WO2004080461A3 - Stable pharmaceutical compositions of desloratadine - Google Patents

Stable pharmaceutical compositions of desloratadine Download PDF

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Publication number
WO2004080461A3
WO2004080461A3 PCT/US2004/007723 US2004007723W WO2004080461A3 WO 2004080461 A3 WO2004080461 A3 WO 2004080461A3 US 2004007723 W US2004007723 W US 2004007723W WO 2004080461 A3 WO2004080461 A3 WO 2004080461A3
Authority
WO
WIPO (PCT)
Prior art keywords
desloratadine
pharmaceutical compositions
stable pharmaceutical
stable
pharmaceutical composition
Prior art date
Application number
PCT/US2004/007723
Other languages
French (fr)
Other versions
WO2004080461A2 (en
Inventor
Zoltan G Toth
Viktor Gyollai
Adrienne Kovacsne-Mezei
Csaba Szabo
Judith Aronhime
Claude Singer
Original Assignee
Biogal Gyogyszergyar
Teva Pharma
Zoltan G Toth
Viktor Gyollai
Adrienne Kovacsne-Mezei
Csaba Szabo
Judith Aronhime
Claude Singer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32996381&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2004080461(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biogal Gyogyszergyar, Teva Pharma, Zoltan G Toth, Viktor Gyollai, Adrienne Kovacsne-Mezei, Csaba Szabo, Judith Aronhime, Claude Singer filed Critical Biogal Gyogyszergyar
Priority to DE602004004453T priority Critical patent/DE602004004453T2/en
Priority to EP04720451A priority patent/EP1507531B1/en
Priority to PL04720451T priority patent/PL1507531T3/en
Publication of WO2004080461A2 publication Critical patent/WO2004080461A2/en
Publication of WO2004080461A3 publication Critical patent/WO2004080461A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Provided is a stable pharmaceutical composition of desloratadine.
PCT/US2004/007723 2003-03-12 2004-03-12 Stable pharmaceutical compositions of desloratadine WO2004080461A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE602004004453T DE602004004453T2 (en) 2003-03-12 2004-03-12 STABLE PHARMACEUTICAL COMPOSITIONS WITH DESLORATADIN
EP04720451A EP1507531B1 (en) 2003-03-12 2004-03-12 Stable pharmaceutical compositions of desloratadine
PL04720451T PL1507531T3 (en) 2003-03-12 2004-03-12 Stable pharmaceutical compositions of desloratadine

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US45429903P 2003-03-12 2003-03-12
US60/454,299 2003-03-12
US51535403P 2003-10-28 2003-10-28
US60/515,354 2003-10-28
US51690403P 2003-11-03 2003-11-03
US60/516,904 2003-11-03
US52633903P 2003-12-01 2003-12-01
US60/526,339 2003-12-01

Publications (2)

Publication Number Publication Date
WO2004080461A2 WO2004080461A2 (en) 2004-09-23
WO2004080461A3 true WO2004080461A3 (en) 2004-10-28

Family

ID=32996381

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2004/007553 WO2004108700A1 (en) 2003-03-12 2004-03-12 Processes for preparation of polymorphic forms of desloratadine
PCT/US2004/007723 WO2004080461A2 (en) 2003-03-12 2004-03-12 Stable pharmaceutical compositions of desloratadine

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2004/007553 WO2004108700A1 (en) 2003-03-12 2004-03-12 Processes for preparation of polymorphic forms of desloratadine

Country Status (8)

