WO2004105688A3 - Bactericidal composition and associated method - Google Patents

Bactericidal composition and associated method Download PDF

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Publication number
WO2004105688A3
WO2004105688A3 PCT/US2004/015908 US2004015908W WO2004105688A3 WO 2004105688 A3 WO2004105688 A3 WO 2004105688A3 US 2004015908 W US2004015908 W US 2004015908W WO 2004105688 A3 WO2004105688 A3 WO 2004105688A3
Authority
WO
WIPO (PCT)
Prior art keywords
associated method
bactericidal composition
gentamicin
exhibits
disclosed
Prior art date
Application number
PCT/US2004/015908
Other languages
French (fr)
Other versions
WO2004105688A2 (en
Inventor
Bruce A Molitoris
Ruben M Sandoval Jr
Original Assignee
Advanced Res & Tech Inst
Bruce A Molitoris
Ruben M Sandoval Jr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Res & Tech Inst, Bruce A Molitoris, Ruben M Sandoval Jr filed Critical Advanced Res & Tech Inst
Publication of WO2004105688A2 publication Critical patent/WO2004105688A2/en
Publication of WO2004105688A3 publication Critical patent/WO2004105688A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Disclosed is an antibiotic composition consisting essentially of at least one of the C2 and C2a components of gentamicin, which exhibits a bactericidal effect comparable to the native gentamicin complex, but with substantially reduced nephrotoxicity.
PCT/US2004/015908 2003-05-21 2004-05-20 Bactericidal composition and associated method WO2004105688A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47217103P 2003-05-21 2003-05-21
US60/472,171 2003-05-21

Publications (2)

Publication Number Publication Date
WO2004105688A2 WO2004105688A2 (en) 2004-12-09
WO2004105688A3 true WO2004105688A3 (en) 2005-03-31

Family

ID=33490490

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/015908 WO2004105688A2 (en) 2003-05-21 2004-05-20 Bactericidal composition and associated method

Country Status (1)

Country Link
WO (1) WO2004105688A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008067491A2 (en) 2006-11-29 2008-06-05 Indiana University Research And Technology Corporation Materials and methods for treating diseases caused by genetic disorders using aminoglycosides and derivatives thereof which exhibit low nephrotoxicity
WO2016196964A1 (en) 2015-06-05 2016-12-08 Indiana University Research And Technology Corporation Materials and methods for treating bacterial infections using c-1 gentamicin

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3651042A (en) * 1968-12-24 1972-03-21 Schering Corp Separation of the components of the gentamicin complex
US3984395A (en) * 1972-07-07 1976-10-05 Schering Corporation Method of isolating gentamicin C2a
US4252971A (en) * 1979-07-30 1981-02-24 The Upjohn Company Chromatographic process

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3651042A (en) * 1968-12-24 1972-03-21 Schering Corp Separation of the components of the gentamicin complex
US3984395A (en) * 1972-07-07 1976-10-05 Schering Corporation Method of isolating gentamicin C2a
US4252971A (en) * 1979-07-30 1981-02-24 The Upjohn Company Chromatographic process

Also Published As

Publication number Publication date
WO2004105688A2 (en) 2004-12-09

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