WO2005013173A3 - Methode et systeme de selection de cibles therapeutiques par l'utilisation de reseaux dynamiques d'interactions moleculaires - Google Patents

Methode et systeme de selection de cibles therapeutiques par l'utilisation de reseaux dynamiques d'interactions moleculaires Download PDF

Info

Publication number
WO2005013173A3
WO2005013173A3 PCT/FR2004/002064 FR2004002064W WO2005013173A3 WO 2005013173 A3 WO2005013173 A3 WO 2005013173A3 FR 2004002064 W FR2004002064 W FR 2004002064W WO 2005013173 A3 WO2005013173 A3 WO 2005013173A3
Authority
WO
WIPO (PCT)
Prior art keywords
dynamic model
therapeutic targets
molecular interactions
biological
molecular interaction
Prior art date
Application number
PCT/FR2004/002064
Other languages
English (en)
Other versions
WO2005013173A2 (fr
Inventor
Todor Vujasinovic
Original Assignee
Helios Biosciences
Todor Vujasinovic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Helios Biosciences, Todor Vujasinovic filed Critical Helios Biosciences
Priority to EP04786022A priority Critical patent/EP1649405A2/fr
Priority to CA002534401A priority patent/CA2534401A1/fr
Publication of WO2005013173A2 publication Critical patent/WO2005013173A2/fr
Publication of WO2005013173A3 publication Critical patent/WO2005013173A3/fr
Priority to US11/342,707 priority patent/US20060235670A1/en

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • G16B5/30—Dynamic-time models
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • G16B5/10—Boolean models
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • G16B5/20—Probabilistic models

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Molecular Biology (AREA)
  • Physiology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Evolutionary Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne le domaine de l'analyse intégrative des interactions moléculaires dans un système biologique. Elle porte en particulier sur un procédé d'obtention d'un modèle dynamique d'un réseau d'interactions moléculaires dans un système biologique, permettant l'analyse desdites interactions lorsqu'un stimulus est appliqué au modèle dynamique, en vue notamment de hiérarchiser des molécules biologiques ou de sélectionner des cibles thérapeutiques vis-à-vis d'un problème biologique donné, pour en particulier définir une action thérapeutique à appliquer auxdites molécules. L'invention porte également sur un système informatique pour l'obtention d'un modèle dynamique d'un réseau d'interactions moléculaires dans un système biologique, et l'analyse de ces interactions moléculaires lorsqu'un stimulus est appliqué au modèle dynamique, le système informatique comprenant au moins une unité centrale de traitement de données relié à au moins une base de données expérimentales quantitatives.
PCT/FR2004/002064 2003-08-01 2004-07-30 Methode et systeme de selection de cibles therapeutiques par l'utilisation de reseaux dynamiques d'interactions moleculaires WO2005013173A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP04786022A EP1649405A2 (fr) 2003-08-01 2004-07-30 METHODE ET SYSTEME DE SELECTION DE CIBLES THERAPEUTIQUES PAR L'UTILISATION DE RESEAUX DYNAMIQUES D INTERACTIONS MOLECULA IRES
CA002534401A CA2534401A1 (fr) 2003-08-01 2004-07-30 Methode et systeme de selection de cibles therapeutiques par l'utilisation de reseaux dynamiques d'interactions moleculaires
US11/342,707 US20060235670A1 (en) 2003-08-01 2006-01-31 Method and system for selecting therapeutic targets using molecular interaction dynamic networks

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0309557 2003-08-01
FR0309557A FR2858446B1 (fr) 2003-08-01 2003-08-01 Methode d'analyse de reseaux d'interactions moleculaires biologiques

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/342,707 Continuation US20060235670A1 (en) 2003-08-01 2006-01-31 Method and system for selecting therapeutic targets using molecular interaction dynamic networks

Publications (2)

Publication Number Publication Date
WO2005013173A2 WO2005013173A2 (fr) 2005-02-10
WO2005013173A3 true WO2005013173A3 (fr) 2005-09-29

Family

ID=34043752

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2004/002064 WO2005013173A2 (fr) 2003-08-01 2004-07-30 Methode et systeme de selection de cibles therapeutiques par l'utilisation de reseaux dynamiques d'interactions moleculaires

Country Status (5)

Country Link
US (1) US20060235670A1 (fr)
EP (1) EP1649405A2 (fr)
CA (1) CA2534401A1 (fr)
FR (1) FR2858446B1 (fr)
WO (1) WO2005013173A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7987234B1 (en) * 2004-10-14 2011-07-26 Oracle America, Inc. Monitoring alert conditions
US8577619B2 (en) 2008-05-27 2013-11-05 Sloan Kettering Institute For Cancer Research Models for combinatorial perturbations of living biological systems
EP2530615A1 (fr) * 2011-06-01 2012-12-05 Albert-Ludwigs-Universität Freiburg Procédé de modélisation, optimisation, paramétrage, test et/ou validation des perturbations de réseau dynamique
EP2715586A2 (fr) * 2011-06-01 2014-04-09 Albert-Ludwigs-Universität Freiburg Procédé de modélisation, d'optimisation, de paramétrage, de test et / ou de validation d'un réseau dynamique ou de perturbations de réseau
EP3298524A4 (fr) 2015-05-22 2019-03-20 CSTS Health Care Inc. Mesures thermodynamiques portant sur des réseaux d'interaction protéine-protéine pour le traitement du cancer
US11456053B1 (en) 2017-07-13 2022-09-27 X Development Llc Biological modeling framework
CN109635439B (zh) * 2018-12-12 2023-05-05 新疆大学 基于传播动力学的扰动环境下生产网络连锁效应研究方法
CN116844645B (zh) * 2023-08-31 2023-11-17 云南师范大学 一种基于多视角分层超图的基因调控网络推断方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002044992A2 (fr) * 2000-11-28 2002-06-06 Physiome Sciences, Inc. Systeme de modelisation de mecanismes biologiques
WO2003017127A2 (fr) * 2001-08-16 2003-02-27 Biotech Research Ventures Pte Limited Modelisation de chemins biochimiques

