WO2005012336A3 - Peptides chelatant l'uranium et leurs applications - Google Patents

Peptides chelatant l'uranium et leurs applications Download PDF

Info

Publication number
WO2005012336A3
WO2005012336A3 PCT/FR2004/001698 FR2004001698W WO2005012336A3 WO 2005012336 A3 WO2005012336 A3 WO 2005012336A3 FR 2004001698 W FR2004001698 W FR 2004001698W WO 2005012336 A3 WO2005012336 A3 WO 2005012336A3
Authority
WO
WIPO (PCT)
Prior art keywords
residues
site
uranium
calmodulin
residues selected
Prior art date
Application number
PCT/FR2004/001698
Other languages
English (en)
Other versions
WO2005012336A2 (fr
Inventor
Claudio Vita
Clainche Loic Le
Veronique Monjardet
Original Assignee
Commissariat Energie Atomique
Claudio Vita
Clainche Loic Le
Veronique Monjardet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Commissariat Energie Atomique, Claudio Vita, Clainche Loic Le, Veronique Monjardet filed Critical Commissariat Energie Atomique
Priority to CA2531231A priority Critical patent/CA2531231C/fr
Priority to US10/562,323 priority patent/US7888311B2/en
Priority to ES04767541.8T priority patent/ES2543162T3/es
Priority to EP04767541.8A priority patent/EP1641815B1/fr
Priority to JP2006516341A priority patent/JP5086636B2/ja
Publication of WO2005012336A2 publication Critical patent/WO2005012336A2/fr
Publication of WO2005012336A3 publication Critical patent/WO2005012336A3/fr
Priority to US12/979,787 priority patent/US9321849B2/en
Priority to US15/080,821 priority patent/US20180134810A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4728—Calcium binding proteins, e.g. calmodulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4727—Calcium binding proteins, e.g. calmodulin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Purification Treatments By Anaerobic Or Anaerobic And Aerobic Bacteria Or Animals (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Processing Of Solid Wastes (AREA)

Abstract

Peptides chélatant l'uranium ainsi que leurs applications pour la décontamination des sols et des eaux, ainsi que pour la détection et le traitement des personnes contaminées par l'uranium. Lesdits peptides possèdent une structure du type hélice-boucle-hélice comprenant la séquence d'une boucle de la calmoduline incluant au moins une mutation en résidus neutres sélectionnés dans le groupe constitué par S, T, C, H,Y, N et Q, d'un, deux ou trois résidus d'au moins l'un des quatre sites de fixation du calcium de la calmoduline : site I : résidus sélectionnés parmi les résidus D20, D22 et D24, site II : résidus sélectionnés parmi les résidus D56, D58 et N60, site III : résidus sélectionnés parmi les résidus D93, D95 et N97, site IV : résidus sélectionnés parmi les résidus D129, D131 et D133, lesdites positions étant indiquées en référence à la séquence de la calmoduline humaine.
PCT/FR2004/001698 2003-07-04 2004-07-01 Peptides chelatant l'uranium et leurs applications WO2005012336A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA2531231A CA2531231C (fr) 2003-07-04 2004-07-01 Peptides chelatant l'uranium et leurs applications
US10/562,323 US7888311B2 (en) 2003-07-04 2004-07-01 Uranium-chelating peptides and uses thereof
ES04767541.8T ES2543162T3 (es) 2003-07-04 2004-07-01 Péptidos quelantes del uranio y sus aplicaciones
EP04767541.8A EP1641815B1 (fr) 2003-07-04 2004-07-01 Peptides chelatant l uranium et leurs applications
JP2006516341A JP5086636B2 (ja) 2003-07-04 2004-07-01 ウラン−キレートペプチド及びそれらの使用
US12/979,787 US9321849B2 (en) 2003-07-04 2010-12-28 Uranium-chelating peptides and uses thereof
US15/080,821 US20180134810A1 (en) 2003-07-04 2016-03-25 Uranium-chelating peptides and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0308211A FR2857014B1 (fr) 2003-07-04 2003-07-04 Peptides chelatant l'uranium et leurs applications
FR03/08211 2003-07-04

