WO2004094599A3 - Disease prevention and vaccination following thymic reactivation - Google Patents

Disease prevention and vaccination following thymic reactivation Download PDF

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Publication number
WO2004094599A3
WO2004094599A3 PCT/US2004/011913 US2004011913W WO2004094599A3 WO 2004094599 A3 WO2004094599 A3 WO 2004094599A3 US 2004011913 W US2004011913 W US 2004011913W WO 2004094599 A3 WO2004094599 A3 WO 2004094599A3
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WIPO (PCT)
Prior art keywords
lhrh
patient
thymus
selective
disease prevention
Prior art date
Application number
PCT/US2004/011913
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French (fr)
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WO2004094599A2 (en
Inventor
Richard Boyd
Original Assignee
Norwood Immunology Ltd
Richard Boyd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority claimed from US10/419,068 external-priority patent/US20050002913A1/en
Priority claimed from US10/418,747 external-priority patent/US20040018180A1/en
Priority claimed from US10/418,727 external-priority patent/US20040013641A1/en
Priority claimed from US10/419,066 external-priority patent/US20040037817A1/en
Priority claimed from US10/749,122 external-priority patent/US20040259803A1/en
Priority claimed from US10/748,450 external-priority patent/US20040241842A1/en
Priority claimed from US10/749,118 external-priority patent/US20040265285A1/en
Priority claimed from US10/748,831 external-priority patent/US20050020524A1/en
Application filed by Norwood Immunology Ltd, Richard Boyd filed Critical Norwood Immunology Ltd
Priority to EP04759971A priority Critical patent/EP1620545A4/en
Publication of WO2004094599A2 publication Critical patent/WO2004094599A2/en
Publication of WO2004094599A3 publication Critical patent/WO2004094599A3/en

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    • A61K35/26—Lymph; Lymph nodes; Thymus; Spleen; Splenocytes; Thymocytes
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Abstract

The present disclosure provides methods for preventing or treating illness, improving responsiveness to immunization, and improving the efficacy of gene therapy in a patient, by disrupting sex steroid mediated signaling and reactivating the patient's thymus. In some embodiments, the patient's thymus is reactivated by interruption or ablation of sex steroid mediated signaling by the administration of LHRH agonists, LHRH antagonists, anti-LHRH receptor antibodies, anti-LHRH vaccines, anti-androgens, anti-estrogens, selective estrogen receptor modulators (SERMs), selective androgen receptor modulators (SARMs), selective progesterone response modulators (SPRMs), ERDs, aromatase inhibitors, or various combinations thereof.
PCT/US2004/011913 2003-04-18 2004-04-19 Disease prevention and vaccination following thymic reactivation WO2004094599A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP04759971A EP1620545A4 (en) 2003-04-18 2004-04-19 Disease prevention and vaccination following thymic reactivation

Applications Claiming Priority (18)

Application Number Priority Date Filing Date Title
US10/419,068 US20050002913A1 (en) 1999-04-15 2003-04-18 Hematopoietic stem cell gene therapy
US10/418,747 US20040018180A1 (en) 1999-04-15 2003-04-18 Stimulation of thymus for vaccination development
US10/419,068 2003-04-18
US10/418,747 2003-04-18
US10/418,727 2003-04-18
US10/419,066 2003-04-18
US10/418,727 US20040013641A1 (en) 1999-04-15 2003-04-18 Disease prevention by reactivation of the thymus
US10/419,066 US20040037817A1 (en) 1999-04-15 2003-04-18 Normalization of defective T cell responsiveness through manipulation of thymic regeneration
US52700103P 2003-12-05 2003-12-05
US60/527,001 2003-12-05
US10/748,831 2003-12-30
US10/749,122 US20040259803A1 (en) 1999-04-15 2003-12-30 Disease prevention by reactivation of the thymus
US10/748,450 US20040241842A1 (en) 1999-04-15 2003-12-30 Stimulation of thymus for vaccination development
US10/749,118 2003-12-30
US10/748,450 2003-12-30
US10/749,118 US20040265285A1 (en) 1999-04-15 2003-12-30 Normalization of defective T cell responsiveness through manipulation of thymic regeneration
US10/749,122 2003-12-30
US10/748,831 US20050020524A1 (en) 1999-04-15 2003-12-30 Hematopoietic stem cell gene therapy

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EP1620126A4 (en) * 2003-04-18 2007-07-04 Norwood Immunology Ltd Disease prevention and vaccination prior to thymic reactivations
CN100425288C (en) * 2005-01-28 2008-10-15 北京金迪克生物技术研究所 Nasal cavity spraying inactivated influenza virus vaccine and its prepn process
GB0519303D0 (en) * 2005-09-21 2005-11-02 Oxford Biomedica Ltd Chemo-immunotherapy method
KR20170005148A (en) 2008-04-21 2017-01-11 티슈 리제너레이션 쎄라퓨틱스, 인코포레이티드 Genetically modified human umbilical cord perivascular cells for prophylaxis against or treatment of biological or chemical agents
US20110144032A1 (en) * 2008-08-08 2011-06-16 Christopher Hovens Biological applications of steroid binding domains
US20110086051A1 (en) * 2009-10-08 2011-04-14 Dartmouth-Hitchcock Clinic System and method for monitoring and optimizing immune status in transplant recipients
MX2015004759A (en) * 2012-10-15 2015-10-12 Chamaeleo Pharma Bvba Fosfestrol for use in curative or palliative treatment of cancer in female mammals.
AU2018209239B2 (en) 2017-01-20 2023-02-02 ISR Immune System Regulation Holding AB (publ) Novel compounds (immunorhelins- intracellular infections)
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AU2018225391A1 (en) * 2017-02-22 2019-10-03 ISR Immune System Regulation Holding AB (publ) Gonadotropin-releasing hormones for use as adjuvant immunotherapeutics

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EP1620126A4 (en) * 2003-04-18 2007-07-04 Norwood Immunology Ltd Disease prevention and vaccination prior to thymic reactivations

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