WO2004101023A3 - A method for altering insulin pharmacokinetics - Google Patents

A method for altering insulin pharmacokinetics Download PDF

Info

Publication number
WO2004101023A3
WO2004101023A3 PCT/US2004/014033 US2004014033W WO2004101023A3 WO 2004101023 A3 WO2004101023 A3 WO 2004101023A3 US 2004014033 W US2004014033 W US 2004014033W WO 2004101023 A3 WO2004101023 A3 WO 2004101023A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
insulin delivery
prevention
treatment
present
Prior art date
Application number
PCT/US2004/014033
Other languages
French (fr)
Other versions
WO2004101023A2 (en
Inventor
Ronald J Pettis
Noel Harvey
Barry Ginsberg
Original Assignee
Becton Dickinson Co
Ronald J Pettis
Noel Harvey
Barry Ginsberg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/429,973 external-priority patent/US7722595B2/en
Priority claimed from US10/704,035 external-priority patent/US20050010193A1/en
Application filed by Becton Dickinson Co, Ronald J Pettis, Noel Harvey, Barry Ginsberg filed Critical Becton Dickinson Co
Priority to CA002524444A priority Critical patent/CA2524444A1/en
Priority to AU2004238257A priority patent/AU2004238257A1/en
Priority to MXPA05011768A priority patent/MXPA05011768A/en
Priority to JP2006532794A priority patent/JP2007517768A/en
Priority to BRPI0409984-2A priority patent/BRPI0409984A/en
Priority to EP04751427A priority patent/EP1620145A4/en
Publication of WO2004101023A2 publication Critical patent/WO2004101023A2/en
Publication of WO2004101023A3 publication Critical patent/WO2004101023A3/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/46Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for controlling depth of insertion
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/32Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3286Needle tip design, e.g. for improved penetration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

The present invention relates to methods for administration of insulin into the intradermal compartment of subject's skin, preferably to the dermal vasculature of the intradermal compartment. The methods of the present invention enhance the pharmacokinetic and pharmacodynamic parameters of insulin delivery and effectively result in a superior clinical efficacy in the treatment and/or prevention of diabetes mellitus. The methods of the instant invention provide an improved glycemic control of both non-fasting (i.e., post-prandial) and fasting blood glucose levels and thus have an enhanced therapeutic efficacy in treatment, prevention and/or management of diabetes relative to traditional methods of insulin delivery, including subcutaneous insulin delivery.
PCT/US2004/014033 2003-05-06 2004-05-06 A method for altering insulin pharmacokinetics WO2004101023A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA002524444A CA2524444A1 (en) 2003-05-06 2004-05-06 A method for altering insulin pharmacokinetics
AU2004238257A AU2004238257A1 (en) 2003-05-06 2004-05-06 A method for altering insulin pharmacokinetics
MXPA05011768A MXPA05011768A (en) 2003-05-06 2004-05-06 A method for altering insulin pharmacokinetics.
JP2006532794A JP2007517768A (en) 2003-05-06 2004-05-06 How to change the pharmacokinetics of insulin
BRPI0409984-2A BRPI0409984A (en) 2003-05-06 2004-05-06 process for changing insulin pharmacokinetics
EP04751427A EP1620145A4 (en) 2003-05-06 2004-05-06 A method for altering insulin pharmacokinetics

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US10/429,973 2003-05-06
US10/429,973 US7722595B2 (en) 2002-05-06 2003-05-06 Method and device for controlling drug pharmacokinetics
US50095603P 2003-09-05 2003-09-05
US60/500,956 2003-09-05
US10/704,035 2003-11-06
US10/704,035 US20050010193A1 (en) 2002-05-06 2003-11-06 Novel methods for administration of drugs and devices useful thereof
US52383103P 2003-11-19 2003-11-19
US60/523,831 2003-11-19

Publications (2)

Publication Number Publication Date
WO2004101023A2 WO2004101023A2 (en) 2004-11-25
WO2004101023A3 true WO2004101023A3 (en) 2007-03-01

Family

ID=33459121

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/014033 WO2004101023A2 (en) 2003-05-06 2004-05-06 A method for altering insulin pharmacokinetics

Country Status (8)

Country Link
EP (1) EP1620145A4 (en)
JP (1) JP2007517768A (en)
KR (1) KR20060009303A (en)
AU (1) AU2004238257A1 (en)
BR (1) BRPI0409984A (en)
CA (1) CA2524444A1 (en)
MX (1) MXPA05011768A (en)
WO (1) WO2004101023A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8465468B1 (en) 2000-06-29 2013-06-18 Becton, Dickinson And Company Intradermal delivery of substances
US10105317B2 (en) * 2009-07-07 2018-10-23 Anpac Bio-Medical Science Co., Ltd. Method of drug delivery
MX2016013979A (en) * 2014-04-25 2017-01-11 Sanofi Sa New administration routes of insulin, insulin analogs or derivatives of insulin.

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6565532B1 (en) * 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
US6607513B1 (en) * 2000-06-08 2003-08-19 Becton, Dickinson And Company Device for withdrawing or administering a substance and method of manufacturing a device
US6623457B1 (en) * 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020156453A1 (en) * 1999-10-14 2002-10-24 Pettis Ronald J. Method and device for reducing therapeutic dosage
JP2004528896A (en) * 2001-04-13 2004-09-24 ベクトン・ディキンソン・アンド・カンパニー How to inject a substance intradermally
CA2451816A1 (en) * 2001-06-29 2003-01-09 Becton, Dickinson And Company Intradermal delivery of vaccines and gene therapeutic agents via microcannula
EP1432466B1 (en) * 2001-09-12 2012-08-15 Becton, Dickinson and Company Microneedle-based pen device for drug delivery and method for using same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6623457B1 (en) * 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance
US6607513B1 (en) * 2000-06-08 2003-08-19 Becton, Dickinson And Company Device for withdrawing or administering a substance and method of manufacturing a device
US6565532B1 (en) * 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1620145A4 *

Also Published As

Publication number Publication date
JP2007517768A (en) 2007-07-05
MXPA05011768A (en) 2006-01-26
WO2004101023A2 (en) 2004-11-25
KR20060009303A (en) 2006-01-31
AU2004238257A1 (en) 2004-11-25
BRPI0409984A (en) 2006-05-09
EP1620145A2 (en) 2006-02-01
CA2524444A1 (en) 2004-11-25
EP1620145A4 (en) 2010-08-25

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