WO2004103445A1 - Powder inhalation device - Google Patents

Powder inhalation device Download PDF

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Publication number
WO2004103445A1
WO2004103445A1 PCT/CH2004/000309 CH2004000309W WO2004103445A1 WO 2004103445 A1 WO2004103445 A1 WO 2004103445A1 CH 2004000309 W CH2004000309 W CH 2004000309W WO 2004103445 A1 WO2004103445 A1 WO 2004103445A1
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WO
WIPO (PCT)
Prior art keywords
housing
wall
chamber
distance
capsule
Prior art date
Application number
PCT/CH2004/000309
Other languages
French (fr)
Inventor
Jean-Marc Aiache
Jean-Michel Cardot
Yann Roard
Jean-Denis Sauzade
Original Assignee
Jean-Marc Aiache
Jean-Michel Cardot
Yann Roard
Jean-Denis Sauzade
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jean-Marc Aiache, Jean-Michel Cardot, Yann Roard, Jean-Denis Sauzade filed Critical Jean-Marc Aiache
Priority to EP04734201A priority Critical patent/EP1624918A1/en
Publication of WO2004103445A1 publication Critical patent/WO2004103445A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/0048—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged in a plane, e.g. on diskettes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/07—General characteristics of the apparatus having air pumping means

Definitions

  • the present invention relates to the field of powder inhalation devices. More specifically, it relates to inhalation devices triggerable by aspiration.
  • the present invention aims to offer an improved inhalation device compared to those of the prior art.
  • Mode 1 ( Figures 1 to 6) comprises a device having very approximate shape of a disc, the 2nd guide ( Figures 7 to 1 1) having substantially a tubular shape.
  • Figures 1, 2 and 5 illustrate a device in the armed position
  • the needle (15) is positioned above the capsule (14) to be pierced
  • valve (7) is in the high position so that there is a seal between the chamber (4 ') located above the valve (7) and the chamber (4 ") located below the valve
  • the patient applies his lips to the nozzle so as to hermetically seal the chamber located below the valve.
  • the valve then moves downwards, a displacement of the order of 2 mm being sufficient to release the top bellows part from the sliding shell.
  • the force of the part 16 on the part 17 is no longer balanced by the presence of the valve behind the lug: the removal of the valve causes the lug 17 to move towards the axis of revolution of the sliding shell by its own elasticity.
  • the part 16 is then no longer blocked by 17, which causes the top bellows 5 part to move downward under the action of the bellows spring.
  • the needle being integral with the high bellows 5, it descends at the same time. It first pierces the upper membrane of the cell (14), then secondly the lower membrane of the cell.
  • Figures 3 and 4 show the device in the storage position. In this configuration, the end piece 2 is obstructed.
  • the needle 15 remains housed in the passage 13 containing the capsule 14 last drilled.
  • the height of the device is reduced, eg less than 40 mm.
  • the two springs 21, 22 are compressed.
  • FIG. 6 shows the device following its activation " .
  • the two springs 21, 22 are relaxed.
  • the upper part 4 ′ of the chamber is at its minimum volume.
  • the powder has been expelled from the capsule 14. To put the device in storage position, simply compress it in a vertical direction.
  • Figures 7 and 10 illustrate a tubular device in the armed position.
  • the configuration and operation of this variant are very similar to that of the "disk" variant previously exposed. Besides its height, it differs in that the mouthpiece is placed under the device.
  • FIGS 8 and 9 show the device in the storage position.
  • FIG. 11 shows the device following its activation.
  • the invention is not limited to the devices described above.
  • the means for releasing the contents of the capsules are not necessarily perforating members.
  • the capsules can be opened by crushing and tearing their membrane.
  • the external shape of the housing is not necessarily cylindrical.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)

Abstract

The invention relates to a powder inhalation device, which may be started by suction, comprising a housing (1) with a variable volume chamber (4', 4''), defined by upper (5) lateral (6) and lower (7) walls distinct from the walls (8-11) of the housing. Said chamber further comprises an intermediate wall (12) with at least one passage (13) for housing a powder capsule (14), arranged such as to divide said chamber into two volumes, the upper wall being mobile and comprising means (15) for releasing the contents of a capsule, the lower wall being able to be displaced by a distance (dinf) towards the lower end (3) of the housing on a suction by the patient being carried out. The device comprises means for locking/release (17) of the upper wall, fixed to the lower wall, the distance (dinf) being less than the distance of displacement of the upper wall (dsup). The lower wall comprises communication means (18, 19) for communication of the interior of said chamber with the mouthpiece (2) when the lower wall is lowered by a distance significantly greater than the distance (dinf).

