WO2004080461A3 - Stable pharmaceutical compositions of desloratadine - Google Patents
Stable pharmaceutical compositions of desloratadine Download PDFInfo
- Publication number
- WO2004080461A3 WO2004080461A3 PCT/US2004/007723 US2004007723W WO2004080461A3 WO 2004080461 A3 WO2004080461 A3 WO 2004080461A3 US 2004007723 W US2004007723 W US 2004007723W WO 2004080461 A3 WO2004080461 A3 WO 2004080461A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- desloratadine
- pharmaceutical compositions
- stable pharmaceutical
- stable
- pharmaceutical composition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Transplantation (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE602004004453T DE602004004453T2 (en) | 2003-03-12 | 2004-03-12 | STABLE PHARMACEUTICAL COMPOSITIONS WITH DESLORATADIN |
EP04720451A EP1507531B1 (en) | 2003-03-12 | 2004-03-12 | Stable pharmaceutical compositions of desloratadine |
PL04720451T PL1507531T3 (en) | 2003-03-12 | 2004-03-12 | Stable pharmaceutical compositions of desloratadine |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45429903P | 2003-03-12 | 2003-03-12 | |
US60/454,299 | 2003-03-12 | ||
US51535403P | 2003-10-28 | 2003-10-28 | |
US60/515,354 | 2003-10-28 | ||
US51690403P | 2003-11-03 | 2003-11-03 | |
US60/516,904 | 2003-11-03 | ||
US52633903P | 2003-12-01 | 2003-12-01 | |
US60/526,339 | 2003-12-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004080461A2 WO2004080461A2 (en) | 2004-09-23 |
WO2004080461A3 true WO2004080461A3 (en) | 2004-10-28 |
Family
ID=32996381
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2004/007553 WO2004108700A1 (en) | 2003-03-12 | 2004-03-12 | Processes for preparation of polymorphic forms of desloratadine |
PCT/US2004/007723 WO2004080461A2 (en) | 2003-03-12 | 2004-03-12 | Stable pharmaceutical compositions of desloratadine |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2004/007553 WO2004108700A1 (en) | 2003-03-12 | 2004-03-12 | Processes for preparation of polymorphic forms of desloratadine |
Country Status (8)
Country | Link |
---|---|
US (2) | US20040242619A1 (en) |
EP (2) | EP1507774A1 (en) |
AT (1) | ATE352305T1 (en) |
DE (1) | DE602004004453T2 (en) |
ES (2) | ES2232332T3 (en) |
PL (1) | PL1507531T3 (en) |
PT (1) | PT1507531E (en) |
WO (2) | WO2004108700A1 (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1507774A1 (en) * | 2003-03-12 | 2005-02-23 | Biogal Gyogyszergyar Rt. | Processes for preparation of polymorphic forms of desloratadine |
US20060135547A1 (en) * | 2003-03-12 | 2006-06-22 | Toth Zoltan G | Stable pharmaceutical compositions of desloratadine and processes for preparation of polymorphic forms of desloratadine |
EP1696881A2 (en) | 2003-12-23 | 2006-09-06 | Sun Pharmaceutical Industries Limited | Stable oral composition |
US20100129310A1 (en) * | 2004-08-09 | 2010-05-27 | Pavak Rajnikanth Mehta | Stabilized desloratadine composition |
EP1951703A2 (en) * | 2005-11-17 | 2008-08-06 | Teva Pharmaceutical Industries Ltd. | Desloratadine crystalline forms mixtures having a low level of residual solvents |
MX2008010707A (en) * | 2006-03-14 | 2009-01-27 | Merck & Co Inc | Processes and apparatuses for the production of crystalline organic microparticle compositions by micro-milling and crystallization on micro-seed and their use. |
EP1862462A1 (en) * | 2006-04-10 | 2007-12-05 | Ranbaxy Laboratories Limited | Process for the preparation of desloratadine |
EP1860105A1 (en) * | 2006-05-24 | 2007-11-28 | Ranbaxy Laboratories Limited | Process for the preparation of desloratadine |
RU2008151047A (en) * | 2006-06-07 | 2010-07-20 | Сандоз АГ (CH) | STABLE AND BIOAVAILABLE COMPOSITIONS AND A NEW FORM OF DESLORATADIN |