Country Link
US (2) US20040242619A1 (en)
EP (2) EP1507774A1 (en)
AT (1) ATE352305T1 (en)
DE (1) DE602004004453T2 (en)
ES (2) ES2232332T3 (en)
PL (1) PL1507531T3 (en)
PT (1) PT1507531E (en)
WO (2) WO2004108700A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1507774A1 (en) * 2003-03-12 2005-02-23 Biogal Gyogyszergyar Rt. Processes for preparation of polymorphic forms of desloratadine
US20060135547A1 (en) * 2003-03-12 2006-06-22 Toth Zoltan G Stable pharmaceutical compositions of desloratadine and processes for preparation of polymorphic forms of desloratadine
EP1696881A2 (en) 2003-12-23 2006-09-06 Sun Pharmaceutical Industries Limited Stable oral composition
US20100129310A1 (en) * 2004-08-09 2010-05-27 Pavak Rajnikanth Mehta Stabilized desloratadine composition
EP1951703A2 (en) * 2005-11-17 2008-08-06 Teva Pharmaceutical Industries Ltd. Desloratadine crystalline forms mixtures having a low level of residual solvents
MX2008010707A (en) * 2006-03-14 2009-01-27 Merck & Co Inc Processes and apparatuses for the production of crystalline organic microparticle compositions by micro-milling and crystallization on micro-seed and their use.
EP1862462A1 (en) * 2006-04-10 2007-12-05 Ranbaxy Laboratories Limited Process for the preparation of desloratadine
EP1860105A1 (en) * 2006-05-24 2007-11-28 Ranbaxy Laboratories Limited Process for the preparation of desloratadine
RU2008151047A (en) * 2006-06-07 2010-07-20 Сандоз АГ (CH) STABLE AND BIOAVAILABLE COMPOSITIONS AND A NEW FORM OF DESLORATADIN
WO2008107777A2 (en) * 2007-03-06 2008-09-12 Cadila Pharmaceuticals Limited Improved method for the preparation of desloratadine with reduced levels of organic solvents
MA39033A1 (en) 2013-11-15 2017-11-30 Akebia Therapeutics Inc Solid forms of {[5- (3-chlorophenyl) -3-hydroxypyridine-2-carbonyl] amino} acetic acid, compositions and uses thereof
CN111093632A (en) * 2017-06-15 2020-05-01 展旺生命科技股份有限公司 Method for producing active ingredient particles
CN113230235B (en) * 2021-04-15 2022-11-11 海南普利制药股份有限公司 Compound sustained-release capsule containing desloratadine and preparation method thereof

Citations (7)

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US4659716A (en) * 1984-02-15 1987-04-21 Schering Corporation Antihistaminic 8-(halo)-substituted 6,11-dihydro-11-(4-piperidylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridines
EP0270818A1 (en) * 1986-10-31 1988-06-15 Schering Corporation Benzo(5,6)cycloheptapyridines, compositions and method of use
WO1995010515A1 (en) * 1993-10-15 1995-04-20 Schering Corporation Tricyclic carbamate compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
WO1999001450A1 (en) * 1997-07-02 1999-01-14 Schering Corporation POLYMORPHS OF 8-CHLORO-6, 11-DIHYDRO-11- (4-PIPERIDYLIDENE) -5H-BENZO[5,6] CYCLOHEPTA[1,2-b]PYRIDINE
US6506767B1 (en) * 1997-07-02 2003-01-14 Schering Corporation 8-chloro-6,11-dihydro-11-(4-piperidylidine)-5H-benzo[5,6]cyclohepta[1-2-b] pyridine
WO2003086275A2 (en) * 2002-04-15 2003-10-23 Sun Pharmaceutical Industries Limited Preperation of desloratatine
WO2004012738A1 (en) * 2002-08-05 2004-02-12 Sandoz Ag Novel salt and polymorphs of desloratadine hemifumarate

