WO2004096844A3 - Group 1 mite polypeptide variants - Google Patents

Group 1 mite polypeptide variants Download PDF

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Publication number
WO2004096844A3
WO2004096844A3 PCT/DK2004/000280 DK2004000280W WO2004096844A3 WO 2004096844 A3 WO2004096844 A3 WO 2004096844A3 DK 2004000280 W DK2004000280 W DK 2004000280W WO 2004096844 A3 WO2004096844 A3 WO 2004096844A3
Authority
WO
WIPO (PCT)
Prior art keywords
group
polypeptide variants
mite polypeptide
mite
polypeptide
Prior art date
Application number
PCT/DK2004/000280
Other languages
French (fr)
Other versions
WO2004096844A2 (en
Inventor
Nanna Kristensen Soni
Esben Peter Friis
Erwin Ludo Roggen
Stina Thulesen Lyngstrand
Original Assignee
Novozymes As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novozymes As filed Critical Novozymes As
Priority to EP04729048A priority Critical patent/EP1620461A2/en
Priority to AU2004233940A priority patent/AU2004233940A1/en
Priority to JP2006504364A priority patent/JP2007525155A/en
Priority to CA002523402A priority patent/CA2523402A1/en
Publication of WO2004096844A2 publication Critical patent/WO2004096844A2/en
Publication of WO2004096844A3 publication Critical patent/WO2004096844A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43531—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from mites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Insects & Arthropods (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

This invention concerns variants of group 1 mite polypeptides, wherein the mature polypeptide of the variant comprise one or more mutations in the positions or corresponding to the positions consisting of A10, A12, E13, G29, G30, G32, A46, Y47, S54, L55, D64, A66, S67, G73, T75, I80, Q84, N86, G87, S92, Y93, Y96, A98, R99, E100, Q101, R104, R105, P106, Q109, R110, F111, G112, I113, A132, I144, K145, D146, D148, R151, I158, I159, Q160, R161, D162, N163, G164, Y165, Q166, N179, A180, G182, V183, D184, A205, I208 of SEQ ID NO: 1 or 10, 12, 13, 29, 30, 32, 46, 47, 54, 55, 64, 66, 67, 73, 75, I80, 84, 86, 87, 92, Y93, 96, 98, 99, 100, 101, 104, 105, 106, 109, 110, 111, 112, 113, 132, 144, 145, 146, 148, 151, 158, 159, 160, 161, 162, 163, 164, 165, 166, 179, 180, 182, 183, 184, 205, 208 of the mature Der p 1 polypeptide.
PCT/DK2004/000280 2003-04-25 2004-04-23 Group 1 mite polypeptide variants WO2004096844A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP04729048A EP1620461A2 (en) 2003-04-25 2004-04-23 Group 1 mite polypeptide variants
AU2004233940A AU2004233940A1 (en) 2003-04-25 2004-04-23 Group 1 mite polypeptide variants
JP2006504364A JP2007525155A (en) 2003-04-25 2004-04-23 Group 1 mite polypeptide variant
CA002523402A CA2523402A1 (en) 2003-04-25 2004-04-23 Group 1 mite polypeptide variants

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DKPA200300628 2003-04-25
DKPA200300628 2003-04-25
DKPA200301093 2003-07-21
DKPA200301093 2003-07-21

Publications (2)

Publication Number Publication Date
WO2004096844A2 WO2004096844A2 (en) 2004-11-11
WO2004096844A3 true WO2004096844A3 (en) 2004-12-16

Family

ID=33420357

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2004/000280 WO2004096844A2 (en) 2003-04-25 2004-04-23 Group 1 mite polypeptide variants

Country Status (5)

Country Link
EP (1) EP1620461A2 (en)
JP (1) JP2007525155A (en)
AU (1) AU2004233940A1 (en)
CA (1) CA2523402A1 (en)
WO (1) WO2004096844A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1756150A2 (en) * 2004-04-23 2007-02-28 Novozymes A/S Group 1 mite polypeptide variants
EP1756275A1 (en) * 2004-04-23 2007-02-28 Novozymes A/S Method for obtaining mature protease by enzymatic digestion

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5820862A (en) * 1994-04-14 1998-10-13 Immulogic Pharmaceutical Corporation T cell epitopes of the major allergens from dermatophagoides (house dust mite)
WO1999025823A2 (en) * 1997-11-19 1999-05-27 Smithkline Beecham Biologicals S.A. Recombinant allergen with reduced enzymatic activity
WO2001029078A2 (en) * 1999-10-15 2001-04-26 Heska Corporation Method for production and use of mite group 1 proteins
WO2001083559A2 (en) * 2000-04-28 2001-11-08 Novozymes A/S Production and use of protein variants having modified immunogenecity
WO2003016340A1 (en) * 2001-08-17 2003-02-27 Glaxosmithkline Biologicals S.A. Derp1 and proderp1 allergen derivatives

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5820862A (en) * 1994-04-14 1998-10-13 Immulogic Pharmaceutical Corporation T cell epitopes of the major allergens from dermatophagoides (house dust mite)
WO1999025823A2 (en) * 1997-11-19 1999-05-27 Smithkline Beecham Biologicals S.A. Recombinant allergen with reduced enzymatic activity
WO2001029078A2 (en) * 1999-10-15 2001-04-26 Heska Corporation Method for production and use of mite group 1 proteins
WO2001083559A2 (en) * 2000-04-28 2001-11-08 Novozymes A/S Production and use of protein variants having modified immunogenecity
WO2003016340A1 (en) * 2001-08-17 2003-02-27 Glaxosmithkline Biologicals S.A. Derp1 and proderp1 allergen derivatives

Also Published As

Publication number Publication date
JP2007525155A (en) 2007-09-06
EP1620461A2 (en) 2006-02-01
AU2004233940A1 (en) 2004-11-11
CA2523402A1 (en) 2004-11-11
WO2004096844A2 (en) 2004-11-11

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