WO2005003292A3 - Composition and method for self-assembly and mineralization of peptide amphiphiles - Google Patents

Composition and method for self-assembly and mineralization of peptide amphiphiles Download PDF

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Publication number
WO2005003292A3
WO2005003292A3 PCT/US2003/035902 US0335902W WO2005003292A3 WO 2005003292 A3 WO2005003292 A3 WO 2005003292A3 US 0335902 W US0335902 W US 0335902W WO 2005003292 A3 WO2005003292 A3 WO 2005003292A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptide
mineral
amphiphiles
mineralization
solution
Prior art date
Application number
PCT/US2003/035902
Other languages
French (fr)
Other versions
WO2005003292A2 (en
Inventor
Samuel I Stupp
Elia Beniash
Jeffrey D Hartgerink
Original Assignee
Univ Northwestern
Samuel I Stupp
Elia Beniash
Jeffrey D Hartgerink
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2003/004779 external-priority patent/WO2003070749A2/en
Application filed by Univ Northwestern, Samuel I Stupp, Elia Beniash, Jeffrey D Hartgerink filed Critical Univ Northwestern
Priority to AU2003304280A priority Critical patent/AU2003304280A1/en
Priority to US10/534,097 priority patent/US7554021B2/en
Publication of WO2005003292A2 publication Critical patent/WO2005003292A2/en
Publication of WO2005003292A3 publication Critical patent/WO2005003292A3/en
Priority to US12/489,401 priority patent/US8124583B2/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

Abstract

The present invention is directed to a composition useful for making homogeneously mineralized self assembled peptide-amphiphile nanofibers and nanofiber gels. The composition is generally a solution comprised of a positively or negatively charged peptide-amphiphile and a like signed ion from the mineral. Mixing this solution with a second solution containing a dissolved counter-ion of the mineral and/or a second oppositely charged peptide amphiphile, results in the rapid self assembly of the peptide-amphiphiles into a nanofiber gel and templated mineralization of the ions. Templated mineralization of the initially dissolved mineral cations and anions in the mixture occurs with preferential orientation of the mineral crystals along the fiber surfaces within the nanofiber gel. One advantage of the present invention is that it results in homogenous growth of the mineral throughout the nanofiber gel. Another advantage of the present invention is that the nanofiber gel formation and mineralization reactions occur in a single mixing step and under substantially neutral or physiological pH conditions. These homogeneous nanostructured composite materials are useful for medical applications especially the regeneration of damaged bone in mammals. This invention is directed to the synthesis of peptide-amphiphiles with more than one amphiphilic moment and to supramolecular compositions comprised of such multi-dimensional peptide-amphiphiles. Supramolecular compositions can be formed by self assembly of multi-dimensional peptide-amphiphiles by mixing them with a solution comprising a monovalent cation.
PCT/US2003/035902 2002-11-12 2003-11-12 Composition and method for self-assembly and mineralization of peptide amphiphiles WO2005003292A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2003304280A AU2003304280A1 (en) 2002-11-12 2003-11-12 Composition and method for self-assembly and mineralization of peptide amphiphiles
US10/534,097 US7554021B2 (en) 2002-11-12 2003-11-12 Composition and method for self-assembly and mineralization of peptide amphiphiles
US12/489,401 US8124583B2 (en) 2002-11-12 2009-06-22 Composition and method for self-assembly and mineralization of peptide-amphiphiles

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US42553602P 2002-11-12 2002-11-12
US42568902P 2002-11-12 2002-11-12
US60/425,689 2002-11-12
US60/425,536 2002-11-12
PCT/US2003/004779 WO2003070749A2 (en) 2002-02-15 2003-02-18 Self-assembly of peptide-amphiphile nanofibers under physiological conditions
USPCT/US03/04779 2003-02-18

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10534097 A-371-Of-International 2003-11-12
US12/489,401 Division US8124583B2 (en) 2002-11-12 2009-06-22 Composition and method for self-assembly and mineralization of peptide-amphiphiles

Publications (2)

Publication Number Publication Date
WO2005003292A2 WO2005003292A2 (en) 2005-01-13
WO2005003292A3 true WO2005003292A3 (en) 2005-04-28

Family

ID=33568404

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/035902 WO2005003292A2 (en) 2002-11-12 2003-11-12 Composition and method for self-assembly and mineralization of peptide amphiphiles

Country Status (2)