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002044992A2 (fr) * 2000-11-28 2002-06-06 Physiome Sciences, Inc. Systeme de modelisation de mecanismes biologiques
WO2003017127A2 (fr) * 2001-08-16 2003-02-27 Biotech Research Ventures Pte Limited Modelisation de chemins biochimiques

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CURTO R ET AL: "Mathematical models of purine metabolism in man", MATHEMATICAL BIOSCIENCES, ELSEVIER, NEW YORK, NY, US, vol. 151, no. 1, July 1998 (1998-07-01), pages 1 - 49, XP002250783, ISSN: 0025-5564 *
GORYANIN I ET AL: "Mathematical simulation and analysis of cellular metabolism and regulation", BIOINFORMATICS, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 15, no. 9, September 1999 (1999-09-01), pages 749 - 758, XP002190906, ISSN: 1367-4803 *
SEDAGHAT AHMAD R ET AL: "A mathematical model of metabolic insulin signaling pathways.", AMERICAN JOURNAL OF PHYSIOLOGY, vol. 283, no. 5 Part 1, November 2002 (2002-11-01), pages E1084 - E1101, XP002289933, ISSN: 0002-9513 *

Also Published As

Publication number Publication date
FR2858446A1 (fr) 2005-02-04
US20060235670A1 (en) 2006-10-19
CA2534401A1 (fr) 2005-02-10
WO2005013173A2 (fr) 2005-02-10
EP1649405A2 (fr) 2006-04-26
FR2858446B1 (fr) 2007-11-09

Similar Documents

Publication Publication Date Title
Hamelberg et al. Relating kinetic rates and local energetic roughness by accelerated molecular-dynamics simulations
RU2008126454A (ru) Системы и способы для проектирования экспериментов
WO2007019446A3 (fr) Systeme et methode securises de reeducation a distance
WO2004041160A3 (fr) Procedes et cobaye animal d'analyse de la degenerescence maculaire liee a l'age
WO2005013173A3 (fr) Methode et systeme de selection de cibles therapeutiques par l'utilisation de reseaux dynamiques d'interactions moleculaires
WO2002056135A3 (fr) Systeme et procede fournissant une analyse et une interpretation de donnees
DE50214185D1 (de) Verfahren zur analyse genomischer methylierungsmuster
WO2003087771A3 (fr) Procede de fabrication d'une surface lisse au niveau moleculaire
RS20050230A (en) Method of determining specific groups forming heparins
WO2004081535A3 (fr) Etablissement de bases de donnees de profils de structures de proteomes et utilisations desdites bases de donnees
WO2002075609A3 (fr) Predire la stabilite metabolique de molecules medicamenteuses
WO2004051544A3 (fr) Procedes et produits permettant de representer et d'analyser des complexes de molecules biologiques
AU2001287082A1 (en) Unsupervised method of identifying aberrant behavior by an entity with respect to healthcare claim transactions and associated computer software program product, computer device, and system
DE60327902D1 (de) Audioverarbeitungssystem
Grab et al. Flavorspace: A Technology for the Measurement of Fast Dynamic Changes of Flavor Release during Eating
WO2005067649A3 (fr) Procedes d'utilisation de base de donnees pour la creation de jeux ordonnes de microechantillons d'expression genetique, jeux ordonnes de microechantillons crees par ces procedes, et l'utilisation de jeux ordonnes de microechantillons
CA2505606A1 (fr) Procede et systeme permettant d'activer alternativement une unite materielle remplacable
Volovikova Microsemantic analysis as a method of investigation of thinking and personality
SE0100166D0 (sv) Configuration system
Wood et al. WHO Expert Committee on Biological Standardization: highlights of the 50th meeting, October 1999
Kalghatgi et al. Toxicity analysis of direct nonthermal plasma treatment of living tissue
Gispen Human rights and drug control: access to controlled essential medicines in resource-constrained countries
Eriksen The structures, playing techniques and teaching methods of four community brass bands in the Cape Peninsula
Kawato Beyond correlation-closing the loop between brain and theory by extracting representations and altered feedbacks
Pan et al. Biological Networks-Based Analysis of Gene Expression Signatures

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2004786022

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2534401

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 11342707

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 2004786022

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 11342707

Country of ref document: US