WO2004094462A3 - Methods of peptide preparation - Google Patents
Methods of peptide preparation Download PDFInfo
- Publication number
- WO2004094462A3 WO2004094462A3 PCT/GB2004/001791 GB2004001791W WO2004094462A3 WO 2004094462 A3 WO2004094462 A3 WO 2004094462A3 GB 2004001791 W GB2004001791 W GB 2004001791W WO 2004094462 A3 WO2004094462 A3 WO 2004094462A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- peptide
- amino acids
- sector
- cationic
- methods
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 3
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 125000002091 cationic group Chemical group 0.000 abstract 2
- 230000000975 bioactive effect Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- -1 cationic amino acids Chemical class 0.000 abstract 1
- 238000010348 incorporation Methods 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The present invention relates to a method of producing a bioactive peptide, wherein said peptide is 4 to 25 amino acids in length, has at least 2 cationic amino acids and is capable of forming an amphipathic helical structure, which method comprises identification of a cationic sector and division of the remaining part of the peptide into three further sectors which are substantially equal in size, and incorporation of at least 65 % of the bulk and lipophilicity provided by the amino acids R groups into the sector flanking the right side of the cationic sector; and to uses of the peptides produced thereby in therapy, particularly in the treatment of benign or malignant tumours.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO20031818A NO20031818D0 (en) | 2003-04-23 | 2003-04-23 | Process of bioactive peptide preparation |
| NO20031818 | 2003-04-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2004094462A2 WO2004094462A2 (en) | 2004-11-04 |
| WO2004094462A3 true WO2004094462A3 (en) | 2005-02-10 |
Family
ID=19914696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/GB2004/001791 WO2004094462A2 (en) | 2003-04-23 | 2004-04-23 | Methods of peptide preparation |
Country Status (2)
| Country | Link |
|---|---|
| NO (1) | NO20031818D0 (en) |
| WO (1) | WO2004094462A2 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009094634A1 (en) | 2008-01-24 | 2009-07-30 | Esperance Pharmaceuticals | Lytic domain fusion constructs and methods of making and using same |
| US9492563B2 (en) | 2012-10-30 | 2016-11-15 | Esperance Pharmaceuticals, Inc. | Antibody/drug conjugates and methods of use |
| TWI577697B (en) * | 2013-11-28 | 2017-04-11 | 國立清華大學 | Salt and protease-resistance of antimicrobial peptide and the manufacture thereof |
| GB201401877D0 (en) | 2014-02-04 | 2014-03-19 | Univ Tromsoe | Peptides |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000012541A2 (en) * | 1998-08-28 | 2000-03-09 | Alpharma As | Cytotoxic peptides modified by bulky or lipophilic moieties |
| WO2001019852A2 (en) * | 1999-08-31 | 2001-03-22 | Alpharma As | Methods of peptide preparation |
| WO2001066147A2 (en) * | 2000-03-09 | 2001-09-13 | Alpharma As | Antimicrobial compounds and formulations |
-
2003
- 2003-04-23 NO NO20031818A patent/NO20031818D0/en unknown
-
2004
- 2004-04-23 WO PCT/GB2004/001791 patent/WO2004094462A2/en active Application Filing
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000012541A2 (en) * | 1998-08-28 | 2000-03-09 | Alpharma As | Cytotoxic peptides modified by bulky or lipophilic moieties |
| WO2001019852A2 (en) * | 1999-08-31 | 2001-03-22 | Alpharma As | Methods of peptide preparation |
| WO2001066147A2 (en) * | 2000-03-09 | 2001-09-13 | Alpharma As | Antimicrobial compounds and formulations |
Non-Patent Citations (2)
| Title |
|---|
| JONG EUN OH ET AL: "SYNTHESIS OF NOVEL UNNATURAL AMINO ACID AS A BUILDING BLOCK AND ITSINCORPORATION INTO AN ANTIMICROBIAL PEPTIDE", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER SCIENCE LTD, GB, vol. 7, no. 12, 1999, pages 2985 - 2990, XP001053315, ISSN: 0968-0896 * |
| PUYAL C ET AL: "DESIGN OF A SHORT MEMBRANE-DESTABILIZING PEPTIDE COVALENTLY BOUND TO LIPOSOMES", BIOCHIMICA ET BIOPHYSICA ACTA, AMSTERDAM, NL, vol. 1195, no. 2, 1994, pages 259 - 266, XP001053363, ISSN: 0006-3002 * |
Also Published As
| Publication number | Publication date |
|---|---|
| NO20031818D0 (en) | 2003-04-23 |
| WO2004094462A2 (en) | 2004-11-04 |
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