Country Link
AU (1) AU2003304280A1 (en)
WO (1) WO2005003292A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7491690B2 (en) 2001-11-14 2009-02-17 Northwestern University Self-assembly and mineralization of peptide-amphiphile nanofibers
US7371719B2 (en) 2002-02-15 2008-05-13 Northwestern University Self-assembly of peptide-amphiphile nanofibers under physiological conditions
AU2003262760A1 (en) 2002-08-21 2004-03-11 Northwestern University Charged peptide-amphiphile solutions and self-assembled peptide nanofiber networks formed therefrom
US7554021B2 (en) 2002-11-12 2009-06-30 Northwestern University Composition and method for self-assembly and mineralization of peptide amphiphiles
AU2003298647A1 (en) 2002-11-14 2004-06-15 Claussen, Randal, C. Synthesis and self-assembly of abc triblock bola peptide
CA2515651A1 (en) 2003-02-11 2004-08-26 Northwestern University Methods and materials for nanocrystalline surface coatings and attachment of peptide amphiphile nanofibers thereon
WO2005056039A1 (en) 2003-12-05 2005-06-23 Northwestern University Self-assembling peptide amphiphiles and related methods for growth factor delivery
EP1696944A4 (en) * 2003-12-05 2008-11-05 Univ Northwestern Branched peptide amphiphiles, related epitope compounds and self assembled structures thereof
CN101150954A (en) 2005-01-21 2008-03-26 西北大学 Methods and compositions for encapsulation of cells
KR20070108555A (en) 2005-03-04 2007-11-12 노오쓰웨스턴 유니버시티 Angiogenic heparin binding peptide amphiphiles
EP3219294A1 (en) 2006-06-20 2017-09-20 Ben-Gurion University of The Negev Research and Development Authority Amphiphilic peptides and hydrogel matrices thereof for bone repair
US8076295B2 (en) 2007-04-17 2011-12-13 Nanotope, Inc. Peptide amphiphiles having improved solubility and methods of using same
WO2009072119A2 (en) 2007-12-04 2009-06-11 Ben-Gurion University Of The Negev Research And Development Authority Amphiphilic peptide matrices for treatment of osteoporosis
CA2758522A1 (en) 2009-04-13 2010-10-21 Northwestern University Novel peptide-based scaffolds for cartilage regeneration and methods for their use
KR101102984B1 (en) * 2009-09-01 2012-01-05 연세대학교 산학협력단 Mineralization of metal magnetite particle on self-assembled bio-mimicked molecule in buffer solution

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030176335A1 (en) * 2001-07-10 2003-09-18 Shuguang Zhang Surfactant peptide nanostructures, and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030176335A1 (en) * 2001-07-10 2003-09-18 Shuguang Zhang Surfactant peptide nanostructures, and uses thereof

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BUSQUÉ F. ET AL.: "Progress toward a peptidomimetic of laminin-derived pentapeptide YIGSR: synthesis of the unique tricyclic core structure", J. ORG. CHEM., vol. 67, August 2002 (2002-08-01), pages 6097 - 6103, XP002984886 *
FISCHBACH, M. ET AL.: "Solute equilibration curves, crossing time for urea and glucose during peritoneal dialysis: a function of age in children", ADV PERIT DIAL., vol. 7, 1991, pages 262 - 265, XP008044795 *
HARTGERINK, J.D. ET AL.: "Peptide-amphiphile nanofibers: a versatile scaffold for the preparation of self-assembling materials", PROC.NATL.ACAD.SCI. USA, vol. 99, April 2002 (2002-04-01), pages 5133 - 5138, XP002972643 *
HARTGERINK, J.D. ET AL.: "Self-assembly and mineralization of peptide-amphiphile nanofibers", SCIENCE, vol. 294, November 2001 (2001-11-01), pages 1684 - 1688, XP002972644 *
ISSAC, R. AND CHMIELEWSKI, J.: "Approaching exponential growth with a self-replicating peptide", J.AM.CHEM.SOC., vol. 124, January 2002 (2002-01-01), pages 6808 - 6809, XP002984885 *
NIECE, K.L. ET AL.: "Self-assembly combining two bioactive peptide-amphiphile molecules into nanofibers by electrostatic attraction", J. AM CHEM SOC., vol. 125, June 2003 (2003-06-01), pages 7146 - 7147, XP002984887 *
ZHANG, S.: "Fabrication of novel biomaterials through molecular self-assembly", NAT. BIOTECHNOL., vol. 21, October 2003 (2003-10-01), pages 1171 - 1178, XP002305982 *

Also Published As

Publication number Publication date
WO2005003292A2 (en) 2005-01-13
AU2003304280A8 (en) 2005-01-21
AU2003304280A1 (en) 2005-01-21

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