WO2004099266A2

WO2004099266A2 - Oxyfunctionalization of polyolefins

Info

Publication number: WO2004099266A2
Application number: PCT/US2004/012715
Authority: WO
Inventors: Nicole K. Boaen; Marc A. Hillmyer; Stephen F. Hahn
Original assignee: Dow Global Technologies Inc.; University Of Minnesota
Priority date: 2003-05-01
Filing date: 2004-04-26
Publication date: 2004-11-18
Also published as: WO2004099266A3

Abstract

The present invention is a method for oxyfunctionalizing, that is, introducing oxygen functionality to, a polyolefin such as polypropylene and poly(ethylene-alt-propylene). The polyolefin is contacted with an oxygen source such as a persulfate and catalytic amounts of a metal porphyrin complex under mild conditions to yield an oxyfunctionalized polymer that has a polydispersity that is very similar to that of the starting polymer.

Description

OXYFUNCTIONALIZATION OF POLYOLEFINS

Saturated polyolefϊns, such as polyethylene and polypropylene are inexpensive, commodity polymers that find a wide array of uses because of their toughness, ease of processability, and resistance to degradation. In spite of these attractive properties, the absence of polar functional groups such as hydroxyl or carbonyl groups renders them ill- suited for applications requiring miscibility with polar pigments, adhesion, or barrier properties. Although polar functionality can be introduced into the backbone of these polymers, for example, by grafting of an anhydride such as maleic anhydride followed by imidization with a diamine or an alcohol amine, such methods tend to promote polymer cleavage, which lowers the molecular weight and/or increases the polydispersity of the polymer, thereby resulting in a polymer with poorer physical properties. It would, therefore, be desirable to provide a simple way of introducing polar functionality onto the backbone of polyolefins without substantially changing either the number average molecular weight or the polydispersity of the product with respect to the starting material.

The present invention addresses a deficiency in the art by providing a method of oxyfunctionalizing a polyolefin comprising the steps of contacting a) a polyolefin having a number average molecular weight (M_n) of at least 2000 Daltons with b) an oxygen source and c) a catalytic amount of a metal poφhyrin complex, under such conditions to incorporate oxygen into the polyolefin.

In a second aspect, the present in invention is a method of oxyfunctionalizing a polyolefin comprising the steps of contacting a) a polyolefin having a number average molecular weight (M_n) of at least 2000 Daltons with b) a persulfate c) a nitrogen- containing base; and d) a catalytic amount of a metal poφhyrin complex, under such conditions to incoφorate oxygen into the polyolefin.

The present invention is a method of oxyfunctionalizing a polyolefin comprising the step of reacting the polyolefin with an oxygen source and in the presence of a metal poφhyrin complex under such conditions to oxyfunctionalize the polyolefin. As used herein, the term "oxyfunctionalize" is used to describe either the introduction of hydroxyl groups or carbonyl groups or both into the polyolefin. A preferred oxyfunctionalization includes the addition of hydroxyl groups into the polyolefin. The polyolefin that is to be oxyfunctionalized may be any hydrocarbon having a number average molecular weight (M_n) of at least 2000 Daltons, more preferably at least 4000 Daltons, and most preferably greater than 40,000 Daltons. The polymer may also include other functionality in addition to hydrogen and carbon groups and may be completely saturated or contain some degree of unsaturation. Examples of polyolefin starting materials include polyethylene, random ethylene-α-olefin copolymers such as ethylene-1-octene and ethylene-1-octene copolymers, polypropylene, and hydrogenated polyisoprene (also known as poly(ethylene-α/t-propylene)). Because it is believed that the presence of tertiary carbon centers (methine groups) in the starting polymer facilitate the creation of hydroxyl groups in the oxyfunctionalization reaction of the present invention, polyolefins such as polypropylene and poly(ethylene-α/t-propylene) are preferred where hydroxylation is a preferred reaction. In contrast, the presence of secondary carbon centers (methylene groups) are believed to promote the complete oxidation of the center to carbonyl groups.