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10/562,323 A-371-Of-International US7888311B2 (en) 2003-07-04 2004-07-01 Uranium-chelating peptides and uses thereof
US12/979,787 Division US9321849B2 (en) 2003-07-04 2010-12-28 Uranium-chelating peptides and uses thereof

Publications (2)

Publication Number Publication Date
WO2005012336A2 WO2005012336A2 (fr) 2005-02-10
WO2005012336A3 true WO2005012336A3 (fr) 2005-05-26

Family

ID=33522781

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2004/001698 WO2005012336A2 (fr) 2003-07-04 2004-07-01 Peptides chelatant l'uranium et leurs applications

Country Status (8)

Country Link
US (3) US7888311B2 (fr)
EP (1) EP1641815B1 (fr)
JP (1) JP5086636B2 (fr)
CA (1) CA2531231C (fr)
ES (1) ES2543162T3 (fr)
FR (1) FR2857014B1 (fr)
RU (1) RU2006103257A (fr)
WO (1) WO2005012336A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8793787B2 (en) * 2004-04-01 2014-07-29 Fireeye, Inc. Detecting malicious network content using virtual environment components
US9255019B2 (en) 2012-04-12 2016-02-09 The University Of Chicago Protein scaffolds for selective enrichment of metal ions
EP2981555B1 (fr) * 2013-03-28 2020-04-15 Commissariat à l'Énergie Atomique et aux Énergies Alternatives Nouveaux peptides d'uranium-chélateur dérivés de motif de liaison au calcium ef-hand utiles pour la biodétection et biodécontamination d'uranium
EP2784094A1 (fr) 2013-03-28 2014-10-01 Commissariat A L'energie Atomique Et Aux Energies Alternatives Nouveaux peptides d'uranium-chélateur dérivés de motif de liaison au calcium EF-hand utiles pour la biodétection et biodécontamination d'uranium
CN115991757B (zh) * 2022-07-15 2023-08-11 南宁师范大学 信号增强型检测汞离子的荧光蛋白探针及其制备与应用

Non-Patent Citations (19)

