A3 WO 2005014653A3
Authority
WO
WIPO (PCT)
Prior art keywords
antibodies
chicken antibodies
humanized
humanized chicken
provides
Prior art date
Application number
PCT/US2004/006343
Other languages
French (fr)
Other versions
WO2005014653A2 (en
Inventor
Naoya Tsurushita
Shankar Kumar
Maximiliano Vasquez
Original Assignee
Protein Design Labs Inc
Naoya Tsurushita
Shankar Kumar
Maximiliano Vasquez
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Protein Design Labs Inc, Naoya Tsurushita, Shankar Kumar, Maximiliano Vasquez filed Critical Protein Design Labs Inc
Publication of WO2005014653A2 publication Critical patent/WO2005014653A2/en
Publication of WO2005014653A3 publication Critical patent/WO2005014653A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • C07K16/2854—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72 against selectins, e.g. CD62
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/23—Immunoglobulins specific features characterized by taxonomic origin from birds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention concerns chicken antibodies and humanized chicken antibodies and the method of making such antibodies. In a particular embodiment, it provides humanized chicken antibodies that bind to or neutralize human and/or mouse proteins, such IL-12 or L-selectin. It also provides the method for the prevention or treatment of autoimmune diseases by using such antibodies.
PCT/US2004/006343 2003-02-28 2004-02-26 Humanized chicken antibodies WO2005014653A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45162203P 2003-02-28 2003-02-28
US60/451,622 2003-03-05

Publications (2)

Publication Number Publication Date
WO2005014653A2 WO2005014653A2 (en) 2005-02-17
WO2005014653A3 true WO2005014653A3 (en) 2005-06-16

Family

ID=34135015

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/006343 WO2005014653A2 (en) 2003-02-28 2004-02-26 Humanized chicken antibodies

Country Status (1)

Country Link
WO (1) WO2005014653A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8314213B2 (en) 2008-04-18 2012-11-20 Xencor, Inc. Human equivalent monoclonal antibodies engineered from nonhuman variable regions
JOP20190009A1 (en) 2016-09-21 2019-01-27 Alx Oncology Inc Antibodies against signal-regulatory protein alpha and methods of use
SG11202006217YA (en) 2018-03-14 2020-07-29 Beijing Xuanyi Pharmasciences Co Ltd Anti-claudin 18.2 antibodies
EP3768314A4 (en) 2018-03-21 2022-01-05 ALX Oncology Inc. Antibodies against signal-regulatory protein alpha and methods of use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0678786A (en) * 1992-08-31 1994-03-22 Masayuki Miyasaka Monoclonal antibody reacting with lecam-1 and measurement of lecam-1
WO2001030300A2 (en) * 1999-10-28 2001-05-03 Ophidian Pharmaceuticals, Inc. Prevention and treatment of autoimmune disease with luminally administered polyclonal antibodies

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0678786A (en) * 1992-08-31 1994-03-22 Masayuki Miyasaka Monoclonal antibody reacting with lecam-1 and measurement of lecam-1
WO2001030300A2 (en) * 1999-10-28 2001-05-03 Ophidian Pharmaceuticals, Inc. Prevention and treatment of autoimmune disease with luminally administered polyclonal antibodies

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ANDRIS-WIDHOPF J ET AL: "Methods for the generation of chicken monoclonal antibody fragments by phage display", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 242, no. 1-2, 28 August 2000 (2000-08-28), pages 159 - 181, XP004210719, ISSN: 0022-1759 *
PATENT ABSTRACTS OF JAPAN vol. 018, no. 334 (C - 1216) 24 June 1994 (1994-06-24) *
YAMANAKA H I ET AL: "Chicken monoclonal antibody isolated by a phage display system", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 157, no. 3, 1 August 1996 (1996-08-01), pages 1156 - 1162, XP002203029, ISSN: 0022-1767 *

Also Published As

Publication number Publication date
WO2005014653A2 (en) 2005-02-17

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