WO2005002541A3 - Process for preparing formulations of lipid-regulating drugs - Google Patents

Process for preparing formulations of lipid-regulating drugs Download PDF

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Publication number
WO2005002541A3
WO2005002541A3 PCT/US2004/021361 US2004021361W WO2005002541A3 WO 2005002541 A3 WO2005002541 A3 WO 2005002541A3 US 2004021361 W US2004021361 W US 2004021361W WO 2005002541 A3 WO2005002541 A3 WO 2005002541A3
Authority
WO
WIPO (PCT)
Prior art keywords
lipid
preparing formulations
regulating drugs
regulating
preparing
Prior art date
Application number
PCT/US2004/021361
Other languages
French (fr)
Other versions
WO2005002541A2 (en
Inventor
Yihing Qiu
Jacqueline Wardrop
Original Assignee
Abbott Lab
Yihing Qiu
Jacqueline Wardrop
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab, Yihing Qiu, Jacqueline Wardrop filed Critical Abbott Lab
Priority to MXPA06000111A priority Critical patent/MXPA06000111A/en
Priority to CA2531097A priority patent/CA2531097C/en
Priority to JP2006518798A priority patent/JP5134818B2/en
Priority to EP04777483A priority patent/EP1643975A2/en
Publication of WO2005002541A2 publication Critical patent/WO2005002541A2/en
Publication of WO2005002541A3 publication Critical patent/WO2005002541A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

A process for preparing a formulation of a lipid-regulating drug comprising dissolving said lipid-regulating drug in a solvent free of surfactant, premixing an excipient, wet granulating the drug solution/excipient mixture, drying the mixture and forming a final dosage form.
PCT/US2004/021361 2003-07-02 2004-07-02 Process for preparing formulations of lipid-regulating drugs WO2005002541A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
MXPA06000111A MXPA06000111A (en) 2003-07-02 2004-07-02 Process for preparing formulations of lipid-regulating drugs.
CA2531097A CA2531097C (en) 2003-07-02 2004-07-02 Process for preparing formulations of lipid-regulating drugs
JP2006518798A JP5134818B2 (en) 2003-07-02 2004-07-02 Method for the manufacture of lipid controlled drug formulations
EP04777483A EP1643975A2 (en) 2003-07-02 2004-07-02 Process for preparing formulations of lipid-regulating drugs

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61362203A 2003-07-02 2003-07-02
US10/613,622 2003-07-02

Publications (2)

Publication Number Publication Date
WO2005002541A2 WO2005002541A2 (en) 2005-01-13
WO2005002541A3 true WO2005002541A3 (en) 2005-09-15

Family

ID=33564305

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/021361 WO2005002541A2 (en) 2003-07-02 2004-07-02 Process for preparing formulations of lipid-regulating drugs

Country Status (5)

Country Link
EP (1) EP1643975A2 (en)
JP (2) JP5134818B2 (en)
CA (1) CA2531097C (en)
MX (1) MXPA06000111A (en)
WO (1) WO2005002541A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1982001649A1 (en) * 1980-11-19 1982-05-27 Laruelle Claude New galenic preparation of phenofibrate,method for the obtention thereof,its application as a medicine
EP0625351A1 (en) * 1993-05-19 1994-11-23 MERZ + CO. GmbH & Co. Use of Etofibrate and pharmaceutical compositions containing etofibrate in the treatment of diabetic angio- and retinopathy
US6383517B1 (en) * 1999-01-29 2002-05-07 Abbott Laboratories Process for preparing solid formulations of lipid-regulating agents with enhanced dissolution and absorption

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04103525A (en) * 1990-08-22 1992-04-06 Sanwa Kagaku Kenkyusho Co Ltd Production of sustainable pharmaceutical preparation for poorly water-soluble medicine
GB9806312D0 (en) * 1998-03-24 1998-05-20 Smithkline Beecham Plc Novel formulations
FR2795961B1 (en) * 1999-07-09 2004-05-28 Ethypharm Lab Prod Ethiques PHARMACEUTICAL COMPOSITION CONTAINING MICRONIZED FENOFIBRATE, A SURFACTANT AND A BINDING CELLULOSIC DERIVATIVE AND PREPARATION METHOD

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1982001649A1 (en) * 1980-11-19 1982-05-27 Laruelle Claude New galenic preparation of phenofibrate,method for the obtention thereof,its application as a medicine
EP0625351A1 (en) * 1993-05-19 1994-11-23 MERZ + CO. GmbH & Co. Use of Etofibrate and pharmaceutical compositions containing etofibrate in the treatment of diabetic angio- and retinopathy
US6383517B1 (en) * 1999-01-29 2002-05-07 Abbott Laboratories Process for preparing solid formulations of lipid-regulating agents with enhanced dissolution and absorption

Also Published As

Publication number Publication date
CA2531097C (en) 2012-10-09
JP5134818B2 (en) 2013-01-30
JP2012149078A (en) 2012-08-09
JP2007530415A (en) 2007-11-01
MXPA06000111A (en) 2006-04-27
WO2005002541A2 (en) 2005-01-13
EP1643975A2 (en) 2006-04-12
CA2531097A1 (en) 2005-01-13

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