* Cited by examiner, † Cited by third party
Title
"The EF-hand Calcium-binding Proteins Data Library", XP002318119, Retrieved from the Internet <URL:http://structbio.vanderbilt.edu/cabp_database/> [retrieved on 20050117] *
BABU Y S ET AL: "STRUCTURE OF CALMODULIN REFINED AT 2.2 A RESOLUTION", JOURNAL OF MOLECULAR BIOLOGY, vol. 204, no. 1, 1988, pages 191 - 204, XP009029518, ISSN: 0022-2836 *
BENDER P K ET AL: "THE ABUNDANCE OF CALMODULIN MESSENGER RNA IS REGULATED IN PHOSPHORYLASE-KINASE-DEFICIENT SKELETAL MUSCLE", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 263, no. 20, 1988, pages 9733 - 9737, XP002318462, ISSN: 0021-9258 *
BERTINI IVANO ET AL: "Tuning the affinity for lanthanides of calcium binding proteins.", BIOCHEMISTRY, vol. 42, no. 26, 8 July 2003 (2003-07-08), pages 8011 - 8021, XP002318121, ISSN: 0006-2960 *
BHATTACHARYA SHIBANI ET AL: "Target selectivity in EF-hand calcium binding proteins.", BIOCHIMICA ET BIOPHYSICA ACTA. 6 DEC 2004, vol. 1742, no. 1-3, 15 September 2004 (2004-09-15), pages 69 - 79, XP002318122, ISSN: 0006-3002 *
BUCHTA R ET AL: "PEPTIDES RELATED TO THE CALCIUM BINDING DOMAINS II AND III OF CALMODULIN SYNTHESIS AND CALMODULIN-LIKE FEATURES", INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH, vol. 28, no. 3, 1986, pages 289 - 297, XP009042763, ISSN: 0367-8377 *
DATABASE SWISSPROT [online] 1 May 2005 (2005-05-01), "Calmodulin (CaM)", XP002318463, retrieved from SWISSPROT Database accession no. P62158 *
DATABASE SWISSPROT [online] 15 March 2004 (2004-03-15), "Calmodulin", XP002277766, retrieved from SWISSPROT Database accession no. P02593 *
FINN B E ET AL: "The evolving model of calmodulin structure,function and activation", STRUCTURE, CURRENT BIOLOGY LTD., PHILADELPHIA, PA, US, vol. 3, no. 1, January 1995 (1995-01-01), pages 7 - 11, XP004587826, ISSN: 0969-2126 *
FISCHER R ET AL: "MULTIPLE DEVERGENT MRNAS CODE FOR A SINGLE HUMAN CALMODULIN", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 263, no. 32, 15 November 1988 (1988-11-15), pages 17055 - 17062, XP000073231, ISSN: 0021-9258 *
LE CLAINCHE LOIC ET AL: "Engineering new metal specificity in EF-hand peptides.", JBIC JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, vol. 8, no. 3, 20 November 2002 (2002-11-20), pages 334 - 340, XP002313279, ISSN: 0949-8257 *
MARSDEN B J ET AL: "CALCIUM BINDING PROTEINS ELUCIDATING THE CONTRIBUTIONS TO CALCIUM AFFINITY FROM AN ANALYSIS OF SPECIES VARIANTS AND PEPTIDE FRAGMENTS", BIOCHEMISTRY AND CELL BIOLOGY, vol. 68, no. 3, 1990, pages 587 - 601, XP009042755, ISSN: 0829-8211 *
MCCORMACK ELIZABETH ET AL: "Calmodulins and related potential calcium sensors of Arabidopsis.", NEW PHYTOLOGIST, vol. 159, no. 3, September 2003 (2003-09-01), pages 585 - 598, XP002318120, ISSN: 0028-646X *
NELSON MELANIE R ET AL: "Structures of EF-hand Ca2+-binding proteins: Diversity in the organization, packing and response to Ca2+ binding", BIOMETALS, vol. 11, no. 4, December 1998 (1998-12-01), pages 297 - 318, XP002318123, ISSN: 0966-0844 *
PROCYSHYN RIC M ET AL: "A structure/activity study of calcium affinity and selectivity using a synthetic peptide model of the helix-loop-helix calcium-binding motif", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 269, no. 3, 1994, pages 1641 - 1647, XP002318116, ISSN: 0021-9258 *
REID R E: "SYNTHETIC FRAGMENTS OF CALMODULIN CALCIUM-BINDING SITE III A TEST OF THE ACID PAIR HYPOTHESIS", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 265, no. 11, 1990, pages 5971 - 5976, XP002318118, ISSN: 0021-9258 *
REID RONALD E ET AL: "Engineering magnesium selectivity in the helix-loop-helix calcium-binding motif", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, vol. 323, no. 1, 1995, pages 115 - 119, XP002318479, ISSN: 0003-9861 *
RHYNER J A ET AL: "STRUCTURE OF THE HUMAN CALM1 CALMODULIN GENE AND IDENTIFICATION OF TWO CALM1-RELATED PSEUDOGENES CALM1P1 AND CALM1P2", EUROPEAN JOURNAL OF BIOCHEMISTRY, BERLIN, DE, vol. 225, 1994, pages 71 - 82, XP002949255, ISSN: 0014-2956 *
WILSON M A ET AL: "The 1.0 A crystal structure of Ca<2+>-bound calmodulin: an analysis of disorder and implications for functionally relevant plasticity", JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB, vol. 301, no. 5, 1 September 2000 (2000-09-01), pages 1237 - 1256, XP004461694, ISSN: 0022-2836 *

