WO2004101747A3 - Identification and use of gpr54 and its ligands for reproductive disorders and contraception - Google Patents

Identification and use of gpr54 and its ligands for reproductive disorders and contraception Download PDF

Info

Publication number
WO2004101747A3
WO2004101747A3 PCT/US2004/014195 US2004014195W WO2004101747A3 WO 2004101747 A3 WO2004101747 A3 WO 2004101747A3 US 2004014195 W US2004014195 W US 2004014195W WO 2004101747 A3 WO2004101747 A3 WO 2004101747A3
Authority
WO
WIPO (PCT)
Prior art keywords
identification
gpr54
compounds
contraception
ligands
Prior art date
Application number
PCT/US2004/014195
Other languages
French (fr)
Other versions
WO2004101747A2 (en
Inventor
William F Crowley Jr
Stephanie Seminara
James S Acierno Jr
Original Assignee
Gen Hospital Corp
William F Crowley Jr
Stephanie Seminara
James S Acierno Jr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Hospital Corp, William F Crowley Jr, Stephanie Seminara, James S Acierno Jr filed Critical Gen Hospital Corp
Publication of WO2004101747A2 publication Critical patent/WO2004101747A2/en
Publication of WO2004101747A3 publication Critical patent/WO2004101747A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/76—Human chorionic gonadotropin including luteinising hormone, follicle stimulating hormone, thyroid stimulating hormone or their receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to the identification of compounds for diagnosing and treating a reproductive disorder or other disorders in which the suppression of gonadal steroids has therapeutic benefits. These compounds can be used to treat, for example, polycystic ovarian disease, endometriosis, uterine fibroids, and prostate cancer. Moreover, the compounds identified using the methods of the invention may be used as contraceptives or in treatments for infertility, such as in vitro fertilization. The invention also relates to mutant GPR54 nucleic acid molecules and polypeptides, as well as their use in diagnosis of reproductive disorders.
PCT/US2004/014195 2003-05-07 2004-05-07 Identification and use of gpr54 and its ligands for reproductive disorders and contraception WO2004101747A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46861203P 2003-05-07 2003-05-07
US60/468,612 2003-05-07

Publications (2)

Publication Number Publication Date
WO2004101747A2 WO2004101747A2 (en) 2004-11-25
WO2004101747A3 true WO2004101747A3 (en) 2005-07-14

Family

ID=33452217

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/014195 WO2004101747A2 (en) 2003-05-07 2004-05-07 Identification and use of gpr54 and its ligands for reproductive disorders and contraception

Country Status (1)

Country Link
WO (1) WO2004101747A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104531748A (en) * 2014-11-14 2015-04-22 华中农业大学 Non-antibiotic screening KISS1 eukaryotic expression plasmid and application

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20050090420A (en) 2002-12-26 2005-09-13 다케다 야쿠힌 고교 가부시키가이샤 Metastin derivative and use thereof
EP1604682A4 (en) 2003-03-12 2009-06-24 Takeda Chemical Industries Ltd Gonadal function improving agents
SG153865A1 (en) 2004-06-25 2009-07-29 Takeda Pharmaceutical Metastin derivatives and use thereof
TWI386417B (en) 2005-12-22 2013-02-21 Takeda Pharmaceutical Metastin derivatives and use thereof
US8404643B2 (en) 2005-12-22 2013-03-26 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
TWI404726B (en) 2006-10-25 2013-08-11 Takeda Pharmaceutical Metastin derivatives and use thereof
GB0719592D0 (en) 2007-10-08 2007-11-14 Medical Res Council Compound, use and method
CN102986559A (en) * 2012-10-24 2013-03-27 南京农业大学 Method for improving initial laying rate of laying hen
CN115746146B (en) * 2022-08-31 2024-05-31 安徽农业大学 GnRH recombinant protein antigen, mammal castration recombinant protein vaccine and preparation method

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1126028A1 (en) * 1998-10-27 2001-08-22 Takeda Chemical Industries, Ltd. Novel g protein-coupled receptor proteins, dnas thereof and ligands to the same
WO2002005344A1 (en) * 2000-07-12 2002-01-17 Commissariat A L'energie Atomique Method for cutting a block of material and for forming a thin film

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1126028A1 (en) * 1998-10-27 2001-08-22 Takeda Chemical Industries, Ltd. Novel g protein-coupled receptor proteins, dnas thereof and ligands to the same
WO2002005344A1 (en) * 2000-07-12 2002-01-17 Commissariat A L'energie Atomique Method for cutting a block of material and for forming a thin film

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CLEMENS M.K. ET AL.: "FMRFamide-related neuropeptides are agonists of the orphan G-protein coupled receptor GPR54", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 284, 2001, pages 1189 - 1193, XP002297213 *
KOTANI M. ET AL.: "The metastasis supressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, September 2001 (2001-09-01), pages 34631 - 34636, XP002262291 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104531748A (en) * 2014-11-14 2015-04-22 华中农业大学 Non-antibiotic screening KISS1 eukaryotic expression plasmid and application

Also Published As

Publication number Publication date
WO2004101747A2 (en) 2004-11-25

Similar Documents

Publication Publication Date Title
WO2007084211A3 (en) Use of gpr54 ligands for treatment of reproductive disorders, proliferative disorders, and for contraception
WO2004101747A3 (en) Identification and use of gpr54 and its ligands for reproductive disorders and contraception
MXPA03002413A (en) B7-like molecules and uses thereof.
WO2001055320A3 (en) Nucleic acids, proteins, and antibodies
NZ608860A (en) Methods and reagents for treatment and diagnosis of age-related macular degeneration
DE60230046D1 (en) PEPTIDES BINDING ATHEROSCLEROTIC INJURIES
WO2001032156A3 (en) Methods for treating fibroproliferative diseases
WO2005005462A3 (en) Blys antagonists and uses thereof
WO2008136848A3 (en) Novel anti-notch3 antibodies and their use in the detection and diagnosis of disease
WO2001055317A3 (en) Nucleic acids, proteins, and antibodies
MXPA02012743A (en) Il-17 molecules and uses thereof.
WO2001070095A3 (en) Compositions and methods of diagnosing, monitoring, staging, imaging and treating prostate cancer
MXPA02000680A (en) Vgf polypeptides and methods of treating vgf-related disorders.
MXPA03000979A (en) C3b/C4b COMPLEMENT RECEPTOR-LIKE MOLECULES AND USES THEREOF.
WO2002000691A3 (en) Polynucleotides and polypeptides encoded thereby
WO2001074904A3 (en) G-protein coupled receptors and nucleic acids encoding same
WO2002079398A3 (en) Therapeutic polypeptides, nucleic acids encoding same, and methods of use
PL374550A1 (en) Il-17 like molecules and uses thereof
WO2002099116A8 (en) Therapeutic polypeptides, nucleic acids encoding same, and methods of use
WO2001074851A3 (en) Novel proteins and nucleic acids encoding same
WO2001074903A3 (en) Cd20/ige-receptor like molecules and uses thereof
WO2001081361A8 (en) Compositions and method for diagnosing and treating conditions, disorders, or diseases involving cell death
WO2002012343A3 (en) Proteins and nucleic acids encoding g-protein coupled receptors
WO2002044737A3 (en) Diagnostic and therapeutic compositions and methods related to anaphylatoxin c3a receptor
WO2002026985A3 (en) G-protein coupled recptors

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase