WO2004089305A3 - Heparin/heparosan synthase from p.multocida, soluble and single action catalysts thereof and methods of making and using same - Google Patents

Heparin/heparosan synthase from p.multocida, soluble and single action catalysts thereof and methods of making and using same Download PDF

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Publication number
WO2004089305A3
WO2004089305A3 PCT/US2004/009742 US2004009742W WO2004089305A3 WO 2004089305 A3 WO2004089305 A3 WO 2004089305A3 US 2004009742 W US2004009742 W US 2004009742W WO 2004089305 A3 WO2004089305 A3 WO 2004089305A3
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WIPO (PCT)
Prior art keywords
heparin
methods
soluble
presently
heparosan
Prior art date
Application number
PCT/US2004/009742
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French (fr)
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WO2004089305A2 (en
Inventor
Paul Deangelis
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Paul Deangelis
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Publication date
Application filed by Paul Deangelis filed Critical Paul Deangelis
Publication of WO2004089305A2 publication Critical patent/WO2004089305A2/en
Publication of WO2004089305A3 publication Critical patent/WO2004089305A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The presently claimed and disclosed invention relates, in general, to single action, dual action and soluble heparin synthases and, more particularly, to single action, dual action and soluble heparin synthases obtained from Pasteurella multocida. The presently claimed and disclosed invention also relates to heparosan, heparin and heparin-like molecules provided by recombinant techniques and methods of using such molecules. The presently claimed and disclosed invention also relates to methods, and molecules produced according to such methods, for using the presently claimed and disclosed heparosan and/or heparin synthase for polymer grafting and the production of non­naturally occurring chimeric polymers incorporating stretches of one or more acidic GAG molecules, such as heparin, chondroitin, hyaluronan, and/or heparosan.
PCT/US2004/009742 2003-03-31 2004-03-31 Heparin/heparosan synthase from p.multocida, soluble and single action catalysts thereof and methods of making and using same WO2004089305A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45893903P 2003-03-31 2003-03-31
US60/458,939 2003-03-31

Publications (2)

Publication Number Publication Date
WO2004089305A2 WO2004089305A2 (en) 2004-10-21
WO2004089305A3 true WO2004089305A3 (en) 2006-09-28

Family

ID=33159608

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/009742 WO2004089305A2 (en) 2003-03-31 2004-03-31 Heparin/heparosan synthase from p.multocida, soluble and single action catalysts thereof and methods of making and using same

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WO (1) WO2004089305A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111154819B (en) * 2020-01-15 2022-08-30 山东大学 Non-animal source low molecular weight heparin and preparation method and application thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002089742A2 (en) * 2001-05-08 2002-11-14 The Board Of Regents Of The University Of Oklahoma Heparin/heparosan synthase and methods of making and using same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002089742A2 (en) * 2001-05-08 2002-11-14 The Board Of Regents Of The University Of Oklahoma Heparin/heparosan synthase and methods of making and using same

Also Published As

Publication number Publication date
WO2004089305A2 (en) 2004-10-21

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