Also Published As

Publication number Publication date
US20180134810A1 (en) 2018-05-17
WO2005012336A2 (fr) 2005-02-10
ES2543162T3 (es) 2015-08-17
JP5086636B2 (ja) 2012-11-28
FR2857014B1 (fr) 2006-11-24
US20100015056A1 (en) 2010-01-21
RU2006103257A (ru) 2006-07-27
US20110093964A1 (en) 2011-04-21
EP1641815A2 (fr) 2006-04-05
CA2531231C (fr) 2014-04-01
CA2531231A1 (fr) 2005-02-10
EP1641815B1 (fr) 2015-05-27
US7888311B2 (en) 2011-02-15
FR2857014A1 (fr) 2005-01-07
JP2007537695A (ja) 2007-12-27
US9321849B2 (en) 2016-04-26

Similar Documents

Publication Publication Date Title
WO2006110883A3 (fr) Traitement et compositions a base d&#39;antagoniste du facteur de croissance nerveuse contre les douleurs d&#39;arthrose
Gruba et al. Tree species affect cation exchange capacity (CEC) and cation binding properties of organic matter in acid forest soils
EP2270048A3 (fr) Anticorps anti-NGF et leurs procédés d&#39;utilisation
WO2005116032A3 (fr) Mimetiques de coudes inverses et procede associe
Gruba et al. Effect of parent material on soil acidity and carbon content in soils under silver fir (Abies alba Mill.) stands in Poland
WO2004093828A3 (fr) Mimetiques de coudes inverses et procede associe
Kupryianchyk et al. Positioning activated carbon amendment technologies in a novel framework for sediment management
ATE398129T1 (de) Reverse-turn-mimetika und diese betreffendes verfahren
WO2005012336A3 (fr) Peptides chelatant l&#39;uranium et leurs applications
DE602004016499D1 (de) Zusammensetzungen und verfahren zur behandlung von entzündlicher darmerkrankung
WO2002020768A3 (fr) Peptides de caveoline et leur utilisation comme agents therapeutiques
ATE357917T1 (de) Behandlung von dyskinesie durch mu-selektive opioidantagonisten
PT1137413E (pt) Antagonistas nao-peptidicos do receptor de glp-1 e metodos de utilizacao
WO2001090366A3 (fr) Nouveaux polynucleotides humains et polypeptides codes par celui-ci
ATE462977T1 (de) Verfahren zum nachweis von autoimmunantikörpern gegen den tsh-rezeptor und neue tsh- rezeptorchimären
Martínez et al. Hominin multiple occupations in the Early and Middle Pleistocene sequence of Vallparadís (Barcelona, Spain)
de Boer et al. Certified reference materials for organic contaminants for use in monitoring of the aquatic environment
Pickering Artificial reefs of bulk waste materials: a scientific and legal review of the suitability of using the cement stabilised by-products of coal-fired power stations
KR20240112618A (ko) 팩, 커피, 기저귀, 부산물, 불가사리가 이용되는 공사 재료, 자재, 방법
KR20240057544A (ko) Ess, 충전기, 충전소, 파워뱅크, 폐배터리, 전기장치 및 이가 이용되는 공사, 건설, 건축, 정화, 청정, 작업, 재활용, 리사이클링 방법
Cahill The excavations at Tell el-Hammah: a prelude to Amihai Mazar’s Beth-Shean Valley regional project
Gaudant et al. Occurrence of pharyngeal teeth of the carp, Cyprinus Linnaeus (Teleostei, Cyprinidae) in the Middle and Upper Miocene of Andalusia (southern Spain): A puzzling disconnected palaeobiogeographical distribution
US10882087B2 (en) Method for stimulation and enhancement of processes of reduction, transformation and metabolization of polluting substances present in soils and/or waters, by treatment with mixture of enhanced mineral powders
MXPA05008194A (es) Composiciones para liberacion controlada de productos de control de peste en ambientes acuaticos.
CN107309259A (zh) 一种铜污染农田稳定化‑田间管控联合修复方法

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2006516341

Country of ref document: JP

ENP Entry into the national phase

Ref document number: 2531231

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2004767541

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2006103257

Country of ref document: RU

WWP Wipo information: published in national office

Ref document number: 2004767541

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 10562323

Country of ref document: US