WO2004094465A3 - Synthetic molecules that mimic chemokines - Google Patents

Synthetic molecules that mimic chemokines Download PDF

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Publication number
WO2004094465A3
WO2004094465A3 PCT/US2004/012708 US2004012708W WO2004094465A3 WO 2004094465 A3 WO2004094465 A3 WO 2004094465A3 US 2004012708 W US2004012708 W US 2004012708W WO 2004094465 A3 WO2004094465 A3 WO 2004094465A3
Authority
WO
WIPO (PCT)
Prior art keywords
mimic
chemokines
synthetic molecules
polypeptides
treatment
Prior art date
Application number
PCT/US2004/012708
Other languages
French (fr)
Other versions
WO2004094465A2 (en
WO2004094465A8 (en
Inventor
Ziwei Huang
Original Assignee
Univ Illinois
Ziwei Huang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Illinois, Ziwei Huang filed Critical Univ Illinois
Publication of WO2004094465A2 publication Critical patent/WO2004094465A2/en
Publication of WO2004094465A8 publication Critical patent/WO2004094465A8/en
Publication of WO2004094465A3 publication Critical patent/WO2004094465A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/522—Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Abstract

The invention is directed to synthetic polypeptides that mimic chemokine function. These polypeptides are useful for the treatment of chemokine-related disorders, as well as the treatment and prevention of HIV infection. Novel synthetic methods for these polypeptides are also provided.
PCT/US2004/012708 2003-04-23 2004-04-23 Synthetic molecules that mimic chemokines WO2004094465A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46471403P 2003-04-23 2003-04-23
US60/464,714 2003-04-23

Publications (3)

Publication Number Publication Date
WO2004094465A2 WO2004094465A2 (en) 2004-11-04
WO2004094465A8 WO2004094465A8 (en) 2004-12-23
WO2004094465A3 true WO2004094465A3 (en) 2006-03-02

Family

ID=33310942

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/012708 WO2004094465A2 (en) 2003-04-23 2004-04-23 Synthetic molecules that mimic chemokines

Country Status (1)

Country Link
WO (1) WO2004094465A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI340142B (en) * 2005-04-08 2011-04-11 Lonza Ag Method of peptide synthesis
US8628750B2 (en) 2006-02-27 2014-01-14 Technische Universitat Munchen Cancer imaging and treatment
US7696309B2 (en) 2006-10-23 2010-04-13 The Brigham And Women's Hospital, Inc. Protease resistant mutants of stromal cell derived factor-1 in the repair of tissue damage
EP2053060A1 (en) * 2007-10-24 2009-04-29 Protaffin Biotechnologie AG SDF-1-based glyocosaminoglycan antagonists and methods of using same
US8921415B2 (en) 2009-01-29 2014-12-30 Mapi Pharma Ltd. Polymorphs of darunavir
WO2011092687A1 (en) * 2010-01-28 2011-08-04 Mapi Pharma Hk Limited Process for the preparation of darunavir and darunavir intermediates
US9308277B2 (en) 2010-02-25 2016-04-12 Mesoblast International Sàrl Protease-resistant mutants of stromal cell derived factor-1 in the repair of tissue damage
EP2717894B1 (en) 2011-06-07 2018-01-24 Mesoblast International Sàrl Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived factor-1
PT3007717T (en) * 2013-06-12 2018-12-04 Pharis Biotec Gmbh Peptides with antagonistic activities against natural cxcr4
CN107325187B (en) * 2017-07-19 2021-11-09 黄子为 Polypeptide with CXCR4 protein agonistic activity and application and pharmaceutical composition thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2751658A1 (en) * 1996-07-26 1998-01-30 Pasteur Institut USE OF A LESTR / FUSIN / CXCR4 RECEIVER CHEMOKINE (SDF-1) LIGAND TO PREVENT OR TREAT HIV-TYPE INFECTION
WO1999020759A1 (en) * 1997-10-22 1999-04-29 Genetics Institute, Inc. Chemokines with amino-terminal modifications
WO1999047158A2 (en) * 1998-03-13 1999-09-23 The University Of British Columbia Therapeutic chemokine receptor antagonists

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2751658A1 (en) * 1996-07-26 1998-01-30 Pasteur Institut USE OF A LESTR / FUSIN / CXCR4 RECEIVER CHEMOKINE (SDF-1) LIGAND TO PREVENT OR TREAT HIV-TYPE INFECTION
WO1999020759A1 (en) * 1997-10-22 1999-04-29 Genetics Institute, Inc. Chemokines with amino-terminal modifications
WO1999047158A2 (en) * 1998-03-13 1999-09-23 The University Of British Columbia Therapeutic chemokine receptor antagonists

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHEN WEN-JI ET AL: "Recombinant human CXC-chemokine receptor-4 in melanophores are linked to Gi protein: Seven transmembrane coreceptors for human immunodeficiency virus entry into cells", MOLECULAR PHARMACOLOGY, vol. 53, no. 2, February 1998 (1998-02-01), pages 177 - 181, XP002325707, ISSN: 0026-895X *
LOETSCHER ET AL: "N-TERMINAL PEPTIDES OF STROMAL CELL-DERIVED FACTOR WITH CXC CHEMOKINE RECEPTOR 4 AGONIST AND ANTAGONIST ACTIVITIES", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 273, no. 35, 28 August 1998 (1998-08-28), pages 22279 - 22283, XP002115696, ISSN: 0021-9258 *
MERZOUK A ET AL: "RATIONAL DESIGNING OF CXCR-4 AGONISTS AND ANTAGONISTS: SYNTHESIS OF NOVEL CYCLAM DERIVATIVES OF STROMAL CELL-DERIVED FACTOR (SDF-1)", PEPTIDES: THE WAVE OF THE FUTURE: PROCEEDINGS OF THE INTERNATIONAL AND THE AMERICAN PEPTIDE SYMPOSIUM, 9 June 2001 (2001-06-09), pages 789 - 790, XP009046707 *
THIERRY ANNE-CHRISTINE ET AL: "Long synthetic peptides as biologically active proteins: The example of the chemokines", BIOLOGICALS, ACADEMIC PRESS LTD., LONDON, GB, vol. 29, no. 3-4, September 2001 (2001-09-01), pages 259 - 263, XP002274174, ISSN: 1045-1056 *

Also Published As

Publication number Publication date
WO2004094465A2 (en) 2004-11-04
WO2004094465A8 (en) 2004-12-23

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