WO2008107777A2 (en) * | 2007-03-06 | 2008-09-12 | Cadila Pharmaceuticals Limited | Improved method for the preparation of desloratadine with reduced levels of organic solvents |
MA39033A1 (en) | 2013-11-15 | 2017-11-30 | Akebia Therapeutics Inc | Solid forms of {[5- (3-chlorophenyl) -3-hydroxypyridine-2-carbonyl] amino} acetic acid, compositions and uses thereof |
CN111093632A (en) * | 2017-06-15 | 2020-05-01 | 展旺生命科技股份有限公司 | Method for producing active ingredient particles |
CN113230235B (en) * | 2021-04-15 | 2022-11-11 | 海南普利制药股份有限公司 | Compound sustained-release capsule containing desloratadine and preparation method thereof |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4659716A (en) * | 1984-02-15 | 1987-04-21 | Schering Corporation | Antihistaminic 8-(halo)-substituted 6,11-dihydro-11-(4-piperidylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridines |
EP0270818A1 (en) * | 1986-10-31 | 1988-06-15 | Schering Corporation | Benzo(5,6)cycloheptapyridines, compositions and method of use |
WO1995010515A1 (en) * | 1993-10-15 | 1995-04-20 | Schering Corporation | Tricyclic carbamate compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
WO1999001450A1 (en) * | 1997-07-02 | 1999-01-14 | Schering Corporation | POLYMORPHS OF 8-CHLORO-6, 11-DIHYDRO-11- (4-PIPERIDYLIDENE) -5H-BENZO[5,6] CYCLOHEPTA[1,2-b]PYRIDINE |
US6506767B1 (en) * | 1997-07-02 | 2003-01-14 | Schering Corporation | 8-chloro-6,11-dihydro-11-(4-piperidylidine)-5H-benzo[5,6]cyclohepta[1-2-b] pyridine |
WO2003086275A2 (en) * | 2002-04-15 | 2003-10-23 | Sun Pharmaceutical Industries Limited | Preperation of desloratatine |
WO2004012738A1 (en) * | 2002-08-05 | 2004-02-12 | Sandoz Ag | Novel salt and polymorphs of desloratadine hemifumarate |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL132137C (en) * | 1963-04-24 | |||
US4282233B1 (en) * | 1980-06-19 | 2000-09-05 | Schering Corp | Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines |
ES2058061T3 (en) * | 1985-10-25 | 1994-11-01 | Beecham Group Plc | DERIVED FROM PIPERIDINE, ITS PREPARATION AND ITS USE AS A MEDICINAL PRODUCT. |
US4863931A (en) * | 1988-09-15 | 1989-09-05 | Schering Corporation | Antihistaminic fluoro substituted benzocycloheptapyridines |
US5178878A (en) * | 1989-10-02 | 1993-01-12 | Cima Labs, Inc. | Effervescent dosage form with microparticles |
US5556839A (en) * | 1991-04-29 | 1996-09-17 | Eli Lilly And Company | Form II Dirithromycin |
ES2042421B1 (en) * | 1992-05-22 | 1994-08-01 | Uriach & Cia Sa J | PROCEDURE FOR OBTAINING 8-CHLORINE-11- * 1 - * (5-METHYL-3-PIRIDIL) METHYL * -4-PIPERIDILIDEN * -6,11-DIHYDRO-5H-BENZO * 5,6 * CYCLOHEPTA * 1 , 2-B * PIRIDINE. |
US7211582B1 (en) * | 1994-12-30 | 2007-05-01 | Sepracor Inc. | Methods for treating urticaria using descarboethoxyloratadine |
US7214683B1 (en) * | 1994-12-30 | 2007-05-08 | Sepracor Inc. | Compositions of descarboethoxyloratadine |
EG23659A (en) * | 1995-03-24 | 2007-03-26 | Lilly Co Eli | Process and crystal forms of methyl-thieno-benzodiazepine |
US5607697A (en) * | 1995-06-07 | 1997-03-04 | Cima Labs, Incorporated | Taste masking microparticles for oral dosage forms |
PE71699A1 (en) * | 1997-02-07 | 1999-08-03 | Sepracor Inc | PHARMACEUTICAL COMPOSITION OF DECARBOETOXYLORATADINE WITHOUT LACTOSE, NON-HYGROSCOPIC AND ANHYDRA |
US6084100A (en) * | 1997-05-30 | 2000-07-04 | Medichem, S.A. | Process for the preparation of loratadine |
DE59801792D1 (en) * | 1997-08-08 | 2001-11-22 | Aventis Pharma Gmbh | Crystal form of N- (4-trifluoromethylphenyl) -5-methylisoxazole-4-carboxamide |
US6335347B1 (en) * | 1997-10-10 | 2002-01-01 | Schering Corporation | Ethyl 4-(8-chloro-5,6-dihydro-11 H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidene carboxylate polymorph |
