WO2004097000A3 - Ligand-exchange functional antigens, and use of same in pharmaceutical vaccine compositions - Google Patents

Ligand-exchange functional antigens, and use of same in pharmaceutical vaccine compositions Download PDF

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Publication number
WO2004097000A3
WO2004097000A3 PCT/US2004/013169 US2004013169W WO2004097000A3 WO 2004097000 A3 WO2004097000 A3 WO 2004097000A3 US 2004013169 W US2004013169 W US 2004013169W WO 2004097000 A3 WO2004097000 A3 WO 2004097000A3
Authority
WO
WIPO (PCT)
Prior art keywords
ligand
antigens
same
vaccine compositions
exchange functional
Prior art date
Application number
PCT/US2004/013169
Other languages
French (fr)
Other versions
WO2004097000A2 (en
Inventor
Stanley L Hem
Harm Hogenesch
Original Assignee
Purdue Research Foundation
Stanley L Hem
Harm Hogenesch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation, Stanley L Hem, Harm Hogenesch filed Critical Purdue Research Foundation
Publication of WO2004097000A2 publication Critical patent/WO2004097000A2/en
Publication of WO2004097000A3 publication Critical patent/WO2004097000A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention provides novel modified, hydroxyl replacing antigens, vaccines including the modified antigens, and related methods. Modified antigens include at least one hydroxyl replacing moiety capable of replacing a surface hydroxyl group of a metal hydroxide adjuvant by ligand exchange to form a metal hydroxide adjuvant/antigen complex.
PCT/US2004/013169 2003-04-29 2004-04-29 Ligand-exchange functional antigens, and use of same in pharmaceutical vaccine compositions WO2004097000A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46682603P 2003-04-29 2003-04-29
US60/466,826 2003-04-29

Publications (2)

Publication Number Publication Date
WO2004097000A2 WO2004097000A2 (en) 2004-11-11
WO2004097000A3 true WO2004097000A3 (en) 2007-10-04

Family

ID=33418427

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/013169 WO2004097000A2 (en) 2003-04-29 2004-04-29 Ligand-exchange functional antigens, and use of same in pharmaceutical vaccine compositions

Country Status (1)

Country Link
WO (1) WO2004097000A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9107906B1 (en) 2014-10-28 2015-08-18 Adma Biologics, Inc. Compositions and methods for the treatment of immunodeficiency

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007053781A2 (en) * 2005-11-01 2007-05-10 Novartis Ag Compositions with antigens adsorbed to calcium phosphate
WO2018069520A1 (en) * 2016-10-14 2018-04-19 Brenntag Biosector A.S. Modified mineral micro-particles, methods of preparing the same and uses thereof
US10259865B2 (en) 2017-03-15 2019-04-16 Adma Biologics, Inc. Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection
US11224648B2 (en) 2017-12-19 2022-01-18 Massachusetts Institute Of Technology Antigen-adjuvant coupling reagents and methods of use
EP3990491A1 (en) 2019-06-26 2022-05-04 Massachusetts Institute of Technology Immunomodulatory fusion protein-metal hydroxide complexes and methods thereof
CN114028559B (en) * 2021-12-28 2024-06-18 广东粤港澳大湾区国家纳米科技创新研究院 Aluminum-manganese composite nanocrystalline and preparation method and application thereof

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CHANG ET AL.: "Role of the Electrostatic Attractive Force in the Adsorption of Proteins by Aluminum Hydroxide Adjuvant", PDA JOURNAL OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY, vol. 51, 1997, pages 25 - 29, XP009005780 *
HOGENESCH: "Mechanisms of stimulation of the immune reponse by aluminum adjuvants", VACCINE, vol. 20, 2002, pages S34 - S39, XP004361371 *
IYER ET AL.: "Effect of the degree of phosphate substitution in aluminium hydroxide adjuvant on the adsorption of phosphorylated proteins", PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, vol. 8, no. 1, 2003, pages 81 - 86 *
IYER ET AL.: "Relationship between the degree of antigen adsorption to aluminum hydroxide adjuvant in interstitial fluid and antibody production", VACCINE, vol. 21, 2003, pages 1219 - 1223, XP004404300 *
RINELLA ET AL.: "Effects of Anions on Model Aluminum-Adjuvant-Containing Vaccines", JOURNAL OF COLLOID AND INTERFACE SCIENCE, vol. 172, 1995, pages 121 - 130 *
SHI ET AL.: "Change in the degree of adsorption of proteins by aluminum-containing adjuvants following exposure to interstitial fluid", VACCINES, vol. 20, 2002, pages 80 - 85, XP004305117 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9107906B1 (en) 2014-10-28 2015-08-18 Adma Biologics, Inc. Compositions and methods for the treatment of immunodeficiency

Also Published As

Publication number Publication date
WO2004097000A2 (en) 2004-11-11

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