Description

Dispositif d'inhalation de poudre Powder inhalation device
La présente invention concerne le domaine des dispositifs d'inhalation de poudre. Plus précisément, elle se rapporte aux dispositifs d'inhalation déclenchables par aspiration.The present invention relates to the field of powder inhalation devices. More specifically, it relates to inhalation devices triggerable by aspiration.
On connaît plusieurs dispositifs d'inhalation déclenchables par aspiration. Voir en particulier les documents US 5 388 572 , US 6 012 454, WO 92/04068, DE 41 33 274, WO 02/24265 et US 5 060 643.Several inhalation devices are triggered by suction. See in particular documents US 5,388,572, US 6,012,454, WO 92/04068, DE 41 33 274, WO 02/24265 and US 5,060,643.
La présente invention a pour objectif d'offrir un dispositif d'inhalation amélioré par rapport à ceux de l'état de la technique.The present invention aims to offer an improved inhalation device compared to those of the prior art.
Cet objectif est réalisé avec le dispositif tel que défini à la revendication 1. Des modes préférentiels de réalisation sont décrits dans les revendications dépendantes 2 à 10.This objective is achieved with the device as defined in claim 1. Preferential embodiments are described in dependent claims 2 to 10.
L'invention est décrite ci-après au moyens des figures 1 à 11 qui illustrent deux modes de réalisation particulièrement avantageux. Le 1er mode (figures 1 à 6) présente un dispositif ayant la forme très approximative d'un disque, le 2e mode (figures 7 à 1 1) ayant sensiblement une forme tubulaire.The invention is described below by means of Figures 1 to 11 which illustrate two particularly advantageous embodiments. Mode 1 (Figures 1 to 6) comprises a device having very approximate shape of a disc, the 2nd guide (Figures 7 to 1 1) having substantially a tubular shape.
Les figures 1 , 2 et 5 illustrent un appareil en position armée :Figures 1, 2 and 5 illustrate a device in the armed position:
- l'embout (2) est libre d'accès, - l'encombrement de l'appareil est maximal avec la coque coulissante (8) sortie par l'action du ressort de chargement (21)- the end piece (2) is free to access, - the overall dimensions of the device are maximum with the sliding shell (8) released by the action of the loading spring (21)
- l'aiguille (15) est positionnée au dessus de la gélule (14) à transpercer- the needle (15) is positioned above the capsule (14) to be pierced
- la soupape (7) est en position haute de telle sorte qu'il y a étanchéité entre la chambre (4') située au dessus de la soupape (7) et la chambre (4") située en dessous de la soupape- the valve (7) is in the high position so that there is a seal between the chamber (4 ') located above the valve (7) and the chamber (4 ") located below the valve
- le ressort soufflet (22) est comprimé - Le haut soufflet (5) ne peut pas se déplacer vers le bas sous l'action du ressort soufflet (22) comprimé, celle-ci étant bloquée par l'ergot 17 de la coque coulissante.- the bellows spring (22) is compressed - The high bellows (5) cannot move downwards under the action of the compressed bellows spring (22), the latter being blocked by the lug 17 of the sliding shell.
Le patient applique ses lèvres sur l'embout de manière à obturer hermétiquement la chambre située en dessous de la soupape.The patient applies his lips to the nozzle so as to hermetically seal the chamber located below the valve.
En inspirant, une différence de pression se crée entre la chambre située dessous la soupape et celle située au dessus. Lorsque la différence de pression devient supérieure à 1 kPa, l'effort créé par cette dépression sur la soupape est suffisant pour vaincre les frottements entre les parois de la soupape et les parois de la pièce embout ainsi que ceux entre la soupape et la coque coulissante.When inhaling, a pressure difference is created between the chamber located below the valve and the one located above. When the pressure difference becomes greater than 1 kPa, the force created by this depression on the valve is sufficient to overcome the friction between the walls of the valve and the walls of the end piece as well as those between the valve and the sliding shell. .
La soupape se déplace alors vers le bas, un déplacement de l'ordre de 2 mm étant suffisant pour libérer la pièce Haut Soufflet de la coque coulissante. En effet, l'effort de la pièce 16 sur la pièce 17 n'est plus équilibré par la présence de la soupape derrière l'ergot : l'enlèvement de la soupape provoque le déplacement de l'ergot 17 vers l'axe de révolution de la coque coulissante par son élasticité propre. La pièce 16 n'est alors plus bloquée par 17, ce qui provoque le déplacement de la pièce haut soufflet 5 vers le bas sous l'action du ressort Soufflet. L'aiguille étant solidaire du haut soufflet 5, celle-ci descend par la même occasion. Elle perfore dans un premier temps la membrane supérieure de l'alvéole (14), puis dans un deuxième temps la membrane inférieure de l'alvéole. L'air compris dans la chambre étanche située au dessus des alvéoles est comprimé sous l'action du ressort soufflet jusqu'à ce que les 2 membranes de l'alvéole soient perforées. L'étanchéité est alors rompue et l'air comprimé passe à travers ses perforations, entraînant avec lui la poudre contenue dans l'alvéole. A