US6132758A (en) * | 1998-06-01 | 2000-10-17 | Schering Corporation | Stabilized antihistamine syrup |
US6100274A (en) * | 1999-07-07 | 2000-08-08 | Schering Corporation | 8-chloro-6,11-dihydro-11- ](4-piperidylidine)-5H-benzo[5,6]cyclohepta[1,2-bpyridine oral compositions |
AU2276801A (en) * | 1999-12-20 | 2001-07-03 | Schering Corporation | Extended release oral dosage composition |
WO2001045668A2 (en) * | 1999-12-20 | 2001-06-28 | Schering Corporation | Stable extended release oral dosage composition comprising pseudoephedrine and desloratadine |
US7405223B2 (en) * | 2000-02-03 | 2008-07-29 | Schering Corporation | Treating allergic and inflammatory conditions |
EP1507774A1 (en) * | 2003-03-12 | 2005-02-23 | Biogal Gyogyszergyar Rt. | Processes for preparation of polymorphic forms of desloratadine |
US20060135547A1 (en) * | 2003-03-12 | 2006-06-22 | Toth Zoltan G | Stable pharmaceutical compositions of desloratadine and processes for preparation of polymorphic forms of desloratadine |
WO2005055983A2 (en) * | 2003-12-09 | 2005-06-23 | Medcrystalforms, Llc | Method of preparation of mixed phase co-crystals with active agents |
-
2004
- 2004-03-12 EP EP04720355A patent/EP1507774A1/en not_active Withdrawn
- 2004-03-12 DE DE602004004453T patent/DE602004004453T2/en not_active Revoked
- 2004-03-12 ES ES04720451T patent/ES2232332T3/en not_active Expired - Lifetime
- 2004-03-12 PL PL04720451T patent/PL1507531T3/en unknown
- 2004-03-12 EP EP04720451A patent/EP1507531B1/en not_active Revoked
- 2004-03-12 AT AT04720451T patent/ATE352305T1/en not_active IP Right Cessation
- 2004-03-12 WO PCT/US2004/007553 patent/WO2004108700A1/en active Application Filing
- 2004-03-12 US US10/800,290 patent/US20040242619A1/en not_active Abandoned
- 2004-03-12 WO PCT/US2004/007723 patent/WO2004080461A2/en active IP Right Grant
- 2004-03-12 US US10/800,291 patent/US20040229896A1/en not_active Abandoned
- 2004-03-12 ES ES04720355T patent/ES2232331T1/en active Pending
- 2004-03-12 PT PT04720451T patent/PT1507531E/en unknown
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4659716A (en) * | 1984-02-15 | 1987-04-21 | Schering Corporation | Antihistaminic 8-(halo)-substituted 6,11-dihydro-11-(4-piperidylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridines |
EP0270818A1 (en) * | 1986-10-31 | 1988-06-15 | Schering Corporation | Benzo(5,6)cycloheptapyridines, compositions and method of use |
WO1995010515A1 (en) * | 1993-10-15 | 1995-04-20 | Schering Corporation | Tricyclic carbamate compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
WO1999001450A1 (en) * | 1997-07-02 | 1999-01-14 | Schering Corporation | POLYMORPHS OF 8-CHLORO-6, 11-DIHYDRO-11- (4-PIPERIDYLIDENE) -5H-BENZO[5,6] CYCLOHEPTA[1,2-b]PYRIDINE |
US6506767B1 (en) * | 1997-07-02 | 2003-01-14 | Schering Corporation | 8-chloro-6,11-dihydro-11-(4-piperidylidine)-5H-benzo[5,6]cyclohepta[1-2-b] pyridine |
WO2003086275A2 (en) * | 2002-04-15 | 2003-10-23 | Sun Pharmaceutical Industries Limited | Preperation of desloratatine |
WO2004012738A1 (en) * | 2002-08-05 | 2004-02-12 | Sandoz Ag | Novel salt and polymorphs of desloratadine hemifumarate |
Also Published As
Publication number | Publication date |
---|---|
PL1507531T3 (en) | 2007-06-29 |
ES2232332T1 (en) | 2005-06-01 |
ATE352305T1 (en) | 2007-02-15 |
ES2232331T1 (en) | 2005-06-01 |
PT1507531E (en) | 2007-03-30 |
WO2004080461A2 (en) | 2004-09-23 |
EP1507531A2 (en) | 2005-02-23 |
US20040229896A1 (en) | 2004-11-18 |
WO2004108700A1 (en) | 2004-12-16 |
EP1507531B1 (en) | 2007-01-24 |
ES2232332T3 (en) | 2007-08-16 |
DE602004004453T2 (en) | 2007-11-08 |
US20040242619A1 (en) | 2004-12-02 |
EP1507774A1 (en) | 2005-02-23 |
DE602004004453D1 (en) | 2007-03-15 |
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