The metal poφhyrin complex used in the oxyfunctionalization has the following structure:

where each R is independently alkyl, nitro, or halo, preferably methyl, Cl, or Br; n is an integer in the range of 0 to 5, m an integer in the range of 0 to 2; M is a metal, preferably manganese or iron, more preferably manganese; and X is a halide or acetate (OAc).

A preferred metal poφhyrin complex is a manganese poφhyrin complex, more preferably a halogenated manganese poφhyrin complex. An example of an especially preferred halogenated manganese poφhyrin complex is meso-tetra-2,6- dichlorophenylpoφhyrin acetate, which is known in the art and illustrated below:

The polyolefin is reacted in the presence of the metal poφhyrin complex, an oxygen source, and preferably a nitrogen-containing base. The oxygen source is preferably a peroxide such as a peroxymonosulfate; a hypohalite such as hypochlorites and hypobromites; and perhaloates such as perchlorates, perbromates, and periodates. A more preferred oxygen source is a peroxymonosulfate such as an alkali metal peroxymonosulfate. An example of a commercially available alkali metal peroxymonosulfate is potassium peroxymonosulfate, commerically availabe as Oxone^® oxidant (2KHSO₅ • KHSO₄ * K₂SO₄, a registered trademark of E. I. du Pont De Nemours). The oxygen source is advantageously used in stoichiometric excess with respect to the metal poφhyrin complex. Preferably the mole-to-mole ratio of oxygen source to the metal poφhyrin complex is from 100: 1 to 500: 1.

Similarly, the mole-to-mole ratio of a polyolefin repeat unit to the metal poφhyrin complex is preferably from a 100: 1 to 500: 1. As used herein, the term "polyolefin repeat unit" is used to refer to the monomer repeat unit of the polymer. For example, a monomer repeat unit of poly(ethylene-<2/t-propylene) has the following structure:

CH₃ — CH₂CH₂CH-CH₂- The nitrogen-containing base is advantageously used to promote the oxidation of the polymer. Examples of nitrogen-containing bases include pyridines such as 4-t- butylpyridine and substituted and unsubstituted imidazoles. Preferably, the nitrogen- containing base is used in a stoichiometric excess with respect to the metal poφhyrin complex, more preferably at a mole-to-mole ratio of from 5: 1 to 20: 1.

When a water-soluble oxygen source such as an alkali metal persulfate is used, then it is desirable to use a phase transfer reagent, which is preferably a surfactant that is not easily oxidized. An example of a preferred phase transfer reagent is benzyldimethyltetradecylammonium chloride (BDTAC). When a phase transfer reagent is used, it is preferably used at a mole-to-mole ratio of from 10: 1 to 100: 1 with respect to the metal poφhyrin complex.

It has been suφrisingly discovered that oxygen functionality in the form of hydroxyl groups or carbonyl groups or both can be introduced into a polyolefin without substantially affecting the polydispersity of the polymer. Preferably, the polydispersity (the weight average molecular weight, M_w, divided by the number average molecular weight, M_n) of the oxyfunctionalized polymer is not more than 50 percent, more preferably not more than 20 percent, and most preferably not more than 10 percent higher than the polydispersity of the starting polymer.

The following examples are for illustrative puφoses only and are not intended to limit the scope of the invention.