la fin de la course du haut soufflet 5, toute la poudre contenue dans l'alvéole a été mise en suspension.The valve then moves downwards, a displacement of the order of 2 mm being sufficient to release the top bellows part from the sliding shell. Indeed, the force of the part 16 on the part 17 is no longer balanced by the presence of the valve behind the lug: the removal of the valve causes the lug 17 to move towards the axis of revolution of the sliding shell by its own elasticity. The part 16 is then no longer blocked by 17, which causes the top bellows 5 part to move downward under the action of the bellows spring. The needle being integral with the high bellows 5, it descends at the same time. It first pierces the upper membrane of the cell (14), then secondly the lower membrane of the cell. The air included in the sealed chamber located above the cells is compressed under the action of the bellows spring until the 2 membranes of the cell are perforated. The seal is then broken and the compressed air passes through its perforations, carrying with it the powder contained in the cell. At the end of the stroke of the top bellows 5, all the powder contained in the cell was suspended.
La soupape 7 qui s'était déplacée dans un premier temps par l'inspiration du patient, se déplace dans un second temps sous l'impulsion de la pièce Haut Soufflet. Ce second déplacement coïncide avec la perforation de l'alvéole de telle manière que la chambre située au dessus de la soupape communique maintenant avec la chambre située au dessous : la poudre mise en suspension est ainsi capable d'atteindre les poumons du patient si celui-ci continue son inhalation.The valve 7, which had initially moved by the inspiration of the patient, moves in a second time under the impulse of the part Haut Soufflet. This second movement coincides with the perforation of the cell so that the chamber above the valve now communicates with the chamber below: the powder put in suspension is thus able to reach the patient's lungs if the patient continues to inhale.
Ce déplacement de la poudre vers les poumons est permis avec l'ouverture d'entrées d'air extérieur sur la périphérie du barillet. Cette circulation d'air n'est cependant réalisée qu'après expulsion de la poudre de l'alvéole pour éviter qu'une partie de la poudre ne contamine l'air extérieur.This movement of the powder towards the lungs is permitted with the opening of outside air inlets on the periphery of the barrel. However, this air circulation is only carried out after expelling the powder from the cell to prevent part of the powder from contaminating the outside air.
Les figures 3 et 4 montrent l'appareil en position de stockage. Dans cette configuration, l'embout 2 est obstrué. L'aiguille 15 reste logée de le passage 13 contenant la capsule 14 percée en dernier lieu. La hauteur de l'appareil est réduite, p.ex. inférieure à 40 mm. Les deux ressorts 21,22 sont comprimés.Figures 3 and 4 show the device in the storage position. In this configuration, the end piece 2 is obstructed. The needle 15 remains housed in the passage 13 containing the capsule 14 last drilled. The height of the device is reduced, eg less than 40 mm. The two springs 21, 22 are compressed.
La figure 6 montre l'appareil consécutivement à son activation". Les deux ressorts 21 ,22 sont détendus. La partie supérieure 4' de la chambre est à son volume minimal. La poudre a été expulsée de la capsule 14. Pour remettre l'appareil en position de stockage, il suffit de le comprimer selon une direction verticale.FIG. 6 shows the device following its activation " . The two springs 21, 22 are relaxed. The upper part 4 ′ of the chamber is at its minimum volume. The powder has been expelled from the capsule 14. To put the device in storage position, simply compress it in a vertical direction.
Les figures 7 et 10 illustrent un appareil de forme tubulaire en position armée. La configuration et le fonctionnement de cette variante sont très similaires à celle de la variante "disque" précédemment exposée. Outre sa hauteur, elle diffère en ce que l'embout buccal est disposé sous l'appareil.Figures 7 and 10 illustrate a tubular device in the armed position. The configuration and operation of this variant are very similar to that of the "disk" variant previously exposed. Besides its height, it differs in that the mouthpiece is placed under the device.
Les figures 8 et 9 montrent l'appareil en position de stockage.Figures 8 and 9 show the device in the storage position.
La figure 11 montre l'appareil consécutivement à son activation.Figure 11 shows the device following its activation.
Bien évidemment, l'invention ne se limite pas aux appareils exposés ci-dessus. Les moyens pour libérer le contenu des capsules ne sont pas nécessairement des organes de perforation. A titre d'exemple, les capsules peuvent être ouvertes par écrasement et déchirement de leur membrane.Obviously, the invention is not limited to the devices described above. The means for releasing the contents of the capsules are not necessarily perforating members. For example, the capsules can be opened by crushing and tearing their membrane.
A noter également que la forme extérieur du boîtier n'est pas nécessairement cylindrique. Note also that the external shape of the housing is not necessarily cylindrical.

