WO2004083381A3 - Fibroblast growth factor receptor-1 polynucleotides, polypeptides, and mutants - Google Patents

Fibroblast growth factor receptor-1 polynucleotides, polypeptides, and mutants Download PDF

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Publication number
WO2004083381A3
WO2004083381A3 PCT/US2004/007220 US2004007220W WO2004083381A3 WO 2004083381 A3 WO2004083381 A3 WO 2004083381A3 US 2004007220 W US2004007220 W US 2004007220W WO 2004083381 A3 WO2004083381 A3 WO 2004083381A3
Authority
WO
WIPO (PCT)
Prior art keywords
polypeptides
growth factor
factor receptor
fibroblast growth
polynucleotides
Prior art date
Application number
PCT/US2004/007220
Other languages
French (fr)
Other versions
WO2004083381A2 (en
Inventor
Michael J Econs
Kenneth E White
Original Assignee
Indiana University Advanced Re
Michael J Econs
Kenneth E White
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indiana University Advanced Re, Michael J Econs, Kenneth E White filed Critical Indiana University Advanced Re
Publication of WO2004083381A2 publication Critical patent/WO2004083381A2/en
Publication of WO2004083381A3 publication Critical patent/WO2004083381A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention relates to novel fibroblast growth factor receptor-1 polynucleotides and polypeptides, and to compositions, uses and methods thereof. Further, this invention relates to agonists and antagonists of fibroblast growth factor receptor-1 polypeptides, as well as to methods of treatment of disorders arising from altered fibroblast growth factor receptor-1 polynucleotides and polypeptides.
PCT/US2004/007220 2003-03-13 2004-03-10 Fibroblast growth factor receptor-1 polynucleotides, polypeptides, and mutants WO2004083381A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45439503P 2003-03-13 2003-03-13
US60/454,395 2003-03-13

Publications (2)

Publication Number Publication Date
WO2004083381A2 WO2004083381A2 (en) 2004-09-30
WO2004083381A3 true WO2004083381A3 (en) 2007-07-05

Family

ID=33029878

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/007220 WO2004083381A2 (en) 2003-03-13 2004-03-10 Fibroblast growth factor receptor-1 polynucleotides, polypeptides, and mutants

Country Status (1)

Country Link
WO (1) WO2004083381A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013206768B2 (en) * 2008-04-29 2016-03-31 Novartis Ag Methods of monitoring the modulation of the kinase activity of fibroblast growth factor receptor and uses of said methods
MX2010011959A (en) * 2008-04-29 2010-11-30 Novartis Ag Methods of monitoring the modulation of the kinase activity of fibroblast growth factor receptor and uses of said methods.
JOP20190083A1 (en) 2008-06-04 2017-06-16 Amgen Inc Fgf21 mutant fusion polypeptides and uses thereof
CA2739615C (en) 2008-10-10 2017-12-05 Amgen Inc. Fgf21 mutants comprising polyethylene glycol and uses thereof
CA2760674A1 (en) 2009-05-05 2010-11-11 Amgen Inc. Fgf21 mutants and uses thereof
AU2010246108B2 (en) 2009-05-05 2014-10-23 Amgen Inc. FGF21 mutants and uses thereof
JP2012530493A (en) 2009-06-17 2012-12-06 アムジエン・インコーポレーテツド Chimeric polypeptides and uses thereof
WO2011068893A1 (en) 2009-12-02 2011-06-09 Amgen Inc. BINDING PROTEINS THAT BIND TO HUMAN FGFR1C, HUMAN β-KLOTHO AND BOTH HUMAN FGFR1C AND HUMANβ-KLOTHO
UA109888C2 (en) 2009-12-07 2015-10-26 ANTIBODY OR ANTIBODILITY ANTIBODY OR ITS BINDING TO THE β-CLOTE, FGF RECEPTORS AND THEIR COMPLEXES
WO2012015674A1 (en) 2010-07-26 2012-02-02 Eli Lilly And Company THERAPEUTIC USES OF AN FGFR1c ANTIBODY
CN116688095A (en) * 2023-03-08 2023-09-05 中国人民解放军海军军医大学 Anti-herpesvirus effect of receptor tyrosine kinase FGFR1 and application thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
WHITE ET AL.: "Mutations that Cause Osteoglophonic Dysplasia Define Novel Roles for FGFR1 in Bone Elongation", AM. J. HUM. GENET., vol. 76, 2005, pages 361 - 367, XP003015129 *
YU ET AL.: "Analysis of the Biochemical Mechanisms for the Endocrine Actions of Fibroblast Growth Factor-23", ENDOCRINOLOGY, vol. 146, no. 11, 2005, pages 4647 - 4656, XP003015130 *
YU ET AL.: "FGF23 and disorders of phosphate homeostasis", CYTOKINE & GROWTH FACTOR REVIEWS, vol. 16, 2005, pages 221 - 232, XP004874956 *

Also Published As

Publication number Publication date
WO2004083381A2 (en) 2004-09-30

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