WO2004083402A3 - Spleen necrosis predictive genes - Google Patents

Spleen necrosis predictive genes Download PDF

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Publication number
WO2004083402A3
WO2004083402A3 PCT/US2004/008371 US2004008371W WO2004083402A3 WO 2004083402 A3 WO2004083402 A3 WO 2004083402A3 US 2004008371 W US2004008371 W US 2004008371W WO 2004083402 A3 WO2004083402 A3 WO 2004083402A3
Authority
WO
WIPO (PCT)
Prior art keywords
spleen necrosis
predictive genes
spleen
genes
cdnas
Prior art date
Application number
PCT/US2004/008371
Other languages
French (fr)
Other versions
WO2004083402A2 (en
Inventor
Usha Sankar
Larry Kier
Maher Derbel
Timothy Nolan
Original Assignee
Phase 1 Molecular Toxicology I
Usha Sankar
Larry Kier
Maher Derbel
Timothy Nolan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phase 1 Molecular Toxicology I, Usha Sankar, Larry Kier, Maher Derbel, Timothy Nolan filed Critical Phase 1 Molecular Toxicology I
Publication of WO2004083402A2 publication Critical patent/WO2004083402A2/en
Publication of WO2004083402A3 publication Critical patent/WO2004083402A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Abstract

The present invention provides a system and method for identifying spleen necrosis predictive genes which can be used to predict spleen necrosis in response to one or more agents. A composition comprising a plurality of cDNAs for use in detecting the altered expression of genes in a toxic response of the spleen, wherein said plurality of cDNAs comprises sequences disclosed in Table 17 or the complete complements thereof.
PCT/US2004/008371 2003-03-17 2004-03-17 Spleen necrosis predictive genes WO2004083402A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45544303P 2003-03-17 2003-03-17
US60/455,443 2003-03-17

Publications (2)

Publication Number Publication Date
WO2004083402A2 WO2004083402A2 (en) 2004-09-30
WO2004083402A3 true WO2004083402A3 (en) 2005-05-19

Family

ID=33030000

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/008371 WO2004083402A2 (en) 2003-03-17 2004-03-17 Spleen necrosis predictive genes

Country Status (1)

Country Link
WO (1) WO2004083402A2 (en)

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BUTTE: "The use and analysis of microarray data", NATURE REVIEWS DRUG DISCOVERY, vol. 1, December 2002 (2002-12-01), pages 951 - 960, XP002985915 *
CHIN ET AL: "Application of DNA Microarrays in Pharmacogenomics and Toxicogenomics", PHARMACEUTICAL RESEARCH, vol. 19, no. 12, December 2000 (2000-12-01), pages 1773 - 1778, XP002985914 *

Also Published As

Publication number Publication date
WO2004083402A2 (en) 2004-09-30

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