Claims

Revendications claims
1. Dispositif d'inhalation de poudre déclenchable par aspiration comprenant un boîtier (1) et un embout buccal (2) disposé vers l'extrémité inférieure (3) du boîtier (1), caractérisé en ce que le boîtier (1) comporte une chambre (41, 4") de volume variable délimitée par des parois supérieure (5), latérale (6) et inférieure (7) distinctes des parois (8-11) du boîtier (1), les parois supérieure (5) et inférieure (7) de ladite chambre (4', 4") étant mobiles le long de la paroi latérale (10,11) du boîtier (1), ladite chambre (4', 4") comprenant en outre une paroi intermédiaire (12) disposée entre les parois supérieure (5) et inférieure (7), selon une direction parallèle à celles-ci de manière à diviser ladite chambre (4', 4") en deux volumes Vsup et Vinf , la paroi intermédiaire (12) comportant au moins un passage (13) adapté pour retenir une capsule (14) de poudre, la paroi supérieure (5) comprenant des moyens (15) pour libérer le contenu d'une capsule (14) retenue dans ledit passage (13) de la paroi intermédiaire (12) lorsque la paroi supérieure (5) est suffisamment proche de la paroi intermédiaire (12), la paroi inférieure (7) pouvant être déplacée d'une distance d-,nf vers l'extrémité inférieure (3) du boîtier (1) lors d'une aspiration dans l'embout buccal (2), le dispositif comprenant en outre des moyens de retenue (16) et des moyens de blocage-libération (17) de la paroi supérieure (5), ces derniers (17) étant solidaires de la paroi inférieure (7), la distance dmf étant inférieure à la distance de déplacement de la paroi supérieure (5) dSUp , la paroi inférieure (7) comportant des moyens de communication (18,19) adaptés pour faire communiquer l'intérieur de ladite chambre (4', 4") avec l'embout buccal (2) lorsque la paroi inférieure (7) s'est abaissée d'une distance sensiblement supérieure à la distance djnf.1. Powder inhalation device triggerable by suction comprising a housing (1) and a mouthpiece (2) disposed towards the lower end (3) of the housing (1), characterized in that the housing (1) comprises a chamber (4 1 , 4 ") of variable volume delimited by upper (5), lateral (6) and lower (7) walls distinct from the walls (8-11) of the housing (1), the upper walls (5) and lower (7) of said chamber (4 ', 4 ") being movable along the side wall (10,11) of the housing (1), said chamber (4', 4") further comprising an intermediate wall (12 ) disposed between the upper (5) and lower (7) walls, in a direction parallel to them so as to divide said chamber (4 ', 4 ") into two volumes V sup and V inf , the intermediate wall (12 ) comprising at least one passage (13) suitable for retaining a powder capsule (14), the upper wall (5) comprising means (15) for releasing the contents of a capsule (14) retained in said passage (13) of the intermediate wall (12) when the upper wall (5) is sufficiently close to the intermediate wall (12), the lower wall (7) being able to be displaced by a distance d- , nf towards the lower end (3) of the housing (1) during a suction in the mouthpiece (2), the device further comprising retaining means (16) and locking-release means (17 ) of the upper wall (5), the latter (17) being integral with the lower wall (7), the distance d mf being less than the distance of movement of the upper wall (5) d SU p, the lower wall ( 7) comprising communication means (18,19) adapted to communicate the interior of said chamber (4 ', 4 ") with the mouthpiece (2) when the lower wall (7) has lowered a distance appreciably greater than the distance dj nf .
2. Dispositif selon la revendication 1 caractérisé en ce que le boîtier (1) est constitué de deux parties, soit une partie inférieure fixe (2,3,20) et une partie supérieure (8,10) montée coulissante sur la partie inférieure (2,3,20). 2. Device according to claim 1 characterized in that the housing (1) consists of two parts, either a fixed lower part (2,3,20) and an upper part (8,10) slidably mounted on the lower part ( 2,3,20).
3. Dispositif selon la revendication 2 caractérisé en ce que la partie supérieure du boîtier (8,10) est montée coulissante en rotation sur la partie inférieure (2,3,20).3. Device according to claim 2 characterized in that the upper part of the housing (8,10) is slidably rotatably mounted on the lower part (2,3,20).
