WO2004100986A3 - Utilisation pharmaceutique d'une substance inhibant l'enzyme adam 10 - Google Patents

Utilisation pharmaceutique d'une substance inhibant l'enzyme adam 10 Download PDF

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Publication number
WO2004100986A3
WO2004100986A3 PCT/GB2004/002098 GB2004002098W WO2004100986A3 WO 2004100986 A3 WO2004100986 A3 WO 2004100986A3 GB 2004002098 W GB2004002098 W GB 2004002098W WO 2004100986 A3 WO2004100986 A3 WO 2004100986A3
Authority
WO
WIPO (PCT)
Prior art keywords
adam
pharmaceutical use
inhibitory substance
ectodomain
shedding
Prior art date
Application number
PCT/GB2004/002098
Other languages
English (en)
Other versions
WO2004100986A2 (fr
Inventor
John Bird
Sheila Bridget Mcloughlin
Matthew Joseph Barnes
Original Assignee
Celltech R&D Ltd
John Bird
Sheila Bridget Mcloughlin
Matthew Joseph Barnes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celltech R&D Ltd, John Bird, Sheila Bridget Mcloughlin, Matthew Joseph Barnes filed Critical Celltech R&D Ltd
Publication of WO2004100986A2 publication Critical patent/WO2004100986A2/fr
Publication of WO2004100986A3 publication Critical patent/WO2004100986A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne l'utilisation d'une substance pouvant inhiber ADAM 10, une enzyme impliquée dans l'élimination de l'ectodomaine de CD23, pour produire un médicament servant à traiter des maladies allergiques parmi lesquelles figurent l'asthme, la dermatite atopique ainsi que la rhinite allergique.
PCT/GB2004/002098 2003-05-16 2004-05-13 Utilisation pharmaceutique d'une substance inhibant l'enzyme adam 10 WO2004100986A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0311228.1A GB0311228D0 (en) 2003-05-16 2003-05-16 Assay
GB0311228.1 2003-05-16

Publications (2)

Publication Number Publication Date
WO2004100986A2 WO2004100986A2 (fr) 2004-11-25
WO2004100986A3 true WO2004100986A3 (fr) 2005-01-13

Family

ID=9958169

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2004/002098 WO2004100986A2 (fr) 2003-05-16 2004-05-13 Utilisation pharmaceutique d'une substance inhibant l'enzyme adam 10

Country Status (2)

Country Link
GB (1) GB0311228D0 (fr)
WO (1) WO2004100986A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007025999A1 (fr) * 2005-08-31 2007-03-08 Serentis Limited Utilisation d'un inhibiteur de l'aureolysine pour le traitement de maladies inflammatoires de la peau caracterisees par une colonisation par staphylococcus aureus
GB2453589A (en) 2007-10-12 2009-04-15 King S College London Protease inhibition
US9150865B2 (en) 2010-11-09 2015-10-06 The University Of Chicago Role of ADAM10 and its relevance to disease and therapeutics

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0921197A2 (fr) * 1997-08-25 1999-06-09 Smithkline Beecham Disintegrin-métalloprotéase humaine liée au gène KUZ de Drosophila
WO2000056871A2 (fr) * 1999-03-08 2000-09-28 Falk Fahrenholz CELLULES COEXPRIMANT UNE PROTEINE PRECURSEUR AMYLOIDE ET UNE α-SECRETASE, ET LEURS UTILISATIONS DANS DES METHODES D'ESSAI ET A DES FINS DE DIAGNOSTIC
WO2003051825A1 (fr) * 2001-12-14 2003-06-26 Exelixis, Inc. Inhibiteurs de l'adam-10 humaine

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0921197A2 (fr) * 1997-08-25 1999-06-09 Smithkline Beecham Disintegrin-métalloprotéase humaine liée au gène KUZ de Drosophila
WO2000056871A2 (fr) * 1999-03-08 2000-09-28 Falk Fahrenholz CELLULES COEXPRIMANT UNE PROTEINE PRECURSEUR AMYLOIDE ET UNE α-SECRETASE, ET LEURS UTILISATIONS DANS DES METHODES D'ESSAI ET A DES FINS DE DIAGNOSTIC
WO2003051825A1 (fr) * 2001-12-14 2003-06-26 Exelixis, Inc. Inhibiteurs de l'adam-10 humaine

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
AMOUR AUGUSTIN ET AL: "The in vitro activity of ADAM-10 is inhibited by TIMP-1 and TIMP-3", FEBS LETTERS, vol. 473, no. 3, 19 May 2000 (2000-05-19), pages 275 - 279, XP004337152, ISSN: 0014-5793 *
HERMANN P ET AL: "The vitronectin receptor and its associated CD47 molecule mediates proinflammatory cytokine synthesis in human monocytes by interaction with soluble CD23.", THE JOURNAL OF CELL BIOLOGY. 22 FEB 1999, vol. 144, no. 4, 22 February 1999 (1999-02-22), pages 767 - 775, XP002298911, ISSN: 0021-9525 *
MAROLEWSKI A E ET AL: "CD23 (FcepsilonRII) release from cell membranes is mediated by a membrane-bound metalloprotease.", THE BIOCHEMICAL JOURNAL. 1 AUG 1998, vol. 333 ( Pt 3), 1 August 1998 (1998-08-01), pages 573 - 579, XP002298908, ISSN: 0264-6021 *
PARKIN EDWARD T ET AL: "Structure-activity relationship of hydroxamate-based inhibitors on the secretases that cleave the amyloid precursor protein, angiotensin converting enzyme, CD23, and pro-tumor necrosis factor-alpha.", BIOCHEMISTRY. 16 APR 2002, vol. 41, no. 15, 16 April 2002 (2002-04-16), pages 4972 - 4981, XP002298909, ISSN: 0006-2960 *
SAWA MASAAKI ET AL: "New type of metalloproteinase inhibitor: design and synthesis of new phosphonamide-based hydroxamic acids.", JOURNAL OF MEDICINAL CHEMISTRY. 14 FEB 2002, vol. 45, no. 4, 14 February 2002 (2002-02-14), pages 919 - 929, XP002299083, ISSN: 0022-2623 *
SUTTON B J ET AL: "THE HUMAN IGE NETWORK", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 366, 2 December 1993 (1993-12-02), pages 421 - 428, XP000421323, ISSN: 0028-0836 *

Also Published As

Publication number Publication date
GB0311228D0 (en) 2003-06-18
WO2004100986A2 (fr) 2004-11-25

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