Example 1 - Oxyfunctionalization of a Low Molecular Weight Poly(ethylene-α/t- propylene)

A. Starting Materials - Imidazole, benzyldimethyltetradecylammonium chloride (BDTAC), potassium hydrogen persulfate (Oxone^® oxidant), and sec-butyl lithium were obtained from Aldrich. Pyrrole was distilled before use. A cyclohexane solution of the polymer substrate was purified by stirring over H SO , followed by the neutralization of the organic layer by washing with a saturated solution of Na CO₃. The organic layer was dried over MgSO and passed through a column of neutral alumina. The filtrate was concentrated using rotary evaporation. B. Synthesis of Poly(ethylene-α/t-propylene) (PEP) - In a first step, polyisoprene is synthesized via anionic polymerization of isoprene. Catalytic hydrogenation of polyisoprene provides poly(ethylene-α/t-propylene). Isoprene was purified by freeze-thaw degassing then further purified over n-butyl lithium and placed in a buret. Purified cyclohexane (1 L) was added to a dried reactor under argon with stirring and maintained at 40 °C. An initiator, sec-butyl lithium, was added via syringe as a 1.46 M solution in cyclohexane (13.75 mL, 0.02 mol sec-butyl lithium). The isoprene buret (91.24 g, 1.34 mol) was then opened to the reactor and the reaction was stirred at 40 °C for 5 h, after which time the reaction was quenched by the addition of an excess of degassed methanol (8 mL, 0.20 mol). The cyclohexane solution of the polymer was concentrated, and purified through a short column of alumina. A small quantity of the polymer solution was concentrated and dried for molecular characterization of the product. The purified cyclohexane solution was concentrated and transferred to a 1-L stainless steel reactor along with Dow Hydrogenation Catalyst (Pt/SiO ) (10:1 mass ratio of polymer to catalyst). The reactor was closed, heated, degassed, and maintained under nitrogen with stirring at 50 °C. The reactor was pressurized to 500 psi H and the temperature was increased to 80 °C. As the pressure in the reactor dropped, H₂ was added periodically. The reaction was allowed to proceed overnight. The reactor was cooled, the solution was filtered to remove the catalyst and then precipitated in a 50/50 mixture of ice-cold methanol and isopropanol. The solvent was then carefully decanted and the viscous, semitransparent liquid polymer was dried in vacuo at 80 °C for approximately 36 hours. The number-average molecular weight, M_n, of the polyisoprene precursor was calculated by end-group analysis using 1H NMR to be 4800 g/mol. Analysis by size exclusion chromatography (SEC) provided M_n of 6000 g/mol relative to polystyrene standards, and a molecular weight distribution, or polydispersity index (PDI), of 1.03. After hydrogenation, SEC analysis of the hydrogenated product, low-molecular-weight PEP, showed the parameters of the model starting material were retained: M_n for the low molecular weight PEP, 8310 g/mol, relative to polystyrene standards, and a PDI of 1.07.

C. Synthesis of Manganese meso-(tetra-2,6-dichlorophenylpoφhyrin) Acetate - [Mn(TDCPP)OAc]. Mn(TDCPP)OAc was prepared in 2 steps. First, the free base poφhyrin, tetra-2,6-dichlorophenylpoφhyrin (H₂TDCPP) was synthesized following a modified Lindsey procedure. Freshly distilled pyrrole (2.17 mL, 31.3 mmol) and 2,6- dichorobenzaldehyde (5.54 g, 31.3 mmol) were dissolved in 1.8 L of CH₂C1₂ in a 2-L, 3- necked flask. BF OEt₂ (1.17 mL, 9.2 mmol) was added with stirring. The reaction was stirred at room temperature for 2 h under N₂, after which, the solution was brought slowly to a gentle reflux, and 2,3-dichloro-5,6-dicyano-l,4-benzoquinone (5.44 g, 23.5 mmol) was added as a powder. The reaction was stirred under reflux for 30 minutes. The reaction mixture was cooled, concentrated, and the product was washed with methanol until the filtrate was clear to remove impurities. The product was further purified by column chromatography (neutral alumina, CH C1₂). (1.71 g, 25 percent yield).

