WO2004072094A3 - Domaine de liaison de modulateur de la proteine 1 de la famille b des hmg - Google Patents

Domaine de liaison de modulateur de la proteine 1 de la famille b des hmg Download PDF

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Publication number
WO2004072094A3
WO2004072094A3 PCT/IB2004/000986 IB2004000986W WO2004072094A3 WO 2004072094 A3 WO2004072094 A3 WO 2004072094A3 IB 2004000986 W IB2004000986 W IB 2004000986W WO 2004072094 A3 WO2004072094 A3 WO 2004072094A3
Authority
WO
WIPO (PCT)
Prior art keywords
binding domain
hmgb1
modulator binding
modulator
hmgb
Prior art date
Application number
PCT/IB2004/000986
Other languages
English (en)
Other versions
WO2004072094A2 (fr
Inventor
Marco E Bianchi
Giovanna Alessandra Musco
Original Assignee
San Raffaele Centro Fond
Fond Telethon
Marco E Bianchi
Giovanna Alessandra Musco
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by San Raffaele Centro Fond, Fond Telethon, Marco E Bianchi, Giovanna Alessandra Musco filed Critical San Raffaele Centro Fond
Priority to EP04710953A priority Critical patent/EP1592707A2/fr
Publication of WO2004072094A2 publication Critical patent/WO2004072094A2/fr
Publication of WO2004072094A3 publication Critical patent/WO2004072094A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens

Abstract

La présente invention a trait à un domaine de liaison de modulateur de la protéine 1 de la famille B des HMG présentant une structure essentiellement représentée par les sphères de remplissage d'espaces dans la Figure 4 ou la Figure 11.
PCT/IB2004/000986 2003-02-14 2004-02-13 Domaine de liaison de modulateur de la proteine 1 de la famille b des hmg WO2004072094A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP04710953A EP1592707A2 (fr) 2003-02-14 2004-02-13 Domaine de liaison de modulateur de la proteine 1 de la famille b des hmg

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44731603P 2003-02-14 2003-02-14
US60/447,316 2003-02-14

Publications (2)

Publication Number Publication Date
WO2004072094A2 WO2004072094A2 (fr) 2004-08-26
WO2004072094A3 true WO2004072094A3 (fr) 2005-05-19

Family

ID=32869622

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2004/000986 WO2004072094A2 (fr) 2003-02-14 2004-02-13 Domaine de liaison de modulateur de la proteine 1 de la famille b des hmg

Country Status (2)

Country Link
EP (1) EP1592707A2 (fr)
WO (1) WO2004072094A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2552944B1 (fr) 2010-03-29 2019-08-14 University Of Southern California Compositions et procédés d'élimination des biofilms
EP2613797B1 (fr) 2010-09-09 2015-11-04 University Of Southern California Compositions et procédés pour éliminer des biofilms
CN102552280A (zh) * 2011-09-09 2012-07-11 中国科学院生物物理研究所 甘草酸或盐及其衍生物的制药用途
US11274144B2 (en) 2013-06-13 2022-03-15 Research Institute At Nationwide Children's Hospital Compositions and methods for the removal of biofilms
US9745366B2 (en) 2013-09-23 2017-08-29 University Of Southern California Compositions and methods for the prevention of microbial infections
US11248040B2 (en) 2013-09-26 2022-02-15 Trellis Bioscience, Llc Binding moieties for biofilm remediation
US10233234B2 (en) 2014-01-13 2019-03-19 Trellis Bioscience, Llc Binding moieties for biofilm remediation
CA2993009A1 (fr) 2015-07-31 2017-02-09 Research Institute At Nationwide Children's Hospital Peptides et anticorps pour l'elimination de biofilms
US11746136B2 (en) 2017-03-15 2023-09-05 Research Institute At Nationwide Children's Hospital Composition and methods for disruption of bacterial biofilms without accompanying inflammation

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
HARDMAN COLIN H ET AL: "Structure of the A-domain of HMG1 and its interaction with DNA as studied by heteronuclear three- and four-dimensional NMR spectroscopy", BIOCHEMISTRY, vol. 34, no. 51, 1995, pages 16596 - 16607, XP002300628, ISSN: 0006-2960 *
OKANO MAIKO ET AL: "Biochemical characterization of cholesterol-3-sulfate as the sole effector for the phosphorylation of HMG1 by casein kinase I in vitro", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 281, no. 5, 16 March 2001 (2001-03-16), pages 1325 - 1330, XP002300630, ISSN: 0006-291X *
SAKAMOTO RYOKO ET AL: "Inhibitory effect of glycyrrhizin on the phosphorylation and DNA-binding abilities of high mobility group proteins 1 and 2 in vitro", BIOLOGICAL AND PHARMACEUTICAL BULLETIN, vol. 24, no. 8, August 2001 (2001-08-01), pages 906 - 911, XP002300629, ISSN: 0918-6158 *
THOMAS J O ET AL: "HMG1 and 2, and related 'architectural' DNA-binding proteins", TIBS TRENDS IN BIOCHEMICAL SCIENCES, ELSEVIER PUBLICATION, CAMBRIDGE, EN, vol. 26, no. 3, 1 March 2001 (2001-03-01), pages 167 - 174, XP004229458, ISSN: 0968-0004 *
YANG HUAN ET AL: "HMGB1 as a cytokine and therapeutic target", JOURNAL OF ENDOTOXIN RESEARCH, CHURCHILL LIVINGSTONE, EDINBURGH, GB, vol. 8, no. 6, 2002, pages 469 - 472, XP009020930, ISSN: 0968-0519 *

Also Published As

Publication number Publication date
EP1592707A2 (fr) 2005-11-09
WO2004072094A2 (fr) 2004-08-26

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