WO2004100986A3 - Utilisation pharmaceutique d'une substance inhibant l'enzyme adam 10 - Google Patents
Utilisation pharmaceutique d'une substance inhibant l'enzyme adam 10 Download PDFInfo
- Publication number
- WO2004100986A3 WO2004100986A3 PCT/GB2004/002098 GB2004002098W WO2004100986A3 WO 2004100986 A3 WO2004100986 A3 WO 2004100986A3 GB 2004002098 W GB2004002098 W GB 2004002098W WO 2004100986 A3 WO2004100986 A3 WO 2004100986A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- adam
- pharmaceutical use
- inhibitory substance
- ectodomain
- shedding
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
L'invention concerne l'utilisation d'une substance pouvant inhiber ADAM 10, une enzyme impliquée dans l'élimination de l'ectodomaine de CD23, pour produire un médicament servant à traiter des maladies allergiques parmi lesquelles figurent l'asthme, la dermatite atopique ainsi que la rhinite allergique.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0311228.1 | 2003-05-16 | ||
GBGB0311228.1A GB0311228D0 (en) | 2003-05-16 | 2003-05-16 | Assay |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004100986A2 WO2004100986A2 (fr) | 2004-11-25 |
WO2004100986A3 true WO2004100986A3 (fr) | 2005-01-13 |
Family
ID=9958169
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2004/002098 WO2004100986A2 (fr) | 2003-05-16 | 2004-05-13 | Utilisation pharmaceutique d'une substance inhibant l'enzyme adam 10 |
Country Status (2)
Country | Link |
---|---|
GB (1) | GB0311228D0 (fr) |
WO (1) | WO2004100986A2 (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070049518A1 (en) * | 2005-08-31 | 2007-03-01 | Chandler Stephen R | Novel method of treatment of inflammatory skin conditions |
GB2453589A (en) | 2007-10-12 | 2009-04-15 | King S College London | Protease inhibition |
EP2637679A4 (fr) * | 2010-11-09 | 2015-09-23 | Univ Chicago | Rôle d'adam10 et sa pertinence au plan pathologique et thérapeutique |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0921197A2 (fr) * | 1997-08-25 | 1999-06-09 | Smithkline Beecham | Disintegrin-métalloprotéase humaine liée au gène KUZ de Drosophila |
WO2000056871A2 (fr) * | 1999-03-08 | 2000-09-28 | Falk Fahrenholz | CELLULES COEXPRIMANT UNE PROTEINE PRECURSEUR AMYLOIDE ET UNE α-SECRETASE, ET LEURS UTILISATIONS DANS DES METHODES D'ESSAI ET A DES FINS DE DIAGNOSTIC |
WO2003051825A1 (fr) * | 2001-12-14 | 2003-06-26 | Exelixis, Inc. | Inhibiteurs de l'adam-10 humaine |
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2003
- 2003-05-16 GB GBGB0311228.1A patent/GB0311228D0/en not_active Ceased
-
2004
- 2004-05-13 WO PCT/GB2004/002098 patent/WO2004100986A2/fr active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0921197A2 (fr) * | 1997-08-25 | 1999-06-09 | Smithkline Beecham | Disintegrin-métalloprotéase humaine liée au gène KUZ de Drosophila |
WO2000056871A2 (fr) * | 1999-03-08 | 2000-09-28 | Falk Fahrenholz | CELLULES COEXPRIMANT UNE PROTEINE PRECURSEUR AMYLOIDE ET UNE α-SECRETASE, ET LEURS UTILISATIONS DANS DES METHODES D'ESSAI ET A DES FINS DE DIAGNOSTIC |
WO2003051825A1 (fr) * | 2001-12-14 | 2003-06-26 | Exelixis, Inc. | Inhibiteurs de l'adam-10 humaine |
Non-Patent Citations (6)
Title |
---|
AMOUR AUGUSTIN ET AL: "The in vitro activity of ADAM-10 is inhibited by TIMP-1 and TIMP-3", FEBS LETTERS, vol. 473, no. 3, 19 May 2000 (2000-05-19), pages 275 - 279, XP004337152, ISSN: 0014-5793 * |
HERMANN P ET AL: "The vitronectin receptor and its associated CD47 molecule mediates proinflammatory cytokine synthesis in human monocytes by interaction with soluble CD23.", THE JOURNAL OF CELL BIOLOGY. 22 FEB 1999, vol. 144, no. 4, 22 February 1999 (1999-02-22), pages 767 - 775, XP002298911, ISSN: 0021-9525 * |
MAROLEWSKI A E ET AL: "CD23 (FcepsilonRII) release from cell membranes is mediated by a membrane-bound metalloprotease.", THE BIOCHEMICAL JOURNAL. 1 AUG 1998, vol. 333 ( Pt 3), 1 August 1998 (1998-08-01), pages 573 - 579, XP002298908, ISSN: 0264-6021 * |
PARKIN EDWARD T ET AL: "Structure-activity relationship of hydroxamate-based inhibitors on the secretases that cleave the amyloid precursor protein, angiotensin converting enzyme, CD23, and pro-tumor necrosis factor-alpha.", BIOCHEMISTRY. 16 APR 2002, vol. 41, no. 15, 16 April 2002 (2002-04-16), pages 4972 - 4981, XP002298909, ISSN: 0006-2960 * |
SAWA MASAAKI ET AL: "New type of metalloproteinase inhibitor: design and synthesis of new phosphonamide-based hydroxamic acids.", JOURNAL OF MEDICINAL CHEMISTRY. 14 FEB 2002, vol. 45, no. 4, 14 February 2002 (2002-02-14), pages 919 - 929, XP002299083, ISSN: 0022-2623 * |
SUTTON B J ET AL: "THE HUMAN IGE NETWORK", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 366, 2 December 1993 (1993-12-02), pages 421 - 428, XP000421323, ISSN: 0028-0836 * |
Also Published As
Publication number | Publication date |
---|---|
WO2004100986A2 (fr) | 2004-11-25 |
GB0311228D0 (en) | 2003-06-18 |
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