WO2004085624A3 - Transaminases, deaminases and aminomutases and compositions and methods for enzymatic detoxification - Google Patents

Transaminases, deaminases and aminomutases and compositions and methods for enzymatic detoxification Download PDF

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Publication number
WO2004085624A3
WO2004085624A3 PCT/US2004/009054 US2004009054W WO2004085624A3 WO 2004085624 A3 WO2004085624 A3 WO 2004085624A3 US 2004009054 W US2004009054 W US 2004009054W WO 2004085624 A3 WO2004085624 A3 WO 2004085624A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
fumonisin
aminomutases
deaminases
transaminases
Prior art date
Application number
PCT/US2004/009054
Other languages
French (fr)
Other versions
WO2004085624A2 (en
Inventor
Lishan Zhao
David Paul Weiner
Leslie Hickle
Original Assignee
Diversa Corp
Lishan Zhao
David Paul Weiner
Leslie Hickle
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diversa Corp, Lishan Zhao, David Paul Weiner, Leslie Hickle filed Critical Diversa Corp
Publication of WO2004085624A2 publication Critical patent/WO2004085624A2/en
Publication of WO2004085624A3 publication Critical patent/WO2004085624A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Fodder In General (AREA)

Abstract

In one aspect, the invention provides methods of enzymatic detoxification of aminated toxins, e.g., mycotoxins, such as fumonisin. The invention provides methods to enzymatically detoxify plants, foods or feeds or any contaminated product or surface, including detoxification of mycotoxins, such as fumonisin, e.g., fumonisin B1 and fumonisin B2. The invention provides methods to prevent the contamination of plants, foods or feeds or any contaminated product or surface by application or a polypeptide having a deaminase activity. In one aspect, the invention relates to polypeptides having an aminotransferase, an aminomutase and/or a deaminase activity, polynucleotides encoding these enzymes, methods of making and using these polynucleotides and polypeptides.
PCT/US2004/009054 2003-03-24 2004-03-24 Transaminases, deaminases and aminomutases and compositions and methods for enzymatic detoxification WO2004085624A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US45782403P 2003-03-24 2003-03-24
US60/457,824 2003-03-24
US47504203P 2003-05-30 2003-05-30
US60/475,042 2003-05-30
US48007103P 2003-06-19 2003-06-19
US60/480,071 2003-06-19

Publications (2)

Publication Number Publication Date
WO2004085624A2 WO2004085624A2 (en) 2004-10-07
WO2004085624A3 true WO2004085624A3 (en) 2006-04-27

Family

ID=33102176

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/009054 WO2004085624A2 (en) 2003-03-24 2004-03-24 Transaminases, deaminases and aminomutases and compositions and methods for enzymatic detoxification

Country Status (1)

Country Link
WO (1) WO2004085624A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7572607B2 (en) 2002-04-23 2009-08-11 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of monatin and its precursors
US8372989B2 (en) 2002-04-23 2013-02-12 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of monatin and its precursors
CN1890377B (en) 2003-10-21 2013-06-05 嘉吉有限公司 Production of monatin and monatin precursors
AT501359B1 (en) * 2004-11-16 2007-10-15 Erber Ag METHOD AND MICROORGANISM FOR THE DETOXIFICATION OF FUMONISINES AND THEIR USE AND FEED ADDITIVE
WO2006113897A2 (en) 2005-04-20 2006-10-26 Cargill, Incorporated Products and methods for in vivo secretion of monatin
US8158389B2 (en) 2005-04-20 2012-04-17 Cargill, Incorporated Products and methods for in vivo secretion of monatin
US8076108B2 (en) 2005-04-26 2011-12-13 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
JP4648837B2 (en) * 2006-01-12 2011-03-09 ダイセル化学工業株式会社 Amine transaminase and method for producing optically active amine using amine transaminase
JP5441417B2 (en) 2006-03-07 2014-03-12 カーギル・インコーポレイテッド Aldose, nucleic acid encoding it, and methods of generating and using it
AU2008347234B2 (en) * 2008-01-03 2015-05-28 Basf Enzymes Llc Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them
CA2726928A1 (en) * 2008-01-03 2009-07-16 Cargill, Incorporated Aminotransferase and oxidoreductase nucleic acids and polypeptides and methods of using
WO2010031100A1 (en) 2008-09-18 2010-03-25 Erber Aktiengesellschaft Method for the production of a feed additive for the oxygen-independent, enzymatic decomposition of mycotoxins, feed additive, and use thereof
AR073602A1 (en) 2008-09-18 2010-11-17 Erber Ag METHOD TO PRODUCE AN ADDITIVE FOR THE ENZYMATIC DEGRADATION OF MICOTOXINS AND ADDITIVE AND USE OF THE SAME
EP2961838B1 (en) 2013-02-28 2018-04-18 Merck Sharp & Dohme Corp. Immobilized transaminases and process for making and using immobilized transaminase
CN107208077A (en) 2015-02-24 2017-09-26 爱尔伯股份公司 Crack the purposes of the polypeptide variants, the additive comprising the polypeptide variants and the additive of fusarium toxin, and the method for cracking fusarium toxin
WO2016198665A1 (en) 2015-06-12 2016-12-15 C-Lecta Gmbh Transaminases
CN114381413B (en) * 2021-12-04 2024-05-24 天津科技大学 Acetic acid bacteria for improving vinegar flavor and construction method thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE EST [online] July 2000 (2000-07-01), accession no. GenCore Database accession no. (BE234331) *
PODAR M. ET AL: "Evolution of microbial nitrilase gene family: a comparative and environmental genomics study.", BMC EVOL BIOL., vol. 5, August 2005 (2005-08-01), pages 1 - 13 *
ROBERTSON D.E. ET AL: "Recent progress in biocatalyst discovery and optimization.", CURR. OPIN. CHEM. BIOL., vol. 8, April 2004 (2004-04-01), pages 141 - 149 *
ZENGLER K. ET AL: "Cultivating the uncultured.", PROC. NATL. ACAD. SCI., vol. 99, no. 24, November 2002 (2002-11-01), pages 15681 - 15686 *

Also Published As

Publication number Publication date
WO2004085624A2 (en) 2004-10-07

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