WO2004089426A3 - Radiolabelled cytokines for scintigraphic imaging of chronic lymphocyte-mediated inflammation - Google Patents

Radiolabelled cytokines for scintigraphic imaging of chronic lymphocyte-mediated inflammation Download PDF

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Publication number
WO2004089426A3
WO2004089426A3 PCT/IT2004/000176 IT2004000176W WO2004089426A3 WO 2004089426 A3 WO2004089426 A3 WO 2004089426A3 IT 2004000176 W IT2004000176 W IT 2004000176W WO 2004089426 A3 WO2004089426 A3 WO 2004089426A3
Authority
WO
WIPO (PCT)
Prior art keywords
radiolabelled
cytokines
chronic lymphocyte
mediated inflammation
scintigraphic imaging
Prior art date
Application number
PCT/IT2004/000176
Other languages
French (fr)
Other versions
WO2004089426A2 (en
Inventor
Alberto Signore
Alessio Annovazzi
Original Assignee
Univ Roma
Alberto Signore
Alessio Annovazzi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Roma, Alberto Signore, Alessio Annovazzi filed Critical Univ Roma
Publication of WO2004089426A2 publication Critical patent/WO2004089426A2/en
Publication of WO2004089426A3 publication Critical patent/WO2004089426A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention relates to cytokines radiolabelled with radioactive isotopes suitable for the in vivo diagnostics able to interact with the Th1 lymphocytes to be advantageously used in the imaging of the chronic lymphocyte-mediated inflammations.
PCT/IT2004/000176 2003-04-07 2004-04-05 Radiolabelled cytokines for scintigraphic imaging of chronic lymphocyte-mediated inflammation WO2004089426A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITRM2003A000159 2003-04-07
IT000159A ITRM20030159A1 (en) 2003-04-07 2003-04-07 RADIO-MARKED CYTOKINES AND THEIR USES AS SCINTIGRAPHIC TRACKERS FOR THE VISUALIZATION OF CHRONIC LYMPHOCYTE-MEDIATED INFLAMMATIONS.

Publications (2)

Publication Number Publication Date
WO2004089426A2 WO2004089426A2 (en) 2004-10-21
WO2004089426A3 true WO2004089426A3 (en) 2004-11-18

Family

ID=29765751

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IT2004/000176 WO2004089426A2 (en) 2003-04-07 2004-04-05 Radiolabelled cytokines for scintigraphic imaging of chronic lymphocyte-mediated inflammation

Country Status (2)

Country Link
IT (1) ITRM20030159A1 (en)
WO (1) WO2004089426A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4832940A (en) * 1985-10-22 1989-05-23 Nycomed As Method of locating or imaging activated T-lymphocytes with a targeting polypeptide

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4832940A (en) * 1985-10-22 1989-05-23 Nycomed As Method of locating or imaging activated T-lymphocytes with a targeting polypeptide

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
ANNOVAZZI A (REPRINT) ET AL: "I-123-labelled interleukin-12, a new radiopharmaceutical for imaging Th1-mediated chronic inflammation: In vitro and animal studies", CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS, VOL. 18, NO. 2, PP. 280-280. PUBLISHER: MARY ANN LIEBERT INC PUBL, 2 MADISON AVENUE, LARCHMONT, NY 10538 USA. ISSN: 1084-9785., April 2003 (2003-04-01), XP009036325 *
CHIZZONITE R ET AL: "IL-12 RECEPTOR. CHARACTERIZATION OF THE RECPTOR ON PHYTOHEMAGGLUTININ-ACTIVATED HUMAN LYMPHOBLASTS", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 148, no. 10, 15 May 1992 (1992-05-15), pages 3117 - 3124, XP000672916, ISSN: 0022-1767 *
DE JONG J L O ET AL: "INTERACTION OF IL-15 WITH THE SHARED IL-2 RECEPTOR BETA AND GAMMAC SUBUNITS", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 156, no. 4, 15 February 1996 (1996-02-15), pages 1339 - 1348, XP002056004, ISSN: 0022-1767 *
DESAI B B ET AL: "IL-12 RECEPTOR. DISTRIBUTION AND REGULATION OF RECEPTOR EXPRESSION", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 148, no. 10, 15 May 1992 (1992-05-15), pages 3125 - 3132, XP000672914, ISSN: 0022-1767 *
KUNIYASU HIROKI ET AL: "Interleukin-15 expression is associated with malignant potential in colon cancer cells", PATHOBIOLOGY, vol. 69, no. 2, December 2001 (2001-12-01), pages 86 - 95, XP009036296, ISSN: 1015-2008 *
PRESKY DH ET AL: "A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 93, 26 November 1996 (1996-11-26), pages 14002 - 14007, XP002028387, ISSN: 0027-8424 *
SIGNORE A ET AL: "Biological imaging for the diagnosis of inflammatory conditions", BIODRUGS 2002 NEW ZEALAND, vol. 16, no. 4, 2002, pages 241 - 259, XP009036297, ISSN: 1173-8804 *
SIGNORE A ET AL: "Radiolabelled lymphokines and growth factors for in vivo imaging of inflammation, infection and cancer", TRENDS IN IMMUNOLOGY, ELSEVIER, CAMBRIDGE, GB, vol. 24, no. 7, July 2003 (2003-07-01), pages 395 - 402, XP004437496, ISSN: 1471-4906 *
SIGNORE A ET AL: "The developing role of cytokines for imaging inflammation and infection.", CYTOKINE. OCT 2000, vol. 12, no. 10, October 2000 (2000-10-01), pages 1445 - 1454, XP002295946, ISSN: 1043-4666 *

Also Published As

Publication number Publication date
ITRM20030159A0 (en) 2003-04-07
WO2004089426A2 (en) 2004-10-21
ITRM20030159A1 (en) 2004-10-08

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