WO2005011649A3 - Methods of treating severe acute respiratory syndrome virus infections - Google Patents

Methods of treating severe acute respiratory syndrome virus infections Download PDF

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Publication number
WO2005011649A3
WO2005011649A3 PCT/US2004/015536 US2004015536W WO2005011649A3 WO 2005011649 A3 WO2005011649 A3 WO 2005011649A3 US 2004015536 W US2004015536 W US 2004015536W WO 2005011649 A3 WO2005011649 A3 WO 2005011649A3
Authority
WO
WIPO (PCT)
Prior art keywords
acute respiratory
respiratory syndrome
virus infections
severe acute
methods
Prior art date
Application number
PCT/US2004/015536
Other languages
French (fr)
Other versions
WO2005011649A2 (en
Inventor
Mark Denison
Original Assignee
Univ Vanderbilt
Mark Denison
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Vanderbilt, Mark Denison filed Critical Univ Vanderbilt
Publication of WO2005011649A2 publication Critical patent/WO2005011649A2/en
Publication of WO2005011649A3 publication Critical patent/WO2005011649A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention provides methods for inhibiting severe acute respiratory syndrome (SARS) virus infections. Specifically, cysteine proteinase inhibitors are proposed as therapeutics for SARS, potentially used in combination with interferons.
PCT/US2004/015536 2003-05-19 2004-05-18 Methods of treating severe acute respiratory syndrome virus infections WO2005011649A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47160403P 2003-05-19 2003-05-19
US60/471,604 2003-05-19

Publications (2)

Publication Number Publication Date
WO2005011649A2 WO2005011649A2 (en) 2005-02-10
WO2005011649A3 true WO2005011649A3 (en) 2005-03-17

Family

ID=34115298

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/015536 WO2005011649A2 (en) 2003-05-19 2004-05-18 Methods of treating severe acute respiratory syndrome virus infections

Country Status (1)

Country Link
WO (1) WO2005011649A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8232240B2 (en) 2005-02-23 2012-07-31 The Brigham And Women's Hospital, Inc. Inhibitors of enveloped virus infectivity
CN115666550A (en) * 2020-04-16 2023-01-31 阿尔伯特-路德维希-弗莱堡大学 Cysteine protease inhibitors for the prevention and/or treatment of coronaviruses

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991008769A1 (en) * 1989-12-18 1991-06-27 Transgene S.A. Pharmaceutical composition for treating or preventing retroviral infections
US5763576A (en) * 1995-10-06 1998-06-09 Georgia Tech Research Corp. Tetrapeptide α-ketoamides
WO1999054317A1 (en) * 1998-04-23 1999-10-28 Cortech Inc. Cysteine protease inhibitors
WO2001046448A1 (en) * 1999-12-23 2001-06-28 The Board Of Regents Of The University Of Texas System Inhibition of cellular proteases
WO2004101742A2 (en) * 2003-05-06 2004-11-25 Cytovia, Inc Protease inhibitors for coronaviruses and sars-cov and the use thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991008769A1 (en) * 1989-12-18 1991-06-27 Transgene S.A. Pharmaceutical composition for treating or preventing retroviral infections
US5763576A (en) * 1995-10-06 1998-06-09 Georgia Tech Research Corp. Tetrapeptide α-ketoamides
WO1999054317A1 (en) * 1998-04-23 1999-10-28 Cortech Inc. Cysteine protease inhibitors
WO2001046448A1 (en) * 1999-12-23 2001-06-28 The Board Of Regents Of The University Of Texas System Inhibition of cellular proteases
WO2004101742A2 (en) * 2003-05-06 2004-11-25 Cytovia, Inc Protease inhibitors for coronaviruses and sars-cov and the use thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ANAND KANCHAN ET AL: "Coronavirus main proteinase (3CLpro) structure: Basis for design of anti-SARS drugs", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 300, no. 5626, 13 June 2003 (2003-06-13), pages 1763 - 1767, XP002291115, ISSN: 0036-8075 *
KLEINA L G ET AL: "ANTIVIRAL EFFECTS OF A THIOL PROTEASE INHIBITOR ON FOOT-AND-MOUTH DISEASE VIRUS", JOURNAL OF VIROLOGY, NEW YORK, US, US, vol. 66, no. 12, 1 December 1992 (1992-12-01), pages 7168 - 7175, XP000616699, ISSN: 0022-538X *
SELMI C ET AL: "THE SEARCH FOR A PRACTICAL APPROACH TO EMERGING DISEASES: THE CASE OF SEVERE ACUTE RESPIRATORY SYNDROME (SARS)", DEVELOPMENTAL IMMUNOLOGY, HARWOOD ACADEMIC PUBLISHERS, NEW YORK, NY,, US, vol. 9, no. 3, September 2002 (2002-09-01), pages 113 - 117, XP009036520, ISSN: 1044-6672 *
SIRCAR S ET AL: "INHIBITION OF ADENOVIRUS INFECTION WITH PROTEASE INHIBITORS", ANTIVIRAL RESEARCH, ELSEVIER SCIENCE BV., AMSTERDAM, NL, vol. 30, no. 2/3, May 1996 (1996-05-01), pages 147 - 153, XP001076687, ISSN: 0166-3542 *

Also Published As

Publication number Publication date
WO2005011649A2 (en) 2005-02-10

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