WO2005011593A2 - Liaison amelioree du pantoprazole et de la pompe a acide - Google Patents

Liaison amelioree du pantoprazole et de la pompe a acide Download PDF

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Publication number
WO2005011593A2
WO2005011593A2 PCT/US2004/024678 US2004024678W WO2005011593A2 WO 2005011593 A2 WO2005011593 A2 WO 2005011593A2 US 2004024678 W US2004024678 W US 2004024678W WO 2005011593 A2 WO2005011593 A2 WO 2005011593A2
Authority
WO
WIPO (PCT)
Prior art keywords
pantoprazole
acid
enantiomer
substantially free
human
Prior art date
Application number
PCT/US2004/024678
Other languages
English (en)
Other versions
WO2005011593A3 (fr
Inventor
Richard J. Heaslip
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Publication of WO2005011593A2 publication Critical patent/WO2005011593A2/fr
Publication of WO2005011593A3 publication Critical patent/WO2005011593A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole

Definitions

  • Examples of active compounds from this group which are commercially available or in clinical development are 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methylsulphinyl]-1 H-benzimidazole (INN: omeprazole), (S)-5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methylsulphinyl]-1 H-benzimidazole (INN: esomeprazole), 5-difluoromethoxy-2-[(3,4-dimethoxy-2-pyridinyl)methylsulphinyl]-1 H-benzimidazole (INN: pantoprazole), 2-[(3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl)methylsulphinyl]-1H- benzimidazole (INN: lansoprazole), 2- ⁇ [4-(3-methoxypropoxy)-3-methyp
  • a further aspect of the present invention is the use of (+)-pantoprazole, substantially free of the (-)- enantiomer, or a pharmaceutically acceptable salt thereof for the production of a medicament intended for inhibiting gastric acid secretion in a human by selectively blocking cysteine 822 of the proton pump in the canaliculus of the parietal cell, thus rendering the acid pump irreversibly incapable of secreting acid.
  • the international patent application WO92/08716 describes a chemical process which allows pyridin-2-ylmethylsulphinyl-1H-benzimidazoles to be separated into their optical antipodes.
  • the international patent application WO92/08716 mentions that the optical antipodes of the pyridin-2-ylmethylsulphinyl-1 H-benzimidazoles, i.e.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne une certaine forme de pantoprazole se liant sélectivement à la pompe à protons, ce qui permet d'améliorer le degré et la durée d'une inhibition d'acide.
PCT/US2004/024678 2003-07-31 2004-07-30 Liaison amelioree du pantoprazole et de la pompe a acide WO2005011593A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49127303P 2003-07-31 2003-07-31
US60/491,273 2003-07-31

Publications (2)

Publication Number Publication Date
WO2005011593A2 true WO2005011593A2 (fr) 2005-02-10
WO2005011593A3 WO2005011593A3 (fr) 2005-09-01

Family

ID=34115485

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/024678 WO2005011593A2 (fr) 2003-07-31 2004-07-30 Liaison amelioree du pantoprazole et de la pompe a acide

Country Status (1)

Country Link
WO (1) WO2005011593A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102786483A (zh) * 2011-05-19 2012-11-21 复旦大学 4-（4-苯基哌嗪基）喹唑啉类衍生物的药用用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994025028A1 (fr) * 1993-04-27 1994-11-10 Sepracor, Inc. Procedes et compositions de traitement de troubles gastriques a l'aide de pantoprazole (+) optiquement pur

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994025028A1 (fr) * 1993-04-27 1994-11-10 Sepracor, Inc. Procedes et compositions de traitement de troubles gastriques a l'aide de pantoprazole (+) optiquement pur

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE BIOBASE [Online] SCHUBERT M.K. ET AL: 'Gastric Secretion' Retrieved from STN Database accession no. (2003267791) & CURRENT OPINION IN GASTEROENTEROLOGY vol. 19, no. 6, 2003, pages 519 - 525 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102786483A (zh) * 2011-05-19 2012-11-21 复旦大学 4-（4-苯基哌嗪基）喹唑啉类衍生物的药用用途

Also Published As

Publication number Publication date
WO2005011593A3 (fr) 2005-09-01

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