WO2005006940A3 - Detection of mutations in nucleic acid sequences - Google Patents

Detection of mutations in nucleic acid sequences Download PDF

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Publication number
WO2005006940A3
WO2005006940A3 PCT/US2004/019618 US2004019618W WO2005006940A3 WO 2005006940 A3 WO2005006940 A3 WO 2005006940A3 US 2004019618 W US2004019618 W US 2004019618W WO 2005006940 A3 WO2005006940 A3 WO 2005006940A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
mutation
acid sequence
patient
target nucleic
Prior art date
Application number
PCT/US2004/019618
Other languages
French (fr)
Other versions
WO2005006940A2 (en
Inventor
James S Goydos
Original Assignee
Univ New Jersey Med
James S Goydos
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ New Jersey Med, James S Goydos filed Critical Univ New Jersey Med
Publication of WO2005006940A2 publication Critical patent/WO2005006940A2/en
Publication of WO2005006940A3 publication Critical patent/WO2005006940A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C12Q1/683—Hybridisation assays for detection of mutation or polymorphism involving restriction enzymes, e.g. restriction fragment length polymorphism [RFLP]

Abstract

The present invention is directed to a novel method for detecting a mutation in a target nucleic acid sequence. Such methods may be used to detect a mutation in a target nucleic acid sequence derived from a biological sample. Exemplary biological samples include, but are not limited to, samples derived from patients such as bodily fluids, tissues or cells. The methods of the invention are useful for detecting a mutation in a target nucleic acid sequence in such patient samples and thus, are of utility for diagnosing a disease in a patient and/or predicting a predisposition of a patient for a disease.
PCT/US2004/019618 2003-06-19 2004-06-18 Detection of mutations in nucleic acid sequences WO2005006940A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47989603P 2003-06-19 2003-06-19
US60/479,896 2003-06-19

Publications (2)

Publication Number Publication Date
WO2005006940A2 WO2005006940A2 (en) 2005-01-27
WO2005006940A3 true WO2005006940A3 (en) 2005-06-30

Family

ID=34079045

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/019618 WO2005006940A2 (en) 2003-06-19 2004-06-18 Detection of mutations in nucleic acid sequences

Country Status (1)

Country Link
WO (1) WO2005006940A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101347613B1 (en) * 2004-03-31 2014-01-06 다나-파버 캔서 인스티튜트 인크. Method for determining the likelihood of effectiveness of an epidermal growth factor receptor targeting treatment in a human patient affected with cancer, kit, nucleic acid probe, and primer pair
GB201317881D0 (en) * 2013-10-09 2013-11-20 Vela Operations Pte Ltd NRAS assay

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639611A (en) * 1988-12-12 1997-06-17 City Of Hope Allele specific polymerase chain reaction
US5945290A (en) * 1998-09-18 1999-08-31 Isis Pharmaceuticals, Inc. Antisense modulation of RhoA expression
US5994075A (en) * 1996-05-17 1999-11-30 Hexagen Technology Limited Methods for identifying a mutation in a gene of interest without a phenotypic guide

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639611A (en) * 1988-12-12 1997-06-17 City Of Hope Allele specific polymerase chain reaction
US5994075A (en) * 1996-05-17 1999-11-30 Hexagen Technology Limited Methods for identifying a mutation in a gene of interest without a phenotypic guide
US5945290A (en) * 1998-09-18 1999-08-31 Isis Pharmaceuticals, Inc. Antisense modulation of RhoA expression

Also Published As

Publication number Publication date
WO2005006940A2 (en) 2005-01-27

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