WO2004089534A3 - Multi-station reaction apparatus - Google Patents

Multi-station reaction apparatus Download PDF

Info

Publication number
WO2004089534A3
WO2004089534A3 PCT/GB2004/001569 GB2004001569W WO2004089534A3 WO 2004089534 A3 WO2004089534 A3 WO 2004089534A3 GB 2004001569 W GB2004001569 W GB 2004001569W WO 2004089534 A3 WO2004089534 A3 WO 2004089534A3
Authority
WO
WIPO (PCT)
Prior art keywords
refluxing
cell block
reaction apparatus
contact
cell
Prior art date
Application number
PCT/GB2004/001569
Other languages
French (fr)
Other versions
WO2004089534A2 (en
Inventor
Keith John Stuart
De Vyver Ivan Van
Original Assignee
Electrothermal Eng Ltd
Keith John Stuart
De Vyver Ivan Van
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Electrothermal Eng Ltd, Keith John Stuart, De Vyver Ivan Van filed Critical Electrothermal Eng Ltd
Publication of WO2004089534A2 publication Critical patent/WO2004089534A2/en
Publication of WO2004089534A3 publication Critical patent/WO2004089534A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N25/00—Investigating or analyzing materials by the use of thermal means
    • G01N25/14—Investigating or analyzing materials by the use of thermal means by using distillation, extraction, sublimation, condensation, freezing, or crystallisation
    • G01N25/145—Accessories, e.g. cooling devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00281—Individual reactor vessels
    • B01J2219/00283—Reactor vessels with top opening
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00308—Reactor vessels in a multiple arrangement interchangeably mounted in racks or blocks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00331—Details of the reactor vessels
    • B01J2219/00333—Closures attached to the reactor vessels
    • B01J2219/00335—Septa
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00331—Details of the reactor vessels
    • B01J2219/00333—Closures attached to the reactor vessels
    • B01J2219/00344—Caps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00331—Details of the reactor vessels
    • B01J2219/00333—Closures attached to the reactor vessels
    • B01J2219/00344—Caps
    • B01J2219/00346—Screw-caps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00373—Hollow needles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00477—Means for pressurising the reaction vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00479—Means for mixing reactants or products in the reaction vessels
    • B01J2219/00484—Means for mixing reactants or products in the reaction vessels by shaking, vibrating or oscillating of the reaction vessels
    • B01J2219/00486—Means for mixing reactants or products in the reaction vessels by shaking, vibrating or oscillating of the reaction vessels by sonication or ultrasonication
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00495—Means for heating or cooling the reaction vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00698—Measurement and control of process parameters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4022—Concentrating samples by thermal techniques; Phase changes
    • G01N2001/4033—Concentrating samples by thermal techniques; Phase changes sample concentrated on a cold spot, e.g. condensation or distillation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/028—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Clinical Laboratory Science (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

Refluxing means (30) of a refluxing head (3) for use with a multi-station reaction apparatus (1) comprise an array of frusto-conical cooled members (31) each having a slanted end face (33). The refluxing head may include a device (306) for facilitating location of the refluxing means within each reaction vessel. The refluxing head may comprise a plate (301) movable between an engaged position, in which it engages the reaction vessels so as to prevent withdrawal thereof from the cells (5), and a disengaged position. The multi-station reaction apparatus may comprise cell blocks (4) each shaped so as to have an upper portion having a surface (41) in which cavities constituting cells are formed and a lower portion comprising a foot (40) which is smaller in area than the area of the surface of the upper portion. In the reaction apparatus a cell block (4), thermoelectric device (7) and heat exchanger (9) may be clamped to the base of the apparatus by means of a clamping system (8) having one point of contact with the cell block on one side thereof and two points of contact with the cell block on the other side thereof, such that the points of contact are in a triangular formation. Each cell block may be shaped so as to provide, adjacent to the cell, a group of recesses (45) for receiving respective electromagnetic stirring coils (46), such that adjacent cells in the array share such coils.
PCT/GB2004/001569 2003-04-11 2004-04-08 Multi-station reaction apparatus WO2004089534A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0308461.3 2003-04-11
GB0308461A GB2400334B (en) 2003-04-11 2003-04-11 Multi-station reaction apparatus

