WO2004069918A3 - Crystalline, high-compliance glycolide copolymers and applications thereof - Google Patents

Crystalline, high-compliance glycolide copolymers and applications thereof Download PDF

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Publication number
WO2004069918A3
WO2004069918A3 PCT/US2004/002914 US2004002914W WO2004069918A3 WO 2004069918 A3 WO2004069918 A3 WO 2004069918A3 US 2004002914 W US2004002914 W US 2004002914W WO 2004069918 A3 WO2004069918 A3 WO 2004069918A3
Authority
WO
WIPO (PCT)
Prior art keywords
compliance
crystalline
applications
glycolide
glycolide copolymers
Prior art date
Application number
PCT/US2004/002914
Other languages
French (fr)
Other versions
WO2004069918A2 (en
Inventor
Shalaby W Shalaby
Original Assignee
Poly Med Inc
Shalaby W Shalaby
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Poly Med Inc, Shalaby W Shalaby filed Critical Poly Med Inc
Publication of WO2004069918A2 publication Critical patent/WO2004069918A2/en
Publication of WO2004069918A3 publication Critical patent/WO2004069918A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/06—At least partially resorbable materials
    • A61L17/10—At least partially resorbable materials containing macromolecular materials
    • A61L17/12—Homopolymers or copolymers of glycolic acid or lactic acid
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/60—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from the reaction of a mixture of hydroxy carboxylic acids, polycarboxylic acids and polyhydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/91—Polymers modified by chemical after-treatment
    • C08G63/914—Polymers modified by chemical after-treatment derived from polycarboxylic acids and polyhydroxy compounds
    • C08G63/916—Dicarboxylic acids and dihydroxy compounds
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F6/00—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof
    • D01F6/58—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolycondensation products
    • D01F6/62—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolycondensation products from polyesters
    • D01F6/625—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolycondensation products from polyesters derived from hydroxy-carboxylic acids, e.g. lactones
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2261/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G2261/10—Definition of the polymer structure
    • C08G2261/12—Copolymers
    • C08G2261/126—Copolymers block
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2913—Rod, strand, filament or fiber
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31786—Of polyester [e.g., alkyd, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Materials Engineering (AREA)
  • Textile Engineering (AREA)
  • Materials For Medical Uses (AREA)
  • Polyesters Or Polycarbonates (AREA)

Abstract

The present invention is directed toward an absorbable crystalline segmented copolymer comprising a polyalkylene succinate segment end-grafted in a single-step with a mixture of monomers comprising caprolactone, 1-lactide, and/or glycolide. The present invention is also directed toward an absorbable crystalline segmented copolymer arising from a trihydroxy compound that is reacted in a single-step with a mixture of monomer comprising ∈-caprolactone, 1-lactide, and/or glycolide to produce monocentric polyaxial polymers.
PCT/US2004/002914 2003-01-31 2004-02-02 Crystalline, high-compliance glycolide copolymers and applications thereof WO2004069918A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US44402703P 2003-01-31 2003-01-31
US60/444,027 2003-01-31
US10/767,975 2004-01-29
US10/767,975 US7435789B2 (en) 2003-01-31 2004-01-29 Crystalline high-compliance glycolide copolymers and applications thereof

Publications (2)

Publication Number Publication Date
WO2004069918A2 WO2004069918A2 (en) 2004-08-19
WO2004069918A3 true WO2004069918A3 (en) 2006-01-12

Family

ID=32853351

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/002914 WO2004069918A2 (en) 2003-01-31 2004-02-02 Crystalline, high-compliance glycolide copolymers and applications thereof

Country Status (2)

Country Link
US (1) US7435789B2 (en)
WO (1) WO2004069918A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020161168A1 (en) * 2000-10-27 2002-10-31 Shalaby Shalaby W. Amorphous polymeric polyaxial initiators and compliant crystalline copolymers therefrom
US8927001B2 (en) * 2005-06-15 2015-01-06 Poly-Med, Inc. Bioswellable, crystalline, amphiphilic, block/graft polymers and applications thereof
US8784861B2 (en) 2005-06-15 2014-07-22 Poly-Med, Inc. Swellable fiber- and microfiber-forming polyether-esters and applications thereof
US8865205B2 (en) * 2005-06-15 2014-10-21 Poly-Med, Inc. Bioswellable sutures
EP3009477B1 (en) 2006-07-20 2024-01-24 Orbusneich Medical Pte. Ltd Bioabsorbable polymeric composition for a medical device
US7959942B2 (en) 2006-10-20 2011-06-14 Orbusneich Medical, Inc. Bioabsorbable medical device with coating
US8691321B2 (en) 2006-10-20 2014-04-08 Orbusneich Medical, Inc. Bioabsorbable polymeric composition and medical device background
US8278409B2 (en) 2008-04-22 2012-10-02 Ethicon, Inc. Copolymers of epsilon-caprolactone and glycolide for melt blown nonwoven applications
US8501875B2 (en) * 2010-10-28 2013-08-06 Covidien Lp Surface induced ring-opening polymerization and medical devices formed therefrom
US20130236499A1 (en) * 2012-03-12 2013-09-12 Sasa Andjelic Segmented, Semicrystalline Poly(Lactide-co-epsilon-Caprolactone) Absorbable Copolymers
US9896560B2 (en) 2015-06-02 2018-02-20 Ethicon, Inc. Lyophilized foams of end block containing absorbable polymers

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6255408B1 (en) * 1998-11-06 2001-07-03 Poly-Med, Inc. Copolyesters with minimized hydrolytic instability and crystalline absorbable copolymers thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4700704A (en) 1982-10-01 1987-10-20 Ethicon, Inc. Surgical articles of copolymers of glycolide and ε-caprolactone and methods of producing the same
US4605730A (en) 1982-10-01 1986-08-12 Ethicon, Inc. Surgical articles of copolymers of glycolide and ε-caprolactone and methods of producing the same
US5133739A (en) 1990-02-06 1992-07-28 Ethicon, Inc. Segmented copolymers of ε-caprolactone and glycolide
US6494898B1 (en) 1998-02-25 2002-12-17 United States Surgical Corporation Absorbable copolymers and surgical articles fabricated therefrom
US6498229B1 (en) * 2001-09-05 2002-12-24 Poly-Med, Inc. Direct synthesis of segmented glycolide copolymers and crystalline materials therefrom
US6861503B2 (en) * 2002-02-27 2005-03-01 Poly-Med, Inc. Interlinked solid polyethylene glycols and copolymers thereof
US7348364B2 (en) * 2002-10-31 2008-03-25 Poly-Med, Inc. Segmented copolyesters as compliant, absorbable coatings and sealants for vascular devices
US7138464B2 (en) * 2002-10-31 2006-11-21 Poly Med, Inc Functionalized, absorbable, segmented copolyesters and related copolymers
US20050208096A1 (en) * 2004-03-17 2005-09-22 Shalaby Shalaby W Color-fast radiation sterilized implants and precursors thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6255408B1 (en) * 1998-11-06 2001-07-03 Poly-Med, Inc. Copolyesters with minimized hydrolytic instability and crystalline absorbable copolymers thereof
US6503991B2 (en) * 1998-11-06 2003-01-07 Poly-Med, Inc. Copolyesters with minimized hydrolytic instability and crystalline absorbable copolymers thereof

Also Published As

Publication number Publication date
US20050171299A1 (en) 2005-08-04
US7435789B2 (en) 2008-10-14
WO2004069918A2 (en) 2004-08-19

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