WO2005009481A3 - Surfactant-containing bone cement - Google Patents

Surfactant-containing bone cement Download PDF

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Publication number
WO2005009481A3
WO2005009481A3 PCT/DE2004/001572 DE2004001572W WO2005009481A3 WO 2005009481 A3 WO2005009481 A3 WO 2005009481A3 DE 2004001572 W DE2004001572 W DE 2004001572W WO 2005009481 A3 WO2005009481 A3 WO 2005009481A3
Authority
WO
WIPO (PCT)
Prior art keywords
surfactant
bone cement
polyoxyethylene sorbitan
pmma
relates
Prior art date
Application number
PCT/DE2004/001572
Other languages
German (de)
French (fr)
Other versions
WO2005009481A2 (en
Inventor
Berthold Nies
Frank Schilke
Hanns Pietsch
Original Assignee
Biomet Deutschland Gmbh
Berthold Nies
Frank Schilke
Hanns Pietsch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomet Deutschland Gmbh, Berthold Nies, Frank Schilke, Hanns Pietsch filed Critical Biomet Deutschland Gmbh
Priority to DE112004001799T priority Critical patent/DE112004001799D2/en
Publication of WO2005009481A2 publication Critical patent/WO2005009481A2/en
Publication of WO2005009481A3 publication Critical patent/WO2005009481A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
    • A61L24/0094—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
    • A61L2300/802—Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Composite Materials (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The invention relates to a bone cement based on PMMA, comprising a liquid component and a solid component, whereby said liquid component contains 50 - 85 wt. % of monomeric methylmethacrylate, 5 - 50 wt. % of surfactant, 0.2 - 5 wt. % of an accelerator and optionally small amounts of other adjuvants. Said invention also relates to the use of non-ionic surfactants, such as sorbitan monolaurate, sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate or polyoxyethylene sorbitan trioleate in PMMA bone cements containing active substances, for an improved release of antibiotic agents.
PCT/DE2004/001572 2003-07-18 2004-07-16 Surfactant-containing bone cement WO2005009481A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE112004001799T DE112004001799D2 (en) 2003-07-18 2004-07-16 Surfactant-containing bone cement

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10332687 2003-07-18
DE10332687.1 2003-07-18

Publications (2)

Publication Number Publication Date
WO2005009481A2 WO2005009481A2 (en) 2005-02-03
WO2005009481A3 true WO2005009481A3 (en) 2005-03-24

Family

ID=34088675

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2004/001572 WO2005009481A2 (en) 2003-07-18 2004-07-16 Surfactant-containing bone cement

Country Status (2)

Country Link
DE (1) DE112004001799D2 (en)
WO (1) WO2005009481A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10032220A1 (en) 2000-07-03 2002-01-24 Sanatis Gmbh Magnesium ammonium phosphate cements, their manufacture and use
US7273523B2 (en) 2002-06-07 2007-09-25 Kyphon Inc. Strontium-apatite-cement-preparations, cements formed therefrom, and uses thereof
MXPA06012420A (en) 2004-04-27 2007-03-28 Kyphon Inc Bone substitute compositions and method of use.
US7416602B2 (en) 2005-04-08 2008-08-26 Howmedica Leibinger, Inc. Calcium phosphate cement
US7459018B2 (en) 2005-04-08 2008-12-02 Howmedica Leibinger Inc. Injectable calcium phosphate cement
US7651701B2 (en) 2005-08-29 2010-01-26 Sanatis Gmbh Bone cement composition and method of making the same
WO2007106256A2 (en) * 2006-03-01 2007-09-20 Poly-Med, Inc. Antimicrobial, radiopaque, microfiber-reinforced, polymeric methacrylate bone cement
US7754005B2 (en) 2006-05-02 2010-07-13 Kyphon Sarl Bone cement compositions comprising an indicator agent and related methods thereof
US7507286B2 (en) 2006-06-08 2009-03-24 Sanatis Gmbh Self-foaming cement for void filling and/or delivery systems
DE102007015698B4 (en) * 2007-03-27 2009-05-14 Innotere Gmbh Implant material based on a polymer system and its use as well as application set
US7968616B2 (en) 2008-04-22 2011-06-28 Kyphon Sarl Bone cement composition and method
JP5847097B2 (en) * 2010-03-05 2016-01-20 ジンテス ゲゼルシャフト ミット ベシュレンクテル ハフツング Bone cement system for bone formation
ES2714701T3 (en) 2010-11-10 2019-05-29 Stryker European Holdings I Llc Process for the preparation of a polymeric bone foam

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2552070A1 (en) * 1975-11-20 1977-05-26 Beiersdorf Ag SURGICAL PLASTIC MATERIAL
DE2715532A1 (en) * 1977-04-07 1978-10-19 Beiersdorf Ag Acrylic! bone cements for surgical applications prepn. - by mixing powdered PMMA with emulsion contg. methyl methacrylate, accelerator and hexa:fatty acid ester of polyoxyethylene sorbitol
US4588583A (en) * 1982-12-11 1986-05-13 Beiersdorf Aktiengesellschaft Surgical material
DE3738422A1 (en) * 1987-11-12 1989-05-24 Beiersdorf Ag SURGICAL MATERIAL

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2552070A1 (en) * 1975-11-20 1977-05-26 Beiersdorf Ag SURGICAL PLASTIC MATERIAL
DE2715532A1 (en) * 1977-04-07 1978-10-19 Beiersdorf Ag Acrylic! bone cements for surgical applications prepn. - by mixing powdered PMMA with emulsion contg. methyl methacrylate, accelerator and hexa:fatty acid ester of polyoxyethylene sorbitol
US4588583A (en) * 1982-12-11 1986-05-13 Beiersdorf Aktiengesellschaft Surgical material
DE3738422A1 (en) * 1987-11-12 1989-05-24 Beiersdorf Ag SURGICAL MATERIAL

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
EDITIO CANTOR VERLAG FÜR MEDIZIN UND NATURWISSENSCHAFTEN GMBH, AULENDORF: "Rote Liste 2002", 2002, ROTE LISTE SERVICE GMBH, FRANKFURT A.M., GERMANY, XP002313466 *
LOSCHE D ET AL: "Preparation of a bone cement containing cytostatic agents", PHARMAZIE 1987 GERMANY, vol. 42, no. 2, 1987, pages 97 - 99, XP001204737 *

Also Published As

Publication number Publication date
DE112004001799D2 (en) 2006-07-06
WO2005009481A2 (en) 2005-02-03

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