WO2004069998A3 - Oxindole derivatives as antimicrobial agents - Google Patents

Oxindole derivatives as antimicrobial agents Download PDF

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Publication number
WO2004069998A3
WO2004069998A3 PCT/GB2004/000426 GB2004000426W WO2004069998A3 WO 2004069998 A3 WO2004069998 A3 WO 2004069998A3 GB 2004000426 W GB2004000426 W GB 2004000426W WO 2004069998 A3 WO2004069998 A3 WO 2004069998A3
Authority
WO
WIPO (PCT)
Prior art keywords
antimicrobial agents
oxindole derivatives
oxindole
derivatives
biosynthesis
Prior art date
Application number
PCT/GB2004/000426
Other languages
French (fr)
Other versions
WO2004069998A2 (en
Inventor
Richard Angell
Karen Reynolds
James Lumley
Original Assignee
Arrow Therapeutics Ltd
Richard Angell
Karen Reynolds
James Lumley
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arrow Therapeutics Ltd, Richard Angell, Karen Reynolds, James Lumley filed Critical Arrow Therapeutics Ltd
Publication of WO2004069998A2 publication Critical patent/WO2004069998A2/en
Publication of WO2004069998A3 publication Critical patent/WO2004069998A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/36—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings
    • A01N43/38—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Use of an oxindole derivative of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in treating or preventing infection by an organism in which the biosynthesis of aromatic amino acids is effected via the shikimate pathway.
PCT/GB2004/000426 2003-02-03 2004-02-03 Oxindole derivatives as antimicrobial agents WO2004069998A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0302512.9 2003-02-03
GBGB0302512.9A GB0302512D0 (en) 2003-02-03 2003-02-03 Compounds

Publications (2)

Publication Number Publication Date
WO2004069998A2 WO2004069998A2 (en) 2004-08-19
WO2004069998A3 true WO2004069998A3 (en) 2004-11-18

Family

ID=9952387

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2004/000426 WO2004069998A2 (en) 2003-02-03 2004-02-03 Oxindole derivatives as antimicrobial agents

Country Status (2)

Country Link
GB (1) GB0302512D0 (en)
WO (1) WO2004069998A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0504998D0 (en) * 2005-03-11 2005-04-20 Univ Strathclyde Antimicrobial compounds
CN110204538B (en) * 2019-06-04 2022-02-08 烟台大学 Aryl thiazole-tryptamine ocean red tide algae algicide and preparation method and application thereof
KR102214988B1 (en) * 2019-06-20 2021-02-10 영남대학교 산학협력단 Novel oxindole derivatives and anti-bacterial composition comprising the same as an active ingredient

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1504037A (en) * 1966-10-21 1967-12-01 Chimetron Sarl Sulfenylindolinones
JPS6239564A (en) * 1985-08-13 1987-02-20 Kanegafuchi Chem Ind Co Ltd Alpha-benzylidene-gamma-butyrolactone or gamma-butyrolactam derivative
EP0304493A1 (en) * 1987-03-11 1989-03-01 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Hydroxystyrene derivatives
EP0549892A1 (en) * 1991-12-31 1993-07-07 American Cyanamid Company Substituted indolinones useful as herbicidal agents
WO1998007695A1 (en) * 1996-08-23 1998-02-26 Sugen, Inc. Indolinone combinatorial libraries and related products and methods for the treatment of disease
WO1998050356A1 (en) * 1997-05-07 1998-11-12 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity
WO2001040188A1 (en) * 1999-12-03 2001-06-07 Emory University Curcumin analogues for treating cancer
US20020091107A1 (en) * 2000-09-08 2002-07-11 Madar David J. Oxazolidinone antibacterial agents
CN1115640C (en) * 1998-11-02 2003-07-23 无敌科技(西安)有限公司 Data processing method of bilanguage electron dictionary

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1504037A (en) * 1966-10-21 1967-12-01 Chimetron Sarl Sulfenylindolinones
JPS6239564A (en) * 1985-08-13 1987-02-20 Kanegafuchi Chem Ind Co Ltd Alpha-benzylidene-gamma-butyrolactone or gamma-butyrolactam derivative
EP0304493A1 (en) * 1987-03-11 1989-03-01 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Hydroxystyrene derivatives
EP0549892A1 (en) * 1991-12-31 1993-07-07 American Cyanamid Company Substituted indolinones useful as herbicidal agents
WO1998007695A1 (en) * 1996-08-23 1998-02-26 Sugen, Inc. Indolinone combinatorial libraries and related products and methods for the treatment of disease
WO1998050356A1 (en) * 1997-05-07 1998-11-12 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity
CN1115640C (en) * 1998-11-02 2003-07-23 无敌科技(西安)有限公司 Data processing method of bilanguage electron dictionary
WO2001040188A1 (en) * 1999-12-03 2001-06-07 Emory University Curcumin analogues for treating cancer
US20020091107A1 (en) * 2000-09-08 2002-07-11 Madar David J. Oxazolidinone antibacterial agents

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; RASHBA, O. YA.: "Certain components of arenarin and their antibacterial action", XP002282430, retrieved from STN Database accession no. 1964:457422 *
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; SHIRAISHI, TADAYOSHI ET AL: "L-Benzylidene-.gamma.-butyrolactone or .gamma.-butyrolactam derivatives", XP002282428, retrieved from STN Database accession no. 1987:496584 *
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; YANG, CHUNZHENG ET AL: "Application of 3-substituted aryl oxidized indole compounds", XP002282429, retrieved from STN Database accession no. 1999:317549 *
LANZI C ET AL: "Inhibition of transforming activity of the ret/ptc1 oncoprotein by a 2-indolinone derivative", INTERNATIONAL JOURNAL OF CANCER, NEW YORK, NY, US, vol. 85, no. 3, 1 February 2000 (2000-02-01), pages 384 - 390, XP002224100, ISSN: 0020-7136 *
MIKROBIOL. ZH., AKAD. NAUK UKR. RSR , 26(2), 26-31, 1964 *
SUN ET AL: "Synthesis and Biological Evaluation of 3-Substituted Indolin-2-ones : A novel Class of Tyrosine Kinase Inhibitors That Exhibit Selectivity toward Particualr Receptor Tyrosine Kinases", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 41, no. 14, July 1998 (1998-07-01), pages 2588 - 2603, XP002122185, ISSN: 0022-2623 *

Also Published As

Publication number Publication date
GB0302512D0 (en) 2003-03-05
WO2004069998A2 (en) 2004-08-19

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