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NL132137C (en) * 1963-04-24
US4282233B1 (en) * 1980-06-19 2000-09-05 Schering Corp Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines
ES2058061T3 (en) * 1985-10-25 1994-11-01 Beecham Group Plc DERIVED FROM PIPERIDINE, ITS PREPARATION AND ITS USE AS A MEDICINAL PRODUCT.
US4863931A (en) * 1988-09-15 1989-09-05 Schering Corporation Antihistaminic fluoro substituted benzocycloheptapyridines
US5178878A (en) * 1989-10-02 1993-01-12 Cima Labs, Inc. Effervescent dosage form with microparticles
US5556839A (en) * 1991-04-29 1996-09-17 Eli Lilly And Company Form II Dirithromycin
ES2042421B1 (en) * 1992-05-22 1994-08-01 Uriach & Cia Sa J PROCEDURE FOR OBTAINING 8-CHLORINE-11- * 1 - * (5-METHYL-3-PIRIDIL) METHYL * -4-PIPERIDILIDEN * -6,11-DIHYDRO-5H-BENZO * 5,6 * CYCLOHEPTA * 1 , 2-B * PIRIDINE.
US7211582B1 (en) * 1994-12-30 2007-05-01 Sepracor Inc. Methods for treating urticaria using descarboethoxyloratadine
US7214683B1 (en) * 1994-12-30 2007-05-08 Sepracor Inc. Compositions of descarboethoxyloratadine
EG23659A (en) * 1995-03-24 2007-03-26 Lilly Co Eli Process and crystal forms of methyl-thieno-benzodiazepine
US5607697A (en) * 1995-06-07 1997-03-04 Cima Labs, Incorporated Taste masking microparticles for oral dosage forms
PE71699A1 (en) * 1997-02-07 1999-08-03 Sepracor Inc PHARMACEUTICAL COMPOSITION OF DECARBOETOXYLORATADINE WITHOUT LACTOSE, NON-HYGROSCOPIC AND ANHYDRA
US6084100A (en) * 1997-05-30 2000-07-04 Medichem, S.A. Process for the preparation of loratadine
DE59801792D1 (en) * 1997-08-08 2001-11-22 Aventis Pharma Gmbh Crystal form of N- (4-trifluoromethylphenyl) -5-methylisoxazole-4-carboxamide
US6335347B1 (en) * 1997-10-10 2002-01-01 Schering Corporation Ethyl 4-(8-chloro-5,6-dihydro-11 H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidene carboxylate polymorph
US6132758A (en) * 1998-06-01 2000-10-17 Schering Corporation Stabilized antihistamine syrup
US6100274A (en) * 1999-07-07 2000-08-08 Schering Corporation 8-chloro-6,11-dihydro-11- ](4-piperidylidine)-5H-benzo[5,6]cyclohepta[1,2-bpyridine oral compositions
AU2276801A (en) * 1999-12-20 2001-07-03 Schering Corporation Extended release oral dosage composition
WO2001045668A2 (en) * 1999-12-20 2001-06-28 Schering Corporation Stable extended release oral dosage composition comprising pseudoephedrine and desloratadine
US7405223B2 (en) * 2000-02-03 2008-07-29 Schering Corporation Treating allergic and inflammatory conditions
EP1507774A1 (en) * 2003-03-12 2005-02-23 Biogal Gyogyszergyar Rt. Processes for preparation of polymorphic forms of desloratadine
US20060135547A1 (en) * 2003-03-12 2006-06-22 Toth Zoltan G Stable pharmaceutical compositions of desloratadine and processes for preparation of polymorphic forms of desloratadine
WO2005055983A2 (en) * 2003-12-09 2005-06-23 Medcrystalforms, Llc Method of preparation of mixed phase co-crystals with active agents

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4659716A (en) * 1984-02-15 1987-04-21 Schering Corporation Antihistaminic 8-(halo)-substituted 6,11-dihydro-11-(4-piperidylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridines
EP0270818A1 (en) * 1986-10-31 1988-06-15 Schering Corporation Benzo(5,6)cycloheptapyridines, compositions and method of use
WO1995010515A1 (en) * 1993-10-15 1995-04-20 Schering Corporation Tricyclic carbamate compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
WO1999001450A1 (en) * 1997-07-02 1999-01-14 Schering Corporation POLYMORPHS OF 8-CHLORO-6, 11-DIHYDRO-11- (4-PIPERIDYLIDENE) -5H-BENZO[5,6] CYCLOHEPTA[1,2-b]PYRIDINE
US6506767B1 (en) * 1997-07-02 2003-01-14 Schering Corporation 8-chloro-6,11-dihydro-11-(4-piperidylidine)-5H-benzo[5,6]cyclohepta[1-2-b] pyridine
WO2003086275A2 (en) * 2002-04-15 2003-10-23 Sun Pharmaceutical Industries Limited Preperation of desloratatine
WO2004012738A1 (en) * 2002-08-05 2004-02-12 Sandoz Ag Novel salt and polymorphs of desloratadine hemifumarate

Also Published As

Publication number Publication date
PL1507531T3 (en) 2007-06-29
ES2232332T1 (en) 2005-06-01
ATE352305T1 (en) 2007-02-15
ES2232331T1 (en) 2005-06-01
PT1507531E (en) 2007-03-30
WO2004080461A2 (en) 2004-09-23
EP1507531A2 (en) 2005-02-23
US20040229896A1 (en) 2004-11-18
WO2004108700A1 (en) 2004-12-16
EP1507531B1 (en) 2007-01-24
ES2232332T3 (en) 2007-08-16
DE602004004453T2 (en) 2007-11-08
US20040242619A1 (en) 2004-12-02
EP1507774A1 (en) 2005-02-23
DE602004004453D1 (en) 2007-03-15

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