WO2004105779A3 - Green tea and oplyphenol inhibitors of bacterial proteases - Google Patents

Green tea and oplyphenol inhibitors of bacterial proteases Download PDF

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Publication number
WO2004105779A3
WO2004105779A3 PCT/IB2004/001997 IB2004001997W WO2004105779A3 WO 2004105779 A3 WO2004105779 A3 WO 2004105779A3 IB 2004001997 W IB2004001997 W IB 2004001997W WO 2004105779 A3 WO2004105779 A3 WO 2004105779A3
Authority
WO
WIPO (PCT)
Prior art keywords
green tea
inhibitors
oplyphenol
bacterial proteases
treatment
Prior art date
Application number
PCT/IB2004/001997
Other languages
French (fr)
Other versions
WO2004105779A2 (en
Inventor
Cesare Montecucco
Original Assignee
Cesare Montecucco
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0319946A external-priority patent/GB0319946D0/en
Application filed by Cesare Montecucco filed Critical Cesare Montecucco
Publication of WO2004105779A2 publication Critical patent/WO2004105779A2/en
Publication of WO2004105779A3 publication Critical patent/WO2004105779A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/64—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with oxygen atoms directly attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/82—Theaceae (Tea family), e.g. camellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Abstract

The use of green tea extract and/or polyphenols as protease inhibitors, in particular as metalloprotease inhibitors, in the treatment of bacterial infections associated with protease activity, in particular for the treatment or prevention of anthrax. Preferred polyphenols are those extractable from green tea, in particular catechins and especially catechin gallate and (-) -epigallocatechin gallate.
PCT/IB2004/001997 2003-05-27 2004-05-27 Green tea and oplyphenol inhibitors of bacterial proteases WO2004105779A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP03425342.7 2003-05-27
EP03425342 2003-05-27
EP03425343 2003-05-28
EP03425343.5 2003-05-28
GB0319946.0 2003-08-26
GB0319946A GB0319946D0 (en) 2003-08-26 2003-08-26 Herbal remedy for bacterial infection

Publications (2)

Publication Number Publication Date
WO2004105779A2 WO2004105779A2 (en) 2004-12-09
WO2004105779A3 true WO2004105779A3 (en) 2005-03-17

Family

ID=33493812

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2004/001997 WO2004105779A2 (en) 2003-05-27 2004-05-27 Green tea and oplyphenol inhibitors of bacterial proteases

Country Status (1)

Country Link
WO (1) WO2004105779A2 (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
ME02970B (en) 2004-06-24 2018-07-20 Vertex Pharma Modulators of ATP-binding cassette transporters
US8354427B2 (en) 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
LT1993360T (en) 2005-12-28 2017-06-12 Vertex Pharmaceuticals Incorporated Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
EP2821400B1 (en) 2009-03-20 2017-09-27 Vertex Pharmaceuticals Incorporated Process for making modulators of cystic fibrosis transmembrane conductance regulator
US8802700B2 (en) 2010-12-10 2014-08-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
WO2013130669A1 (en) 2012-02-27 2013-09-06 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administration thereof
AU2015330923B2 (en) 2014-10-07 2020-03-12 Vertex Pharmaceuticals Incorporated Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator
EP3801496A4 (en) 2018-06-05 2022-07-06 Flagship Pioneering Innovations V, Inc. Active agents and methods of their use for the treatment of metabolic disorders and nonalcoholic fatty liver disease
CA3237199A1 (en) 2021-11-02 2023-05-11 Flare Therapeutics Inc. Pparg inverse agonists and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0397914A1 (en) * 1989-05-17 1990-11-22 Mitsui Norin Co., Ltd. Antitoxins for bacterial exotoxins
JPH05336939A (en) * 1992-06-08 1993-12-21 Asahi Breweries Ltd Mugicha @(3754/24)tea made of barley)
DE19627344A1 (en) * 1996-07-01 1998-01-08 Vitasyn Gmbh Entwicklung & Ver Therapeutic composition containing epicatechin and/or theaflavin

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0397914A1 (en) * 1989-05-17 1990-11-22 Mitsui Norin Co., Ltd. Antitoxins for bacterial exotoxins
JPH05336939A (en) * 1992-06-08 1993-12-21 Asahi Breweries Ltd Mugicha @(3754/24)tea made of barley)
DE19627344A1 (en) * 1996-07-01 1998-01-08 Vitasyn Gmbh Entwicklung & Ver Therapeutic composition containing epicatechin and/or theaflavin

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ASCENZI P ET AL: "Anthrax toxin: A tripartite lethal combination", FEBS LETTERS 20 NOV 2002 NETHERLANDS, vol. 531, no. 3, 20 November 2002 (2002-11-20), pages 384 - 388, XP004392673, ISSN: 0014-5793 *
BENELLI ROBERTO ET AL: "Anti-invasive effects of green tea polyphenol epigallocatechin-3-gallate (EGCG), a natural inhibitor of metallo and serine proteases", BIOLOGICAL CHEMISTRY, vol. 383, no. 1, January 2002 (2002-01-01), pages 101 - 105, XP009037060, ISSN: 1431-6730 *
DELL'AICA ISABELLA ET AL: "Potent inhibitors of anthrax lethal factor from green tea.", EMBO REPORTS. APR 2004, vol. 5, no. 4, April 2004 (2004-04-01), pages 418 - 422, XP002297697, ISSN: 1469-221X *
PATENT ABSTRACTS OF JAPAN vol. 0181, no. 70 (C - 1182) 23 March 1994 (1994-03-23) *
TAYLOR PETER W ET AL: "New ways to treat bacterial infections.", DRUG DISCOVERY TODAY, vol. 7, no. 21, 1 November 2002 (2002-11-01), pages 1086 - 1091, XP002297698, ISSN: 1359-6446 *

Also Published As

Publication number Publication date
WO2004105779A2 (en) 2004-12-09

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