WO2004087204A3 - Microfluidized oil-in-water emulsions and vaccine compositions - Google Patents

Microfluidized oil-in-water emulsions and vaccine compositions Download PDF

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Publication number
WO2004087204A3
WO2004087204A3 PCT/IB2004/000937 IB2004000937W WO2004087204A3 WO 2004087204 A3 WO2004087204 A3 WO 2004087204A3 IB 2004000937 W IB2004000937 W IB 2004000937W WO 2004087204 A3 WO2004087204 A3 WO 2004087204A3
Authority
WO
WIPO (PCT)
Prior art keywords
vaccine compositions
water emulsions
emulsions
microfluidized oil
oil
Prior art date
Application number
PCT/IB2004/000937
Other languages
French (fr)
Other versions
WO2004087204A2 (en
Inventor
Paul Joseph Dominowski
Pamela Kay Klose
Richard Lee Krebs
Ramasamy Mannar Mannan
Original Assignee
Pfizer Prod Inc
Paul Joseph Dominowski
Pamela Kay Klose
Richard Lee Krebs
Ramasamy Mannar Mannan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33131921&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2004087204(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to DK04722345.8T priority Critical patent/DK1613346T3/en
Priority to SI200431984T priority patent/SI1613346T1/en
Priority to AU2004226591A priority patent/AU2004226591B2/en
Priority to PL04722345T priority patent/PL1613346T3/en
Priority to MXPA05010697A priority patent/MXPA05010697A/en
Priority to BRPI0408635-0A priority patent/BRPI0408635B1/en
Priority to NZ542576A priority patent/NZ542576A/en
Priority to JP2006506403A priority patent/JP2006522090A/en
Priority to CN2004800086187A priority patent/CN1767854B/en
Priority to EP04722345A priority patent/EP1613346B8/en
Application filed by Pfizer Prod Inc, Paul Joseph Dominowski, Pamela Kay Klose, Richard Lee Krebs, Ramasamy Mannar Mannan filed Critical Pfizer Prod Inc
Priority to CA2521051A priority patent/CA2521051C/en
Priority to ES04722345T priority patent/ES2398235T3/en
Publication of WO2004087204A2 publication Critical patent/WO2004087204A2/en
Publication of WO2004087204A3 publication Critical patent/WO2004087204A3/en
Priority to NO20054376A priority patent/NO20054376L/en
Priority to HK06106499.7A priority patent/HK1086484A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/0225—Spirochetes, e.g. Treponema, Leptospira, Borrelia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0258—Escherichia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Virology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Cosmetics (AREA)

Abstract

This invention provides submicron oil-in-water emulsions useful as a vaccine adjuvant for enhancing the immunogenicity of antigens. The present invention also provides vaccine compositions containing an antigen combined with such emulsions intrinsically or extrinsically. Methods of preparing the emulsions and vaccines are also provided by the present invention.
PCT/IB2004/000937 2003-04-04 2004-03-22 Microfluidized oil-in-water emulsions and vaccine compositions WO2004087204A2 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
ES04722345T ES2398235T3 (en) 2003-04-04 2004-03-22 Oil emulsions in microfluidized water and vaccine compositions
EP04722345A EP1613346B8 (en) 2003-04-04 2004-03-22 Microfluidized oil-in-water emulsions and vaccine compositions
CN2004800086187A CN1767854B (en) 2003-04-04 2004-03-22 Microfluidized oil-in-water emulsions and vaccine compositions
PL04722345T PL1613346T3 (en) 2003-04-04 2004-03-22 Microfluidized oil-in-water emulsions and vaccine compositions
SI200431984T SI1613346T1 (en) 2003-04-04 2004-03-22 Microfluidized oil-in-water emulsions and vaccine compositions
BRPI0408635-0A BRPI0408635B1 (en) 2003-04-04 2004-03-22 METHOD FOR PREPARATION OF A MICROFLUIDIZED WATER OIL EMULSION IN THE SUBMICROMETER RANGE WITH A LOWER MEDIUM OIL GULIC SIZE AT 0.5? MICROFLUIDIZED VACCINE
NZ542576A NZ542576A (en) 2003-04-04 2004-03-22 Submicron oil-in-water emulsions composed of a non-metabolizable oil, at least one surfactant, and an aqueous component, where the oil is dispersed in the aqueous component with al droplet size in the submicron range
DK04722345.8T DK1613346T3 (en) 2003-04-04 2004-03-22 MICROFLUIDIC OIL-IN-WATER EMULSIONS AND VACCINE COMPOSITIONS
AU2004226591A AU2004226591B2 (en) 2003-04-04 2004-03-22 Microfluidized oil-in-water emulsions and vaccine compositions
MXPA05010697A MXPA05010697A (en) 2003-04-04 2004-03-22 Microfluidized oil-in-water emulsions and vaccine compositions.
JP2006506403A JP2006522090A (en) 2003-04-04 2004-03-22 Microfluidized oil-in-water emulsion and vaccine composition
CA2521051A CA2521051C (en) 2003-04-04 2004-03-22 Microfluidized oil-in-water emulsions and vaccine compositions
NO20054376A NO20054376L (en) 2003-04-04 2005-09-21 Microfluidized oil-in-water emulsions and vaccine mixtures
HK06106499.7A HK1086484A1 (en) 2003-04-04 2006-06-07 Microfluidized oil-in-water emulsions and vaccine compositions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46030103P 2003-04-04 2003-04-04
US60/460,301 2003-04-04

Publications (2)

Publication Number Publication Date
WO2004087204A2 WO2004087204A2 (en) 2004-10-14
WO2004087204A3 true WO2004087204A3 (en) 2004-12-23

Family

ID=33131921

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2004/000937 WO2004087204A2 (en) 2003-04-04 2004-03-22 Microfluidized oil-in-water emulsions and vaccine compositions

Country Status (25)

Country Link
US (2) US20040258701A1 (en)
EP (1) EP1613346B8 (en)
JP (1) JP2006522090A (en)
KR (1) KR100720213B1 (en)
CN (1) CN1767854B (en)
AR (1) AR043803A1 (en)
AU (1) AU2004226591B2 (en)
BR (1) BRPI0408635B1 (en)
CA (1) CA2521051C (en)
CL (1) CL2004000691A1 (en)
CY (1) CY1113546T1 (en)
DK (1) DK1613346T3 (en)
ES (1) ES2398235T3 (en)
HK (1) HK1086484A1 (en)
MX (1) MXPA05010697A (en)
NO (1) NO20054376L (en)
NZ (1) NZ542576A (en)
PL (1) PL1613346T3 (en)
PT (1) PT1613346E (en)
RU (2) RU2005130646A (en)
SI (1) SI1613346T1 (en)
TW (1) TWI353850B (en)
UY (1) UY28256A1 (en)
WO (1) WO2004087204A2 (en)
ZA (1) ZA200507994B (en)

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