In a second step, the metallation reaction, a 1-L, 3-necked flask equipped with a reflux condenser, a thermometer, and a magnetic stir bar, was charged with 500 mL N,N- dimethylformamide (DMF), H₂TDCPP (0.56 g, 0.62 mmol), and 2,4,6-collidine (10 mL, 75.6 mmol). The reaction was heated to reflux under N₂, and manganese acetate tetrahydrate (50g, 289 mmol) was added. The reaction was stirred under reflux for 21 h, and the metallation reaction was monitored by UV/visible spectroscopy (shift in the Soret band from 418 to 478 nm). The reaction mixture was cooled, and the product was precipitated in brine (0 °C), collected by vacuum filtration and washed with cold distilled water. The product, Mn(TDCPP)OAc was purified by Soxhlet extraction with hexanes, followed by extraction with methylene chloride, and subsequent column chromatography (neutral alumina, 100 percent CH C1 to elute unreacted poφhyrin, followed by 100 percent methanol to elute the catalyst). (0.34 g, 54 percent yield). Characterization of the product using ^!H NMR and UV-vis spectroscopy, as well as fast atom bombardment mass spectrometric (FAB-MS) analysis was consistent with that reported in the literature.

D. Oxyfunctionalization of a Low-Molecular- Weight Model Polyolefin (5 kg/mol), poly(ethylene- /t-propylene) (PEP) - A high pressure reactor was charged with Mn(TDCPP)OAc (18.1 mg, 18.1 μmol), imidazole (12.3 mg, 0.18 mmol), BDTAC

(0.2894 g, 0.72 mmol), the low molecular weight PEP (0.5058 g, 7.2 mmol monomer), CH₂C1 (10 mL), and Oxone^® oxidant (3.23 g, 5.25 mmol, added as a solution in 100 mL 0.25 M phosphate buffer, pH 7). The flask was sealed and the biphasic reaction mixture was stirred vigorously for 43 h at 50 °C. The reaction was cooled and worked up in separatory funnel. The lower methylene chloride layer of the reaction was collected and washed with distilled water before drying over magnesium sulfate. The mixture was filtered, and solvent was removed in vacuo. The BDTAC and Mn(TDCPP)OAc were removed and a mixture of products was isolated. Mass yield: 0.2984 g, 45 percent. (Functionalized PEP 0.2897 g; Unreacted PEP recovered, 0.0087g, 12 percent of original PEP, 88 percent conversion).

Spectroscopic characterization of the functionalized PEP by IR, carbon NMR, and proton NMR spectroscopy revealed that oxyfunctionalization occurred. A chemical shift in the proton NMR spectrum near 2.6 ppm suggests the presence of protons attached to a carbon α to a carbonyl group. The carbon NMR spectrum showed a resonance at 73 ppm, which is consistent with introduction of tertiary hydroxyl functionality. An increase in the glass-transition temperature was observed for the functionalized materials relative to the model parent polyolefin from -63° C to -49° C as measured using differential scanning calorimetry.

To determine the degree of hydroxylation, the functionalized PEP was acetylated with an excess of acetyl chloride. This acetylated product was analyzed quantitatively by proton NMR spectroscopy to reveal 5 OH groups per polymer chain, or 2 OH groups per 100 backbone carbon atoms. Size exclusion chromatography (SEC) of the functionalized PEP provided a number average molecular weight, M_n, of 6900 g/mol and a weight average molecular weight (M_w) of 8200 relative to polystyrene standards, and, therefore, a PDI of 1.2. The percent difference is determined by the difference of the PDI of the starting polyolefin (PDIo) and the oxyfunctionalized polyolefin (PDI_f) divided by the PDI of the starting polyolefin all multiplied by 100.

((PDIf - PDIo)/PDIo) x 100

Thus, the PDI of the product is 12 percent higher than the PDI of the starting polyolefin.

Example 2 - Oxyfunctionalization of a High Molecular Weight Poly(ethylene-α/t- propylene)

The high-molecular-weight model PEP polymer was prepared using the procedure described above by changing the reaction stoichiometry. SEC equipped with a light- scattering detector provided an exact value for M_n = 49.6 kg/mol and a PDI of 1.01 for the polyisoprene precursor. The M_n was found to be 55.2 kg/mol relative to polystyrene standards and a PDI of 1.06. SEC of the hydrogenated high-molecular weight model material, PEP, provided an apparent molecular weight of 61.4 kg/mol and a PDI of 1.07.

