WO2004092198A3 - Compositions and methods for the modifying hypoxia induced gene regulation - Google Patents

Compositions and methods for the modifying hypoxia induced gene regulation Download PDF

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Publication number
WO2004092198A3
WO2004092198A3 PCT/US2004/011087 US2004011087W WO2004092198A3 WO 2004092198 A3 WO2004092198 A3 WO 2004092198A3 US 2004011087 W US2004011087 W US 2004011087W WO 2004092198 A3 WO2004092198 A3 WO 2004092198A3
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WO
WIPO (PCT)
Prior art keywords
hypoxia
biological activity
methods
induction
compositions
Prior art date
Application number
PCT/US2004/011087
Other languages
French (fr)
Other versions
WO2004092198A2 (en
Inventor
Mariana Nacht
Original Assignee
Genzyme Corp
Mariana Nacht
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp, Mariana Nacht filed Critical Genzyme Corp
Publication of WO2004092198A2 publication Critical patent/WO2004092198A2/en
Priority to US11/247,103 priority Critical patent/US20070224596A1/en
Publication of WO2004092198A3 publication Critical patent/WO2004092198A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

This invention provides compositions and methods to identify candidate agents capable of altering the biological activity of a polypeptide encoded by a polynucleotide involved in hypoxia-related tumorigenesis. In one aspect, the biological activity is the induction of hypoxia-related gene enolase 2 or a biological equivalent thereof. In another aspect, the biological activity is the induction of a hypoxia-related gene, inducible in the absence of the von Hippel-Lindau tumor suppressor (VHL). In yet a further aspect, the biological activity is differential expression in a neoplastic cell under hypoxia. In an alternative aspect, the biological activity is induction of a gene that is inducible in the absence of VHL, but not hypoxia.
PCT/US2004/011087 2003-04-09 2004-04-09 Compositions and methods for the modifying hypoxia induced gene regulation WO2004092198A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US11/247,103 US20070224596A1 (en) 2004-04-09 2006-01-20 Compositions and methods for the modifying hypoxia induced gene regulation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46171203P 2003-04-09 2003-04-09
US60/461,712 2003-04-09

Publications (2)

Publication Number Publication Date
WO2004092198A2 WO2004092198A2 (en) 2004-10-28
WO2004092198A3 true WO2004092198A3 (en) 2007-07-19

Family

ID=33299855

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/011087 WO2004092198A2 (en) 2003-04-09 2004-04-09 Compositions and methods for the modifying hypoxia induced gene regulation

Country Status (1)

Country Link
WO (1) WO2004092198A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111265658B (en) * 2020-03-05 2022-12-02 中国人民解放军军事科学院军事医学研究院 Hypoxia signal regulation and control molecule and application thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
NGUYEN D.M. ET AL.: "Modulation of Metastasis Phenotypes of Non-Small Cell Lung Cancer Cells by 17-Allylamino 17-Demethoxy Geldanamycin", ANN. THORAC. SURG., vol. 70, 2000, pages 1853 - 1860, XP003015602 *
PARADIS V. ET AL.: "Expression of vascular endothelial growth factor in renal cell carcinomas", VIRCHOW ARCH., vol. 436, 2000, pages 351 - 356, XP003015603 *

Also Published As

Publication number Publication date
WO2004092198A2 (en) 2004-10-28

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