WO2004093779A3 - Process for the preparation of gabapentin form-ii - Google Patents

Process for the preparation of gabapentin form-ii Download PDF

Info

Publication number
WO2004093779A3
WO2004093779A3 PCT/IN2004/000101 IN2004000101W WO2004093779A3 WO 2004093779 A3 WO2004093779 A3 WO 2004093779A3 IN 2004000101 W IN2004000101 W IN 2004000101W WO 2004093779 A3 WO2004093779 A3 WO 2004093779A3
Authority
WO
WIPO (PCT)
Prior art keywords
gabapentin
preparation
gabapentin form
neutralizing
ppm
Prior art date
Application number
PCT/IN2004/000101
Other languages
French (fr)
Other versions
WO2004093779A2 (en
Inventor
Satyanarayana Chava
Seeta Ramanjaneyulu Gorantla
Venkata Sunil Kumar Indukuri
Srinivas Simhadri
Original Assignee
Matrix Lab Ltd
Satyanarayana Chava
Seeta Ramanjaneyulu Gorantla
Venkata Sunil Kumar Indukuri
Srinivas Simhadri
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matrix Lab Ltd, Satyanarayana Chava, Seeta Ramanjaneyulu Gorantla, Venkata Sunil Kumar Indukuri, Srinivas Simhadri filed Critical Matrix Lab Ltd
Publication of WO2004093779A2 publication Critical patent/WO2004093779A2/en
Publication of WO2004093779A3 publication Critical patent/WO2004093779A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention relates to a new industrial feasible process for the preparation of Gabapentin Form-II by converting the Gabapentin hydrochloride salt directly into Form-II without the formation of Form-III by neutralizing the Gabapentin hydrochloride solution with a base at higher temperatures followed by cooling to yield Gabapentin Form-II with chloride ions less than 100 ppm with respect to Gabapentin.
PCT/IN2004/000101 2003-04-21 2004-04-16 Process for the preparation of gabapentin form-ii WO2004093779A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN327/MAS/2003 2003-04-21
IN327CH2003 2003-04-21

Publications (2)

Publication Number Publication Date
WO2004093779A2 WO2004093779A2 (en) 2004-11-04
WO2004093779A3 true WO2004093779A3 (en) 2004-12-16

Family

ID=33307099

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2004/000101 WO2004093779A2 (en) 2003-04-21 2004-04-16 Process for the preparation of gabapentin form-ii

Country Status (1)

Country Link
WO (1) WO2004093779A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20042418A1 (en) 2004-12-17 2005-03-17 Zambon Spa GABAPENTINA PURIFICATION PROCESS
WO2009015685A1 (en) 2007-07-27 2009-02-05 Medichem, S.A. Method for preparing polymorph form ii of gabapentin
WO2010023694A2 (en) * 2008-09-01 2010-03-04 Hikal Ltd Crystalline forms of gabapentin and process thereof
CN112321442B (en) * 2020-11-06 2022-02-11 中国药科大学 Salt of gabapentin and 2, 6-pyridinedicarboxylic acid, preparation method and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998028255A1 (en) * 1996-12-24 1998-07-02 Teva Pharmaceutical Industries Ltd. Preparation of gabapentin
US20040068011A1 (en) * 2000-10-23 2004-04-08 Vincenzo Cannata Process for the preparation of gabapentin

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998028255A1 (en) * 1996-12-24 1998-07-02 Teva Pharmaceutical Industries Ltd. Preparation of gabapentin
US20040068011A1 (en) * 2000-10-23 2004-04-08 Vincenzo Cannata Process for the preparation of gabapentin

Also Published As

Publication number Publication date
WO2004093779A2 (en) 2004-11-04

Similar Documents

Publication Publication Date Title
TW200420541A (en) Crystalline forms
MXPA03004986A (en) Process for preparing emulsion polymers with high purity.
DE602004031744D1 (en) CRYSTALLIZATION OF SOLID FORMS OF CLOPIDOGRELADDITIONAL SALTS
WO2004093779A3 (en) Process for the preparation of gabapentin form-ii
WO2009072501A1 (en) Method for producing carbonate compound
PL378292A1 (en) Process for producing acid adduct salt of polyacidic base compound
ZA200800138B (en) Process for the preparation of crystalline perindopril
HK1084937A1 (en) Process for reductive dehalogenation
WO2004093780A3 (en) Process for the preparation of gabapentin form-ii
EP2080753A4 (en) Method for producing tris(perfluoroalkanesulfonyl)methide acid salt
PL362885A1 (en) New carbazole compounds [3,4-a:3,4-c], method of manufacture of new carbazole compounds [3,4-a:3,4-c] as well as compound pharmaceuticals containing them
WO2007083243A3 (en) An improved process for the preparation of risedronate sodium hemi-pentahydrate
WO2006035960A3 (en) Process for production of 2-chloro-4-nitroimidazole
WO2006134219A3 (en) Atipamezhole hydrochloride crystallization method
SG149005A1 (en) Process for the preparation of thiazolopyrimidines
RS20060157A (en) Method for the manufacture of thip
EP1266898A4 (en) Processes for the production of thienopyrimidine derivatives
MXNL04000051A (en) Process for the production of an immunosuppressant.
MXPA05013604A (en) Process for preparing acylsulfamoylbenzamides.
UA89037C2 (en) Process for preparing venlafaxine acid addition salt
HUP0104648A2 (en) Method for preparing polyhalogenated paratrifluoromethylanilines
PL1615879T3 (en) Process for the production of 9-cis retinoic acid
EA200401328A1 (en) METHOD FOR PRODUCING ACID SALTS OF HEMIFLOXACIN
EP1518856A4 (en) Process for producing quinolonecarboxylic acid derivative
WO2004110342A3 (en) Novel polymorph of gabapentin and its conversion to gabapentin form-ii

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase