WO2004103312A3 - Peptides useful as hiv fusion inhibitors - Google Patents

Peptides useful as hiv fusion inhibitors Download PDF

Info

Publication number
WO2004103312A3
WO2004103312A3 PCT/US2004/015825 US2004015825W WO2004103312A3 WO 2004103312 A3 WO2004103312 A3 WO 2004103312A3 US 2004015825 W US2004015825 W US 2004015825W WO 2004103312 A3 WO2004103312 A3 WO 2004103312A3
Authority
WO
WIPO (PCT)
Prior art keywords
fusion inhibitors
peptides useful
hiv fusion
hiv
useful
Prior art date
Application number
PCT/US2004/015825
Other languages
French (fr)
Other versions
WO2004103312A2 (en
Inventor
William C Olson
Norbert Schuelke
Bryan O'HARA
Original Assignee
Progenics Pharm Inc
William C Olson
Norbert Schuelke
Bryan O'HARA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Progenics Pharm Inc, William C Olson, Norbert Schuelke, Bryan O'HARA filed Critical Progenics Pharm Inc
Publication of WO2004103312A2 publication Critical patent/WO2004103312A2/en
Publication of WO2004103312A3 publication Critical patent/WO2004103312A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

This invention provides polypeptides represented by the formula α-β-Ϝ, which polypeptides are useful for inhibiting fusion between HIV-1 and CD4+ cells. This invention also provides related pharmaceutical compositions, nucleic acids, host-vector systems, articles of manufacture, and related methods of production, prophylaxis and therapy.
PCT/US2004/015825 2003-05-19 2004-05-19 Peptides useful as hiv fusion inhibitors WO2004103312A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US47208203P 2003-05-19 2003-05-19
US60/472,082 2003-05-19
US47333003P 2003-05-23 2003-05-23
US60/473,330 2003-05-23

Publications (2)

Publication Number Publication Date
WO2004103312A2 WO2004103312A2 (en) 2004-12-02
WO2004103312A3 true WO2004103312A3 (en) 2005-08-11

Family

ID=33479314

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2004/015825 WO2004103312A2 (en) 2003-05-19 2004-05-19 Peptides useful as hiv fusion inhibitors
PCT/US2004/015841 WO2005034842A2 (en) 2003-05-19 2004-05-19 Peptides useful as hiv fusion inhibitors

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2004/015841 WO2005034842A2 (en) 2003-05-19 2004-05-19 Peptides useful as hiv fusion inhibitors

Country Status (1)

Country Link
WO (2) WO2004103312A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008528480A (en) * 2005-01-24 2008-07-31 イエダ リサーチ アンド デベロップメント カンパニー リミテッド HIV-1 gp41 fusion peptide for immunomodulation
CN100455594C (en) * 2005-12-14 2009-01-28 中国人民解放军军事医学科学院生物工程研究所 Polypeptide of controlling IIIv virus fusion and its use
MX2009001204A (en) * 2006-08-17 2009-02-11 Hoffmann La Roche A conjugate of an antibody against ccr5 and an antifusogenic peptide.
TW200817438A (en) 2006-08-17 2008-04-16 Hoffmann La Roche A conjugate of an antibody against CCR5 and an antifusogenic peptide
CL2008002092A1 (en) * 2007-07-20 2009-05-29 Hoffmann La Roche Conjugate containing two or more antifusogenic peptides and an anti-cd-4 antibody; Method of production; pharmaceutical composition comprising it; antifusogenic polypeptides and use of the conjugate to treat viral infections.
WO2009108261A2 (en) * 2008-01-23 2009-09-03 Dana Farber Cancer Institute Compositions and methods for the treatment of viral infections
JP5908832B2 (en) 2009-06-18 2016-04-26 ダナ ファーバー キャンサー インスティテュート インコーポレイテッド Constructed viral peptide compositions and methods of use
AR124937A1 (en) * 2021-02-23 2023-05-24 Janssen Vaccines & Prevention Bv STABILIZING MUTATION OF TRIMERES OF HIV ENVELOPE PROTEINS

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5464933A (en) * 1993-06-07 1995-11-07 Duke University Synthetic peptide inhibitors of HIV transmission

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5464933A (en) * 1993-06-07 1995-11-07 Duke University Synthetic peptide inhibitors of HIV transmission
US6133418A (en) * 1993-06-07 2000-10-17 Duke University Synthetic peptide inhibitors of HIV transmission

Also Published As

Publication number Publication date
WO2004103312A2 (en) 2004-12-02
WO2005034842A2 (en) 2005-04-21

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