4. Dispositif selon la revendication 2 ou 3 caractérisé en ce que la partie supérieure (8,10) est montée coulissante en translation de manière à permettre un rapprochement des extrémités inférieure (3) et supérieure (8) du boîtier (1), le dispositif comprenant également des moyens de blocage pour maintenir rapprochées lesdites extrémités inférieure (3) et supérieure4. Device according to claim 2 or 3 characterized in that the upper part (8,10) is slidably mounted in translation so as to allow the lower (3) and upper (8) ends of the housing (1) to be brought together, the device also comprising locking means for keeping said lower (3) and upper ends close together
(8).(8).
5. Dispositif selon la revendication 4 comprenant des moyens de rappel (21 ), par exemple un ressort, pour éloigner lesdites extrémités inférieure (3) et supérieure (8) une fois lesdits moyens de blocage désactivés.5. Device according to claim 4 comprising return means (21), for example a spring, for moving said lower ends (3) and upper (8) once said locking means deactivated.
6. Dispositif selon l'une quelconque des revendications précédentes caractérisé en ce que la partie supérieure (4') de ladite chambre est un soufflet dont la portion supérieure forme ladite paroi supérieure (5) et dont la portion inférieure forme ladite paroi intermédiaire (12), le dispositif comprenant en outre des moyens du type ressort disposés entre l'extrémité supérieure (8) du boîtier (1) et ladite paroi supérieure (5) de manière à pousser ladite paroi supérieur (5) vers l'extrémité inférieure (3) du boîtier (1).6. Device according to any one of the preceding claims, characterized in that the upper part (4 ') of said chamber is a bellows whose upper portion forms said upper wall (5) and whose lower portion forms said intermediate wall (12 ), the device further comprising spring-type means disposed between the upper end (8) of the housing (1) and said upper wall (5) so as to push said upper wall (5) towards the lower end (3 ) of the housing (1).
7. Dispositif selon l'une quelconque des revendications précédentes caractérisé en ce que ladite paroi intermédiaire (12) comporte une pluralité de passages (13) disposés autour de l'axe principal du boîtier (1), le dispositif comprenant également des moyens pour positionner et activer en- dessus et au travers de chaque passage (13), successivement ou simultanément, les moyens (15) de libération du contenu des capsules.7. Device according to any one of the preceding claims, characterized in that said intermediate wall (12) comprises a plurality of passages (13) arranged around the main axis of the housing (1), the device also comprising means for positioning and activate above and through each passage (13), successively or simultaneously, the means (15) for releasing the contents of the capsules.
8. Dispositif selon la revendication 7 caractérisé en ce que l'ensemble comprenant l'extrémité supérieure (8) du boîtier (1) et la partie supérieure (4') de ladite chambre est mobile en rotation autour de l'axe principal du boîtier (1).8. Device according to claim 7 characterized in that the assembly comprising the upper end (8) of the housing (1) and the upper part (4 ') of said chamber is movable in rotation about the main axis of the housing (1).
9. Dispositif selon la revendication 7 caractérisé en ce que la paroi intermédiaire (12) est mobile en rotation autour de l'axe principal du boîtier (1 ) et forme de la sorte un barillet.9. Device according to claim 7 characterized in that the intermediate wall (12) is movable in rotation about the main axis of the housing (1) and thus forms a barrel.
10. Dispositif selon l'une quelconque des revendications précédentes caractérisé en ce que les moyens (15) pour libérer le contenu d'une capsule sont constitués essentiellement d'un organe de perforation, par exemple une aiguille, disposée de manière à percer de part en part une capsule retenue dans ledit passage (13). 10. Device according to any one of the preceding claims, characterized in that the means (15) for releasing the contents of a capsule consist essentially of a perforating member, for example a needle, arranged so as to pierce through in part a capsule retained in said passage (13).
PCT/CH2004/000309 2003-05-21 2004-05-21 Powder inhalation device WO2004103445A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP04734201A EP1624918A1 (en) 2003-05-21 2004-05-21 Powder inhalation device

