WO2004098487A3 - Composes de diagnostic et de therapie utiles pour les maladies associees a la serine protease 5 transmembranaire humaine (tmprss5) - Google Patents

Composes de diagnostic et de therapie utiles pour les maladies associees a la serine protease 5 transmembranaire humaine (tmprss5) Download PDF

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Publication number
WO2004098487A3
WO2004098487A3 PCT/EP2004/004272 EP2004004272W WO2004098487A3 WO 2004098487 A3 WO2004098487 A3 WO 2004098487A3 EP 2004004272 W EP2004004272 W EP 2004004272W WO 2004098487 A3 WO2004098487 A3 WO 2004098487A3
Authority
WO
WIPO (PCT)
Prior art keywords
tmprss5
disorders
therapeutics
diagnostics
serine protease
Prior art date
Application number
PCT/EP2004/004272
Other languages
English (en)
Other versions
WO2004098487A2 (fr
Inventor
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Stefanie Polej
Original Assignee
Bayer Healthcare Ag
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Stefanie Polej
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag, Stefan Golz, Ulf Brueggemeier, Andreas Geerts, Stefanie Polej filed Critical Bayer Healthcare Ag
Publication of WO2004098487A2 publication Critical patent/WO2004098487A2/fr
Publication of WO2004098487A3 publication Critical patent/WO2004098487A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

La présente invention concerne une TMPRSS5 humaine qui est associée aux troubles cardio-vasculaires, aux maladies respiratoires, aux troubles neurologiques, aux maladies dermatologiques, aux troubles gastro-entérologiques et au cancer. Cette invention se rapporte également à des dosages qui permettent d'identifier des composés utiles dans le traitement ou la prévention des troubles cardio-vasculaires, des maladies respiratoires, des troubles neurologiques, des maladies dermatologiques, des troubles gastro-entérologiques et du cancer. Cette invention concerne également des composés qui se lient et/ou qui déclenchent ou inhibent l'activité de TMPRSS5 ainsi que des compositions pharmaceutiques comprenant de tels composés.
PCT/EP2004/004272 2003-05-05 2004-04-22 Composes de diagnostic et de therapie utiles pour les maladies associees a la serine protease 5 transmembranaire humaine (tmprss5) WO2004098487A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03010093 2003-05-05
EP03010093.7 2003-05-05

Publications (2)

Publication Number Publication Date
WO2004098487A2 WO2004098487A2 (fr) 2004-11-18
WO2004098487A3 true WO2004098487A3 (fr) 2005-04-14

Family

ID=33427034

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/004272 WO2004098487A2 (fr) 2003-05-05 2004-04-22 Composes de diagnostic et de therapie utiles pour les maladies associees a la serine protease 5 transmembranaire humaine (tmprss5)

Country Status (1)

Country Link
WO (1) WO2004098487A2 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001083775A2 (fr) * 2000-05-04 2001-11-08 Incyte Genomics, Inc. Proteases
WO2001096538A2 (fr) * 2000-06-13 2001-12-20 Bayer Aktiengesellschaft Regulation de la serine protease transmembranaire humaine
WO2002000860A2 (fr) * 2000-06-26 2002-01-03 Sugen, Inc. Nouvelles proteases

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001083775A2 (fr) * 2000-05-04 2001-11-08 Incyte Genomics, Inc. Proteases
WO2001096538A2 (fr) * 2000-06-13 2001-12-20 Bayer Aktiengesellschaft Regulation de la serine protease transmembranaire humaine
WO2002000860A2 (fr) * 2000-06-26 2002-01-03 Sugen, Inc. Nouvelles proteases

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
WATANABE Y ET AL: "Molecular cloning and tissue-specific expression analysis of mouse spinesin, a type II transmembrane serine protease 5", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 324, no. 1, 5 November 2004 (2004-11-05), pages 333 - 340, XP004605939 *
YAMAGUCHI N ET AL: "Spinesin/TMPRSS5, a novel transmembrane serine protease, cloned from human spinal cord", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 9, 1 March 2002 (2002-03-01), pages 6806 - 6812, XP002311968 *

Also Published As

Publication number Publication date
WO2004098487A2 (fr) 2004-11-18

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