Publications (2)

Publication Number Publication Date
WO2004089534A2 WO2004089534A2 (en) 2004-10-21
WO2004089534A3 true WO2004089534A3 (en) 2004-12-29

Family

ID=9956659

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2004/001569 WO2004089534A2 (en) 2003-04-11 2004-04-08 Multi-station reaction apparatus

Country Status (2)

Country Link
GB (1) GB2400334B (en)
WO (1) WO2004089534A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102010040685A1 (en) * 2010-09-14 2012-03-15 Hamilton Bonaduz Ag Temperature control device for the thermal consolidation of drug beads
CN113019285A (en) * 2021-03-03 2021-06-25 东营职业学院 Petrochemical reaction tank

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19602464A1 (en) * 1996-01-24 1997-07-31 Wolfgang Dr Rapp Apparatus for multiple, simultaneous and parallel synthesis of chemicals
EP0882500A1 (en) * 1996-10-30 1998-12-09 Sumitomo Chemical Company Limited Synthesis experiment automating system, liquid separating treating apparatus and reaction vessel
US5866342A (en) * 1996-09-27 1999-02-02 Glaxo Group Limited Systems and methods for the synthesis of organic compounds
EP1055452A2 (en) * 1999-05-28 2000-11-29 Mettler-Toledo GmbH Pressurized reaction block
WO2001003838A1 (en) * 1999-07-07 2001-01-18 Electrothermal Engineering Limited Temperature control in multi-station reaction apparatus
WO2001093998A2 (en) * 2000-06-03 2001-12-13 Symyx Technologies, Inc. Parallel semicontinuous or continuous reactors
WO2002046774A1 (en) * 2000-12-08 2002-06-13 A H Marks & Company Limited Chemical reactor with tempering means
US20020164275A1 (en) * 2001-04-05 2002-11-07 Symyx Technologies, Inc. Combinatorial chemistry reactor system

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6455316B1 (en) * 1998-08-13 2002-09-24 Symyx Technologies, Inc. Parallel reactor with internal sensing and method of using same
US6238627B1 (en) * 1998-08-26 2001-05-29 Arqule, Inc. Reaction block and cover
US6258323B1 (en) * 1998-11-16 2001-07-10 Rohm And Haas Company Apparatus and method used in multiple, simultaneous synthesis of general compounds

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19602464A1 (en) * 1996-01-24 1997-07-31 Wolfgang Dr Rapp Apparatus for multiple, simultaneous and parallel synthesis of chemicals
US5866342A (en) * 1996-09-27 1999-02-02 Glaxo Group Limited Systems and methods for the synthesis of organic compounds
EP0882500A1 (en) * 1996-10-30 1998-12-09 Sumitomo Chemical Company Limited Synthesis experiment automating system, liquid separating treating apparatus and reaction vessel
EP1055452A2 (en) * 1999-05-28 2000-11-29 Mettler-Toledo GmbH Pressurized reaction block
WO2001003838A1 (en) * 1999-07-07 2001-01-18 Electrothermal Engineering Limited Temperature control in multi-station reaction apparatus
WO2001093998A2 (en) * 2000-06-03 2001-12-13 Symyx Technologies, Inc. Parallel semicontinuous or continuous reactors
WO2002046774A1 (en) * 2000-12-08 2002-06-13 A H Marks & Company Limited Chemical reactor with tempering means
US20020164275A1 (en) * 2001-04-05 2002-11-07 Symyx Technologies, Inc. Combinatorial chemistry reactor system

Also Published As

Publication number Publication date
GB2400334A (en) 2004-10-13
GB2400334B (en) 2006-10-04
WO2004089534A2 (en) 2004-10-21
GB0308461D0 (en) 2003-05-21

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