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH9032003 2003-05-21
CH903/03 2003-05-21

Publications (1)

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WO2004103445A1 true WO2004103445A1 (en) 2004-12-02

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PCT/CH2004/000309 WO2004103445A1 (en) 2003-05-21 2004-05-21 Powder inhalation device

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2433207A (en) * 2006-02-21 2007-06-20 Jianhe Li Breath actuated dry powder inhaler
WO2008101991A1 (en) * 2007-02-21 2008-08-28 Novo Nordisk A/S Breath actuation mechanism for an aerosol generating device

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2238505A1 (en) * 1973-07-23 1975-02-21 Bespak Industries Ltd
DE4133274A1 (en) * 1991-08-22 1993-02-25 Boehringer Ingelheim Kg DEVICE FOR RESPIRATORY SYNCHRONOUS TRIGGERING OF A MECHANICAL SWITCHING PROCESS
FR2738153A1 (en) * 1995-09-04 1997-03-07 Valois INHALATION APPARATUS FOR DELIVERING PRECISE AND REPRODUCIBLE DOSES OF POWDERY PRODUCT
WO2001000263A2 (en) * 1999-06-30 2001-01-04 Inhale Therapeutic Systems, Inc. Systems and methods for aerosolizing pharmaceutical formulations
US20030079743A1 (en) * 2001-10-30 2003-05-01 Genova Perry A. Breath actuated dry powder inhaler

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2238505A1 (en) * 1973-07-23 1975-02-21 Bespak Industries Ltd
DE4133274A1 (en) * 1991-08-22 1993-02-25 Boehringer Ingelheim Kg DEVICE FOR RESPIRATORY SYNCHRONOUS TRIGGERING OF A MECHANICAL SWITCHING PROCESS
FR2738153A1 (en) * 1995-09-04 1997-03-07 Valois INHALATION APPARATUS FOR DELIVERING PRECISE AND REPRODUCIBLE DOSES OF POWDERY PRODUCT
WO2001000263A2 (en) * 1999-06-30 2001-01-04 Inhale Therapeutic Systems, Inc. Systems and methods for aerosolizing pharmaceutical formulations
US20030079743A1 (en) * 2001-10-30 2003-05-01 Genova Perry A. Breath actuated dry powder inhaler

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2433207A (en) * 2006-02-21 2007-06-20 Jianhe Li Breath actuated dry powder inhaler
GB2433207B (en) * 2006-02-21 2009-01-07 Jianhe Li Active suction actuated inhalers with timing devices
US8245705B2 (en) 2006-02-21 2012-08-21 Jianhe Li Inhaler
WO2008101991A1 (en) * 2007-02-21 2008-08-28 Novo Nordisk A/S Breath actuation mechanism for an aerosol generating device

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