The oxyfunctionalization of the high-molecular- weight PEP was performed essentially as described in Example 1 except that chloroform was used as a solvent in place of methylene chloride and the reaction mixture was stirred at room temperature for three days. In this example, the following materials and quantities were used: Mn(TDCPP)OAc (19.5 mg, 19.0 μmol), imidazole (12.4 mg, 0.18 mmol), BDTAC (0.2814 g, 0.70 mmol), high molecular weight PEP (0.4998 g, 7.14 mmol monomer), and 10 mL CHC1₃. Oxone^® oxidant (1.1026g, 1.79 mmol) was added to the reaction mixture as a solution in 36 mL 0.25 M phosphate buffer, pH =7. Mass yield: 0.2926 g, 27 percent. (Functionalized PEP 0.2903 g; Unreacted PEP recovered, 0.0023g, < 1 percent of original PEP, > 99 percent conversion).

Neither proton NMR or IR supported the introduction of ketone functional groups. In this example, acetylation and spectroscopic analysis as described above showed that 12 OH groups were introduced into each polymer chain, or 0.4 OH groups/100 backbone carbons. SEC analysis of the functionalized high molecular weight PEP provided a M_n of 63.7 kg/mol relative to polystyrene standards and a M_w of 72.2 kg/mol, corresponding to a PDI of 1.1. Thus, the PDI of the product is 4 percent higher than the PDI of the starting polyolefin.

Claims

WHAT IS CLAIMED IS:

1. A method of oxyfunctionalizing a polyolefin comprising the steps of contacting a) a polyolefin having a number average molecular weight (M_n) of at least 2000 Daltons with b) an oxygen source and c) a catalytic amount of a metal porphyrin complex, under such conditions to incorporate oxygen into the polyolefin.

2. The method of Claim 1 wherein the polyolefin has an M_n of at least 4000 Daltons and wherein the polydispersity index of the oxyfunctionalized polymer is not more than 20% greater than the polydispersity index of the polyolefin prior to oxyfunctionalization.

3. The method of either of Claims 1 or 2 wherein the polydispersity index of the oxyfunctionalized polymer is not more than 10% greater than the polydispersity index of the polyolefin prior to oxyfunctionalization and wherein the polymer contains methine groups.

4. The method of any of Claims 1 to 3 wherein the polyolefin is a poly(ethylene--ϊ/t- propylene) having a M_n of at least 40,000 Daltons and the metal porphyrin complex is a manganese or an iron porphyrin complex.

5. The method of any of Claims 1 to 3 wherein the polyolefin is a polypropylene or a random ethylene-α-olefin copolymer.

6. A method of oxyfunctionalizing a polyolefin comprising the steps of contacting a) a polyolefin having a number average molecular weight (M_n) of at least 2000

Daltons with b) a persulfate c) a nitrogen-containing base; and d) a catalytic amount of a metal porphyrin complex, under such conditions to incorporate oxygen into the polyolefin.

7. The method of Claim 6 wherein the polyolefin is a poly(ethylene-α/t-propylene) having a M_n of at least 4000 Daltons, the metal porphyrin complex is a manganese or iron poφhyrin complex, and the nitrogen-containing base includes an imidazole or a pyridine.

8. The method of either of Claims 6 or 7 wherein the oxygen source is water soluble and a phase transfer agent is included in the step to make the oxyfunctionalized polyolefin.

9. The method of Claim 8 wherein the oxygen source includes an alkali metal peroxymonosulfate, the phase tranfer agent includes benzyldimethyltetradecylammonium chloride, and the manganese poφhyrin complex is manganese meso-(tetra-2,6-dichlorophenylpoφhyrin) acetate.