WO2005010168A3 - Method and system for detecting chloramphenicol - Google Patents

Method and system for detecting chloramphenicol Download PDF

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Publication number
WO2005010168A3
WO2005010168A3 PCT/US2004/023737 US2004023737W WO2005010168A3 WO 2005010168 A3 WO2005010168 A3 WO 2005010168A3 US 2004023737 W US2004023737 W US 2004023737W WO 2005010168 A3 WO2005010168 A3 WO 2005010168A3
Authority
WO
WIPO (PCT)
Prior art keywords
chloramphenicol
sample
tested
solid phase
phase extraction
Prior art date
Application number
PCT/US2004/023737
Other languages
French (fr)
Other versions
WO2005010168A2 (en
Inventor
Julio Quintana-Rizzo
Steven J Saul
Original Assignee
Charm Sciences Inc
Julio Quintana-Rizzo
Steven J Saul
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Charm Sciences Inc, Julio Quintana-Rizzo, Steven J Saul filed Critical Charm Sciences Inc
Publication of WO2005010168A2 publication Critical patent/WO2005010168A2/en
Publication of WO2005010168A3 publication Critical patent/WO2005010168A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • G01N30/14—Preparation by elimination of some components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N2030/009—Extraction

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Methods and systems for detecting drugs, particularly amphenicols such as chloramphenicol, in samples such as honey and other foods, are described. An aspect includes a method and system for separating chloramphenicol from compounds that could interfere with an immunoassay for detection of chloramphenicol. In one aspect, chloramphenicol is extracted from the sample by buffering the sample and eluting the sample from a solid phase extraction column with a cyclohexyl functional group. The eluent is tested for the presence of chloramphenicol. False positive results are avoided by using mild organic solvents and a solid phase extraction column to separate interfering substances from the substances to be tested.
PCT/US2004/023737 2003-07-24 2004-07-23 Method and system for detecting chloramphenicol WO2005010168A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48973703P 2003-07-24 2003-07-24
US60/489,737 2003-07-24

Publications (2)

Publication Number Publication Date
WO2005010168A2 WO2005010168A2 (en) 2005-02-03
WO2005010168A3 true WO2005010168A3 (en) 2005-04-07

Family

ID=34102930

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/023737 WO2005010168A2 (en) 2003-07-24 2004-07-23 Method and system for detecting chloramphenicol

Country Status (1)

Country Link
WO (1) WO2005010168A2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101943701B (en) * 2010-07-07 2014-01-22 南昌大学 Preparation method of colloidal gold test strip for quickly detecting chloramphenicol residues
CN108088935A (en) * 2017-12-07 2018-05-29 广西质量技术工程学校 A kind of sample-pretreating method for detecting Determination of Chloramphenicol Residues In Aquatic Products By Charm Ii
CN109633004B (en) * 2018-12-27 2021-08-03 嘉兴学院 Method for detecting content of trichlorophenol in leather
CN112180015B (en) * 2020-10-21 2021-10-22 明一国际营养品集团有限公司 Method for detecting antibiotics in milk

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102901778A (en) * 2011-07-29 2013-01-30 内蒙古蒙牛乳业（集团）股份有限公司 Pretreatment method for detecting chloramphenicol in milk or mild products and method for detecting chloramphenicol in milk or mild products
CN102565269A (en) * 2012-03-05 2012-07-11 扬州大学 Method for simultaneously detecting chloramphenicol, thiamphenicol, florfenicol and florfenicol amine residues in eggs
CN104880522A (en) * 2015-04-28 2015-09-02 衢州出入境检验检疫局综合技术服务中心 Method for determining residual quantity of chloramphenicol in bee wax by n-hexane pre-treatment-high performance liquid chromatography-tandem mass spectrometry
CN107121402B (en) * 2017-04-21 2020-02-14 同济大学 Method for detecting chloramphenicol in water based on metal organic framework compound simulated enzyme catalytic property
CN112461823A (en) * 2020-11-10 2021-03-09 苏州慧源安食检测科技有限公司 Rapid detection method of florfenicol
CN112630322B (en) * 2020-11-27 2022-09-16 宁波市产品食品质量检验研究院(宁波市纤维检验所) Method for detecting phenolic compounds in fish
CN112611824B (en) * 2020-11-30 2022-09-16 宁波市产品食品质量检验研究院(宁波市纤维检验所) Method for detecting phenolic compounds in carapace

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5272094A (en) * 1989-05-04 1993-12-21 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Isolation of components from biological specimens via matrix solid phase dispersion

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5272094A (en) * 1989-05-04 1993-12-21 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Isolation of components from biological specimens via matrix solid phase dispersion

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GAUDIN, ET AL.: "Development of a Biosensor-based Immunoassay for Screening of Chloramphenicol Residues in Milk", FOOD AND AGRICULTURAL IMMUNOLOGY, vol. 13, 2001, pages 77 - 86, XP008043436 *
VERZEGNASSI, ET AL.: "Analysis of Chloramphenicol in Honeys of Different Geographical Origin by Liquid Chromatography coupled to Electrospray Ionization Tandem Mass Spectrometry", FOOD ADDITIVES AND CONTAMINANTS, vol. 20, no. 4, April 2003 (2003-04-01), pages 335 - 342, XP008043439 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101943701B (en) * 2010-07-07 2014-01-22 南昌大学 Preparation method of colloidal gold test strip for quickly detecting chloramphenicol residues
CN108088935A (en) * 2017-12-07 2018-05-29 广西质量技术工程学校 A kind of sample-pretreating method for detecting Determination of Chloramphenicol Residues In Aquatic Products By Charm Ii
CN109633004B (en) * 2018-12-27 2021-08-03 嘉兴学院 Method for detecting content of trichlorophenol in leather
CN112180015B (en) * 2020-10-21 2021-10-22 明一国际营养品集团有限公司 Method for detecting antibiotics in milk

Also Published As

Publication number Publication date
WO2005010168A2 (en) 2005-02-03

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